7results about How to "Enhanced osteogenic properties" patented technology

The invention belongs to the technical field of medical materials, and particularly provides a 3D printing bone repair material and a preparation method thereof.The 3D printing bone repair material is prepared from PCL / MnO2 composite microspheres and SiN, PCL has good biocompatibility and biodegradability, the mechanical performance and bone induction performance of the 3D printing bone repair material are enhanced due to addition of SiN, and the 3D printing bone repair material has a good application prospect. MnO2 can release oxygen and manganese ions, and the manganese ions can promote calcium deposition, jointly promote cell infiltration, osteogenic differentiation and matrix mineralization, promote bone precursor cell proliferation, accelerate bone defect repair and promote bone regeneration, so that the bone regeneration rate is increased, and the bone regeneration rate is increased. The prepared 3D printing bone repair material has good mechanical performance, biocompatibility, antibacterial property and biodegradability, cell proliferation is promoted, and bone repair and bone regeneration are accelerated.

The invention belongs to the technical field of biomedical metal, and particularly relates to a preparation method of a hydroxyapatite-doped zinc-copper powder metallurgy degradable bone implant material, which comprises the following steps: firstly putting steel wool into a cold pressing mold, then filling alloy powder doped with hydroxyapatite powder into the periphery of the steel wool, and carrying out cold pressing on the alloy powder; then a green body is obtained through vibration and compression molding, the green body is sintered to obtain a powder metallurgy part, the powder metallurgy part is subjected to heat preservation and then subjected to hot extrusion molding, then a round rod is cut into a square rod, preheating and hot rolling are conducted, and finally a hot-rolled plate sample or a hot-rolled foil sample is obtained after air cooling; a matrix material can be strengthened and toughened by adopting heterogeneous material fiber reinforcement, galvanic corrosion can be caused by the difference between standard electrode potentials of the two materials, in-vivo and in-vitro degradation of the zinc-based bone implant material is accelerated, and based on the osteogenesis performance improvement requirement, the osteogenesis performance of the implant material can be remarkably improved by additionally adding osteogenesis particles such as hydroxyapatite.

The present application relates to the field of medical materials, in particular to a preparation method of high-performance medical tantalum coating. A thin-size-low-diffusion tantalum coating is prepared on the surface of a porous titanium alloy substrate by a chemical vapor deposition method through a halide reaction of hydrogen reduction of metallic tantalum; there is an alloy element interdiffusion zone between the tantalum coating and the porous titanium alloy substrate, and the thickness of the interdiffusion zone is less than the thickness of the tantalum coating. The present application obtains a high-performance thin-size tantalum coating with high purity, small grain size and controllable transition layer suitable for the porous titanium alloy substrate, has higher preparation efficiency and lower cost, realizes high bonding strength of the coating and simultaneous improvement of the strength and plasticity of the porous titanium alloy, avoids dissolution of toxic metal ions such as Al and V, and improves biocompatibility and osteogenic performance. The new tantalum coating porous titanium alloy implant device has obvious advantages of higher mechanical, chemical and biological safety and lower cost, and is suitable for the fields of orthopedics, dental implants and tissue defect fillers.

This invention provides a biocompatible β This invention relates to a method for composite modification of titanium alloy surfaces, belonging to the technical field of alloy modification methods. The invention includes applications in medical... β This invention involves introducing bioactive particles onto the surface of a titanium alloy substrate, performing friction stir processing (FSP) on the substrate to introduce bioactive particles and construct a gradient grain structure, and then subjecting the FSP-treated substrate to compressed plasma flow (CPF) treatment to achieve uniform distribution of bioactive particles and construct a topology with an average surface roughness of 3-6 μm suitable for cell growth. The invention precisely controls the amount of bioactive particles introduced and constructs a gradient grain structure through friction stir processing (FSP); simultaneously, compressed plasma flow (CPF) technology achieves uniform distribution of bioactive particles and an ideal surface roughness of 3-6 μm on the titanium alloy surface. Ultimately, this significantly improves the cell adhesion, proliferation capacity, and osteogenic properties of the material surface, solving the technical problem of low integration efficiency of traditional titanium alloy implants with human bone tissue.

The invention discloses a preparation method of CIMNP / Aln-coated Alg composite hydrogel, which comprises the following steps: adding water into cuttlefish ink sacs, kneading and stirring until the cuttlefish ink sacs are dissolved, and filtering to obtain a suspension; centrifuging the obtained suspension, taking supernate, continuously centrifuging, adding water into precipitate, uniformly stirring and mixing, performing ultrasonic treatment, repeatedly centrifuging for three times to obtain precipitate, dissolving the precipitate in sucrose water, and freeze-drying to obtain cuttlefish ink nano-particles CIMNP; the preparation method comprises the following steps: adding cuttlefish ink nanoparticles into a sodium alginate solution to obtain a CIMNP-coated Alg solution, dissolving alendronate sodium into a calcium gluconate solution, adding into the CIMNP-coated Alg solution, and stirring to obtain the CIMNP / Aln-coated Alg composite hydrogel. The hydrogel prepared by the invention has good mechanical properties (such as compression modulus, storage modulus and the like), and can better adapt to the mechanical environment of bone defect parts. And a stable support and mechanical environment can be provided at a bone defect part, so that the graft can be prevented from shifting or collapsing, and the smooth proceeding of a bone regeneration process is ensured.

The present invention relates to a built-in electromagnetic remote control jaw bone distraction osteogenesis distraction device, comprising a distractor and an electromagnetic remote controller; the distractor comprises an outer sleeve with a slide rail inside, an inner adjustment rod, and nail holes are provided on the outer sleeve and the inner adjustment rod; the inner adjustment rod is slidably connected in the slide rail of the outer sleeve, an automatic driving device is fixed at the rear end inside the outer sleeve, and a plurality of slots distributed side by side are evenly provided on the inner adjustment rod; a magnetic key corresponding to the slot of the inner adjustment rod is provided on the outer sleeve through an elastic sheet, and the magnetic key can be telescopically passed through the telescopic hole on the side wall of the outer sleeve and placed in the slide rail; the electromagnetic remote controller comprises an electromagnetic coil that can be magnetically attracted to the magnetic key, a single chip microcomputer connected in series with the electromagnetic coil, and a power supply. The distractor of the present invention is built-in, reducing the probability of infection; the electromagnetic remote controller can control the distraction process of the inner distractor through the electromagnetic principle and accurately control the distraction length.

The invention belongs to the field of bone regeneration materials, and particularly relates to a nanoparticle-modified oxygen-producing hydrogel microsphere, a preparation method and application of the nanoparticle-modified oxygen-producing hydrogel microsphere in preparation of a bone regeneration material. According to the oxygen-producing hydrogel microsphere, CaO2 serves as a core and serves as an oxygen storage cavern, SiO2 and PDA are sequentially coated, CaO2 coated SiO2 coated PDA (CSP) nanoparticles are effectively integrated with a porous GelMA microsphere (GM) through amido bonds, and therefore the oxygen-producing hydrogel microsphere is endowed with the characteristic of continuously and slowly releasing oxygen and good ROS removing capacity.