79results about How to "Improve retention effect" patented technology

Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and / or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

The invention provides gelatine-PCL (posterior cruciate ligament) dental hemostatic sponge and a preparation method thereof. The preparation method comprises the following steps of: firstly, stirring a gelatine solution with the mass fraction of 5-20% with a PCL solution with the mass fraction of 10-20% at the temperature of 25-60 DEG C to react for 1-5 hours so as to prepare a combined solution, then adding auxiliary additives to the combined solution, continuously stirring for 1-3 hours at the temperature of 25-60 DEG C to prepare a mixed solution, pouring the mixed solution into a mould, freezing for 0.5-4 hours at the temperature of minus 20 DEG C, and finally freeze drying and moulding in a freeze drying machine to obtain the gelatine-PCL hemostatic sponge. The gelatine-PCL hemostatic sponge prepared by the invention has good retention property, hemostatic property and anti-inflammatory bacteriostatic effect; the product is safe and effective without toxic or side effect; waste can be degraded without causing environmental pollution; and the gelatine-PCL hemostatic sponge can be widely applied as a postoperation hemostatic material for dental extraction and other oral surgeries and has a good market application prospect.

The invention relates to a preparation method and application of ball-milling organic modified bentonite for retention and filter aids in papermaking. The preparation method comprises the steps of: dispersing the bentonite in water, stirring and ultrasonically dispersing to form a bentonite suspension; adding octodecyl trimethyl ammonium bromide as a surface active agent into the bentonite suspension, stirring and undergoing a water bath reaction to obtain a reaction liquid; and washing the reaction liquid by utilizing distilled water, carrying out pumping filtration till the filtrate has no white precipitate under the AgNO3 titration, drying the obtained filter cake and carrying out ball-milling to obtain the ball-milling organic modified bentonite. The prepared ball-milling organic modified bentonite has smaller particle size, the particles are basically in submicron to nanometer scale and the size distribution is more uniform; and when the prepared ball-milling organic modified bentonite is cooperated with other retention aids such as cationic polyacrylamide (CPAM), phenolic resin polymer and the like to be applied to paper pulp retention and filter systems, the problems of paper stock molding and shearing can be more effectively solved, the pulp drainage property can be enhanced, the retention effect can be improved, the speed of a paper machine can be enhanced, and therefore, the production efficiency can be increased.

The invention discloses a preparation method of an oil-absorbing material. According to the invention, a monomer A, water and a cross-linking agent are subjected to a suspension polymerization reaction under the effect of an initiator and a dispersant, and produced polymer particles are separated by screening. The monomer A is composed by one or more components selected from acrylic ester, vinyl ester, and styrene monomer organics. The cross-linking agent is composed of olefin ester or olefin containing two or more unsaturated carbon-carbon double bonds. The oil-absorbing material prepared from the method and the raw materials is advantaged in high oil absorption speed, and good oil retaining performance. Oil absorbed into the oil-absorbing material is prevented from being released into the environment during transportation and storage processes, such that secondary pollution is prevented. The oil-absorbing material with the absorbed oil can be used as furnace or boiler fuel for combustion. The preparation method is simple, and the operation is simple.

The invention discloses a modified cationic polyacrylamide papermaking retention agent, and belongs to the field of papermaking additives. The modified cationic polyacrylamide papermaking retention agent is produced by firstly, conducting preliminary modification on kaolin particles, hydrochloric acid and hydrogen peroxide; secondly, embedding the mixture in the surfaces of bamboo poles for further modification; thirdly, mixing modified kaolin particles with bamboo fiber, 2-methacryloyloxyethyl-trimethyl ammonium chloride and acrylamide monomers, placing the mixture in a reaction kettle, and making the mixture react with gamma-aminopropyltriethoxysilane, N,N-diethyl aniline and other substances. Embodiments prove that the prepared modified cationic polyacrylamide papermaking retention agent is simple in preparation process, good in retention effect, free of damage to the environment, remarkable in economic benefit and social benefit, capable of reducing input of paper pulp raw materials and capable of reducing the production cost by 70% or above.

