100results about How to "Enhanced osteogenic properties" patented technology

A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.

The invention discloses a method for preparing alpha-calcium sulfate hemihydrates (alpha-CSH) /beta-tertiary calcium phosphate (beta-TCP) porous granular-type composite artificial bones, which is characterized in that the alpha-CSH is directly synthesized on the surface and/or in the pores of the beta-TCP granules synchronously by the hydrothermal synthesis process and finally the alpha-CSH/beta-TCP porous granular-type artificial bones is prepared. The invention has the advantages that the preparation process is simpler, the preparation period can be effectively reduced, and the preparation efficiency is improved; the proportion between alpha-CSH and beta-TCP phases of the granular-type composite artificial bones can be effectively controlled, thereby controlling the pore structure of the artificial bone granules; meanwhile, the invention guarantees the in-situ solidifying performance and degrading performance of the composite artificial bones, controls the evenness of the product and the porosity and pore diameter of the beta-TCP granules, improves the bone-formation performance and degrading performance of the composite artificial bones and further improves the quality of the product, thereby finally obtaining the composite artificial bones having self-solidifying performance and controllable degradation and having a certain biomechanical strength. The invention has good application and market prospect.

The invention provides a photothermal bone repair material. The photothermal bone repair material consists of a synthetic polymer and metal/metal oxide particles, wherein the metal/metal oxide particles are selected from one of magnesium metal particles, aluminum metal nanometer particles, aluminum oxide nanometer particles, ferrum metal particles, ferric oxide nanometer particles and ferroferricoxide nanometer particles. The photothermal bone repair material provided by the invention has photothermal properties of high light absorption efficiency and high photothermal conversion efficiency,after the photothermal bone repair material is implanted into an tumor nidus excision postoperative position, postoperative osteanagenesis can be promoted, besides, peripheral tumor tissue and potential small niduses are subjected to radical cure, and effects of osteogenesis and treatment are achieved.

The present invention relates to a preparation method and uses of a composite hydrogel containing hydroxyapatite (HAP) nanoparticles, wherein an inorganic component in the composite hydrogel is HAP nanoparticles prepared in an in situ manner, an organic matrix in the composite hydrogel is an overoxidation micelle (pMIC) polyacrylamide gel prepared by using a pre-irradiation method, an overoxidation linear polymer chain polyacrylamide gel or a polyvinyl alcohol gel, and a mass ratio of the HAP to the polymer in the composite hydrogen is 1:5-1:3. According to the present invention, a freezing-defrosting circulation method is adopted to treat a gel, and an electrophoresis method is adopted to generate HAP nanoparticles inside the gel in an in situ manner, such that the HAP nanoparticles are uniformly dispersed in the gel, and HAP having a hollow sphere structure is obtained so as to enhance mechanical property and improve biological activity, such that potential application values in articular cartilage repair and tissue engineering materials are provided.

The invention discloses a preparation method of a microcarrier used for cell three dimensional multiplication culture, and belongs to the field of tissue engineering material. According to the preparation method, Poly-L-lactic acid (PLLA) is taken as a matrix, gelatin is taken as a dispersant, and composite microspheres are prepared; the particle size of the composite microspheres is adjusted viacontrolling the concentration of a PLLA dichloromethane solution, the mass ratio of nano-hydroxyapatite (nHAp) to PLLA, and the using amount of gelatin; the PLLA is taken as the matrix to ensure the mechanical strength and biological degradability of a support; composite nHAp is capable of improving the osteo inductivity and the conductivity of the support, and at the same time, assisting PLLA toimprove cell osteogenic capability, and avoiding damage of cells under an overly acidic environment; the existing of nHAp is capable of forming a large amount of small pores on the surfaces of the PLLA microspheres, the existing of the small pores is capable of improving the mass transfer capability of the support, and providing cells with more abundant attachment sites. The microcarrier possessesexcellent biological performance on osteoblasts, and is suitable to be used in the field of bone tissue engineering.

