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PRP-chitosan-silk fibroin composite material and preparation method therefor

A silk fibroin and composite material technology, applied in pharmaceutical formulations, medical science, absorbent pads, etc., can solve the problems of unsatisfactory hemostatic effect, limited application scope, poor stability, etc., to accelerate the speed of red blood cell clotting and promote the speed of hemostasis , the effect of improving air permeability

Active Publication Date: 2020-02-21
BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor stability and unsatisfactory hemostatic effect of a single fibroin material limit its application range, so researchers need to overcome these shortcomings by combining silk fibroin with other materials

Method used

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  • PRP-chitosan-silk fibroin composite material and preparation method therefor
  • PRP-chitosan-silk fibroin composite material and preparation method therefor
  • PRP-chitosan-silk fibroin composite material and preparation method therefor

Examples

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Effect test

Embodiment 1

[0033] A PRP-chitosan-silk fibroin composite material: the composite material contains chitosan, silk fibroin and human-derived PRP components; the composite material includes the following raw materials in volume percentage: chitosan solution 45%, silk fibroin solution 45%, PRP solution 10%, the sum of the total volume percentage is 100%. Wherein the mass concentration of chitosan solution is 4%, the mass concentration of silk fibroin solution is 3%, and the platelet concentration of PRP solution is 500×10 9 a / L. The raw materials are mixed in proportion and further processed to obtain PRP-chitosan-silk fibroin composite material

[0034] The concrete preparation steps of described composite material are as follows:

[0035] S1: Preparation of 4% chitosan solution: Prepare 2% (V:V) acetic acid solution with pure water, dissolve chitosan with this solution, and prepare chitosan-acetic acid solution with a concentration of 4%. Stir continuously, after the chitosan powder is ...

Embodiment 2

[0044] A PRP-chitosan-silk fibroin composite material, the preparation method of which is as follows:

[0045] 4% chitosan solution (preparation method is the same as Example 1) is mixed with 3% silk fibroin solution (preparation method is the same as Example 1) by volume percentage 22.5%: 67.5%, stirring constantly in the mixing process until The two solutions are uniformly mixed, and a PRP solution accounting for 10% of the total volume of the composite material is added to the mixed solution by a mixing method. The preparation steps of the composite material are similar to the step S4 in Example 1.

Embodiment 3

[0047] A kind of preparation of PRP-chitosan-silk fibroin composite material, its preparation method is as follows:

[0048] 4% chitosan solution (preparation method is the same as in Example 1) and 3% silk fibroin solution (preparation method is the same as in Example 1) are mixed according to the total volume ratio of the stock solution: 67.5%: 22.5%. The total volume ratio of the material is 10% PRP solution. The preparation steps of the composite material are similar to the step S4 in Example 1.

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Abstract

The invention belongs to the technical field of synthesis of biomaterials and particularly relates to a novel PRP-chitosan-silk fibroin composite material capable of rapidly arresting bleeding and a preparation method therefor. The composite material contains a 2%-4% chitosan solution and a 3% silk fibroin solution; and the PRP-chitosan-silk fibroin composite material is prepared by a freeze-drying method through introducing human-derived platelet rich plasma containing a variety of growth factors and a fixed platelet concentration. According to the material disclosed by the invention, ingredients contained are safe and non-irritating; and compared with the prior art, the material has the advantages that the PRP containing the fixed platelet concentration is added, and a substrate structure is changed through adding silk fibroin, so that the rate of coagulation of whole blood is increased, the bleeding time and amount of bleeding of a wound are reduced, the bleeding arresting propertyof the material is improved, and the bleeding arresting speed, pain alleviating and bacterial resistance of the wound are promoted.

Description

technical field [0001] The invention belongs to the technical field of biomaterial synthesis, in particular to a novel PRP-chitosan-silk fibroin sponge dressing for rapid hemostasis and a preparation method thereof. Background technique [0002] Uncontrolled blood loss is the second most common cause of death after trauma in everyday life. In some major accidents, patients are often accompanied by coagulation dysfunction caused by massive blood loss, or severe surgical wound bleeding occurs during the operation, which leads to bleeding in the entire wound site and the bleeding point is not clear. At this time, the commonly used hemostasis methods such as direct compression, ligation and electrocautery are difficult to be effective. At this time, effective and rapid hemostasis materials are needed. [0003] Coagulation is the process by which blood changes from a flowing liquid to an immobile gel. Its essence is a complex process in which plasma gradually forms stable insol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46
CPCA61L15/40A61L15/28A61L15/32A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/236A61L2400/04A61L2300/418A61L2300/402A61L2300/404A61L2300/412C08L5/08C08L89/00
Inventor 韩玎玎贺曾钟锐张学俊王红
Owner BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI
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