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Bone hemostatic material and preparation method thereof

A technology of hemostatic material and sodium silicate aqueous solution, which is applied in the fields of medical formulation, surgery, drug delivery, etc., can solve the problems of non-absorbability limiting clinical application, failure to promote bone wound healing, and affect bone wound repair, so as to facilitate hemostasis and The effect of repairing, promoting bone hemostasis and bone healing, and best implementation effect

Active Publication Date: 2020-09-29
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, bone wax is currently used as a hemostatic material for bone wounds in my country, but its non-absorbability limits its clinical application and increases foreign body reactions, affecting the repair of bone wounds.
Although there have been studies on absorbable bone wound hemostatic materials, there are still unresolved practical problems such as poor adhesion, failure to promote bone wound healing, and rapid degradation in vivo.

Method used

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  • Bone hemostatic material and preparation method thereof
  • Bone hemostatic material and preparation method thereof
  • Bone hemostatic material and preparation method thereof

Examples

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Embodiment 1

[0032] Embodiment 1: Preparation of bone hemostatic material

[0033] The present embodiment provides a bone hemostatic material, in parts by weight, the bone hemostatic material consists of 20 parts of carboxymethyl chitosan, 10 parts of poloxamer 184 and 30 parts of 1% silicic acid Prepared from aqueous sodium solution.

[0034] In another aspect, the present invention provides a method for preparing the above bone hemostatic material, comprising the following steps:

[0035] 1) Blend 20 parts of carboxymethyl chitosan, 10 parts of poloxamer 184 powder, and 30 parts of 1% sodium silicate aqueous solution, and mechanically stir to form a cement-like bone hemostatic material.

[0036] 2) The prepared cement-like bone hemostatic material is molded in a mold to obtain a block bone hemostatic material, which is packaged and used 60 Co ray sterilized to prepare the bone hemostatic material, which was sealed and stored at room temperature.

Embodiment 2

[0038] This embodiment provides a bone hemostatic material. According to parts by weight, the bone hemostatic material described in this embodiment consists of 20 parts of carboxymethyl chitosan, 20 parts of poloxamer 184 and 40 parts of 5% prepared from an aqueous solution of sodium silicate.

[0039] In another aspect, the present invention provides a method for preparing the above bone hemostatic material, comprising the following steps:

[0040] 1) Blend 20 parts of carboxymethyl chitosan, 20 parts of poloxamer 184 powder, and 40 parts of 5% sodium silicate aqueous solution, and mechanically stir to form a cement-like bone hemostatic material.

[0041] 2) The prepared cement-like bone hemostatic material is molded in a mold to obtain a block bone hemostatic material, which is packaged and used 60 Co ray sterilized to prepare the bone hemostatic material, which was sealed and stored at room temperature.

Embodiment 3

[0043] This embodiment provides a bone hemostatic material. According to parts by weight, the bone hemostatic material described in this embodiment consists of 30 parts of carboxymethyl chitosan, 40 parts of poloxamer 184 and 10 parts of 0.5% prepared from an aqueous solution of sodium silicate.

[0044] In another aspect, the present invention provides a method for preparing the above bone hemostatic material, comprising the following steps:

[0045] 1) Blend 30 parts of carboxymethyl chitosan, 40 parts of poloxamer 184 powder, and 10 parts of 0.1% sodium silicate aqueous solution, and mechanically stir to form a cement-like bone hemostatic material.

[0046]2) The prepared cement-like bone hemostatic material is molded in a mold to obtain a block bone hemostatic material, which is packaged and used 60 Co ray sterilized to prepare the bone hemostatic material, which was sealed and stored at room temperature.

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Abstract

The invention provides a bone hemostatic material. The bone hemostatic material is prepared from carboxymethyl chitosan, poloxamer and a sodium silicate aqueous solution. The provided absorbable bonehemostatic material has good hemostatic properties and excellent ductility and adhesion, and is not easy to fall off; and the bone hemostatic material can be degraded and absorbed in vivo, has no immunogenicity, is high in safety and has excellent implementation effects on promoting bone hemostasis and bone healing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone hemostatic material for craniocerebral surgery, orthopedics and orthopedic surgery and a preparation method thereof. Background technique [0002] During orthopedic surgery, continuous or difficult hemostasis of cancellous bone wounds is a difficult problem often encountered by craniocerebral surgery, orthopedic and orthopedic surgeons. The structure of cancellous bone is loose and the blood supply is rich. In addition, the wounds are mostly caused by cutting with sharp instruments and violent blows. The bleeding is mostly oozing, which is different from bleeding in other tissues. It is difficult to stop bleeding by vasoconstriction, and it is also difficult to rely on electrocoagulation during surgery. , forceps, hemostatic gauze, collagen sponge packing and other conventional methods to completely stop bleeding. An ideal hemostatic agent for cancellous bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/02A61L24/04A61L24/08
CPCA61L24/08A61L24/046A61L24/02A61L24/0042A61L2400/04C08L5/08C08L71/02A61L2430/02
Inventor 徐宝艳李艳婷田珍黄文涛
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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