Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing

An anti-infection and wound surface technology, which is applied in the fields of pharmaceutical formula, coating, medical science, etc., can solve the problems of weak effect on large-scale bacterial infection, inconvenient and widely popularized use, and ineffective inhibitory effect. Significant blood coagulation effect and the effect of preventing wound infection

Active Publication Date: 2019-06-07
军事科学院系统工程研究院军用标准研究中心 +2
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  • Claims
  • Application Information

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Problems solved by technology

Silver sulfadiazine has a good antibacterial effect against Pseudomonas aeruginosa, but silver sulfadiazine requires silver as a raw material and is expensive, which is not convenient for widespread use. At the same time, its antibacterial spectrum is relatively narrow, and it is aimed at Staphylococcus aureus, Escherichia coli and other colonies The inhibitory effect of silver ions is not obvi

Method used

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  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing
  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing
  • Wound dressing capable of stopping bleeding and resisting infection and preparation method of wound dressing

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Example Embodiment

[0029] The invention provides a method for preparing a hemostatic and anti-infective wound dressing, which comprises the following steps:

[0030] (1) Dissolve N-hexylated chitosan in an acetic acid solution to obtain an acetic acid solution of N-hexylated chitosan; the degree of substitution of the N-hexylated chitosan is 8%~ 39%;

[0031] (2) Mixing the N-hexanesylated chitosan acetic acid solution, glycerin and Manuka honey to obtain a mixed solution;

[0032] (3) Coating the mixed solution on the dressing substrate and drying to obtain a hemostatic and anti-infective wound dressing.

[0033] In the present invention, N-hexylated chitosan is dissolved in acetic acid solution to obtain N-hexylated chitosan acetic acid solution. In the present invention, the degree of substitution of the N-hexylated chitosan is 8 to 39%, preferably 8 to 20%, and more preferably 19%.

[0034] In the present invention, the preparation method of the N-hexylated chitosan preferably includes the following...

Example Embodiment

[0064] Example 1

[0065] Preparation of N-Hexylated chitosan: Weigh 2.0g of chitosan and dissolve it in 200mL of 2% acetic acid solution, stir magnetically for 4 hours at room temperature until the chitosan is completely dissolved; add 75mL of absolute ethanol and continue to stir for about 1 hour; The molar mass ratio of chitosan monomer unit to hexanal is 1:0.9. Add hexanal, and then add 10% HCl solution dropwise to adjust the pH to 5.1. Continue stirring at room temperature for Schiff base reaction. The reaction time is 4 hours. Obtain the Schiff base reaction solution;

[0066] According to chitosan monomer unit and NaBH 4 Add NaBH to the Schiff base reaction solution at a mass ratio of 1:3 4 The reduction reaction is carried out under stirring, and the reduction reaction time is 12 hours; after the reduction reaction is completed, 10% NaOH solution is added dropwise to the reduction reaction solution to adjust the pH of the reaction solution to 10, and the precipitated produc...

Example Embodiment

[0068] Example 2

[0069] Other conditions are the same as in Example 1, except that the molar ratio of chitosan monomer unit and hexanal is changed to 1:0.49.

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Abstract

The invention provides wound dressing capable of stopping bleeding and resisting infection and a preparation method of the wound dressing, and belongs to the technical field of medical dressing. According to the wound dressing disclosed by the invention, N-alkylated chitosan of which the substitution degree is 8%-39% is used as a bleeding stopping material, so that the blood coagulation effect isnotable, and the bleeding stopping speed is high. Manuka honey is used as an antibacterial agent, so that the antibacterial efficacy is powerful, the activity is stable, and the Manuka honey is not liable to decompose at normal temperature and not liable to decompose by bioactive enzymes. According to the wound dressing, the N-alkylated chitosan and the Manuka honey are combined for use, and the wound dressing which can quickly and effectively stop bleeding, concurrently has the effects of restraining bacterial reproduction and preventing wound from being infected and is good in biocompatibility can be obtained.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a hemostatic and anti-infection wound dressing and a preparation method thereof. Background technique [0002] Excessive blood loss and bacterial infection are the main factors for the death of the wounded at the disaster site. Nearly 50% of the affected population died of excessive blood loss, and nearly 70% died of bacterial infection. Among them, 25% of the affected population died within 10 to 60 minutes after blood loss. Bacterial infections. Due to factors such as destructiveness, suddenness, harsh environment, and untimely rescue at the disaster site, wounded bleeding is often accompanied by pollution from the exposed wound, leading to bacterial invasion and infection. Timely and effective hemostasis and anti-infection treatment Measures are essential to save the lives of the wounded. [0003] Hemostatic gauze with anti-infection effect can be obtained by treat...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/46A61L15/42
CPCA61L15/46A61L15/40A61L15/20A61L2300/418A61L2300/30A61L2300/606A61L2300/232A61L2400/04A61L2420/06A61L15/28A61L2420/02A61L2300/404A61L15/44C08L5/08
Inventor 关静黄姝杰杨健荆妙蕾楚雪欣武继民李志宏
Owner 军事科学院系统工程研究院军用标准研究中心
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