Preparation method for oxidized regenerated cellulose hemostatic material with surface nanostructure

A technology of regenerated cellulose and nanostructures, applied in fiber treatment, medical science, absorbent pads, etc., can solve the problems of slow hemostasis, small specific surface area of ​​oxidized cellulose hemostatic materials, and single mechanism of hemostasis, and achieve excellent blood absorption. , Conducive to platelet adhesion and shorten the time of hemostasis

Active Publication Date: 2013-02-06
WEIGAO HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problems of the existing oxidized cellulose hemostatic materials such as small specific surface area, insoluble in water, single hemostatic mechanism and slow hemostatic speed, thereby providing a preparation of an oxidized regenerated cellulose hemostatic material with a surface layer nanostructure method

Method used

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  • Preparation method for oxidized regenerated cellulose hemostatic material with surface nanostructure
  • Preparation method for oxidized regenerated cellulose hemostatic material with surface nanostructure
  • Preparation method for oxidized regenerated cellulose hemostatic material with surface nanostructure

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specific Embodiment approach 1

[0022] Embodiment 1: A method for preparing an oxidized regenerated cellulose-based hemostatic material with a surface layer nanostructure according to this embodiment is implemented in the following steps:

[0023] 1. Prepare the collagen aqueous solution and store it sealed at 0-4°C;

[0024] Two, take wood pulp viscose long fiber as raw material, adopt knitting machine to prepare viscose fiber gauze; Wherein, described knitting machine width 8~18m, traction belt spacing 4.2~6.2m, traction belt width 4.2~6.2m, traction Speed ​​180~360r / m, mesh width 0.5~2.5mm;

[0025] 3. Oxidize the viscose staple fiber and the viscose fiber gauze made in step 2 by using an oxidizing agent solution, and the oxidized product is subjected to cyclohexane, 50% to 70% ethanol aqueous solution and absolute ethanol respectively. Washing, and then vacuum freeze-drying at -20 to -55°C for 24 to 72 hours to obtain oxidized viscose staple fibers and oxidized viscose fiber gauze, which are sealed and ...

specific Embodiment approach 2

[0034] Embodiment 2: This embodiment differs from Embodiment 1 in that: the mass fraction of collagen in the collagen aqueous solution in step 1 is 0.8-1.5%. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0035] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the reaction temperature in the oxidation reaction process in step 3 is maintained at 18-19.5° C., and the stirring reaction is continued for 24-56 hours. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention provides a preparation method for an oxidized regenerated cellulose hemostatic material with a surface nanostructure. In order to solve problems of small specific surface area, water insolubility, single hemostatic effect mechanism and low hemostatic speed of the traditional oxidized cellulose hemostatic material, the invention provides the preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The method comprises the following steps of: (1) preparing a collagen aqueous solution; (2) preparing a viscose fiber gauze; (3) preparing oxidized viscose staple fiber and oxidized viscose fiber gauze; (4) preparing an oxidized regenerated cellulose sodium solution or an oxidized regenerated cellulose potassium solution; (5) preparing an oxidized regenerated cellulose gauze; and (6) after collagen particles are sprayed, freezing and drying the oxidized regenerated cellulose gauze, so as to finish the preparation of the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure, provided by the invention, is applied to the preparation field of the oxidized regenerated cellulose hemostatic materials.

Description

technical field [0001] The invention relates to a preparation method of an oxidized regenerated cellulose hemostatic material with a surface nanostructure. Background technique [0002] Oxidized regenerated cellulose (ORC) is a kind of cellulose derivative, which has been used in many industries, such as medical industry, as medical absorbable hemostatic gauze. But it has another great potential use: due to the introduction of the active group carboxyl group in the glucosyl ring of cellulose, it can be used as an intermediate product for further modification of cellulose, especially the oxidized cellulose obtained by selective oxidation . [0003] Medical absorbable hemostatic gauze Surgical has two products: oxidized cellulose and redox cellulose. What we usually see is oxidized cellulose. "Suji Yarn" has a small specific surface area and slow hemostasis. It takes 2 to 8 minutes to achieve hemostasis. It is more suitable for wounds with a small amount of bleeding, but it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M11/64D06M11/38D06M15/05D06M15/15A61L15/32A61L15/28A61L15/44
Inventor 黄玉东程玮璐贺金梅吴亚东高山李大龙
Owner WEIGAO HLDG
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