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Photothermal bone repair material for treating osteosarcoma and application of photothermal bone repair material

A technology for bone repair and osteosarcoma, applied to wave energy or particle radiation treatment materials, antineoplastic drugs, medical preparations containing active ingredients, etc., can solve the problem of increased tumor recurrence and secondary metastasis, and the inability to completely remove border tumor tissue Minimize lesions and other problems, achieve the effect of inhibiting bone resorption, high mineralization attachment rate, and improving osteogenesis

Active Publication Date: 2019-10-08
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a photothermal bone repair material for the treatment of osteosarcoma, which aims to solve the problem of increased tumor recurrence and secondary metastasis due to the inability to completely remove border tumor tissue and potential tiny lesions in surgical treatment

Method used

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  • Photothermal bone repair material for treating osteosarcoma and application of photothermal bone repair material
  • Photothermal bone repair material for treating osteosarcoma and application of photothermal bone repair material
  • Photothermal bone repair material for treating osteosarcoma and application of photothermal bone repair material

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preparation example Construction

[0041] The second aspect of the embodiment of the present invention provides a preparation method of a photothermal bone repair scaffold, comprising the following steps:

[0042] S01. Provide a photothermal bone repair material configured as a bone repair slurry; wherein the photothermal bone repair material is composed of synthetic polymers and metal / metal oxide particles, and the metal / metal oxide particles are selected from metal magnesium At least one of particles, metallic aluminum particles, aluminum oxide nanoparticles, metallic iron particles, ferric oxide nanoparticles, and ferric oxide nanoparticles;

[0043] S02. Obtain the parameter data of the photothermal bone repair material to be formed, use computer software to design and build a multi-parameter data model of the photothermal bone repair material, use the rapid prototyping system Aurora software to layer the model, and save it as an STL file;

[0044] S03. Regulate the low-temperature deposition rapid prototyp...

Embodiment 1

[0069] A method for preparing a photothermal bone repair scaffold, comprising the following steps:

[0070] S11. Provide photothermal bone repair materials, select medical grade 1,4-dioxane to configure bone repair slurry, and the weight-to-volume (g / ml) content ratio of the dispersion (1,4-dioxane) is 15%; wherein, the photothermal bone repair material is made of synthetic polymer PLGA (pilot plant of Shandong Academy of Pharmaceutical Sciences, the ratio of glycolide to lactide is 75:25, the molecular weight is 150,000 Daltons, and the viscosity is 1.25dL / g) and metal magnesium particles (Mg, atomized magnesium powder, Tangshan Weihao Magnesium Powder Co., Ltd., particle size is 100 μ m), the weight percentage of the metal magnesium particles is designed to be 5%, 10% respectively , 15%, and the total weight of the photothermal bone repair material is 100%; the mixed material is stirred for 10 hours in a magnetic stirrer at room temperature, and the formed photothermal bone ...

Embodiment 2

[0082] A method for preparing a photothermal bone repair scaffold, comprising the following steps:

[0083] S21. Provide photothermal bone repair materials, select medical grade 1,4-dioxane to configure bone repair slurry, and the weight-volume ratio of the dispersion liquid (1,4-dioxane) is 15%; wherein, The photothermal bone repair material is made of synthetic polymer PLGA (pilot factory of Shandong Academy of Pharmaceutical Sciences, the ratio of glycolide to lactide is 75:25, the molecular weight is 150,000 Daltons, and the viscosity is 1.25dL / g) and metal magnesium particles (Mg, atomized magnesium powder, Tangshan Weihao Magnesium Powder Co., Ltd., particle size of 100 μm), the weight percentage of the metal magnesium particles is designed to be 10%, and the photothermal bone repair material The total weight is 100%; the mixed material was stirred in a magnetic stirrer at room temperature for 10 hours, and the formed photothermal bone repair material was named P10M, as ...

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Abstract

The invention provides a photothermal bone repair material. The photothermal bone repair material consists of a synthetic polymer and metal/metal oxide particles, wherein the metal/metal oxide particles are selected from one of magnesium metal particles, aluminum metal nanometer particles, aluminum oxide nanometer particles, ferrum metal particles, ferric oxide nanometer particles and ferroferricoxide nanometer particles. The photothermal bone repair material provided by the invention has photothermal properties of high light absorption efficiency and high photothermal conversion efficiency,after the photothermal bone repair material is implanted into an tumor nidus excision postoperative position, postoperative osteanagenesis can be promoted, besides, peripheral tumor tissue and potential small niduses are subjected to radical cure, and effects of osteogenesis and treatment are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a photothermal bone repair material used for treating osteosarcoma and a preparation method of a photothermal bone repair bracket used for treating osteosarcoma. Background technique [0002] In my country, the incidence of osteosarcoma is about 3 / 1 million, accounting for 0.2% of malignant tumors. Osteosarcoma, also called osteosarcoma, is a primary malignant bone tumor originating from bone mesenchymal cells, characterized by the direct formation of immature bone or osteoid tissue by proliferating tumor cells, and occurs more often in children under the age of 20. Adolescents or children, the incidence rate ranks third among children and adolescents' malignant tumors. Osteosarcoma is more likely to occur in the metaphysis of long bones, usually the distal femur or proximal tibia, followed by the proximal humerus, and other parts are less common. Osteo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/04A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58A61K41/00A61P35/00
CPCA61K41/0052A61L27/025A61L27/042A61L27/047A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/416A61L2430/02A61P35/00C08L67/04
Inventor 赖毓霄龙晶陈英奇李龙秦岭
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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