117 results about "Supramolecular hydrogels" patented technology

The invention provides a supramolecular hydrogel packer constructed by interaction of a subject and an object as well as a preparation method and application of the supramolecular hydrogel packer, and belongs to the technical field of drilling fluid packing. The supramolecular hydrogel packer constructed by interaction of the subject and the guest comprises the following raw materials in percentage by mass: 12-36% of a copolymerization monomer, 6-10% of a tannic acid grafted polysaccharide aqueous dispersion, 0.5-1.5% of an initiator, 0.3-0.6% of a cross-linking agent and the balance of water, the total amount of the components is 100%. The raw materials are cheap, easy to obtain, simple in composition, low in cost, green, safe and environment-friendly; the preparation method is simple, mild in condition and easy to implement. After crosslinking, the obtained packer has excellent mechanical properties, temperature and pressure resistance and outstanding pH degradation capability, and can effectively pack a crude oil reservoir to form an integral sealing interlayer, so that heavy oil entering a shaft is reduced; meanwhile, degradation of the hydrogel can be effectively realized, and deblocking is achieved.

The invention discloses self-adaptive Janus supramolecular hydrogel, a preparation method and application of the self-adaptive Janus supramolecular hydrogel as a wet tissue surface adhesive. The hydrogel has an integrated structure and two asymmetric surfaces: an adhesion surface and an anti-adhesion surface. The method is suitable for the wet tissue surface bonding field.

The invention discloses zwitter-ion supramolecular hydrogel based on anion-pi as well as a preparation method and application of the zwitter-ion supramolecular hydrogel. The hydrogel is formed by self-assembly of a zwitterionic copolymer and a p-styrenesulfonic acid copolymer. According to the supramolecular hydrogel disclosed by the invention, the supramolecular hydrogel can be rapidly formed only by simply mechanically mixing the zwitterionic polymer copolymer and the p-styrene sulfonate copolymer solution, and the supramolecular hydrogel is endowed with excellent injectability and self-repairing performance due to the dynamic cross-linking characteristic. The hydrogel is composed of zwitterions with excellent immunocompatibility and poly (p-styrene sulfonate) with heparin-imitating performance, so that the hydrogel has excellent immunocompatibility, can play a role in various in-vivo application scenes, and in addition, the hydrogel can be used for preparing an anti-inflammatory drug. The dynamic cross-linked network based on anion-pi interaction and the heparin-like structure are very beneficial to protein preservation, and have wide application prospects in the fields of protein delivery and cell encapsulation.

The invention relates to the technical field of polymer photoelectric materials, in particular to a preparation method of a supramolecular gel electrolyte. The method comprises the following steps: esterifying tetraphenylethylene alcohol and methacryloyl chloride to form tetraphenylethylene methacrylate, and performing staged linear heating polymerization on the tetraphenylethylene methacrylate, 3-(methacrylamido) propyl dimethyl 3-thiopropyl ammonium oxide inner salt, acrylic acid, tetraphenylethylene methacrylate and 4-vinylpyridine under the action of ammonium persulfate to obtain a tetraphenylethylene copolymer. And finally, soaking in a lithium chloride aqueous solution to obtain the supramolecular hydrogel electrolyte. The hydrogel obtained by the invention has high mechanical strength and high ionic conductivity, and is suitable for energy storage devices such as flexible supercapacitors and the like.

The invention belongs to the technical field of biological medicines, and discloses a DSH loaded medicine as well as a preparation method and application thereof. The DSH loading type medicine is DNA (Deoxyribonucleic Acid) supramolecular hydrogel loaded with 2, 2, 6, 6-tetramethylpiperidine-1-oxide, and the DSH loading type medicine is a DNA supramolecular hydrogel loaded with the 2, 2, 6, 6- Wherein the DNA supramolecular hydrogel is formed by assembling a Y type DNA monomer and an L type DNA monomer. The DSH loaded medicine has good anti-inflammatory and peroxy free radical removing effects, and can achieve the purpose of treating knee osteoarthritis. In addition, the DSH loaded medicine can be used for reflecting the content of peroxy free radicals in knee joints by detecting the contrast ratio of knee joint images through magnetic resonance, and early diagnosis of knee osteoarthritis is achieved.

