51 results about "Supramolecular hydrogels" patented technology

The invention relates to the technical field of polymer photoelectric materials, in particular to a preparation method of a supramolecular gel electrolyte. The method comprises the following steps: esterifying tetraphenylethylene alcohol and methacryloyl chloride to form tetraphenylethylene methacrylate, and performing staged linear heating polymerization on the tetraphenylethylene methacrylate, 3-(methacrylamido) propyl dimethyl 3-thiopropyl ammonium oxide inner salt, acrylic acid, tetraphenylethylene methacrylate and 4-vinylpyridine under the action of ammonium persulfate to obtain a tetraphenylethylene copolymer. And finally, soaking in a lithium chloride aqueous solution to obtain the supramolecular hydrogel electrolyte. The hydrogel obtained by the invention has high mechanical strength and high ionic conductivity, and is suitable for energy storage devices such as flexible supercapacitors and the like.

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.

The application provides a silver ion-nucleoside supramolecular hydrogel and a preparation method and application thereof, and belongs to the field of biological materials. The nucleoside supramolecular hydrogel with a three-dimensional spatial structure is prepared by using 2-amino adenosine and silver ions. The hydrogel has good biocompatibility, stability, biodegradability, injectability and antibacterial property, and can be used for intrapocket injection administration. The hydrogel is further used for loading a photothermal reagent to obtain a composite hydrogel. The composite hydrogel can play a role of chemotherapy-photothermal synergistic treatment, has excellent antibacterial and antibiofilm capacity, and has a good application prospect in periodontitis treatment.

The invention discloses a core amino acid sequence for driving any recombinant protein to be self-assembled into supramolecular hydrogel and application of the core amino acid sequence, and aims to solve the problems of complex synthesis, toxic residue, insufficient biocompatibility, difficulty in performance regulation and control and the like of the traditional chemical crosslinking hydrogel. The whole length of Ure2 (1-19) to Ure2 (1-71) and any truncated body and mutant are covered, and the shortest sequence Ure2 (1-19) has efficient driving self-assembly. The core amino acid sequence is fused to any recombinant protein, the obtained fusion protein can form nanofiber-shaped self-assembly aggregation when the concentration is lower than 1 mg / mL, and can form supramolecular hydrogel with the characteristics of shear thinning effect, injectability and the like when the concentration is greater than or equal to 1 mg / mL, and the formation of the hydrogel does not need any additional artificial interference. The preparation can be finished only by standing for a period of time.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The invention discloses an oral ulcer intelligent microneedle patch based on guanosine vesicle slow release and a preparation method thereof, and relates to the technical field of drug research and development, and the key points of the technical scheme are that the intelligent microneedle patch can penetrate through an oral ulcer pseudo membrane to realize targeted delivery of drugs; long-acting slow release of a therapeutic drug (guanosine) is realized through the guanosine vesicles, and continuous anti-inflammatory and tissue repair effects are achieved; the guanosine is a natural nucleoside and is an important construction unit of the supramolecular hydrogel. Therefore, more diversified supramolecular hydrogels based on guanosine and derivatives thereof also appear in continuous modification. The guanosine borate supramolecular hydrogel is used as a nano-scaffold with good biocompatibility and stimulation responsiveness, and has the potential of conveying various therapeutic drugs in the aspect of drug conveying. The intelligent microneedle patch can monitor a plurality of key physiological parameters of an ulcer microenvironment in real time, and diagnosis and treatment integration is achieved.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm / NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam / adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.

The invention provides a structure, preparation and application of a supramolecular hydrogel which is formed by self-assembly of two single components, namely alpha-D-pentagalloylgalactose and alpha-D-pentagalloylmannose, in water under the condition of not being subjected to any structural modification and pretreatment, as well as a preparation method and application of the supramolecular hydrogel. According to the alpha-D-pentagalloyl galactose and alpha-D-pentagalloyl mannose supramolecular hydrogel, the hydrogel can be formed under the condition that no gelator is used, and the hydrogel has excellent gel properties such as injectability, heat sensitivity, self-healing property and stability. Meanwhile, the two supramolecular hydrogels both have good immunoregulation, anti-inflammatory and antioxidant activities, are both superior to clinical first-line drugs (dexamethasone and ascorbic acid), and also show good angiogenesis promoting ability. A large number of tests show that the supramolecular hydrogel has good biological safety, and clinical medication safety can be further guaranteed.

