72 results about "Supramolecular hydrogels" patented technology

The invention relates to the technical field of polymer photoelectric materials, in particular to a preparation method of a supramolecular gel electrolyte. The method comprises the following steps: esterifying tetraphenylethylene alcohol and methacryloyl chloride to form tetraphenylethylene methacrylate, and performing staged linear heating polymerization on the tetraphenylethylene methacrylate, 3-(methacrylamido) propyl dimethyl 3-thiopropyl ammonium oxide inner salt, acrylic acid, tetraphenylethylene methacrylate and 4-vinylpyridine under the action of ammonium persulfate to obtain a tetraphenylethylene copolymer. And finally, soaking in a lithium chloride aqueous solution to obtain the supramolecular hydrogel electrolyte. The hydrogel obtained by the invention has high mechanical strength and high ionic conductivity, and is suitable for energy storage devices such as flexible supercapacitors and the like.

The invention belongs to the technical field of biological medicines, and discloses a DSH loaded medicine as well as a preparation method and application thereof. The DSH loading type medicine is DNA (Deoxyribonucleic Acid) supramolecular hydrogel loaded with 2, 2, 6, 6-tetramethylpiperidine-1-oxide, and the DSH loading type medicine is a DNA supramolecular hydrogel loaded with the 2, 2, 6, 6- Wherein the DNA supramolecular hydrogel is formed by assembling a Y type DNA monomer and an L type DNA monomer. The DSH loaded medicine has good anti-inflammatory and peroxy free radical removing effects, and can achieve the purpose of treating knee osteoarthritis. In addition, the DSH loaded medicine can be used for reflecting the content of peroxy free radicals in knee joints by detecting the contrast ratio of knee joint images through magnetic resonance, and early diagnosis of knee osteoarthritis is achieved.

The invention discloses supramolecular hydrogel and microneedle patch for treating oral mucositis and a preparation method and application thereof, and belongs to the technical field of biological medicine, and the supramolecular hydrogel for treating oral mucositis comprises the following raw materials: guanosine, a potassium hydroxide solution containing metal ion soluble salt and phenylboronic acid lactone drugs. The raw material of the microneedle patch further comprises a water-soluble backing solution. The supramolecular hydrogel or microneedle patch for treating oral mucositis integrates antibacterial, anti-inflammatory, antioxidant and angiogenesis promoting functions, and has a remarkable effect of promoting healing of chemotherapeutic oral mucosal lesion.

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.

The invention discloses a supramolecular hydrogel composition as well as a preparation method and application thereof, and belongs to the technical field of beauty treatment. The supramolecular hydrogel composition provided by the invention is prepared from the following raw materials in percentage by mass: the balance of water; 2 to 30 percent of poloxamer; 1-35% of an active substance; 0.5%-20% of a cross-linking agent; and 1-20% of polyol. The supramolecular hydrogel composition provided by the invention can significantly reduce the irritation to the skin on the basis of effectively improving the content of active substances and the bioavailability of the active substances in the supramolecular hydrogel composition. The invention also provides a preparation method and application of the supramolecular hydrogel composition.

The application provides a silver ion-nucleoside supramolecular hydrogel and a preparation method and application thereof, and belongs to the field of biological materials. The nucleoside supramolecular hydrogel with a three-dimensional spatial structure is prepared by using 2-amino adenosine and silver ions. The hydrogel has good biocompatibility, stability, biodegradability, injectability and antibacterial property, and can be used for intrapocket injection administration. The hydrogel is further used for loading a photothermal reagent to obtain a composite hydrogel. The composite hydrogel can play a role of chemotherapy-photothermal synergistic treatment, has excellent antibacterial and antibiofilm capacity, and has a good application prospect in periodontitis treatment.

The invention discloses a core amino acid sequence for driving any recombinant protein to be self-assembled into supramolecular hydrogel and application of the core amino acid sequence, and aims to solve the problems of complex synthesis, toxic residue, insufficient biocompatibility, difficulty in performance regulation and control and the like of the traditional chemical crosslinking hydrogel. The whole length of Ure2 (1-19) to Ure2 (1-71) and any truncated body and mutant are covered, and the shortest sequence Ure2 (1-19) has efficient driving self-assembly. The core amino acid sequence is fused to any recombinant protein, the obtained fusion protein can form nanofiber-shaped self-assembly aggregation when the concentration is lower than 1 mg / mL, and can form supramolecular hydrogel with the characteristics of shear thinning effect, injectability and the like when the concentration is greater than or equal to 1 mg / mL, and the formation of the hydrogel does not need any additional artificial interference. The preparation can be finished only by standing for a period of time.

