87 results about "Oxidized regenerated cellulose" patented technology

The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and / or into the wound of a patient.

A method of making a composite prosthetic device, such as a hernia repair device, includes providing a support layer, juxtaposing a layer of an absorbable material with the support layer, and disposing an absorbable adhesive between the support layer and the layer of an absorbable material. The method includes heating the layers for melting the absorbable adhesive so as to bond the support layer with the layer of the absorbable material. Before the heating step, the moisture content of at least one of the layers is increased for improving thermal conductivity between the layers so as to enhance the strength of the bonds formed between the layers. The moisture content may be increased by exposing at least one of the layers to an environment having elevated relative humidity. In one embodiment, the support layer is polypropylene mesh, the layer of the absorbable material is oxidized regenerated cellulose, and the absorbable adhesive is polydioxanone.

The invention provides a degradable and absorbable water soluble hemostatic material, which comprises an oxidized regenerated cellulose salt, wherein the carboxylic acid oxidizability of the oxidized regenerated cellulose salt is no less than 5 percent, the degree of etherification of the oxidized regenerated cellulose salt is 0.2 to 1.2, and the number-average molecular weight of the oxidized regenerated cellulose salt is 50,000 to 200,000. The hemostatic material of the invention can be used for stopping bleeding and preventing wound adhesion or used as wound dressing. The hemostatic material has the advantages of remarkable hemostatic effect, convenient absorption by human body and final discharge to the side of a human body and the like, and has high application values in clinic. The invention also provides a preparation method of the hemostatic material.

A composition for reducing pain at a surgical wound site or trauma site comprising oxidized regenerated cellulose and a non-steroidal anti-inflammatory drug or pharmaceutically acceptable salt or ester thereof, where the non-steroidal anti-inflammatory drug is an acid having a secondary amine group; and a method of reducing localized pain at a surgical wound site or trauma site.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

The invention provides a preparation method of an oxidized regenerated cellulose (ORC) absorbable hemostasis material, relates to a preparation method of the ORC absorbable hemostasis material, and aims to solve the problems of high preparation method, environment pollution, difficulty in reaction process and inconvenience in industrial production and the like in a conventional preparation method of the oxidized regenerated cellulose (ORC) absorbable hemostasis material. The preparation method provided by the invention comprises the steps that nitrogen dioxide and cyclohexane are added to a recycle reactor, regenerated cellulose is then added to the recycle reactor, the reactor is sealed, and an oxidation product is obtained after a reaction; the oxidation product is flushed by using cyclohexane, an ethanol aqueous solution and then absolute ethanol; the oxidation product is frozen and dried, and then the ORC absorbable hemostasis material is obtained. The preparation method of the ORC absorbable hemostasis material, which is provided by the invention, has the advantages that the oxidation efficiency of the ORC absorbable hemostasis material is equivalent to that achieved through using traditional solvents, the problems of environmental pollution and climatic influence are solved at the same time, the reaction process is easy to control; and the preparation method is suitable for industrial production.

The invention provides a preparation method for an oxidized regenerated cellulose hemostatic material with a surface nanostructure. In order to solve problems of small specific surface area, water insolubility, single hemostatic effect mechanism and low hemostatic speed of the traditional oxidized cellulose hemostatic material, the invention provides the preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The method comprises the following steps of: (1) preparing a collagen aqueous solution; (2) preparing a viscose fiber gauze; (3) preparing oxidized viscose staple fiber and oxidized viscose fiber gauze; (4) preparing an oxidized regenerated cellulose sodium solution or an oxidized regenerated cellulose potassium solution; (5) preparing an oxidized regenerated cellulose gauze; and (6) after collagen particles are sprayed, freezing and drying the oxidized regenerated cellulose gauze, so as to finish the preparation of the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure, provided by the invention, is applied to the preparation field of the oxidized regenerated cellulose hemostatic materials.

A novel ORC adhesive tape is disclosed. Specifically, the ORC adhesive tape is useful as an alternative to conventional mechanical and non-mechanical wound closure means. The ORC tape has a tape substrate made from neutralized ORC and it contains an adhesive composition such as a bioabsorbable alpha-cyanoacrylate.