This invention relates to the field of supramolecular copolymer hydrogel technology, specifically to a high-strength and tough supramolecular hydrogel with tunable interfacial hydration properties, its preparation method, and its applications. This invention uses N-acryloylaminourea (NASC) monomer and a sulfonate-containing monomer (lubricating molecule) as raw materials, and adds a photoinitiator. A prepolymer solution of an organic solvent and water mixture is prepared using the dehydrogenation effect of an organic solvent. Crosslinking polymerization is carried out under ultraviolet light irradiation to obtain a supramolecular hydrogel. Then, water equilibrium is achieved to obtain a high-strength and tough supramolecular hydrogel with tunable interfacial hydration properties. The high-strength and tough supramolecular hydrogel prepared by this invention possesses high water content, excellent lubrication properties, mechanical properties, structural stability, and long-term service reliability, exhibiting excellent comprehensive performance and meeting the synergistic requirements of multi-dimensional material performance in complex engineering scenarios or biomedical fields.

This invention discloses a composite scaffold for promoting bone regeneration in diabetic patients, its preparation method, and its applications, relating to the field of medical biomaterials technology. The composite scaffold for promoting bone regeneration in diabetic patients comprises: a three-dimensional porous framework; and a bioactive hydrogel layer loaded with naringin. The bioactive hydrogel layer loaded with naringin is coated on the surface and pore walls of the three-dimensional porous framework. The technical solution provided by this invention uses a 3D-printed PLGA / HA porous framework to provide mechanical support and osteoconductivity, and a supramolecular hydrogel coating loaded with naringin to endow it with immunomodulatory and drug sustained-release functions. This scaffold has good hydrophilicity and biocompatibility, and can effectively induce macrophage polarization towards the M2 anti-inflammatory phenotype by activating the JAK-STAT signaling pathway, improving the local inflammatory microenvironment of diabetic bone defects. Simultaneously, it indirectly promotes vascular endothelial cell migration, lumen formation, and osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophages.

The invention discloses dexamethasone eye emulsion supramolecular hydrogel and a preparation method thereof, and belongs to the technical field of medicines. The dexamethasone eye emulsion supramolecular hydrogel is prepared from the following components in percentage by mass volume: 0.02 to 0.06 percent of dexamethasone, 0.5 to 5 percent of liquid oil, 1 to 6 percent of emulsifier and 1 to 5 percent of polyphenol. According to the dexamethasone ophthalmic emulsion supramolecular hydrogel provided by the invention, dexamethasone is used as a main drug, and a nanoemulsion is used as an insoluble drug carrier to improve the solubility of the dexamethasone ophthalmic emulsion supramolecular hydrogel; the emulsifier on the surface of the nanoemulsion can be self-assembled with polyphenol through hydrogen-bond interaction to form a supramolecular hydrogel network. After the preparation is dropped into the conjunctival sac, the drug-loaded nano-emulsion is gradually released and the free drug is further released under the shear thinning action caused by tear dilution and blinking, so that the long-acting treatment concentration is maintained on the ocular surface, and the defects that the drug is easily lost due to nasolacrimal duct drainage, the retention time of the ocular surface is short and the like in the traditional eye drops are effectively overcome.