The invention discloses a PEEK false tooth composite. The PEEK false tooth composite is prepared from, by weight, 110-150 parts of polyether-ether-ketone, 10-20 parts of nano calcium silicate, 8-12 parts of hydroxyl hydroxyapatites, 4-8 parts of barium glass short fibers, 15-22 parts of organic solvent, 8-18 parts of refined paraffin, 1-4 parts of co-binding agent, 8-12 parts of binder, 2-6 parts of antibacterial agent, 6-10 parts of carbide and/or 8-15 parts of oxide. The invention further discloses a preparation method of the PEEK false tooth composite. The preparation method includes the steps that firstly, the raw materials of nano calcium silicate, hydroxyl hydroxyapatites, carbide and/or oxide are mixed, the mixture is heated to 150-220 DEG C, the situation is kept for 10-30 min, cooling is carried out, the refined paraffin is added, mixing and stirring are carried out, and after the mixture is crushed ultrasonically, the organic solvent, polyether-ether-ketone, the co-binding agent, the binder and the antibacterial agent are added to be stirred till uniform paste is obtained; finally the barium glass short fibers are added, ball-milling and drying are carried out, and the finished composite powder is obtained.

The invention relates to the technical field of surgical implants, and provides double-photoresponse type zinc oxide, a preparation method thereof, and a photosensitive coating with antibacterial osteogenesis. In the preparation process of zinc oxide, sodium citrate and hydroxypropyl methyl cellulose are added to control the morphology, a photothermal conversion material is added to enable zinc oxide to have photothermal conversion capacity, and lignin is added to reduce the energy band gap of zinc oxide; and the freeze-dried hydrothermal product is carbonized through microwave irradiation, and the energy band gap is further reduced, so that the material has response capability to yellow light. The zinc oxide prepared by the invention is of a tremella-shaped wrinkle structure, has dual response to yellow light and near-infrared light, has good adsorbability, antibacterial property and photo-thermal stability, and has photo-thermal conversion capability. The zinc oxide has antibacterialproperty and osteogenesis property, can effectively improve the antibacterial and osteogenesis capacity of the implant when being applied to the surface of the implant, and can realize the light-operated effect and on-demand effect of the antibacterial and osteogenesis functions of the implant due to the special photosensitivity of the coating.

The invention discloses a composite material for processing a micro-type bone retention pin and a preparation method of the composite material. The composite material is obtained by the following steps: adding a biologically-active inorganic material and a zeolitic imidazolate structural material ZIF-8 into a solution of a binding material with biological activity, performing stirring at pH of 8-10 and room temperature to make the ZIF-8 coat the biologically-active inorganic material by the binding material with biological activity during polymerization, adding a bone scaffold substrate material, performing uniform dispersion in a high-speed mixing machine, and performing banburying mixing granulation to obtain the composite material. The composite material provided by the invention contains the bone scaffold substrate material, the biologically-active inorganic material and the zeolitic imidazolate structural material ZIF-8, so that the substrate of the bone scaffold substrate material can be strengthened, the early degradation of the material can be delayed, the osteogenesis ability of a body guided by the material and the biocompatibility can be improved, and the inducibility and antibacterial property are given to the bone scaffold substrate material; and the preparation method is simple, has low costs, and is convenient for promotion and application.

The invention provides a method for improving the osteogenesis ability of mesenchymal stem cells, which comprises the following steps: inoculating the mesenchymal stem cells into an alpha-MEM culturemedium containing 10% of fetal calf serum, culturing, digesting and subculturing by 0.2% of pancreatin when the fusion degree of the mesenchymal stem cells is 80-85%, inoculating the obtained mesenchymal stem cells into an alpha-MEM culture medium containing 10% of fetal calf serum for culture, and adding osteogenesis induction liquid and a metformin aqueous solution for induction when the densityof the mesenchymal stem cells is greater than 90% for induction for 14-21 days. The metformin acts on the mesenchymal stem cells, alizarin red staining results show that the metformin can significantly improve the calcium mineralization nodule degree of the cells, and it is indicated that the metformin has a significant induction effect on mesenchymal stem cell osteogenic differentiation, the metformin can significantly improve the expression of the mesenchymal stem cell osteogenic differentiation related genes SIRT1, ALP, COL1A1, RUNX2 and BGLAP, and the improvement of the osteogenic differentiation capacity of the mesenchymal stem cells is of great significance to stem cell transplantation and bone biology research.