A biodegradable and water-soluble hemostatic material is provided. The hemostatic material comprises an oxidized regenerated cellulose salt having a degree of carboxylic acid oxidation not less than 5%, a degree of etherification of 0.2 to 1.2 and a number average molecular weight of 50,000 to 200,000. The hemostatic material according to the present invention offers improved hemostatic effect, absorbability and operability over existing hemostatic products. A method for preparing the hemostatic material is further provided.

Systems, methods, and apparatuses for modulating proteases including matrix metalloproteinase (MMP), elastase, and bacterial protease in a negative pressure therapy system are described. A mesh having a sacrificial substrate is included. The sacrificial substrate includes a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings. The openings of the plurality of openings have an average area between about 0.5 mm2 and about 20 mm2 to permit the flow of negative pressure through the mesh. The sacrificial substrate can also include oxidized regenerated cellulose.

Wound dressing compositions comprising oxidized regenerated cellulose and poly(hexamyethylene biguanide). The compositions preferably also contain a structural protein, such as collagen. Wound dressings are also provided, comprising an absorbent layer comprising the wound dressing compositions.

A dressing for wound healing is provided herein including dehydrated placental tissue, collagen, and oxidized regenerated cellulose. The dehydrated placental tissue may be present in a first layer and the collagen and the oxidized regenerated cellulose may be combined into a second layer. The dehydrated placental tissue may comprise amniotic membrane tissue, chorion tissue, or a combination thereof. The second layer including the collagen and the oxidized regenerated cellulose may comprise about 50% to about 60% collagen by weight and about 40% to about 50% ORC by weight.

Wound dressing compositions comprising: carboxymethyl cellulose, oxidized regenerated cellulose (ORC), and silver. The dressings optionally further comprise non-gelling cellulose fibers. The compositions may comprise a complex of the ORC and silver. Wound dressings are also provided, comprising an absorbent layer comprising the wound dressing compositions.

The invention relates to a water-soluble oxidized regenerated cellulose hemostatic material and a preparation method thereof, solving the problem that the traditional oxidized regenerated cellulose materials are water-insoluble and have the defects of high polymerization degree, poor biological absorbability and slow haemostatic speed. The water-soluble oxidized regenerated cellulose hemostatic material is prepared from an alcoholic solution of oxidized regenerated cellulose and strong alkali. The preparation method comprises the following steps of: (1) neutralizing and modifying; (2) washing; and (3) drying. The product provided by the invention can be used in the medical hemostasis field.

The invention discloses a bandage dressing special for limb war wound first aid, and belongs to the technical field of medical dressings. The bandage dressing is composed of a dressing body and a bandage; the dressing body sequentially comprises an inner layer dressing, a middle layer dressing and an outer layer dressing from the side making contact with the war wound part; the inner layer dressing adopts a non-woven fabric layer formed by blending chitosan fibers and oxidized regenerated cellulose and is used for stopping bleeding and absorbing wound secreta; the middle layer dressing adopts a polyvinyl formal spongy layer and is used for absorbing oozing liquid discharged from meshes and pressing to stop bleeding; the outer layer dressing adopts a cotton weaving gauze layer and is used for fixing and binding; the inner layer dressing is rich in antibacterial agent, and multiple penetrating drainage holes are formed in the inner layer dressing in the thickness direction; a two-way semi-transparent film is arranged between the middle layer dressing and the outer layer dressing. The bandage dressing has the advantages of being reasonable in structural design, efficient in stopping bleeding, resistant to infection, capable of moisturizing and promoting healing, convenient to use and the like.

The invention discloses a preparation method of a bleeding stopping and adherence preventing material. In the method, soluble oxycellulose or oxidized regenerated cellulose is used as a base material, and dextran, fibrinogen and blood coagulation factors are added to the base material in a stirring or spraying mode to prepare a film or liquid. The prepared hemostasis and adherence preventing material has more effective bleeding stopping and adherence preventing effects and can quickly stop bleeding, prevent adherence and promote tissue healing, is completely degraded, can be absorbed and utilized by the human body, and has no side effect and safety use.