The application discloses a self-shrinking, self-healing and multi-stimulus responding rosin-based copper salt supramolecular hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogels. The rosin-based copper salt supramolecular hydrogel is synthesized by means of coordination between copper nitrate and obtained disodium sulfonated dehydroabietic acid after sulfonation reaction and neutralization reaction of dehydroabietic acid as raw material, and has self-shrinking, self-healing and multi-stimulus responding performances. The preparation method of the hydrogel comprises the following steps: (1) preparation of sulfonated dehydroabietic acid; (2) preparation of disodium sulfonated dehydroabietic acid; and (3) preparation of the rosin-based copper salt supramolecular hydrogel. The rosin-based copper salt supramolecular hydrogel can realize self-shrinking of copper ions and maintain three-dimensional shape memory, and simultaneously has comprehensive performances of self-healing, multi-stimulus responding such as pH and oxidation and reduction, visual chiral identification, high conductivity and high swelling rate, and has inhibiting effects on pseudomonas aeruginosa and bacillus subtilis.

A supramolecular hydrogel film for reversible adhesion of frozen food, a production method, and an application are provided. The production method includes mixing the arabinoxylan solution with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and performing an ice bath reaction to obtain the carboxylated arabinoxylan solution; adding dopamine hydrochloride, performing a stirring, dialysis and freeze-drying to obtain the arabinoxylan-dopamine graft; adding acrylic acid and metal ions to the ethanol aqueous solution, mixing with the arabinoxylan-dopamine graft, and performing a stirring, and then mixing with N,N′-methylenebisacrylamide and ammonium persulfate to obtain the supramolecular hydrogel film. The supramolecular hydrogel film has the characteristics of light-controlled reversible adhesion, high mechanical strength, high gas barrier properties and degradability, and is suitable for various frozen foods.

The invention discloses a self-constricting, self-healing and multi-stimulus-responsive rosin-based copper salt supramolecular hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. According to the preparation method, dehydroabietic acid is taken as a raw material, sulfonation reaction and neutralization reaction are carried out in sequence, and then the obtained sulfonated dehydroabietic acid disodium salt and copper nitrate are synthesized into the rosin-based copper salt supramolecular hydrogel through coordination, and the rosin-based copper salt supramolecular hydrogel has self-constriction, self-healing and multi-stimulation response performance. The preparation method of the hydrogel comprises the following steps: (1) preparing sulfonated dehydroabietic acid; (2) preparing sulfonated dehydroabietic acid disodium salt; and (3) preparing the rosin-based copper salt supramolecular hydrogel. The rosin-based copper salt supramolecular hydrogel can realize self-constriction of copper ions and maintain three-dimensional shape memory, has comprehensive properties of self-healing, pH, oxidation reduction and other multiple stimulation responses, visual chiral recognition, high conductivity and high swelling rate, and has an inhibition effect on pseudomonas aeruginosa and bacillus subtilis.

The invention discloses a compound and application thereof in preparation of a medicine for treating radioactive jawbone necrosis, according to the compound, DNA supramolecular hydrogel coats MSC to form a cage type three-dimensional structure, and DNA self-assembly hydrogel in the compound can improve the in-vivo residence time of mesenchymal stem cells. The compound has stable injectability, and can effectively improve the treatment effect of the mesenchymal stem cells on the radioactive jaw necrosis.

The application discloses a preparation method of an in-situ hydrazone bond injectable hydrogel and application thereof to preventing abdominal cavity adhesion, and belongs to the field of medical biomaterials. The application takes 8-arm-PEG10000-CHO with an aldehyde group at a terminal and 8-arm-PEG10000-HZ with a hydrazine group at a terminal as raw materials, forms a hydrazone bond through a Schiff base reaction, and obtains PCA supermolecular hydrogel through in-situ construction; the preparation method of the application does not need a chemical crosslinking agent, can quickly form a gel at room temperature, is simple and controllable in process, and the prepared hydrogel has excellent injectability, self-healing performance, biodegradability and biocompatibility, can form a stable physical barrier in-situ on an abdominal surgery wound, effectively inhibits inflammatory cell infiltration and collagen fiber deposition, has a significant prevention effect on light, medium and severe abdominal cavity adhesion, and especially still has excellent protection capability in a severe inflammatory adhesion model induced by talc, thereby providing a safe and effective new scheme for preventing and treating postoperative abdominal cavity adhesion.