The invention provides a collagen-polycaprolactone (PCL) dental hemostatic sponge and a preparation method thereof. The method comprises the following steps of: blending 0.2 to 1 mass percent of collagen solution and 0.5 to 10 mass percent of PCL solution, stirring at the temperature of between 1 and 30DEG C, reacting for 1 to 6 hours to obtain complex liquid; adding auxiliaries into the complex liquid, continuously stirring at the temperature of between 1 and 30DEG C for 1 to 4 hours to obtain a mixed solution; pouring the mixed solution into a mold, freezing at the temperature of -20DEG C for 0.5 to 4 hours; and performing freeze drying in a freezer dryer to obtain the collagen-PCL hemostatic sponge. The collagen-PCL hemostatic sponge prepared by the method has good retention ability, hemostasia, anti-inflammatory and antibacterial property and biocompatibility, is effective and safe without toxic or side effect, can be widely used as a postoperative hemostatic material for exodontias and other oral surgeries and has good market application prospect; and waste can be degraded and cannot pollute environment.

The invention provides a solution type corn cationic starch and a preparation method thereof, the preparation method comprises the following steps: (1) dissolving corn starch, and dividing an obtainedsolution into two parts; (2) adding a strong oxidant and liquid caustic soda into the first part of solution, and adding liquid caustic soda with the same volume into the second part of solution; (3)removing the oxidant in the first part of solution, mixing the two parts of solutions, and adding a cross-linking agent; (4) carrying out etherification reaction; and (5) adjusting the pH value, sterilizing and sieving to obtain the solution type corn cationic starch. The preparation method of the solution type corn cationic starch provided by the invention has the advantages of lower requirements on equipment and process, lower production cost, uniform reaction in the process of producing the solution type corn cationic starch, less reagent residue and better quality of the produced product,and is more suitable for industrial production compared with ionic starch sold on the market. And a good retention effect is achieved.

A spray starch as interlayer adhesive of paperboard is prepared from raw starch (70-90%), bentone (2-20%), talc powder (0-5%), modified starch (0-25%) and antiseptic (0.1-0.6%) through stirring raw starch and sequentially adding others while stirring. Its advantages are simple technics, high effect and low cost.

The invention discloses a preparation method of a nano silicon dioxide oleophobic reinforced composite chitosan sizing agent. The preparation method comprises the following steps: firstly performing cationic modification for chitosan by virtue of glycidyl trimethyl ammonium chloride, so that the surface has cations, not only can a compounding effect with cationic starch be improved, but also the action on fibers and filler with the surface having negative charges is higher under the synergistic effect, and the retention assistant effect is excellent; and by gluing paper, the surface energy ofthe paper can be reduced, and a given electrostatic adsorption effect for oil drops can be realized; and the added nano silicon dioxide can be reasonably combined with chitosan, when the surface of the paper contacts oily ingredients, a layer of oil drop repelling phase can be formed on the surface of a micro-nano coarse structure, an effect for supporting the oil drops and preventing the oil drops from penetrating into the surface micro structure of solids can be realized, and the barrier performance for the oil can be further improved.

The invention discloses a preparation method of antibacterial paperboard high in bonding strength, and belongs to the technical field of board preparation. An amphoteric polyacrylamide emulsion servesas a bridge and is combined and linked with silver-loaded zeolite and paper pulp, gaps between layers are filled with cationic starch and modified chitosan, and the antibacterial paperboard high in bonding strength is obtained; zeolite of a porous structure is modified through a silver nitrate solution, a catalytic reaction is utilized for sterilization, water molecules and oxygen in the air areactivated with nanometer particles, and then the antibacterial effect of the paperboard is improved, the very good retention effect is achieved for the starch, and the bonding strength, between the layers, of the paperboard is further improved; crosslinked chitosan resin is prepared by mixing the chitosan with epichlorohydrin, formalin and acetic acid, the crosslinked chitosan resin can control loss of the chitosan and enhance adsorptive selectivity of the chitosan, and then the effect of killing bacteria is achieved; the bacterial effect of the paperboard is further improved, and a wide application prospect is achieved.

The invention discloses a papermaking auxiliary agent composition. The papermaking auxiliary agent composition is prepared from the following raw materials in parts by weight: 12-20 parts of hemicellulose, 20-30 parts of nano titanium dioxide, 10-14 parts of zeolite, 3-8 parts of polyethylene glycol, 1-5 parts of magnesium stearate, 2-6 parts of chlorinated paraffin, 1-3 parts of polyoxyethylene nonyl phenyl ether, 2-3 parts of higher alcohol fatty acid ester complex, 1-2 parts of hydroquinone, 2-5 parts of microcrystalline wax, 1-2 parts of carbonyl diamide, 1-4 parts of sodium dihydrogen phosphate and 1-5 parts of mannitol. The papermaking auxiliary agent composition disclosed by the invention also has the good effects that the prepared papermaking auxiliary agent composition has a good retention effect and the tensile strength of paper sheets can be remarkably improved.