The invention discloses a preparation method of a multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material. The preparation method of the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material comprises the following steps: (1) adding multi-wall carbon nano tubes into chitosan / diluted acid solution, and carrying out ultrasonic dispersion, so that uniformly dispersed multi-wall carbon nano tube solution is obtained; and (2) weighing oxidized regenerated cellulose, impregnating in the multi-wall carbon nano tube solution obtained in the step (1), washing with absolute ethyl alcohol after impregnation is finished, and finally prefreezing the washed oxidized regenerated cellulose and then treating in a freezer dryer, so that the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material is obtained. The prepared multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material has the advantages that carbon nano tubes are compounded with the oxidized regenerated cellulose, so that specific area of the oxidized regenerated cellulose is increased; meanwhile, chitosan is added, so that both hemostasis property and antibacterial property of the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material are improved, and the defect that the hemostasis property of common oxidized regenerated cellulose and a composite hemostatic material thereof is slightly improved is overcome.

A biomaterial that includes collagen and an antimicrobial agent such as citric acid is provided herein. The biomaterial may further include a metal, such as silver, and an anionic polysaccharide, such as oxidized regenerated cellulose (ORC). Methods of using the biomaterial in wound therapy and on medical implants, and methods for preparing the biomaterial are also disclosed herein.

An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

The invention discloses a preparation method of a nanocellulose / oxidized regenerated cellulose composite hemostatic material. The method is carried out according to the steps of: 1. preparation of nanocellulose; 2. oxidation of nanocellulose; and 3. preparation of the nanocellulose / oxidized regenerated cellulose composite hemostatic material. According to the nanocellulose / oxidized regenerated cellulose composite hemostatic material provided by the invention, selective oxidation is carried out on the prepared nanocellulose through a TEMPO-NaClO-NaBr oxidation system, a sodium carboxylate structure is introduced to the C6 position of a nanocellulose molecule, and then compounding with oxidized regenerated cellulose is conducted, thereby increasing the specific surface area of oxidized regenerated cellulose, improving the hemostasis performance of the nanocellulose / oxidized regenerated cellulose composite hemostatic material, and overcoming the disadvantage of small improvement amplitude of hemostasis performance in ordinary oxidized regenerated cellulose and its composite hemostatic material. By using the nanocellulose / oxidized regenerated cellulose composite hemostatic material prepared by the method provided by the invention, the hemostasis time is reduced by 5-20%.

The invention discloses a graphene oxide grafted modified oxidized regenerated cellulose hemostatic material and a preparation method thereof, relating to a hemostatic material and a preparation method thereof. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material aims to solve the problems that a modified material of the existing oxidized regenerated cellulose is poor in mechanical strength and biological absorption of the material and small in improvement degree of hemostatic performance. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material is prepared from graphene oxide containing amino groups on the surface and oxidized regenerated cellulose. The preparation method comprises the following steps: I, preparing graphene oxide subjected to acylating chlorination; II, preparing graphene oxide containing the amino groups; and III, performing chemical grafting to obtain the graphene oxide grafted modified oxidized regenerated cellulose hemostatic material. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material disclosed by the invention can be used for reducing the bleeding-stopping time by 7-17% when the material is used for stopping bleeding. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material and the preparation method thereof can be obtained according to the invention.

Hemostatic devices and methods of making same are disclosed. Disclosed hemostatic devices include biocompatible non-oxidized regenerated cellulose. The disclosed hemostatic devices are effective in providing and maintaining hemostasis in cases of moderate to severe bleeding caused by non-compressional and / or non-tourniquetable injuries, among other things. The disclosed methods enable manufacture of a bioabsorbable, biocompatible, biodegradable carboxylmethyl cellulose having high stability and high adherence.

A method of making a composite prosthetic device, such as a hernia repair device, includes providing a support layer, juxtaposing a layer of an absorbable material with the support layer, and disposing an absorbable adhesive between the support layer and the layer of an absorbable material. The method includes heating the layers for melting the absorbable adhesive so as to bond the support layer with the layer of the absorbable material. Before the heating step, the moisture content of at least one of the layers is increased for improving thermal conductivity between the layers so as to enhance the strength of the bonds formed between the layers. The moisture content may be increased by exposing at least one of the layers to an environment having elevated relative humidity. In one embodiment, the support layer is polypropylene mesh, the layer of the absorbable material is oxidized regenerated cellulose, and the absorbable adhesive is polydioxanone.