The invention discloses cefradine supramolecular composite graded gel and a preparation method and application thereof, cefradine and glycosaminoglycan are used as raw materials, and self-assembly of cefradine is controlled through an interface template to form supramolecular hydrogel. And cross-linking and compounding with glycosaminoglycan gel to obtain the double-network supramolecule-polymer graded composite gel. The graded composite gel prepared by the invention has excellent swelling property, tissue adhesion and thixotropy and tensile property similar to that of human skin, so that the graded composite gel can accelerate healing of infected wounds, and due to excellent conductivity, real-time online monitoring of drug release and wound healing conditions can be realized.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The invention discloses an oral ulcer intelligent microneedle patch based on guanosine vesicle slow release and a preparation method thereof, and relates to the technical field of drug research and development, and the key points of the technical scheme are that the intelligent microneedle patch can penetrate through an oral ulcer pseudo membrane to realize targeted delivery of drugs; long-acting slow release of a therapeutic drug (guanosine) is realized through the guanosine vesicles, and continuous anti-inflammatory and tissue repair effects are achieved; the guanosine is a natural nucleoside and is an important construction unit of the supramolecular hydrogel. Therefore, more diversified supramolecular hydrogels based on guanosine and derivatives thereof also appear in continuous modification. The guanosine borate supramolecular hydrogel is used as a nano-scaffold with good biocompatibility and stimulation responsiveness, and has the potential of conveying various therapeutic drugs in the aspect of drug conveying. The intelligent microneedle patch can monitor a plurality of key physiological parameters of an ulcer microenvironment in real time, and diagnosis and treatment integration is achieved.

The invention discloses a hydrogel microneedle with biocompatibility and mechanical strength as well as a preparation method and application of the hydrogel microneedle, and belongs to the technical field of biological materials. The hydrogel microneedle comprises Gel and Ser in a mass ratio of 1: 1. And the molecular weight of the Gel / Ser hydrogel microneedle is 300,000 Da. According to the method, Gel and Ser are subjected to in-situ synthesis under the interaction of hydrogen bonds to obtain the Gel / Ser pure natural supramolecular soluble hydrogel microneedle. The pure natural hydrogel microneedle with biocompatibility and mechanical strength can be used as a drug carrier to promote the proliferation and migration of fibroblasts and the formation of endothelial canals by loading growth factors (GDFx), and further promote the healing of wounds. The prepared pure natural hydrogel microneedle with biocompatibility and mechanical strength is supramolecular hydrogel formed through intermolecular hydrogen-bond interaction, reaction conditions are easy to obtain, and operation is easy.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

The present invention provides a supramolecular hydrogel sealing agent constructed by host-guest interaction, and its preparation method and application, which belong to the technical field of drilling fluid sealing. The supramolecular hydrogel sealing agent constructed by host-guest interaction of the present invention comprises the following raw materials in percentage by mass: 12-36% copolymerization monomer, 6-10% tannic acid grafted polysaccharide aqueous dispersion, 0.5-1.5% initiator, 0.3-0.6% cross-linking agent, and the balance is water; the total amount of each component is 100%. The raw materials of the present invention are cheap and easy to obtain, the raw material composition is simple, the cost is low, and it is green, safe and environmentally friendly; the preparation method is simple, the conditions are mild, and it is easy to implement. The sealing agent obtained by the present invention has excellent mechanical properties, heat and pressure resistance and outstanding pH degradation ability after cross-linking, can effectively seal the crude oil reservoir to form an integral sealing barrier, and reduce the entry of heavy oil into the wellbore; at the same time, it can effectively realize the degradation of the hydrogel to achieve unsealing.

The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm / NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam / adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.

The invention provides a structure, preparation and application of a supramolecular hydrogel which is formed by self-assembly of two single components, namely alpha-D-pentagalloylgalactose and alpha-D-pentagalloylmannose, in water under the condition of not being subjected to any structural modification and pretreatment, as well as a preparation method and application of the supramolecular hydrogel. According to the alpha-D-pentagalloyl galactose and alpha-D-pentagalloyl mannose supramolecular hydrogel, the hydrogel can be formed under the condition that no gelator is used, and the hydrogel has excellent gel properties such as injectability, heat sensitivity, self-healing property and stability. Meanwhile, the two supramolecular hydrogels both have good immunoregulation, anti-inflammatory and antioxidant activities, are both superior to clinical first-line drugs (dexamethasone and ascorbic acid), and also show good angiogenesis promoting ability. A large number of tests show that the supramolecular hydrogel has good biological safety, and clinical medication safety can be further guaranteed.