The invention discloses a preparation method and antipyretic and anti-inflammatory application of a novel carrier-free metal-organic small molecule supramolecular hydrogel derived from Maxing Shigan Decoction. The hydrogel drug raw materials of the invention include pseudoephedrine hydrochloride in Ephedra sinica in the prescription of Maxing Shigan Decoction, amygdalin in Armeniaca vulgaris, magnesium ions in Gypsum fibrosum, and glycyrrhizic acid in Glycyrrhiza uralensis Fisch. The preparation method of the quaternary magnesium hydrogel drug is simple, green, has good stability and high biocompatibility. In a rat fever model induced by lipopolysaccharide at different doses, the antipyretic effect of the hydrogel drug can last up to 12 hours, and the antipyretic effect is significantly better than that of other metal ions such as quaternary calcium hydrogel, quaternary zinc hydrogel, and quaternary copper hydrogel groups. At the same time, it has a more persistent antipyretic effect than the whole prescription of Maxing Shigan Decoction; the hydrogel drug does not require the addition of excipients, has no toxic and side effects, and has a high drug utilization rate.

The present invention provides a type of supramolecular hydrogel compound formed by self-assembly of effective ingredients of Macleaya cordata powder and flavonoid active molecules, a structure, a preparation method and an application. The supramolecular hydrogel compound has excellent selective antibacterial ability. While selectively killing pathogenic bacteria such as Staphylococcus aureus, it does not affect the activity of probiotics such as Bacillus subtilis and Enterococcus faecium in the intestine; it is particularly sensitive to methicillin-resistant Staphylococcus aureus (MRSA); it also has good anti-inflammatory effects and promotes wound healing. Among them, the natural supramolecular hydrogel formed by the self-assembly of effective ingredients of Macleaya cordata powder and flavonoid active molecules has a uniform morphology, good dispersion and stability, forms a gel without the need for excipients, and has the value of being developed into a carrier-free drug delivery preparation. The general structural formula of the compound is shown below:

The invention provides citric acid-cyclodextrin derivative controlled-release composite supramolecular hydrogel and a preparation method thereof.The preparation method comprises the steps that citric acid and cyclodextrin are mixed and fully dissolved through ultrasonic treatment; adjusting the pH value of the solution to 0.5-2.0 to promote a cross-linking reaction, and carrying out the cross-linking reaction for 3-5 hours at 40-60 DEG C based on an optimized temperature condition; cooling the reacted solution to room temperature, and adding a proper amount of cross-linking agent for self-assembly to form gel; and after drying treatment, the gel is molded into a structure with a required form and a stable state. By optimizing the cross-linking reaction conditions of citric acid and cyclodextrin, the hydrogel with a unique net structure and mechanical strength is obtained. The material has excellent water absorption, biocompatibility and mechanical properties, and is especially suitable for the fields of tissue engineering, biomedicine and environmental protection. The preparation process comprises the steps of chemical treatment of raw materials, control of reaction conditions, self-assembly and cross-linking reaction, forming, drying and the like.

The invention belongs to but not limited to the technical field of hydrogel, and particularly relates to a processing method of tough, transparent and adhesive supramolecular hydrogel, which comprises the following steps: step 1, preparing a supramolecular hydrogel precursor with a specific shape; step 2, dissolving the prepared precursor in water; step 3, freezing under a low-temperature condition; step 4, standing the frozen supramolecular hydrogel in air or dry inert gas; step 5, cutting and folding the obtained hydrogel, and processing the hydrogel into another shape; and 6, swelling the processed hydrogel in an acid-containing nutrient solution to obtain the final hydrogel. By adopting a supramolecular strategy and utilizing a high-density supramolecular network formed by tannic acid (TA) and polyvinyl alcohol (PVA), the mechanical property, transparency and adhesiveness of the hydrogel are remarkably improved.

The invention discloses a preparation method of high-strength supramolecular lignin / polyvinyl alcohol hydrogel. The high-strength supramolecular lignin / polyvinyl alcohol hydrogel is prepared by gradually diffusing a lignosulfonate solution into a polyvinyl alcohol (PVA) solution and self-assembling. The supramolecular hydrogel prepared by the method disclosed by the invention has good mechanical properties, freezing resistance, ultraviolet resistance and the like, so that the supramolecular hydrogel has huge application potential in the fields of tissue engineering, rubber, plastic substitution, wearable electronics and the like.

