37results about How to "Promote bone healing" patented technology

A bone screw assembly for joining bone fragments having a screw shaft, a compression head and a sleeve. The compression head has external threads for providing double compression of the bone fragments. The sleeve extends along and around the screw shaft to provide reinforcing strength and alignment to the screw.

The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and / or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and / or cytokines. The bone void filler may include a clotting agent.

The invention relates to a biocompatible bleed-stopping and bone healing promoting material and a preparation method thereof. The material is applied to the bone surface or bone section of a human body or an animal, and is characterized in that the biocompatible bleed-stopping and bone healing promoting material is modified starch prepared by modifying natural starch serving as a raw material, and comprises one or more than two of modified starch granules, modified starch sponges, modified starch films, modified starch foams or modified starch glues, wherein the molecular weight of the modified starch is 15,000 to 10,000,000, and the water absorption rate is 1 to 100 times; in the natural starch serving as the raw material, the content of the amylopectin is at least no less than 70 percent of the total amount of the raw material. The invention fulfills the aim of stopping bleeding through direct spraying, daubing and pasting the biocompatible bleed-stopping and bone healing promoting material to touch the bone bleeding surface of wound; meanwhile, the biocompatible bleed-stopping and bone healing promoting material has a function of promoting bone healing, and can be used in the bleed stopping in the sternotomy of Cardio-Thoracic Surgery, spinal surgeries and joint surgeries of orthopedics department, Craniotomy and maxillo-facial surgery and the bleed stopping in the process of trauma care.

The present invention relates to surgical material. The material includes biological absorbable polymer 10-85 wt%, un-sintered calcium phosphate salt 5-80 wt%, and demineralized bone 1-70 wt%. The biologically absorbable polymer includes polyester, chitosan, hondroitin sulfate, collagen, alginatel, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbable polymer, un-sintered calcium phosphate salt and demineralized bone dispersed in solvent and freeze drying to obtain the hard tissue repairing material. The composition has the function of promoting bone healing and excellent biocompatibility.

A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form.

The present invention relates to surgical material. The material includes biologically absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 5-80 wt%, and bone growth factor less than 10 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbably polymer, un-sintered calcium phosphate salt and bone growth factor dispersed in solvent, molding, freeze drying to eliminate solvent and obtain the composition. The composition has the function of promoting bond healing and excellent biocompatibility.

A coating on an implant, said implant being intended for implantation in / on an implantation area, is provided. The coating comprises nitric oxide (NO) for obtaining an anti-viral, anti-fungal, and anti-bacterial effect, and for promotion of osteo-integration of the implant, bone healing, bone growth, and wound healing at said implantation area. A nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of a therapeutic dosage of nitric oxide (NO). An implant and a kit of implants, comprising said coating are also provided. Furthermore, a manufacturing method for the implant is disclosed.

The invention provides an artificial dental implant, an artificial dental implanting system and an implanting method. A screwed thread is formed in the outer surface of an artificial dental implant, wherein a neck part and a head part are respectively arranged at two ends of the implant; a spiral tapping slot is formed in the outer surface of the head part, the spiral direction of the spiral tapping slot is the same as that of the screwed thread, and the spiral lead angle of the spiral tapping slot is different from that of the screwed thread. When the artificial dental implant is implanted, the cutting force and extrusion force of the implant to the bone tissues at the implanted position are reasonable, and the bone is effectively protected from injury; the artificial dental implant can accommodate bone chips generated in the tapping process, and the bone healing time can be shortened; the artificial dental implant is effectively prevented from rotating or loosing, and the service life of artificial tooth can be prolonged.

The invention discloses multi-medicament loaded calcium phosphate cement powder. The multi-medicament loaded calcium phosphate cement powder is prepared by directly mixing more than one prophase release medicament, polymer microspheres loaded with a long-term release medicament and calcium phosphate cement powder, or performing precipitation blending on more than one prophase release medicament and an ingredient in the calcium phosphate cement powder and uniformly mixing the obtained product with other ingredients of the calcium phosphate cement powder and the polymer microspheres loaded with the long-term release medicament. The powder is suitable for filling and repairing bone defects with different volumes and different shapes; moreover, the loaded prophase release medicaments and the loaded long-term release medicament can be released for co-administration in different time sequences at local positions of the bone defects; and the powder, through the synergism, enhances therapeutic effect, promotes bone healing, improves the success rate of clinical filling and repair of the bone defects, and can reduce the side effect of the medicaments on organisms and meet the clinical demand on bone filling and repair materials at the same time.

Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.