This invention relates to the field of supramolecular copolymer hydrogel technology, specifically to a high-strength and tough supramolecular hydrogel with tunable interfacial hydration properties, its preparation method, and its applications. This invention uses N-acryloylaminourea (NASC) monomer and a sulfonate-containing monomer (lubricating molecule) as raw materials, and adds a photoinitiator. A prepolymer solution of an organic solvent and water mixture is prepared using the dehydrogenation effect of an organic solvent. Crosslinking polymerization is carried out under ultraviolet light irradiation to obtain a supramolecular hydrogel. Then, water equilibrium is achieved to obtain a high-strength and tough supramolecular hydrogel with tunable interfacial hydration properties. The high-strength and tough supramolecular hydrogel prepared by this invention possesses high water content, excellent lubrication properties, mechanical properties, structural stability, and long-term service reliability, exhibiting excellent comprehensive performance and meeting the synergistic requirements of multi-dimensional material performance in complex engineering scenarios or biomedical fields.

This invention discloses a composite scaffold for promoting bone regeneration in diabetic patients, its preparation method, and its applications, relating to the field of medical biomaterials technology. The composite scaffold for promoting bone regeneration in diabetic patients comprises: a three-dimensional porous framework; and a bioactive hydrogel layer loaded with naringin. The bioactive hydrogel layer loaded with naringin is coated on the surface and pore walls of the three-dimensional porous framework. The technical solution provided by this invention uses a 3D-printed PLGA / HA porous framework to provide mechanical support and osteoconductivity, and a supramolecular hydrogel coating loaded with naringin to endow it with immunomodulatory and drug sustained-release functions. This scaffold has good hydrophilicity and biocompatibility, and can effectively induce macrophage polarization towards the M2 anti-inflammatory phenotype by activating the JAK-STAT signaling pathway, improving the local inflammatory microenvironment of diabetic bone defects. Simultaneously, it indirectly promotes vascular endothelial cell migration, lumen formation, and osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophages.

The invention discloses dexamethasone eye emulsion supramolecular hydrogel and a preparation method thereof, and belongs to the technical field of medicines. The dexamethasone eye emulsion supramolecular hydrogel is prepared from the following components in percentage by mass volume: 0.02 to 0.06 percent of dexamethasone, 0.5 to 5 percent of liquid oil, 1 to 6 percent of emulsifier and 1 to 5 percent of polyphenol. According to the dexamethasone ophthalmic emulsion supramolecular hydrogel provided by the invention, dexamethasone is used as a main drug, and a nanoemulsion is used as an insoluble drug carrier to improve the solubility of the dexamethasone ophthalmic emulsion supramolecular hydrogel; the emulsifier on the surface of the nanoemulsion can be self-assembled with polyphenol through hydrogen-bond interaction to form a supramolecular hydrogel network. After the preparation is dropped into the conjunctival sac, the drug-loaded nano-emulsion is gradually released and the free drug is further released under the shear thinning action caused by tear dilution and blinking, so that the long-acting treatment concentration is maintained on the ocular surface, and the defects that the drug is easily lost due to nasolacrimal duct drainage, the retention time of the ocular surface is short and the like in the traditional eye drops are effectively overcome.

The application discloses a self-shrinking, self-healing and multi-stimulus responding rosin-based copper salt supramolecular hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogels. The rosin-based copper salt supramolecular hydrogel is synthesized by means of coordination between copper nitrate and obtained disodium sulfonated dehydroabietic acid after sulfonation reaction and neutralization reaction of dehydroabietic acid as raw material, and has self-shrinking, self-healing and multi-stimulus responding performances. The preparation method of the hydrogel comprises the following steps: (1) preparation of sulfonated dehydroabietic acid; (2) preparation of disodium sulfonated dehydroabietic acid; and (3) preparation of the rosin-based copper salt supramolecular hydrogel. The rosin-based copper salt supramolecular hydrogel can realize self-shrinking of copper ions and maintain three-dimensional shape memory, and simultaneously has comprehensive performances of self-healing, multi-stimulus responding such as pH and oxidation and reduction, visual chiral identification, high conductivity and high swelling rate, and has inhibiting effects on pseudomonas aeruginosa and bacillus subtilis.