The invention relates to a transition prosthesis bonded and planted adjacent to teeth, especially to a 3D-printed detachable transition prosthesis bonded and planted adjacent to teeth. The 3D-printed detachable transition prosthesis comprises first printed parts and a second printed part, wherein each first printed part comprises a tongue-side flange dually adjacent to a tooth and an edentulous tongue-side keyway basal part; the second printed part comprises a dental crown part of the detachable transition prosthesis and a key part at a tongue side; and the first printed parts are fixedly connected with the second printed part. The transition prosthesis prepared through 3D printing can realize maximal precision; since the transition prosthesis is completely prepared by using a computer, artificial errors are avoided; and the transition prosthesis is perfectly engaged with the tongue sides of adjacent teeth, so the probability of falling of the transition prosthesis after bonding is reduced, and economic cost and time of patients are substantially lowered.

The invention discloses a personalized temporal-mandibular joint fossa implant which comprises an outer side retainer wing plate and a condyle process supporting surface, wherein the inner side face of the outer side retainer wing plate is in retaining fit with the outer side face of zygomatic arch of a patient; the lower edge of the outer side retainer wing plate and the condyle process supporting surface are connected into a whole; a top bulge is formed on the top surface of the condyle process supporting surface and positioned in a direction of the inner side face of the outer side retainer wing plate; the top surface of the condyle process supporting surface with the top bulge is attached to the temporal-mandibular joint fossa of the patient; the bottom surface of the condyle process supporting surface is attached to the lower condyle process head in a wrapped form; and the shape and size of the top bulge of the condyle process supporting surface and at least one of the width of the top surface and the width of the bottom surface of the condyle process supporting surface are in personalized matching according to the temporal-mandibular joint fossa and the lower condyle process head of the patient. The implant can be in close fit with the temporal-mandibular joint fossa of the patient, traumas and injuries of temporal-mandibular joint fossa implant surgery on peripheral tissues of the temporal-mandibular joint fossa can be reduced, and the joint fossa implant has high stability.

The invention discloses a damping pin for a computer chassis. The damping pin is characterized by comprising an elastic body of the pin, wherein the elastic body is in a longitudinal symmetric shape, the middle section of the elastic body is a concave arc cylinder, two ends of the elastic body are in a circular truncated cone shape; and except the part of the middle section, the inside of two ends of the elastic body is hollow in accordance with the appearance. Hardness of the elastic body of the pin of the structure ensures excellent elasticity to absorb vibration and sufficient weight to endure a supporting body, so the pin cannot be deformed remarkably. A hollow cylinder on one end of the elastic body of the pin is inserted into a corresponding pin hole on a back plate of the chassis, while a hollow cylinder on the other end of the elastic body of the pin is inserted in a spacing ring. The special structure of the damping pin can greatly reduce vibration and noise. The damping pin can be applied to vibration of the computer chassis, and also can be used in instruments in any weight without excessive resonance noise.

The invention discloses a construction method and system of a retention accessory and a bracket-free invisible orthodontic appliance. The construction method comprises the following steps: acquiring a dentition model and a shell-shaped appliance model matched with the dentition model; selecting an installation point in an accessory installation selectable area on the dentition model, and constructing the retention accessory based on the installation point, specifically, taking off the shell-shaped appliance model worn on the dentition model from the dentition model, and obtaining a movement track of a reference point, corresponding to the installation point, of the shell-shaped appliance model; and establishing a tangent line of a key position point in the movement track, or establishing a direct connection line of two key position points in the movement track, and constructing the retention accessory according to a predetermined rule based on the tangent line or the direct connection line. Therefore, the retention force of the accessory to the appliance is improved, and the appliance is prevented from accidentally falling off.

The invention provides a convenient medical positive-pressure remaining needle which comprises a puncture needle, a catheter, an extension tube, an infusion tube line and a water stop. The water stop comprises a water stop body, an extension-tube passage, a wheel shaft groove and a toothed pulley, the extension-tube passage is arranged in the water stop body and used for accommodating one section of the extension tube, a plurality of protruding teeth arranged on the circumferential surface of the toothed pulley and a wheel shaft extending along an axis of the protruding teeth are arranged on the toothed pulley, the wheel shaft groove is arranged in the water stop body along the length direction of the extension-tube passage, and the wheel shaft of the toothed pulley is mounted in the wheel shaft groove and can move along the wheel shaft groove back and forth. The water stop is structurally characterized in that with forward movement of the wheel shaft of the toothed pulley in the wheel shaft groove, the distance between the wheel shaft of the toothed pulley and the extension tube in the extension-tube passage gets shorter, till the protruding teeth of the toothed pulley are completely pressed against a section of the extension tube located in the extension-tube passage. The convenient medical positive-pressure remaining needle has the advantages of good tube-sealing effect, convenience and rapidness in operation, good remaining effect, good security and the like.