The invention discloses a supramolecular hydrogel coating film reversibly adhering to frozen food and a production method and application thereof, belongs to the technical field of food packaging materials, and provides a production method of the supramolecular hydrogel coating film reversibly adhering to frozen food. The preparation method comprises the following steps: mixing 2, 3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and carrying out an ice bath reaction to obtain a carboxylation modified araboxylan solution; adding dopamine hydrochloride into the arabinoxylan, stirring, dialyzing and freeze-drying to obtain an arabinoxylan-dopamine graft; adding acrylic acid and metal ions into an ethanol water solution, mixing with the araboxylan-dopamine graft, stirring, mixing with N, N '-methylene bisacrylamide and ammonium persulfate, and polymerizing to obtain the supramolecular hydrogel covering film. The supramolecular hydrogel coating film has the characteristics of light-operated reversible adhesion, high mechanical strength and degradability, and is suitable for various frozen foods.

A supramolecular hydrogel capable of delivering lipophilic medicaments, a preparation method therefor, and uses thereof are provided. The structure of the supramolecular hydrogel is represented by Formula I, in which R1 and R2 are each independently selected from palmitoyl or oleoyl, respectively. The hydrogel can be used as a drug delivery system, and encapsulate and load various medicaments. In particular, it has good controlled-release for hydrophobic medicaments.

The invention discloses supramolecular hydrogel and microneedle patch for treating oral mucositis and a preparation method and application thereof, and belongs to the technical field of biological medicine, and the supramolecular hydrogel for treating oral mucositis comprises the following raw materials: guanosine, a potassium hydroxide solution containing metal ion soluble salt and phenylboronic acid lactone drugs. The raw material of the microneedle patch further comprises a water-soluble backing solution. The supramolecular hydrogel or microneedle patch for treating oral mucositis integrates antibacterial, anti-inflammatory, antioxidant and angiogenesis promoting functions, and has a remarkable effect of promoting healing of chemotherapeutic oral mucosal lesion.

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.

The invention discloses a supramolecular hydrogel composition as well as a preparation method and application thereof, and belongs to the technical field of beauty treatment. The supramolecular hydrogel composition provided by the invention is prepared from the following raw materials in percentage by mass: the balance of water; 2 to 30 percent of poloxamer; 1-35% of an active substance; 0.5%-20% of a cross-linking agent; and 1-20% of polyol. The supramolecular hydrogel composition provided by the invention can significantly reduce the irritation to the skin on the basis of effectively improving the content of active substances and the bioavailability of the active substances in the supramolecular hydrogel composition. The invention also provides a preparation method and application of the supramolecular hydrogel composition.

The application provides a silver ion-nucleoside supramolecular hydrogel and a preparation method and application thereof, and belongs to the field of biological materials. The nucleoside supramolecular hydrogel with a three-dimensional spatial structure is prepared by using 2-amino adenosine and silver ions. The hydrogel has good biocompatibility, stability, biodegradability, injectability and antibacterial property, and can be used for intrapocket injection administration. The hydrogel is further used for loading a photothermal reagent to obtain a composite hydrogel. The composite hydrogel can play a role of chemotherapy-photothermal synergistic treatment, has excellent antibacterial and antibiofilm capacity, and has a good application prospect in periodontitis treatment.

The present invention provides a polyrotaxane having a chemical structure in which an axial molecule represented by Formula (2) is threaded into a cyclodextrin ring in a compound represented by Formula (1). In Formula (1), CD is a cyclodextrin ring, L2 is a divalent organic group, L3 is an ethylene group or a propylene group, RA is a hydrogen atom or a C1-6 alkyl group, and m is an integer of 0 to 35. Provided that when L2 and N are linked by a double bond, RA is not present. In Formula (2), R is a hydrocarbon group larger than an inner diameter of the cyclodextrin ring, X is a divalent organic group, and a is an integer of 100 to 1000.