A supramolecular hydrogel film for reversible adhesion of frozen food, a production method, and an application are provided. The production method includes mixing the arabinoxylan solution with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and performing an ice bath reaction to obtain the carboxylated arabinoxylan solution; adding dopamine hydrochloride, performing a stirring, dialysis and freeze-drying to obtain the arabinoxylan-dopamine graft; adding acrylic acid and metal ions to the ethanol aqueous solution, mixing with the arabinoxylan-dopamine graft, and performing a stirring, and then mixing with N,N′-methylenebisacrylamide and ammonium persulfate to obtain the supramolecular hydrogel film. The supramolecular hydrogel film has the characteristics of light-controlled reversible adhesion, high mechanical strength, high gas barrier properties and degradability, and is suitable for various frozen foods.

The present invention provides a polyrotaxane having a chemical structure in which an axial molecule represented by Formula (2) is threaded into a cyclodextrin ring in a compound represented by Formula (1). In Formula (1), CD is a cyclodextrin ring, L2 is a divalent organic group, L3 is an ethylene group or a propylene group, RA is a hydrogen atom or a C1-6 alkyl group, and m is an integer of 0 to 35. Provided that when L2 and N are linked by a double bond, RA is not present. In Formula (2), R is a hydrocarbon group larger than an inner diameter of the cyclodextrin ring, X is a divalent organic group, and a is an integer of 100 to 1000.

The invention discloses a self-constricting, self-healing and multi-stimulus-responsive rosin-based copper salt supramolecular hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. According to the preparation method, dehydroabietic acid is taken as a raw material, sulfonation reaction and neutralization reaction are carried out in sequence, and then the obtained sulfonated dehydroabietic acid disodium salt and copper nitrate are synthesized into the rosin-based copper salt supramolecular hydrogel through coordination, and the rosin-based copper salt supramolecular hydrogel has self-constriction, self-healing and multi-stimulation response performance. The preparation method of the hydrogel comprises the following steps: (1) preparing sulfonated dehydroabietic acid; (2) preparing sulfonated dehydroabietic acid disodium salt; and (3) preparing the rosin-based copper salt supramolecular hydrogel. The rosin-based copper salt supramolecular hydrogel can realize self-constriction of copper ions and maintain three-dimensional shape memory, has comprehensive properties of self-healing, pH, oxidation reduction and other multiple stimulation responses, visual chiral recognition, high conductivity and high swelling rate, and has an inhibition effect on pseudomonas aeruginosa and bacillus subtilis.

The invention discloses a compound and application thereof in preparation of a medicine for treating radioactive jawbone necrosis, according to the compound, DNA supramolecular hydrogel coats MSC to form a cage type three-dimensional structure, and DNA self-assembly hydrogel in the compound can improve the in-vivo residence time of mesenchymal stem cells. The compound has stable injectability, and can effectively improve the treatment effect of the mesenchymal stem cells on the radioactive jaw necrosis.

The invention relates to a supramolecular hydrogel formed by self-assembly of hydrophilic macromolecules modified by fatty acids, the hydrophilic macromolecules are selected from natural polysaccharides, other hydrophilic polymers and blends of the polysaccharides or the hydrophilic polymers, and the fatty acids comprise saturated and unsaturated fatty acids. The supramolecular hydrogel disclosed by the invention has a multi-stage structure of a microscopic nano lipid micelle-macroscopic porous gel network, and has high affinity with cartilage while having good lubricating property. The micelle can be used for delivery and slow release of loaded hydrophobic drugs, released nano-scale and micron-scale micelles are easy to be ingested by cells, and the delivery efficiency of the drugs is improved. The supramolecular hydrogel is simple in preparation method, does not need to use a cross-linking agent, and has injectability, self-healing property and shape adaptability.

The invention relates to supramolecular hydrogel formed through subject-object interaction and Schiff base bond dynamic crosslinking and a preparation method of the supramolecular hydrogel. The hydrogel is formed by self-assembly of biological macromolecules modified by hydrophobic groups, cyclodextrin modified by active carbonyl groups and biological macromolecules modified by amino or hydrazide groups, and the biological macromolecules serve as basic materials of the hydrogel and are selected from hyaluronic acid, gelatin, chitosan, glucan, pectin or carboxymethyl cellulose. The preparation method of the hydrogel comprises the following steps: mixing hydrophobic group modified biomacromolecules and active carbonyl modified cyclodextrin to prepare an aqueous solution A; preparing an aqueous solution B from the amino or hydrazide group modified biological macromolecules; and mixing the aqueous solution A and the aqueous solution B to obtain the dynamic crosslinking supramolecular hydrogel. The supramolecular hydrogel disclosed by the invention has self-healing property and shear thinning property, meanwhile, the plasticity is enhanced, and cell migration, proliferation and differentiation can be promoted.