The invention relates to functionalized graphene modified porous polyether-ether-ketone (PEEK) and a preparation method thereof. The porous PEEK is subjected to surface modification through the graphene oxide, so that the biological inertness of the PEEK is enhanced, and the bone conductivity and the antibacterial activity are improved. The method mainly comprises the following three steps: (1) preparing porous PEEK with soluble salt or soluble acid salt as filling particles; (2) preparing high-dispersion graphene oxide with controllable concentration throguh cross-flow membrane filtration; and (3) assembling the functionalized graphene on the porous PEEK. Through implantation of graphene oxide, a large number of active sites can be provided; the interaction with protein is improved through hydrophobic and electrostatic effects, so that the osteogenesis difference of cells is favorably enhanced.

The invention relates to an application of mangiferin in preparing a drug for promoting bone defect repair and solves the problems that a host micro-environment in a conventional bone repair mode is short of blood supply, apoptosis of seed cells in an anaerobic environment is easily caused, the ossifying effect is poor and the like. By means of a policy of combining mangiferin with an endochondral ossification system for bone repair as the mangiferin not only plays a protecting role, but also promotes the osteogenic capability of seed cells, mesenchymal stem cells are planted on a porous bone scaffold material to construct a tissue engineering composite, then chondrogenic differentiation inductive culture is performed in vitro for two weeks, and the composite is implanted into a defect region to repair after hypertrophic chondrogenic differentiation inductive culture is performed for two weeks; the mangiferin can be loaded on the porous bone scaffold material and can be integrally systematically administrated; an in vivo research result shows that the repair method provided by the invention can repair bone defects successfully, and has a good application prospect in tissue engineering bone construction and bone defect repair.

The invention discloses a bone repair material able to guide bone tissue regeneration. The material is a composition of calcined bone powder with different particle sizes and a bioabsorbable high polymer material. The bone repair material is characterized in that: the particle sizes of the calcined bone powder range from 0.1-2mm; and the bioabsorbable high polymer material is one or more of collagen, chitin, chitosan, hyaluronic acid, chondroitin sulfate, calcium alginate, fibrous protein, and elastin. The bone repair material provided in the invention has an obvious bone healing guiding effect and good biocompatibility. Also with certain hardness and strength, the bone repair material is easy to shape and has rich sources, thus solving the making problems of artificial synthetic materials in the aspects of porosity, pore traffic and pore size, etc.

The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time.

A reaming product taking device through a negative pressure extractor pipeline adopts the negative pressure extractor pipeline. The front end of the negative pressure extractor pipeline is a sucker, and the tail is communicated with a negative pressure drainage bottle. The device is characterized in that the negative extractor pipeline is provided with a reaming product cut-off device in series. The invention can realize the recovery of the reaming product passing through the negative pressure extractor pipeline, and the reaming product can be used effectively in the internal fixation with nail in marrow, thus healing the fracture.

The invention discloses a method for preparing a multifunctional sodium alginate stent embedded with drug-loaded microspheres by using a 3D printing technology based on in-situ emulsification, and aims to provide a preparation method of a multifunctional bone defect repair stent material. The method is characterized by comprising the following steps: by taking a bioactive substance lecithin as an emulsifier, dispersing an amination modified polylactic acid solution dissolved with an antibacterial or anti-inflammatory drug into a sodium alginate solution to form a stable emulsion, then constructing the sodium alginate stent embedded with the drug-loaded microspheres in situ by utilizing a low-temperature 3D printing technology, and using divalent strontium ions (Sr<2+>) as a cross-linking agent to improve the mechanical properties and osteogenic activity of the stent. The method has the characteristics that the prepared tent can be individually designed according to the characteristics of the bone defect part of a patient, and the prepared stent has multiple functions of good biological activity, osteogenic ability, mechanical property, antisepsis, anti-inflammation and the like, and has potential application prospects in the field of bone tissue engineering.