The invention discloses a core amino acid sequence for driving any recombinant protein to be self-assembled into supramolecular hydrogel and application of the core amino acid sequence, and aims to solve the problems of complex synthesis, toxic residue, insufficient biocompatibility, difficulty in performance regulation and control and the like of the traditional chemical crosslinking hydrogel. The whole length of Ure2 (1-19) to Ure2 (1-71) and any truncated body and mutant are covered, and the shortest sequence Ure2 (1-19) has efficient driving self-assembly. The core amino acid sequence is fused to any recombinant protein, the obtained fusion protein can form nanofiber-shaped self-assembly aggregation when the concentration is lower than 1 mg / mL, and can form supramolecular hydrogel with the characteristics of shear thinning effect, injectability and the like when the concentration is greater than or equal to 1 mg / mL, and the formation of the hydrogel does not need any additional artificial interference. The preparation can be finished only by standing for a period of time.

The invention discloses a polypeptide derivative, a nanofiber and application of the polypeptide derivative and the nanofiber in preparation of a product for repairing subfissure of teeth, the sequence of the polypeptide derivative comprises Nap-Phe-Phe-Gly-Asp-His-Thr-Lys-Glu, and Nap is 2-naphthylacetic acid. The polypeptide derivative is clear in chemical structure, small in molecular weight, single in component, simple in preparation process, low in cost, high in yield and easy to store. The polypeptide derivative disclosed by the invention is self-assembled in an aqueous solution to form the supramolecular hydrogel with a nanofiber microstructure, and the supramolecular hydrogel is high in stability and good in biocompatibility. The nanofiber hydrogel of the polypeptide derivative can interact with mineral ions and can form a crystal structure very close to natural hydroxyapatite, so that ordered formation of mineral crystals is induced at enamel and dentin hidden cracks.

The invention discloses cefradine supramolecular composite graded gel and a preparation method and application thereof, cefradine and glycosaminoglycan are used as raw materials, and self-assembly of cefradine is controlled through an interface template to form supramolecular hydrogel. And cross-linking and compounding with glycosaminoglycan gel to obtain the double-network supramolecule-polymer graded composite gel. The graded composite gel prepared by the invention has excellent swelling property, tissue adhesion and thixotropy and tensile property similar to that of human skin, so that the graded composite gel can accelerate healing of infected wounds, and due to excellent conductivity, real-time online monitoring of drug release and wound healing conditions can be realized.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The invention discloses an oral ulcer intelligent microneedle patch based on guanosine vesicle slow release and a preparation method thereof, and relates to the technical field of drug research and development, and the key points of the technical scheme are that the intelligent microneedle patch can penetrate through an oral ulcer pseudo membrane to realize targeted delivery of drugs; long-acting slow release of a therapeutic drug (guanosine) is realized through the guanosine vesicles, and continuous anti-inflammatory and tissue repair effects are achieved; the guanosine is a natural nucleoside and is an important construction unit of the supramolecular hydrogel. Therefore, more diversified supramolecular hydrogels based on guanosine and derivatives thereof also appear in continuous modification. The guanosine borate supramolecular hydrogel is used as a nano-scaffold with good biocompatibility and stimulation responsiveness, and has the potential of conveying various therapeutic drugs in the aspect of drug conveying. The intelligent microneedle patch can monitor a plurality of key physiological parameters of an ulcer microenvironment in real time, and diagnosis and treatment integration is achieved.

The invention discloses a hydrogel microneedle with biocompatibility and mechanical strength as well as a preparation method and application of the hydrogel microneedle, and belongs to the technical field of biological materials. The hydrogel microneedle comprises Gel and Ser in a mass ratio of 1: 1. And the molecular weight of the Gel / Ser hydrogel microneedle is 300,000 Da. According to the method, Gel and Ser are subjected to in-situ synthesis under the interaction of hydrogen bonds to obtain the Gel / Ser pure natural supramolecular soluble hydrogel microneedle. The pure natural hydrogel microneedle with biocompatibility and mechanical strength can be used as a drug carrier to promote the proliferation and migration of fibroblasts and the formation of endothelial canals by loading growth factors (GDFx), and further promote the healing of wounds. The prepared pure natural hydrogel microneedle with biocompatibility and mechanical strength is supramolecular hydrogel formed through intermolecular hydrogen-bond interaction, reaction conditions are easy to obtain, and operation is easy.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

