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Aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection

A technology of freeze-dried powder injection and aminotoluic acid, which is applied in the field of aminotoluic acid freeze-dried powder injection pharmaceutical composition for injection, and can solve problems such as inability to block

Active Publication Date: 2015-06-24
山东北大高科华泰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin

Method used

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  • Aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection
  • Aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection
  • Aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0082] Preparation Example 1, Preparation of Powder Injection Containing Aminotoluic Acid

[0083] formula:

[0084] Aminomethylbenzoic acid

100mg,

Mannitol

95 mg,

Dextran-20

5 mg,

pH regulator

to pH4.0,

Water for Injection

Appropriate amount, add to 4ml.

[0085] Preparation:

[0086] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0087] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder dilute...

preparation example 2

[0091] Preparation Example 2, Preparation of Powder Injection Containing Aminotoluic Acid

[0092] formula:

[0093] Aminomethylbenzoic acid

100mg,

Mannitol

50mg,

Dextran-20

10mg,

pH regulator

to pH4.5,

Water for Injection

Appropriate amount, add to 6ml.

[0094] Preparation:

[0095] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0096] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder dilute...

preparation example 3

[0100] Preparation Example 3, Preparation of Powder Injection Containing Aminotoluic Acid

[0101] formula:

[0102] Aminomethylbenzoic acid

100mg,

Mannitol

150mg,

Dextran-40

2 mg,

pH regulator

to pH3.5,

Water for Injection

Appropriate amount, add to 5ml.

[0103] Preparation:

[0104] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0105] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder diluted...

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PUM

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Abstract

The invention relates to an aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection. Specifically, on one hand, the invention relates to a freeze-dried powder injection medicine composition. The freeze-dried powder injection medicine composition contains aminomethylbenzoic acid, a freeze-drying excipient such as mannitol, and an optional acid-base regulator; the freeze-drying excipient is selected from saccharose, glucose, mannitol, lactose, sorbitol and glycine, and the weight ratio of the aminomethylbenzoic acid to the freeze-drying excipient is 100: (50 to 500). On the other hand, the invention further relates to a method for preparing the aminomethylbenzoic acid freeze-dried powder injection medicine composition, wherein the method is carried out according to a conventional freeze-dried powder injection medicine preparation method. The aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection disclosed by the invention can be used for treating such bleeding caused by excessive primary fibrinolysis as acute and chronic, local or general high fibrinolytic bleeding which is common in carcinoma, leukaemia, gynaecology and obstetrics accidences, serious liver disease bleeding and the like, and anticipated good properties can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a hemorrhage that can be used for hemorrhage caused by excessive primary fibrinolysis, including acute and chronic, localized or systemic hyperfibrinolytic hemorrhage, which is common in cancer, leukemia, The pharmaceutical composition of freeze-dried powder injection for obstetrics and gynecology accidents, severe liver disease bleeding, etc., especially relates to a pharmaceutical composition of freeze-dried powder injection containing aminomethylbenzoic acid. The freeze-dried powder injection pharmaceutical composition of the present invention has expected good properties. Background technique [0002] Aminomethylbenzoic acid (Aminomethylbenzoic Acid), p-aminomethylbenzoic acid monohydrate, also known as anti-blood fibrinolytic aromatic acid, p-carboxybenzylamine, 4-(aminomethyl)benzoic acid, 4-aminomethylbenzoic acid , p-aminomethylbenzoic acid; 4-(Amino metmyl)benzoic acid, ...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/195A61P7/04
Inventor 李英红姜长通赵文涛卢家振李锐
Owner 山东北大高科华泰制药有限公司
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