The invention discloses an image denoising method based on residual learning and a convolutional neural network. The image denoising method comprises the following steps: firstly, denoising an input noisy image by adopting a convolutional neural network method and a residual learning method respectively; denoising the noisy image by adopting a method of combining the convolutional neural network method and the residual learning method, adding padding into the convolutional neural network, performing batch normalization operation, adding a spanning connection structure from a shallow layer to adeep layer into the network, and performing training by adopting the convolutional neural network of an Adam algorithm; and finally, outputting the denoised image. The network depth can be expanded,network degradation and loss and loss of information in a transmission project are effectively avoided, and the maintaining effects of the depth and structural information of a convolutional neural network denoising model are improved.

The invention provides a continuously-inflatable packaging airbag, which comprises an airbag body and an inflating channel. A plurality of hot streak edges are pressed on the airbag body; every two adjacent hot streak edges form an air chamber; the inflating channel is formed by air valves and an inlet channel; each air chamber is communicated with the inlet channel through the corresponding air valves; a printing ink layer and hot streak points are coated on the inner wall of the air valve; the air valves and an opening of the airbag body are pressed and sealed to form the hot streak edges; and the hot streak edges are positioned in areas of the printing ink layers; and through holes allowing air to pass through are reserved in the middle of the printing ink layers. When the airbag is used, goods to be packaged are put on the airbag body, the air is blown to the valves through the inlet channel to be filled into each air chamber, and then each air chamber is expanded to package and fix the goods to be packaged tightly to prevent the goods from swaying and being damaged during carrying, so the problems of high cost and poor retention effect of the conventional packaging measures are solved. The continuously-inflatable packaging airbag has light weight and the shape capable of being randomly changed according to different object shapes without limitation, is simple and easy to use, and makes contributions to the advocacy of conservation-minded society.

The invention relates to the technical field of dental implants, specifically to a one-time implantation type composite dental implant.. According to the invention, in the whole conventional dental restoration process, expensive multi-component structures need to be combined together; operation is complex; and the effect is poor. The one-time implantation type composite dental implant provided bythe invention sequentially comprises an integrated retention structure, a gingiva penetrating section and a spiral retention body from top to bottom, wherein the retention structure comprises a central bolt channel, a retention plane and a retention outer wall; the retention outer wall comprises an upper retention outer wall and a lower retention outer wall; the upper retention outer wall and thelower retention outer wall are discontinuous slopes under the same taper; the gingiva penetrating section comprises a gingiva penetrating platform and a platform transferring section; the central boltchannel is located in the centers of the retention structure and the gingiva penetrating platform; and the platform transferring section and the spiral retention body are of solid structures. The one-time implantation type composite dental implant provided by the invention has the following advantages: the whole operation is completed through one-time implantation; the retention performance is excellent; dental diseases are not prone to being caused; human health is not affected; and the one-time implantation type composite dental implant has good development prospects in the technical fieldof dental implants.

The invention relates to a preparation method and a paper pulp retention aiding application of a bead-like cationic polyacrylamide retention aid. An inverse emulsion polymerization process is used, and a reaction micro-environment chamber in the acrylamide polymerization process is accurately regulated to effectively regulate the molecular weight and the polymerization mode of acrylamide in orderto control the physical form of the PAM product and obtain the easily-dispersed bead-like PAM product having a diameter of 0.8-1.5 mm. The bead-like PAM avoids the x agglomeration phenomenon in water,so the dissolving rate of the bead-like PAM in water is greatly increased, and the dust pollution caused by powdery PAM is solved, thereby the addition process is simplified, the requirements for devices are reduced, the production cost is reduced, and the large-scale commercial application is benefited.

