Collagen-polycaprolactone (PCL) dental hemostatic sponge and preparation method thereof

A collagen and hemostatic sponge technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor mechanical properties of collagen, inability to repair and heal wounds, fast degradation speed, etc., and achieve good retention and long-term maintenance Hemostasis, good effect

Inactive Publication Date: 2011-11-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method of compressing hemostasis with cotton balls or gauze balls has the following disadvantages and shortcomings: it takes a long time to achieve complete hemostasis; cotton gauze can compress and stop bleeding on small bleeding gum wounds after tooth extraction, but it is difficult to stop bleeding on larger wounds. Hemostatic powder and hemostatic agent, or suture the wound to stop bleeding; in addition, cotton gauze hemostasis is only a physical hemostasis method, and cannot repair and heal the wound.
However, collagen itself has the disadvantages of poor mechanical properties and rapid degradation, which limit its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The PCL trifluoro ethanol solution with a quality score of 1%of the collagen and the mass score of 1%is mixed with a ratio of 1: 4 in accordance with the proportion of collagen to PCL. Stir in 20 ° C for 6 hours to get collagenProtein and PCL complex solution.According to the proportion of auxiliary additives (according to the proportion of tea polyphenols and coordinase to 1: 1) to add auxiliary additives to the composite liquid of collagen and PCL with a proportion of composite liquid weight ratios of 1: 400, at 20 ° C at 20 ° C ° CStir for 1 hour and configure a mixture of collagen, PCL and auxiliary additives.Inject collagen, PCL, and auxiliary additives into the mold into the mold for 2 hours at -20 ° C, and finally placed in the frozen dried machine, and kept it under -70 ° C for about 10 hours.Then remove the mold and get the collagen-PCL dental hemostatic sponge.

Embodiment 2

[0030] Pll hexofluoropropylopropstine solution with a mass score of 0.5%of 0.5%of 0.5%is 2.5%PCL hexofluoropropine solution in a total of 1: 5 in accordance with the proportion of collagen to PCL.Get the complex solution of collagen and PCL in 5 hours.According to the auxiliary additives (according to the proportion of tea polyphenols, chitosan, glycrase, white and dry weight ratio of 2: 1: 2: 1), the weight ratio of the composite solution is 1: 600 to collagen and PCLAdd auxiliary additives to the composite solution and stir at 20 ° C for about 2 hours to configure mixture of collagen, PCL and auxiliary additives.Inject collagen, PCL, and auxiliary additives into the mold into the mold for 4 hours at -20 ° C, and finally place it in the freezer of the frozen dried machine, and keep it under -70 ° C for about 10 hours.Then remove the mold and get the collagen-PCL dental hemostatic sponge.

Embodiment 3

[0032] Pll triofluoro ethanol solution with a collagen with a quality score of 0.5%and a mass score of 5%is mixed with a proportion of 1:10 according to the proportion of collagen to PCL.Collagen and PCL complex solution.According to the proportion of auxiliary additives (according to the proportion of tea polyphenols, cymbal phenols to the dry weight ratio of 1: 1), the proportion of composite liquid weight ratios with a composite liquid is added to the composite liquid of collagen and PCL.Auxiliary additives are stirred for about 4 hours at 30 ° C, and mixture of collagen, PCL and auxiliary additives is configured.Inject collagen, PCL, and auxiliary additives into the mold into the mold for 1 hour at -20 ° C, and finally place it in the freezer of the frozen dried machine, and keep it under -50 ° C for about 15 hours.Then remove the mold and get the collagen-PCL dental hemostatic sponge.

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Abstract

The invention provides a collagen-polycaprolactone (PCL) dental hemostatic sponge and a preparation method thereof. The method comprises the following steps of: blending 0.2 to 1 mass percent of collagen solution and 0.5 to 10 mass percent of PCL solution, stirring at the temperature of between 1 and 30DEG C, reacting for 1 to 6 hours to obtain complex liquid; adding auxiliaries into the complex liquid, continuously stirring at the temperature of between 1 and 30DEG C for 1 to 4 hours to obtain a mixed solution; pouring the mixed solution into a mold, freezing at the temperature of -20DEG C for 0.5 to 4 hours; and performing freeze drying in a freezer dryer to obtain the collagen-PCL hemostatic sponge. The collagen-PCL hemostatic sponge prepared by the method has good retention ability, hemostasia, anti-inflammatory and antibacterial property and biocompatibility, is effective and safe without toxic or side effect, can be widely used as a postoperative hemostatic material for exodontias and other oral surgeries and has good market application prospect; and waste can be degraded and cannot pollute environment.

Description

Technical field [0001] The present invention involves the field of medical materials preparation technology. Specifically, it involves a good mechanical performance, solidity, degradability, and better hemostatic, anti -inflammatory, bacterichilation, biocompatibility, and biochemical available.Degradable collagen-PCL dental hematopoietic sponge and its preparation methods. Background technique [0002] At present, the number of patients with clinical dental diseases is increasing, and patients are involved in children, youth, and middle -aged and elderly people.Tooth extraction is one of the common operations of the dental department, and bleeding after tooth extraction is a common complication after tooth extraction.The clinically used clinical postplaying hemostasis methods mainly include compression, suture legal, and filling method. Among them, the oppression method is the most commonly used traditional hemostatic method.Such as: the use of Yunnan Baiyao Disinfection gauze c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/26A61L15/44
Inventor 穆畅道张云凤谭欢李德富
Owner SICHUAN UNIV
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