The invention discloses a universal vertebral pedicle screw system capable of moving slightly, which consists of a screw bar (1) and at least two vertebral pedicle screw assemblies arranged on the screw bar (1). Each vertebral pedicle screw assembly comprises a screw seat (2), a vertebral pedicle screw (3), a limiting block (6) and a plug screw (5), and a screw cap (3-2) of each vertebral pedicle screw (3) is spherical; a through hole is arranged in each screw seat (2), inner threads are arranged on the upper portion of each through hole, and a lower hemispherical pit (4-1) is arranged on the lower portion of each through hole; and each limiting block (6) is arranged in the through hole of the corresponding screw seat (2), an upper hemispherical pit (4-2) is arranged on the lower end surface of each limiting block (6) and is combined with the corresponding lower hemispherical pit (4-1) to form a spherical hole (4) capable of covering the corresponding spherical screw cap (3-2), and each spherical hole (4) is in movable fit with the spherical screw cap (3-2) of the corresponding vertebral pedicle screw (3).

A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form.

The invention discloses a novel method of controlling the open circuit potential (OCP) of a medical implant by coupling it with small amounts of metals having a lower OCP than the implant. Coupling of Mg to less than 1% of the surface area of a titanium implant is shown to induce cathodic polarization of the titanium that inhibits cell proliferation at the surface of the implant. Mg—Ti coupling in medical devices promises to attenuate or eliminate potential complications of surgery such as peri-implantitis and bacterial infections at the site of implantation.

The invention discloses an anti-rotation implant device which comprises an implant, an abutment and a central bolt. The anti-rotation implant device is characterized in that the implant comprises a gum penetrating neck and a head; a thread is arranged on the outer surface of the head; at least two helical self-tapping grooves are formed in the outer surface of the head; connecting holes are formed in the implant and are a positioning hole and a threaded blind hole which are coaxially connected in sequence; at least two positioning embossments are arranged on the upper end surface of the implant body; the abutment comprises a dental crown connecting section and an implant connecting section; an annular positioning table is arranged between the dental crown connecting section and the implant connecting section; positioning grooves matched with the positioning embossments are formed in the annular positioning table; a ladder hole matched with the central bolt is formed in the abutment; the central bolt penetrates through the ladder hole to be connected with the threaded blind hole so as to fix the abutment to the implant. According to the anti-rotation implant device, the positioning embossments on the upper end surface of the implant are matched with the annular positioning table on the abutment, so that a relatively large rotary torque can be born, connection is relatively firm, and the service life is prolonged.

The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.

The invention provides an injectable hydrogel microsphere for treating orthopedic diseases as well as a preparation method and application thereof. A hydrogel microsphere is taken as a matrix, a substance capable of enhancing the biological reaction activity is doped into the hydrogel microsphere, and a functionalized hydrogel microsphere is prepared by adopting a microfluidic technology and a photochemical cross-linking reaction. The orthopedic diseases include refractory bone healing or osteoarthritis. The substance capable of enhancing the biological reaction activity includes any one of fullerol nanocrystals, lipidosome loaded with KGN, and a copolymer obtained from dopamine methacrylamide and sulfobetaine methacrylate. The preparation method provided by the invention is simple, a prepared microgel material can effectively remove ROS, a good microenvironment is created for survival of mesenchymal stem cells, and osteogenic differentiation of the mesenchymal stem cells is promoted; and meanwhile, the drug loading stability can be improved, the controlled release of a drug is realized, and the effect of well treating and repairing the orthopedic diseases can be achieved.

The present invention discloses one kind of fracture-treating externally applied medicine and its preparation process. The fracture-treating externally applied medicine is prepared with angelica, Chinese ligusticum, trogopterus dung, rhubarb, licorice and other three kinds of Chinese medicinal materials in certain weight proportion. The preparation process includes the steps of grinding the Chinese medicinal materials into fine powder, 800-mesh sieving, mixing the medicine powder with egg white to form medicine liquid, and soaking gauze inside the medicine liquid to form medicated bandage. When used, the medicated bandage is wrapped to the fracture part and the fracture part is fixed with splint. The fracture-treating externally applied medicine can speed the healing of fracture.

The invention discloses a novel method of controlling the open circuit potential (OCP) of a medical implant by coupling it with small amounts of metals having a lower OCP than the implant. Coupling of Mg to less than 1% of the surface area of a titanium implant is shown to induce cathodic polarization of the titanium that inhibits cell proliferation at the surface of the implant. Mg—Ti coupling in medical devices promises to attenuate or eliminate potential complications of surgery such as peri-implantitis and bacterial infections at the site of implantation.

The invention discloses an antibacterial absorbable bone wax for promoting osteogenesis. The bone wax comprises the following components in parts by weight: 60-90 parts of an alkylene oxide copolymer,5-30 parts of a shaping agent, 2-30 parts of a thickening agent and 5-30 parts of a calcium sulfate-based repair component. The absorbable bone wax has good hemostatic performance and degradation performance, can be completely absorbed by a human body, promotes bone tissue regeneration, has a good continuous antibacterial effect and prevents wound infection. And the related preparation method issimple, is convenient to operate clinically, can meet the requirements of different patients, and is expected to be widely applied.

