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Calcium phoshate bone cement powder containing traditional Chinese medicine and its preparation method

A technology of calcium phosphate bone cement and tricalcium phosphate, applied in the field of medical biomaterials and drugs, can solve problems such as difficult to repair, lack of shape, and inability to self-solidify, and achieve the effects of reducing circulation, easy absorption, and easy degradation.

Inactive Publication Date: 2007-07-18
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this calcium phosphate / traditional Chinese medicine composite bone replacement material is in powder form, cannot solidify by itself, and lacks a certain shape. Bone defects of complex shape, especially in load-bearing areas

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] It is 54 grams of beta-type tricalcium phosphate that contains dry matter that is synthesized by wet method, adopts the tensio-active agent of alkenoic acid series, carries out surface modification as polyacrylic acid, makes uniformly dispersed suspension; The compound salvia miltiorrhiza injection was made into a uniformly dispersed suspension containing salvia miltiorrhiza, mixed thoroughly, and then spray-dried to obtain β-type tricalcium phosphate powder containing salvia miltiorrhiza.

[0023] Get 64 grams of β-type tricalcium phosphate powder containing traditional Chinese medicine with a particle diameter of 5-100 microns obtained in the previous step, and 9 grams of hydroxyapatite and 27 grams of calcium dihydrogen phosphate with the same particle size. Mix evenly to obtain the calcium phosphate bone cement powder containing traditional Chinese medicine of the present invention, and its dry matter weight ratio is: 90 parts of calcium phosphate bone cement powder ...

Embodiment 2

[0025] It is 24 grams of calcium dihydrogen phosphate that contains dry matter that is synthesized by wet method, adopts diisocyanic acid, carries out surface modification to calcium dihydrogen phosphate as tensio-active agent, makes the suspension liquid of uniform dispersion; 1 gram of Astragalus Injection is made into a uniformly dispersed suspension containing Astragalus, and after the calcium dihydrogen phosphate precipitate is fully mixed with Astragalus Injection, it is spray-dried to obtain a Chinese medicine-containing calcium dihydrogen phosphate powder.

[0026] Get 25 grams of calcium dihydrogen phosphate powder containing traditional Chinese medicine with a particle diameter of 5-100 microns obtained in the previous step, 8.5 grams of hydroxyapatite synthesized by wet method with the same particle diameter, 58 grams of α-type tricalcium phosphate, carbonic acid Mix 8.5 grams of calcium evenly to obtain the calcium phosphate bone cement powder containing traditional...

Embodiment 3

[0028] Take the mixture of 43 grams of hydroxyapatite and β-type tricalcium phosphate obtained by wet synthesis, wherein the ratio of hydroxyapatite to β-type tricalcium phosphate is 64:9, and the surface of the alkyl acid series is adopted. Active agent, the mixture of hydroxyapatite and β-tricalcium phosphate is surface-modified to make a uniformly dispersed suspension; add safflower injection containing 30 grams of safflower dry matter to make a uniform safflower-containing After the dispersed suspension is fully mixed with the mixture of hydroxyapatite and β-type tricalcium phosphate and safflower injection, it is spray-dried to obtain calcium phosphate powder containing traditional Chinese medicine.

[0029] Get 73 grams of hydroxyapatite / β-type tricalcium phosphate powder containing traditional Chinese medicine with a particle diameter of 5-100 microns obtained in the previous step, and mix evenly with 27 grams of calcium dihydrogen phosphate of the same particle size to ...

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PUM

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Abstract

A calcium phosphate cement containing Chinese medicine for promoting bone union and treating bone diseases is disclosed. Its advantaegs are quickly self-hardening, high plasticity, and high curative effect.

Description

Technical field [0001] The invention relates to the fields of medical biomaterials and medicines, in particular to a calcium phosphate bone cement powder for repairing bone defects and a preparation method thereof. Background technique [0002] Calcium phosphate bone cement has good biocompatibility and bioactivity, and has been successfully used clinically. However, clinically, large-volume bone defects or bone defects under pathological conditions are often encountered. Because pathological conditions will weaken the bone healing ability of the host bone, calcium phosphate biomaterials with only osteoconductive ability are difficult to repair the bone defects in the above situations. , clinically called bone nonunion or delayed union (Carl A. et. al. Potential applications and delivery strategies for bone morphogenetic proteins. Advanced Drug Delivery Review, 2000; 43: 45-92.). In order to solve the clinical difficulties, it is necessary to study bone replacement material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B12/02C04B24/00A61K36/00A61L27/12
Inventor 屈树新翁杰李茂红冯波
Owner SOUTHWEST JIAOTONG UNIV
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