The present invention discloses a zwitterionic supramolecular hydrogel based on anion-π and its preparation method and application. The hydrogel is self-assembled by a zwitterionic copolymer and a p-styrene sulfonic acid copolymer. In the present invention, the supramolecular hydrogel only needs to be rapidly formed by simply mechanically mixing the zwitterionic polymer copolymer and the p-styrene sulfonate copolymer solution, and the dynamic cross-linking characteristics give it excellent injectability and self-repairing properties. This hydrogel is composed of zwitterions with excellent immune compatibility and poly (p-styrene sulfonate) with heparin-like properties, so it has excellent immune compatibility and can play a role in various in vivo application scenarios. In addition, this dynamic cross-linking network based on anion-π interaction and the heparin-like structure are very beneficial to the preservation of proteins and have broad application prospects in the fields of protein delivery and cell encapsulation.

The application discloses a preparation method of an in-situ hydrazone bond injectable hydrogel and application thereof to preventing abdominal cavity adhesion, and belongs to the field of medical biomaterials. The application takes 8-arm-PEG10000-CHO with an aldehyde group at a terminal and 8-arm-PEG10000-HZ with a hydrazine group at a terminal as raw materials, forms a hydrazone bond through a Schiff base reaction, and obtains PCA supermolecular hydrogel through in-situ construction; the preparation method of the application does not need a chemical crosslinking agent, can quickly form a gel at room temperature, is simple and controllable in process, and the prepared hydrogel has excellent injectability, self-healing performance, biodegradability and biocompatibility, can form a stable physical barrier in-situ on an abdominal surgery wound, effectively inhibits inflammatory cell infiltration and collagen fiber deposition, has a significant prevention effect on light, medium and severe abdominal cavity adhesion, and especially still has excellent protection capability in a severe inflammatory adhesion model induced by talc, thereby providing a safe and effective new scheme for preventing and treating postoperative abdominal cavity adhesion.

The invention belongs to the technical field of lubricating materials, and particularly relates to layered hydrogel, a preparation method and application thereof and a recovery method of a lubricating coating. The invention provides layered hydrogel. The layered hydrogel comprises a substrate and a lubricating layer compounded on any surface of the substrate, the substrate is a copolymer of polymethylacrylic acid and polymethacrylamide, and the lubricating layer is obtained by dissociating a substrate material in a PBS (Phosphate Buffer Solution). In the invention, the micro-phase separated substrate provides excellent mechanical properties, and the lubricating layer on the surface contributes to an extremely low friction coefficient. The layered hydrogel can achieve both high bearing capacity and low friction characteristics. According to the preparation method, microphase separation is induced through solvent replacement, supramolecular hydrogel with a uniform structure and high strength is directly constructed, a lubricating layer is formed on the surface through a simple dissociation process, and integration of bearing and lubricating is achieved. A solvent replacement method is adopted, so that the body hydrogel has more excellent mechanical strength and lubricating property.

This invention provides a method for preparing a polypeptide hydrogel and its applications. The structure of the polypeptide hydrogel is shown in the figure below. The basic framework of the hydrogel is constructed from arginine and naphthaleneacetic acid, naproxen, phenylalanine, and glycine as basic units. Naproxen, as an anti-inflammatory drug, is introduced into the hydrogel to increase its bioactivity. Glycine and phenylalanine act as hydrophilic / hydrophobic modulators, while arginine and histidine regulate the hydrogel's properties. This polypeptide can be synthesized via solid-phase synthesis, and the preparation process is mature and readily available. The polypeptide of this invention can self-assemble into a supramolecular hydrogel in water, which can scavenge reactive oxygen species, inhibit the expression of TLR4-related gene pathways, and improve the inflammatory environment by downregulating NF-κB. The polypeptide hydrogel of this invention can also promote macrophage polarization, improve the wound environment through immunomodulation, and promote wound healing, showing broad application prospects in diabetic wound repair.

The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm / NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam / adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.