The invention discloses a calcium silicate / magnesium silicate biological-bone porous implant as well as a preparation method and application thereof and belongs to the technical field of biomedical materials. According to the prepared porous implant, a porous matrix is obtained by taking calcium silicate and magnesium silicate as matrixes of the implant, drawing a three-dimensional model through calculation, implementing forming and high-temperature degreasing of a green body by using a digital light treatment technology, and carrying out sintering, a surface coating material is obtained through taking a polyvinyl alcohol solution as a binder and adding polycaprolactone (PCL) powder particles prepared in advance, and the porous implant is finally prepared through placing an implant into the coating material, carrying out sufficient stirring, then, carrying out drying, and then, carrying out heating in a water bath until the PCL is completely molten to the surface. The method can achieve the design of a porous structure, the porous implant has certain biological activity and degradability, can be applied to bone tissue engineering and can be used as a bone filler, a bone repair material or a scaffold for in-vitro cell culture.

The invention provides a bone hemostatic material. The bone hemostatic material is prepared from carboxymethyl chitosan, poloxamer and a sodium silicate aqueous solution. The provided absorbable bonehemostatic material has good hemostatic properties and excellent ductility and adhesion, and is not easy to fall off; and the bone hemostatic material can be degraded and absorbed in vivo, has no immunogenicity, is high in safety and has excellent implementation effects on promoting bone hemostasis and bone healing.

The invention provides an external fixed bracket assembly for promoting bone healing. The external fixed bracket assembly comprises an external fixed bracket arranged at a bone injury part of a patient, a medicine seepage device which is assembled on the external fixed bracket and is in contact with the bone injury part of the patient, and a bone stimulation device which is assembled on the external fixed bracket and is located between the external fixed bracket and the medicine seepage device, wherein the external fixed bracket comprises a body assembled on the bone injury part and a cover body assembled on the body; the external fixed bracket is provided with an accommodating cavity surrounded by the body; the medicine seepage device is assembled on the body and is located in the accommodating cavity; and the bone stimulation device is assembled in a region, where the medicine seepage device is located, on the body. The external fixed bracket assembly for promoting bone healing can realize filling of medicines through the medicine seepage device and enable the medicines to seep from seepage holes in the medicine seepage device to realize uniform medicine supplying; furthermore, circulation of the medicines is promoted by micro vibration emitted by the bone stimulation device arranged on the body; and meanwhile, blood circulation of the affected part can be accelerated, and healing of the bone at the affected part can be promoted.

A calcium phosphate cement containing Chinese medicine for promoting bone union and treating bone diseases is disclosed. Its advantaegs are quickly self-hardening, high plasticity, and high curative effect.

The invention discloses an anti-rotation implant device, which comprises an implant, an abutment and a central bolt. There are also at least two spiral self-tapping grooves on the top; there are connecting holes inside the implant, and the connecting holes include coaxial and sequentially connected positioning holes and threaded blind holes; there are at least two positioning protrusions on the upper end of the implant ;The abutment includes a crown connection section and an implant connection section; a ring positioning platform is provided between the crown connection section and the implant connection section, and a positioning groove matching the positioning protrusion is provided on the ring positioning platform ; The inside of the abutment is provided with a stepped hole matching the central bolt; the central bolt passes through the stepped hole and is connected with the threaded blind hole to fix the abutment on the implant. In the present invention, the positioning protrusion on the upper end surface of the implant fits with the circular positioning platform on the abutment, so that it can bear greater rotational torque, make the connection more firm, and prolong the service life.

The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and / or cytokines. The bone void filler may include a clotting agent.

The invention provides a spine posterior device. The device comprises a device body and a connection part; the device body is arranged on the side, away from the vertebral body of the human body, of the spine, and is used for promoting bone ingrowth; the connection part is arranged on the device body and used for being connected with a posterior nail bar to fix the device body. According to the spine posterior device, the connection part is connected with the posterior nail bar, accordingly, the device body is positioned at the osteotomy portion, the position of the device body is equal to theposterior column part, the device body can promote bone ingrowth, bone healing of the posterior column part is promoted, finally the posterior column part of the spine is rebuilt, long-term stabilityis achieved, and the post-operation risk is lowered.

The invention provides an external fixed bracket assembly for promoting bone healing. The external fixed bracket assembly comprises an external fixed bracket arranged at a bone injury part of a patient, a medicine seepage device which is assembled on the external fixed bracket and is in contact with the bone injury part of the patient, and a bone stimulation device which is assembled on the external fixed bracket and is located between the external fixed bracket and the medicine seepage device, wherein the external fixed bracket comprises a body assembled on the bone injury part and a cover body assembled on the body; the external fixed bracket is provided with an accommodating cavity surrounded by the body; the medicine seepage device is assembled on the body and is located in the accommodating cavity; and the bone stimulation device is assembled in a region, where the medicine seepage device is located, on the body. The external fixed bracket assembly for promoting bone healing can realize filling of medicines through the medicine seepage device and enable the medicines to seep from seepage holes in the medicine seepage device to realize uniform medicine supplying; furthermore, circulation of the medicines is promoted by micro vibration emitted by the bone stimulation device arranged on the body; and meanwhile, blood circulation of the affected part can be accelerated, and healing of the bone at the affected part can be promoted.