Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing

An anti-infection and wound surface technology, which is applied in the fields of pharmaceutical formula, coating, medical science, etc., can solve the problems of weak effect on large-scale bacterial infection, inconvenient and widely popularized use, and ineffective inhibitory effect. Significant blood coagulation effect and the effect of preventing wound infection

Active Publication Date: 2019-06-07
军事科学院系统工程研究院军用标准研究中心 +2
View PDF11 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Silver sulfadiazine has a good antibacterial effect against Pseudomonas aeruginosa, but silver sulfadiazine requires silver as a raw material and is expensive, which is not convenient for widespread use. At the same time, its antibacterial spectrum is relatively narrow, and it is aimed at Staphylococcus aureus, Escherichia coli and other colonies The inhibitory effect of silver ions is not obvious, and there has been controversy in the academic circles about the systemic metabolism of heavy metal silver ions
Povidone iodine (Povidone iodine) is a loose compound formed by combining elemental iodine and a polymer carrier. It is mainly used for skin fungal infection and disinfection of small areas of mild burns, but its effect on large areas of bacterial infections is relatively low. weak

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing
  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing
  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] The invention provides a preparation method of a hemostatic anti-infection wound dressing, comprising the following steps:

[0030] (1) N-hexylized chitosan is dissolved in acetic acid solution to obtain N-hexylated chitosan acetic acid solution; the degree of substitution of the N-hexanylized chitosan is 8%~ 39%;

[0031] (2) the N-hexyl chitosan acetic acid solution, glycerin and manuka honey are mixed to obtain a mixed solution;

[0032] (3) The mixed solution is coated on a dressing base material, and dried to obtain a hemostatic and anti-infective wound dressing.

[0033] The invention dissolves N-hexylated chitosan in acetic acid solution to obtain N-hexylated chitosan acetic acid solution. In the present invention, the degree of substitution of the N-hexylated chitosan is 8-39%, preferably 8-20%, more preferably 19%.

[0034] In the present invention, the preparation method of described N-hexyl chitosan preferably comprises the following steps:

[0035] Chito...

Embodiment 1

[0065] Preparation of N-hexylated chitosan: Weigh 2.0g of chitosan and dissolve it in 200mL of 2% acetic acid solution, stir magnetically at room temperature for 4h until the chitosan is completely dissolved; add 75mL of absolute ethanol and continue stirring for about 1h; The molar mass ratio of chitosan monomer unit and hexanal adds hexanal in the ratio of 1:0.9, then add 10% HCl solution dropwise to adjust pH to 5.1, continue to stir at room temperature and carry out Schiff base reaction, the reaction time is 4 hours, Obtain Schiff's base reaction solution;

[0066] According to chitosan monomer unit and NaBH 4 Add NaBH to the Schiff base reaction solution in a mass ratio of 1:3 4 , carry out reduction reaction under stirring, and the time of reduction reaction is 12 hours; After reduction reaction is finished, add 10% NaOH solution dropwise in reduction reaction solution and adjust reaction solution pH to 10, filter the precipitated product that generates with Buchner fun...

Embodiment 2

[0069] Other conditions are identical with embodiment 1, only change the mol ratio of chitosan monomer unit and hexanal into 1:0.49.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides wound dressing capable of stopping bleeding and resisting infection and a preparation method of the wound dressing, and belongs to the technical field of medical dressing. According to the wound dressing disclosed by the invention, N-alkylated chitosan of which the substitution degree is 8%-39% is used as a bleeding stopping material, so that the blood coagulation effect isnotable, and the bleeding stopping speed is high. Manuka honey is used as an antibacterial agent, so that the antibacterial efficacy is powerful, the activity is stable, and the Manuka honey is not liable to decompose at normal temperature and not liable to decompose by bioactive enzymes. According to the wound dressing, the N-alkylated chitosan and the Manuka honey are combined for use, and the wound dressing which can quickly and effectively stop bleeding, concurrently has the effects of restraining bacterial reproduction and preventing wound from being infected and is good in biocompatibility can be obtained.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a hemostatic and anti-infection wound dressing and a preparation method thereof. Background technique [0002] Excessive blood loss and bacterial infection are the main factors for the death of the wounded at the disaster site. Nearly 50% of the affected population died of excessive blood loss, and nearly 70% died of bacterial infection. Among them, 25% of the affected population died within 10 to 60 minutes after blood loss. Bacterial infections. Due to factors such as destructiveness, suddenness, harsh environment, and untimely rescue at the disaster site, wounded bleeding is often accompanied by pollution from the exposed wound, leading to bacterial invasion and infection. Timely and effective hemostasis and anti-infection treatment Measures are essential to save the lives of the wounded. [0003] Hemostatic gauze with anti-infection effect can be obtained by treat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L15/28A61L15/44A61L15/46A61L15/42
CPCA61L15/46A61L15/40A61L15/20A61L2300/418A61L2300/30A61L2300/606A61L2300/232A61L2400/04A61L2420/06A61L15/28A61L2420/02A61L2300/404A61L15/44C08L5/08
Inventor 关静黄姝杰杨健荆妙蕾楚雪欣武继民李志宏
Owner 军事科学院系统工程研究院军用标准研究中心
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com