The present invention provides a supramolecular hydrogel sealing agent constructed by host-guest interaction, and its preparation method and application, which belong to the technical field of drilling fluid sealing. The supramolecular hydrogel sealing agent constructed by host-guest interaction of the present invention comprises the following raw materials in percentage by mass: 12-36% copolymerization monomer, 6-10% tannic acid grafted polysaccharide aqueous dispersion, 0.5-1.5% initiator, 0.3-0.6% cross-linking agent, and the balance is water; the total amount of each component is 100%. The raw materials of the present invention are cheap and easy to obtain, the raw material composition is simple, the cost is low, and it is green, safe and environmentally friendly; the preparation method is simple, the conditions are mild, and it is easy to implement. The sealing agent obtained by the present invention has excellent mechanical properties, heat and pressure resistance and outstanding pH degradation ability after cross-linking, can effectively seal the crude oil reservoir to form an integral sealing barrier, and reduce the entry of heavy oil into the wellbore; at the same time, it can effectively realize the degradation of the hydrogel to achieve unsealing.

The invention discloses supramolecular hydrogel capable of being used as a carrier as well as a synthesis method and application of the supramolecular hydrogel. The drug-loaded supramolecular hydrogel is prepared from the following raw materials: laponite, beta-cyclodextrin modified sodium hyaluronate, (ferrocenyl methyl) trimethyl ammonium bromide and the balance of deionized water. Wherein the hectorite is a substance for forming the network structure of the supramolecular hydrogel serving as the carrier. The supramolecular hydrogel can be used as a macrophage extracellular vesicle carrier for treating burn wounds, has injectable, proper viscosity, porous structure, antibacterial property and the like, is beneficial to wound closure, tissue regeneration, collagen synthesis, cell proliferation and angiogenesis, and is beneficial to tissue regeneration and remodeling.

The invention belongs to the field of medical treatment, and particularly relates to a preparation method of a blood perfusion diagnosis and treatment device based on guanosine supramolecular gel, which comprises the following steps: preparing guanosine-boric acid supramolecular hydrogel combined with TMPyP, the guanosine-boric acid supramolecular hydrogel being GB hydrogel; the GB hydrogel combined with the TMPyP probe is attached to the surface of the U-shaped optical fiber; the optical fiber attached with the GB hydrogel is immersed in a lead ion solution for adsorption, meanwhile, the adsorption amount is monitored through electrical and optical bimodal signals, after adsorption is completed, adsorbed lead ions can be replaced for regeneration, and cyclic adsorption is achieved. The adsorption material for blood perfusion, which has high selectivity, excellent blood compatibility, reproducibility and fluid shearing resistance, is integrated with an optical fiber detection device, so that the integration of treatment and monitoring is realized; the GB hydrogel realizes selective adsorption and real-time monitoring of heavy metal ions through a G4 tetramer structure unit.

The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm / NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam / adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.

The invention provides a structure, preparation and application of a supramolecular hydrogel which is formed by self-assembly of two single components, namely alpha-D-pentagalloylgalactose and alpha-D-pentagalloylmannose, in water under the condition of not being subjected to any structural modification and pretreatment, as well as a preparation method and application of the supramolecular hydrogel. According to the alpha-D-pentagalloyl galactose and alpha-D-pentagalloyl mannose supramolecular hydrogel, the hydrogel can be formed under the condition that no gelator is used, and the hydrogel has excellent gel properties such as injectability, heat sensitivity, self-healing property and stability. Meanwhile, the two supramolecular hydrogels both have good immunoregulation, anti-inflammatory and antioxidant activities, are both superior to clinical first-line drugs (dexamethasone and ascorbic acid), and also show good angiogenesis promoting ability. A large number of tests show that the supramolecular hydrogel has good biological safety, and clinical medication safety can be further guaranteed.

The present invention belongs to the field of medicine, and specifically relates to a Euphorbia licorice supramolecular hydrogel and a preparation method and use thereof. The supramolecular hydrogel comprises Euphorbia ethyl acetate extract and glycyrrhizic acid, and the Euphorbia ethyl acetate extract and the glycyrrhizic acid interact with each other to form nanoparticles by self-assembly. The preparation method of the Euphorbia licorice supramolecular hydrogel comprises the following steps: weighing the Euphorbia ethyl acetate extract and glycyrrhizic acid and placing them in a round-bottom flask, adding an appropriate amount of deionized water, and decocting for 0.5 to 2 hours. Experimental results show that the Euphorbia licorice supramolecular hydrogel of the present invention has a good anti-hepatoma ascites effect and has excellent safety compared with conventional chemotherapy drugs.