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Biocompatible bleed-stopping and bone healing promoting material and preparation method thereof

A biocompatible and healing material technology, applied in the field of biocompatible hemostatic and bone healing materials and its preparation, can solve the problems of difficult metabolism and absorption of bone wax, nonunion, infection, etc., and achieve good hemostatic effect , promote healing and prevent infection

Inactive Publication Date: 2010-07-28
纪欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Beeswax is a kind of unsaturated fatty acid, but it is difficult for the human body to metabolize and absorb bone wax, and bone wax is easy to cause complications such as nonunion and infection

Method used

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  • Biocompatible bleed-stopping and bone healing promoting material and preparation method thereof
  • Biocompatible bleed-stopping and bone healing promoting material and preparation method thereof
  • Biocompatible bleed-stopping and bone healing promoting material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Using dry, non-deteriorating, non-caking, and impurity-free tapioca starch as raw material, it is made into hydroxypropyl distarch phosphate after undergoing etherification, cross-linking, and esterification with chemical reagents such as propylene oxide and phosphoric acid. Then pre-gelatinized and denatured by spray drying method to make pre-gelatinized hydroxypropyl distarch phosphate; then granulated by a granulator, controlling the temperature of the machine to 40-50°C, the wind speed to 700-800r / min, and the water-adding speed to 20- 30r / min; then sieve, the average particle size of the granules is 50-200 mesh; fill the modified starch granules in the bottle; sterilize after packaging, and the finished product 51# hemostatic and bone healing granules is obtained.

Embodiment 2

[0040] Dissolve 2 g of the 51# hemostatic and bone healing granules in Example 1 in 30 ml of water at 37° C., and stir continuously with a magnetic stirrer to fully swell the starch granules and disperse them in the water to form a uniform suspension. Then pour it into a rectangular container, pre-cool it in a low-temperature storage box at -40°C for 24 hours, then put it into a freeze dryer, and freeze-dry it for 24 hours at -50°C and a vacuum degree of less than 10 Pa to obtain 51# hemostatic and Bone healing sponge.

Embodiment 3

[0042]Use dry, non-deteriorating, non-caking, and impurity-free potato starch as raw material, and make cross-linked carboxymethyl starch sodium modified starch after chemical denaturation, and then granulate through a granulator. 700-800r / min, water adding speed 20-30r / min; then sieve, the granule size is 50-200 mesh; fill the granule in a bottle; sterilize after packaging, the finished product GND66 hemostatic and bone healing granule is obtained.

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PUM

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Abstract

The invention relates to a biocompatible bleed-stopping and bone healing promoting material and a preparation method thereof. The material is applied to the bone surface or bone section of a human body or an animal, and is characterized in that the biocompatible bleed-stopping and bone healing promoting material is modified starch prepared by modifying natural starch serving as a raw material, and comprises one or more than two of modified starch granules, modified starch sponges, modified starch films, modified starch foams or modified starch glues, wherein the molecular weight of the modified starch is 15,000 to 10,000,000, and the water absorption rate is 1 to 100 times; in the natural starch serving as the raw material, the content of the amylopectin is at least no less than 70 percent of the total amount of the raw material. The invention fulfills the aim of stopping bleeding through direct spraying, daubing and pasting the biocompatible bleed-stopping and bone healing promoting material to touch the bone bleeding surface of wound; meanwhile, the biocompatible bleed-stopping and bone healing promoting material has a function of promoting bone healing, and can be used in the bleed stopping in the sternotomy of Cardio-Thoracic Surgery, spinal surgeries and joint surgeries of orthopedics department, Craniotomy and maxillo-facial surgery and the bleed stopping in the process of trauma care.

Description

technical field [0001] The invention relates to a biocompatible material for hemostasis and bone healing and a preparation method thereof, which is used for hemostasis on bone surfaces and bone sections caused by trauma and surgery in humans and animals, and is made of biocompatible modified starch Powder, foam, sponge, film or jelly can be sprayed, smeared and pasted directly to stop bleeding when it comes into contact with bone bleeding wounds; at the same time, it can promote bone healing and can be used for sternotomy in cardiothoracic surgery, Hemostasis in orthopedic spine, joint surgery, craniotomy and maxillofacial surgery and trauma treatment. Background technique [0002] Hemostasis on the bone surface and bone fracture caused by trauma or surgery has always been a difficult problem. For some patients, such as children, the elderly, especially osteoporosis patients, during thoracotomy and craniotomy, the bleeding on the sternum and skull sections is difficult to c...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/60C08J3/12C08J9/00C08J5/18C08L3/04
Inventor 纪欣
Owner 纪欣
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