An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

The invention discloses a method for preparing oxidized cellulose. The preparation method comprises the following steps: a, putting an oxidized cellulose material into inert solution; b, adding an oxidant into the inert solution, sealing the solution, stirring the solution for 10 to 12 hours by using a magnetic stirrer at the temperature of between 20 and 60 DEG C; c, taking the oxidized cellulose material out, and washing the oxidized cellulose material with purified water; d, drying the oxidized cellulose material by using a centrifugal machine, and then washing the oxidized cellulose material by cleaning solution; and e, drying the oxidized cellulose material to obtain a finished product. Because the inert solution is used as a reaction solvent, the oxidization reaction can be performed under the controllable conditions, the reaction is even, and the manufactured oxidized cellulose and oxidized regenerated cellulose products are stable and easy to store; and the reaction solvent and the oxidant can be reclaimed for recycle, so the method is economic and environment-friendly, and the production cost is greatly reduced.

The invention relates to a customizable, solvent-free sustained release medical device for wound closure, wound healing, and the sustained release of an active. The device of the invention is composed of at least a polymeric carrier layer and optionally an oxidized regenerated cellulose layer(s). Polymeric barrier layers can be added to modify the release profile (burst, time of release, etc.) of the selected bioactive agent(s).

The invention discloses a single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method of the hemostatic material, aims at solving the problems that the original form of the oxidized regenerated cellulose cannot be ensured when an oxidized regenerated cellulose modified material is taken as the hemostatic material, thrill is generated to mammal skin and other body cells of the contact part in the use procedure, and the hemostatic performance is slightly improved. The single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material is prepared from a single-walled carbon nanotube containing an amino group on the surface, and oxidized regenerated cellulose; and the preparation method comprises the following steps: 1, preparing the single-walled carbon nanotube for acylating chlorination; 2, preparing the single-walled carbon nanotube containing the amino group in the surface; and 3, carrying out chemical grafting. The haemostasis time of the prepared material is reduced by 4.6%-18.5%; and the single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material and the preparation method thereof can be obtained.

The invention relates to the field of medicines, and in particular relates to a preparation method and a preparation device of oxidized regenerated cellulose absorbable hemostatic gauze. The oxidized regenerated cellulose absorbable hemostatic gauze is characterized in that the preparation device comprises a liquid dispensing tank, a soaking groove and a liquid guiding module for connecting the liquid dispensing tank and the soaking groove, wherein the liquid dispensing tank consists of a capsule-shaped tank and three horizontal legs arranged at the bottom of the tank; the tank comprises a feeding part arranged on the top of the tank, a material receiving part arranged in the middle of the tank and a discharging part arranged at the bottom of the tank; a cleaning pipe is arranged in the center of the top of the feeding part and is embedded into the feeding part; a spray head is arranged at the bottom of the cleaning pipe; a manhole is formed in one side of the cleaning pipe; a water inlet hole is formed in the other side of the cleaning pipe; a backflow pipe and a liquid inlet pipe are arranged between the cleaning pipe and the water inlet hole.

The invention discloses a nanogold / lysine / oxidized regenerated cellulose composite hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method thereof, and aims at solving the problems of obstruction to the biological absorption of a hemostatic material and slight improvement of the hemostatic performance due to a fact that the skin of a mammal is irritant to other body cells at a contact position and a large whitish granulation lump is formed at a use position in the use process of an existing oxidized regenerated cellulose modified material serving as the hemostatic material. The nanogold / lysine / oxidized regenerated cellulose composite hemostatic material is prepared from the nanogold and the oxidized regenerated cellulose on the surface of which the lysine is grafted; the preparation method of the hemostatic material comprises the steps of firstly, chemically grafting the lysine to the oxidized regenerated cellulose, secondly, preparing the aqueous dispersion of the nanogold, and 3, carrying out self-assembling of the nanogold, thereby obtaining the nanogold / lysine / oxidized regenerated cellulose composite hemostatic material. The invention successfully provides the nanogold / lysine / oxidized regenerated cellulose composite hemostatic material and the preparation method thereof.