The invention relates to a papermaking retention aid and a preparation method and application thereof, and belongs to the technical field of aids to be added to pulps. The papermaking retention aid ismade by polymerizing a nonionic biopolysaccharide having molecular weight of 3000000-5000000, cations and alkenyl amide having unsaturated double bonds. The preparation method of the papermaking retention aid comprises the steps of polymerizing; sealing to hold temperature, and extracting a product. The papermaking retention aid prepared herein by means of grafting and polymerization of the biopolysaccharide has excellent properties, is widely applicable to the market and has good social and economic benefits.

The invention relates to a synthetic method of a paper retention and filter aid. The method adopts the scheme that the nonionic monomer, the cationic monomer and the deionized water are mixed according to the proportion (300-500:35-75:320-510) of weight ratio after nitrogen charging and oxygen removal at the temperature of 10-30 DEG C and under the stirring condition; and a water-soluble initiator with weight ratio of 0.12-0.83 is added with water for dissolution and then is added in the mixed liquor; and the polyreaction is carried out for 3-8 hours at the temperature of 0-90 DEG C. The invention is the copolymer of the acrylamide and the cationic monomer, the copolymer and the particles in the pulp are flocculated after electrical neutralization or bridging to be retained on the filter cloth, and the invention can improve the retention rate of the fiber fines and the filler particles on the net, promote the dehydration of the paper and reduce the loss volume of the fiber in the white water; and the invention not only can improve the surface properties of the paper, but also can enhance the tensile property of the paper.

The invention discloses a method for using a constraint bonded-bridge type artificial tooth, which comprises the following steps: respectively forming 0.5mm deep indicating grooves by grinding at the positions 0.5mm at a palate side neck edge and 0.5mm at a jaw edge, at the flat palate edge and the jaw edge, removing the tooth tissues between the indicating grooves by grinding; preparing a 1mm deep inlay hole at the position of a facial rest, and extending a shaft wall outwards for 15 degrees; preparing wax models of wing plates and connectors at the palatoglossal side and the adjacent surface thereof on a phosphate model, then embedding and casting the wax models; carrying out abrasive blasting, grinding and polishing on the obtained wax models; preparing an inner crown wax model of an artificial tooth on the connector of a tongue device; connecting the inner crown wax model of the artificial tooth and a wax model of the inlay rest into a whole, then embedding, casting and debugging in place; debugging the tongue device in place from the tongue direction; taking a jaw device in position from the jaw direction; then bonding the max models by resin adhesives. By using the method disclosed by the invention, the production process of the artificial tooth is simple, the abutment preparation quantity is less, the method is easy to operate, anesthesia is not required, and no side effect is caused; and the tooth preparation method is simple and easy to master, the operation time of the method is short, the repair effect is good, and the retention effect is good.

The invention relates to a device for coiling and retaining a power communication optical cable, in particular to an enclosed type optical cable coiling and retaining frame. The enclosed type optical cable coiling and retaining frame comprises a cross and a cylindrical protective cover. Four ends of the same side of the cross are respectively and fixedly provided with a straight panel perpendicular to the plane where the cross is located. The panel surfaces of the straight panels at the opposite positions are opposite. The end of each straight panel is branched, wherein one branch is bent 90 degrees towards the center of the cross to form an inward bent piece, the other branch is bent in the direction deviating from the center of the cross to form an outward bent piece, and each inward bent piece is provided with a threaded hole. The bottom face of the cylindrical protective cover is provided with threaded holes corresponding to the threaded holes formed in the inward bent pieces. The opening diameter of the cylindrical protective cover is larger than the linear distance between the ends of any two opposite outward bent pieces. Through the enclosed type optical cable coiling and retaining frame, the optical cable coiled and retained on the cross can be covered with the cylindrical protective cover, the optical cable can not be damaged accidentally, and the optical cable can not be damaged when a cable joint is ignited in the detonation process; thus, the enclosed type optical cable coiling and retaining frame can effectively protect the power communication optical cable.

The invention discloses a device special for drainage. The device comprises a drainage pipe, an annular gasbag and a blocking head which is in sliding fit with the inner side wall of the drainage pipe; the upper end of the drainage pipe serves as a liquid inlet end, and the lower end of the drainage pipe serves as a liquid outlet end and is detachably connected with a drainage bag through a connecting joint; the gasbag fixedly sleeves the outer side of the drainage pipe and is arranged close to the liquid inlet end; an inflation pipeline communicated with an inner cavity of the gasbag is connected to the gasbag; an air inflation nozzle is connected to the inflation pipeline at the air inlet end, and a pressure adjusting valve is further connected to the portion, close to the air inlet end,of the air inflation pipeline; multiple drainage holes are formed in the section, between the air inlet end and the gasbag, of the drainage pipe in the length direction of the drainage pipe; the blocking head is in a shape of a bullet, and is arranged at the inner side of the liquid inlet end of the drainage pipe and connected with a silica gel strip, and the free end of the silica gel strip penetrates through the drainage pipe and penetrates out of the liquid outlet end. The device has a good fixing effect in the body of a patient, and does not easily fall off; meanwhile, the drainage smoothness of the device is good, and the drainage effect is ideal.

