Molybdenum disulfide-based material with photo-thermal and photodynamic properties and preparation method thereof

A molybdenum disulfide, photodynamic technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., can solve the problem of poor water solubility, poor light stability of TCPP, biological Low utilization and other problems, to achieve the effect of improving photostability, good absorption and uptake ability, and high retention effect

Active Publication Date: 2021-07-13
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: The present invention aims at the problems that there is no material with both photothermal and photodynamic effects in the prior art, and on the other hand, the photodynamic material TCPP has poor photostability, poor water solubility, and low bioavailability, and provides a kind of material with both photothermal and photodynamic effects Molybdenum disulfide-based materials with photothermal and photodynamic properties

Method used

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  • Molybdenum disulfide-based material with photo-thermal and photodynamic properties and preparation method thereof
  • Molybdenum disulfide-based material with photo-thermal and photodynamic properties and preparation method thereof
  • Molybdenum disulfide-based material with photo-thermal and photodynamic properties and preparation method thereof

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Effect test

Embodiment 1

[0027] Weigh 1g blocky molybdenum disulfide, disperse in 10mL hexane solution containing 1.025g n-butyllithium, stir continuously for 2 days under nitrogen protection, filter and collect molybdenum disulfide solid, and collect molybdenum disulfide Disperse the solid in water, treat it ultrasonically for 1 hour, and perform centrifugation to separate the solid and liquid after ultrasonic treatment. After centrifugation, the collected sheet-shaped molybdenum disulfide is dispersed in water again, and the small molecular impurities adsorbed on the molybdenum disulfide nanosheets are removed by dialysis to obtain Molybdenum disulfide aqueous solution; add 2mol lipoic acid and 2mol cysteamine to molybdenum disulfide aqueous solution, react for 12h; add equivalent 1-(3-dimethylaminopropyl)-3-ethyl to the mixed material after reaction Carbodiimide hydrochloride and N-hydroxysuccinimide, add 2molTCPP and 1molNH 2 -PEG-TPP, continue to react for 30 minutes; after the reaction, the reac...

Embodiment 2

[0029]Weigh 1g blocky molybdenum disulfide, disperse in 10mL hexane solution containing 1.025g n-butyllithium, stir continuously for 2 days under nitrogen protection, filter and collect molybdenum disulfide solid, and collect molybdenum disulfide Disperse the solid in water, treat it ultrasonically for 1 hour, and perform centrifugation to separate the solid and liquid after ultrasonic treatment. After centrifugation, the collected sheet-shaped molybdenum disulfide is dispersed in water again, and the small molecular impurities adsorbed on the molybdenum disulfide nanosheets are removed by dialysis to obtain Molybdenum disulfide aqueous solution; add 2mol lipoic acid and 2mol cysteamine to molybdenum disulfide aqueous solution, react for 13h; add equivalent 1-(3-dimethylaminopropyl)-3-ethyl to the mixed material after reaction Carbodiimide hydrochloride and N-hydroxysuccinimide, add 2molTCPP and 1molNH 2 -PEG-TPP, continue to react for 35 minutes; after the reaction, the react...

Embodiment 3

[0031] Weigh 1g blocky molybdenum disulfide, disperse in 10mL hexane solution containing 0.925g n-butyllithium, stir continuously for 2 days under nitrogen protection, filter and collect molybdenum disulfide solid, and collect molybdenum disulfide Disperse the solid in water, treat it ultrasonically for 1 hour, and perform centrifugation to separate the solid and liquid after ultrasonic treatment. After centrifugation, the collected sheet-shaped molybdenum disulfide is dispersed in water again, and the small molecular impurities adsorbed on the molybdenum disulfide nanosheets are removed by dialysis to obtain Molybdenum disulfide aqueous solution; add 2mol lipoic acid and 2mol cysteamine to molybdenum disulfide aqueous solution, react for 12h; add equivalent 1-(3-dimethylaminopropyl)-3-ethyl to the mixed material after reaction Carbodiimide hydrochloride and N-hydroxysuccinimide, add 2molTCPP and 1molNH 2 -PEG-TPP, continue to react for 35 minutes; after the reaction, the reac...

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Abstract

The invention discloses a molybdenum disulfide-based material with photo-thermal and photodynamic properties at the same time, the material takes a molybdenum disulfide nanosheet as a carrier, TCPP is coupled to the surface of the molybdenum disulfide nanosheet through cysteamine, and NH2-PEG-TPP is coupled to the surface of the molybdenum disulfide nanosheet through lipoic acid. Molybdenum disulfide in the molybdenum disulfide-based material has good biocompatibility, and permeability of the molybdenum disulfide in an organism can be improved when the molybdenum disulfide is prepared into a sheet for application; in addition, as a nano-scale material, the material also has a high retention effect in a living body; lastly, flaky molybdenum disulfide is adopted as a carrier, after TCPP and NH2-PEG-TPP are coupled, on one hand, the pharmacokinetics of TCPP in vivo can be changed, on the other hand, TCPP can be separated and cannot be gathered, so that the light stability of TCPP is improved, by introducing a targeting group, photo-thermal and photodynamic materials can be targeted to mitochondria of tumor cells, and the killing effect of photo-thermal and photodynamic materials on cancer cells is further enhanced.

Description

technical field [0001] The invention relates to a molybdenum disulfide-based material having both photothermal and photodynamic properties, and also relates to a preparation method of the molybdenum disulfide-based material having both photothermal and photodynamic properties. Background technique [0002] Photothermal therapy for cancer is a new non-invasive anti-cancer method that has emerged in recent years. It kills malignant tumor cells by light-induced local high temperature in the tumor, and has almost no side effects on normal human tissues, so it is called "green therapy" by the international medical community. In recent years, a large number of studies have shown that molybdenum disulfide has good optical properties, and its light-to-heat conversion efficiency (35%) is significantly higher than that of gold nanorods (20%). Therefore, compared with other photothermal conversion materials, molybdenum disulfide has stronger photothermal conversion advantages in tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/60A61K47/52A61P35/00
CPCA61K41/0052A61K41/0071A61K47/60A61K47/52A61P35/00A61K2300/00
Inventor 孙柏旺高志国李瑶嘉陈芳慧安佩景
Owner SOUTHEAST UNIV
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