Powder absorbable haemostat and its preparation method

A hemostatic agent and powdered technology, applied in the field of new hemostatic materials, can solve the problem of no hemostatic material found, and achieve the effects of good hemostatic performance, moderate viscosity and fast hemostasis.

Inactive Publication Date: 2012-01-11
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching patents, no hemostatic material combining the above three materials was found

Method used

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  • Powder absorbable haemostat and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] ①Dissolve 1g of chitosan, 1g of sodium alginate, and 1g of hyaluronic acid in 100ml of 2wt% acetic acid solution to obtain solution A;

[0034] ② Add A dropwise to 500ml of soybean oil B, stir at room temperature for 30 minutes at high speed, then add 100ml of calcium chloride solution with a concentration of 1 wt%, continue to stir at room temperature for 30 minutes, let stand for precipitation, and obtain cross-linked composite microspheres;

[0035] ③Wash the precipitate with 50ml of petroleum ether for 3 times, and distill the precipitate under reduced pressure at 60°C, and finally blow dry it at 80°C to form a powder C;

[0036] ④ After C was sterilized by ultraviolet rays for 15 minutes, the finished product D was obtained.

Embodiment 2

[0038] ① Dissolving 2g of chitosan, 2g of sodium alginate, and 1g of hyaluronic acid in 100ml of acetic acid solution with a concentration of 3wt% to obtain solution A;

[0039] ② Add A dropwise to 400ml of soybean oil B, stir at room temperature for 30 minutes at high speed, then add 100ml of calcium chloride solution with a concentration of 2wt%, continue to stir at room temperature for 30 minutes, let stand for precipitation, and obtain cross-linked composite microspheres;

[0040] ③Wash the precipitate with 50ml of petroleum ether for 3 times, and distill the precipitate under reduced pressure at 60°C, and finally blow dry it at 80°C to form a powder C;

[0041] ④ After C was sterilized by ultraviolet rays for 10 minutes, the finished product D was obtained.

Embodiment 3

[0043] ①Dissolve 3g chitosan, 3g sodium alginate, and 1g hyaluronic acid in 100ml of 3wt% acetic acid solution to obtain solution A;

[0044] ② Add A dropwise to 600ml of soybean oil B, stir at room temperature for 30 minutes at high speed, then add 100ml of calcium chloride solution with a concentration of 3wt%, continue to stir at room temperature for 30 minutes at high speed, let it stand for precipitation, and obtain cross-linked composite microspheres;

[0045] ③Wash the precipitate with 60ml of petroleum ether for 3 times, and distill the precipitate under reduced pressure at 60°C, and finally blow dry it at 80°C to form a powder C;

[0046] ④ After C was sterilized by ultraviolet rays for 20 minutes, the finished product D was obtained.

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Abstract

The invention discloses a powder absorbable haemostat and its preparation method, which belongs to the technical field of novel hemostatic material. The main components are chitosan, sodium alginate and hyaluronic acid. The weight ratio of chitosan to sodium alginate to hyaluronic acid is (0.1-10): (0.1-10): 1, The mass fraction of a cross-linking agent calcium chloride solution is 0.5-5 wt%. The invention also discloses a preparation method of the powder absorbable haemostat. According to the invention, the soybean oil is taken as an oil phase, calcium chloride is taken as a cross-linking agent, composite microspheres of chitosan, sodium alginate and hyaluronic acid can be obtained through a simple emulsification crosslinking process, the composite microspheres is dried to obtain the powder absorbable haemostat. According to the invention, the performance advantages of chitosan, sodium alginate and hyaluronic acid are combined by the product, so that the product has a plurality of haemostasis mechanisms which can rapidly suck water and swell, and the powder absorbable haemostat has the good anti-adhesion performance and characteristic of promoting the heal of the wound.

Description

technical field [0001] The invention belongs to the technical field of novel hemostatic materials, and in particular relates to a powdery absorbable hemostatic preparation with simple preparation, convenient application and remarkable effect and a preparation method thereof. Background technique [0002] In the emergency treatment of sudden accidents, trauma hemostasis during surgery, etc., it is very important for patients to quickly and effectively stop bleeding locally. Currently used and reported hemostatic materials mainly include gelatin sponge, collagen sponge, zeolite dressing, calcium alginate dressing and fibrin patch, etc., and each hemostatic material has its own characteristics. However, in the selection of clinical application, many factors will be considered, including the bleeding site, wound shape and size, wound packing requirements, the performance of different hemostatic materials, and their compatibility with the body. There is currently no material tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42
Inventor 甘少磊任卫卫
Owner 北京博恩康生物科技有限公司
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