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Single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material and preparation method thereof

A technology of single-walled carbon nanotubes and regenerated cellulose, which is used in medical science, bandages, absorbent pads, etc. The effect of reducing performance and hemostasis time

Active Publication Date: 2015-03-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that existing oxidized regenerated cellulose modified materials cannot guarantee the original form of oxidized regenerated cellulose as a hemostatic material, and it will stimulate mammalian skin and other body cells at the contact point during use. In order to solve the problem of small increase in performance and hemostatic performance, a single-walled carbon nanotube grafted modified oxidized regenerated cellulose hemostatic material and its preparation method are provided

Method used

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specific Embodiment approach 1

[0025] Embodiment 1: This embodiment is a hemostatic material grafted with single-walled carbon nanotubes modified by oxidized regenerated cellulose, which is prepared from single-walled carbon nanotubes containing amino groups on the surface and oxidized regenerated cellulose; the surface The mass ratio of the single-walled carbon nanotubes containing amino groups to the filament fabric of oxidized regenerated cellulose is (0.05-2):100.

[0026] In the third step of this embodiment, the amino groups in the single-walled carbon nanotubes containing amino groups on the surface react with the carboxyl groups in the oxidized regenerated cellulose structure to form amide bonds, thereby chemically grafting the walled carbon nanotubes onto the oxidized regenerated cellulose .

[0027] The advantage of this implementation mode:

[0028] 1. In step 3 of this embodiment, the amino groups in the single-walled carbon nanotubes containing amino groups on the surface react with the carbox...

specific Embodiment approach 2

[0031] Embodiment 2: The difference between this embodiment and Embodiment 1 is: the carboxyl content in the oxidized regenerated fiber is 16% to 24%; the oxidized regenerated cellulose is made of short filaments, filaments or fabric form exists. Others are the same as the first embodiment.

specific Embodiment approach 3

[0032] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the preparation method of the single-walled carbon nanotubes containing amino groups on the surface is specifically completed according to the following steps: 1. Preparation of acid chloride Single-walled carbon nanotubes: ① Add carboxylated single-walled carbon nanotubes to N,N-dimethylformamide, and then ultrasonically treat them for 15min-60min at an ultrasonic power of 160W-400W, then add chlorinated Sulfone, stirred at a temperature of 60°C-100°C and a stirring speed of 300r / min-750r / min for 16h-48h, then naturally cooled to room temperature, and then used a rotary evaporator for rotary evaporation to obtain a mixture A;② 1. Using dichloromethane as a cleaning agent, use a rotary evaporator to rotate the mixture A; 3. Repeat step 1.2 4 to 6 times to obtain acid-chlorinated single-walled carbon nanotubes;

[0033] The volume ratio of the mass of the carboxylated...

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Abstract

The invention discloses a single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method of the hemostatic material, aims at solving the problems that the original form of the oxidized regenerated cellulose cannot be ensured when an oxidized regenerated cellulose modified material is taken as the hemostatic material, thrill is generated to mammal skin and other body cells of the contact part in the use procedure, and the hemostatic performance is slightly improved. The single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material is prepared from a single-walled carbon nanotube containing an amino group on the surface, and oxidized regenerated cellulose; and the preparation method comprises the following steps: 1, preparing the single-walled carbon nanotube for acylating chlorination; 2, preparing the single-walled carbon nanotube containing the amino group in the surface; and 3, carrying out chemical grafting. The haemostasis time of the prepared material is reduced by 4.6%-18.5%; and the single-walled carbon nanotube-grafted modified oxidized regenerated cellulose hemostatic material and the preparation method thereof can be obtained.

Description

technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] Various accidents inevitably occur in daily life. During emergency treatment and operation, medical accidents or even death may be caused by massive bleeding. Therefore, local and effective rapid hemostasis of patients is very important, and effective control of bleeding and reducing bleeding time have become important measures to reduce the mortality of patients. Commonly used clinical hemostatic materials such as hemostatic gauze, hemostatic fiber, and hemostatic bandage have limitations in use, such as longer hemostasis time, easy adhesion to the wound and difficult dressing change, and powerlessness to wound infection and suppuration. Rapid hemostasis and functional hemostasis will be the development direction of hemostatic drugs in the future. [0003] Commonly used absorbable hemostatic materials include fibrin glue, gelatin sponge, ox...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44C08B15/02
Inventor 吴亚东黄玉东贺金梅王芳
Owner HARBIN INST OF TECH
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