The invention discloses an anti-bumping heat preservation box for cold chain transportation, and relates to the technical field of transportation accessories. The anti-bumping heat preservation box comprises a box shell, a box cover is hinged to the box shell, lifting handles are hinged to the outer walls of the two sides of the box shell, two buckle bases are symmetrically arranged on the outer wall of the front face of the box shell, two buckle pieces used in cooperation with the buckle bases are symmetrically arranged on the box cover, and a storage assembly is arranged in the box shell and comprises a storage box. A plurality of storage boxes are arranged on the outer walls of the front surface and the back surface of the storage box; and a storage structure is arranged in the storage box. The storage structure and an air supply structure are used in cooperation, reagents of different sizes can be effectively stored, the reagents of different shapes and sizes can be flexibly and uniformly fixed, a good retention effect can be achieved, the inflation and deflation processes of an air bag are convenient and rapid, therefore, the practicability of the anti-bumping heat preservation box is improved.

The invention discloses a resin support gingiva imitation type stopper which comprises a base support plate attached to the surface of an oral vestibule, wherein a sac cavity plug is arranged at the position, corresponding to a sac cavity stoma, of the side, attached to the oral vestibule, of the base support plate, and the base support plate is further provided with retention columns matched withinverted concave shapes between teeth. By timely and correctly wearing the resin support gingiva imitation type stopper postoperatively, a wound after a sac windowing decompression operation can be temporarily sealed, so that the stopper plays a key role in preventing premature healing of a sac cavity window; meanwhile, the resin support gingiva imitation type stopper can prevent food from entering a sac cavity during eating, and thus is beneficial to cleaning of the sac cavity; and periodic grinding of the stopper is beneficial to reduction of sacs and growth of the sacs in the opening direction.

The invention discloses a molybdenum disulfide-based material with photo-thermal and photodynamic properties at the same time, the material takes a molybdenum disulfide nanosheet as a carrier, TCPP is coupled to the surface of the molybdenum disulfide nanosheet through cysteamine, and NH2-PEG-TPP is coupled to the surface of the molybdenum disulfide nanosheet through lipoic acid. Molybdenum disulfide in the molybdenum disulfide-based material has good biocompatibility, and permeability of the molybdenum disulfide in an organism can be improved when the molybdenum disulfide is prepared into a sheet for application; in addition, as a nano-scale material, the material also has a high retention effect in a living body; lastly, flaky molybdenum disulfide is adopted as a carrier, after TCPP and NH2-PEG-TPP are coupled, on one hand, the pharmacokinetics of TCPP in vivo can be changed, on the other hand, TCPP can be separated and cannot be gathered, so that the light stability of TCPP is improved, by introducing a targeting group, photo-thermal and photodynamic materials can be targeted to mitochondria of tumor cells, and the killing effect of photo-thermal and photodynamic materials on cancer cells is further enhanced.

The invention discloses a digital double-blocking-plate corrector with oral respiration and mandibular retraction and a manufacturing method, and belongs to the technical field of correctors. According to CBCT image data, the mandibular leading amount of a target position is accurately determined, the upper jaw inclined plane magnetic type positioning nail and the lower jaw inclined plane magnetic type positioning nail are symmetrically designed on the occlusion inclined plane, the problem of night dislocation of the functional orthosis is reduced, and the detachable breathing gear can adjust the oral cavity air inflow and promote nasal breathing. The double-resistance-plate straightener disclosed by the invention is more accurate to manufacture by utilizing a digital program, the manufacturing time of the straightener can be shortened, the rework rate of the straightener can be effectively reduced, and benzene and dust pollution in a traditional process can also be avoided. Meanwhile, more reasonable step-by-step design and staged corrector manufacturing can be carried out on the lower jaw leading amount by utilizing a tooth jaw model and jaw bone three-dimensional data of a patient, so that the comfort level and the treatment safety of the patient are effectively improved, and meanwhile, the method can be synchronously used for auxiliary treatment of oral respiration.