The invention belongs to the technical field of lubricating materials, and particularly relates to layered hydrogel, a preparation method and application thereof and a recovery method of a lubricating coating. The invention provides layered hydrogel. The layered hydrogel comprises a substrate and a lubricating layer compounded on any surface of the substrate, the substrate is a copolymer of polymethylacrylic acid and polymethacrylamide, and the lubricating layer is obtained by dissociating a substrate material in a PBS (Phosphate Buffer Solution). In the invention, the micro-phase separated substrate provides excellent mechanical properties, and the lubricating layer on the surface contributes to an extremely low friction coefficient. The layered hydrogel can achieve both high bearing capacity and low friction characteristics. According to the preparation method, microphase separation is induced through solvent replacement, supramolecular hydrogel with a uniform structure and high strength is directly constructed, a lubricating layer is formed on the surface through a simple dissociation process, and integration of bearing and lubricating is achieved. A solvent replacement method is adopted, so that the body hydrogel has more excellent mechanical strength and lubricating property.

This invention provides a method for preparing a polypeptide hydrogel and its applications. The structure of the polypeptide hydrogel is shown in the figure below. The basic framework of the hydrogel is constructed from arginine and naphthaleneacetic acid, naproxen, phenylalanine, and glycine as basic units. Naproxen, as an anti-inflammatory drug, is introduced into the hydrogel to increase its bioactivity. Glycine and phenylalanine act as hydrophilic / hydrophobic modulators, while arginine and histidine regulate the hydrogel's properties. This polypeptide can be synthesized via solid-phase synthesis, and the preparation process is mature and readily available. The polypeptide of this invention can self-assemble into a supramolecular hydrogel in water, which can scavenge reactive oxygen species, inhibit the expression of TLR4-related gene pathways, and improve the inflammatory environment by downregulating NF-κB. The polypeptide hydrogel of this invention can also promote macrophage polarization, improve the wound environment through immunomodulation, and promote wound healing, showing broad application prospects in diabetic wound repair.

The invention provides a “host-guest” supramolecular hydrogel. The hydrogel contains an AAm / NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam / adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.

Provided are a polypeptide, an anti-aging transdermal hydrogel, and a use, relating to the fields of biomedicine and novel drug development. The sequence of the polypeptide is (C12)-FGGRGGHGGGG-(3-Aminobenzeneboronic acid), wherein C12 represents lauric acid, 3-Aminobenzeneboronic acid represents 3-aminophenylboronic acid, F represents phenylalanine, G represents glycine, R represents arginine, and H represents histidine. The polypeptide can be chemically modified and self-assembled in an aqueous solution to form a supramolecular hydrogel. Experiments show that the polypeptide hydrogel has strong transdermal permeability, can reach the corium layer within2 h, can significantly inhibit aging phenotypes such as transcription of SASP factors, activation of P53, up-regulation of β-Gal, and expression of γH2AX, can be used for preparing anti-aging products, and has good market prospects and application potential.

The application provides a metal ion independent supramolecular hydrogel and a preparation method and application thereof, and belongs to the field of biomedical materials. The guanosine supramolecular hydrogel is prepared from 8-hydroxyguanosine or 8-aminoguanosine, boric acid and water in a weak alkali environment with a pH value of 7.5-8, and the ratio of 8-hydroxyguanosine or 8-aminoguanosine, boric acid and water is (0.025-0.1) mmol:(0.0125-0.1) mmol:1000 muL. The supramolecular hydrogel prepared from 8-hydroxyguanosine (C8) instead of guanosine derivatives can be gelled without metal ions, and also has good mechanical properties, so that the supramolecular hydrogel has a wide application prospect.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin hybrid supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the cyclodextrin hybrid supramolecular hydrogel comprises quaternary ammonium salt modified beta-cyclodextrin and hectorite which interacts with the quaternary ammonium salt modified beta-cyclodextrin in an electrostatic manner; plant hormones are included in a cavity of the quaternary ammonium salt modified beta-cyclodextrin. The cavity of the quaternary ammonium salt modified beta-cyclodextrin can effectively include plant hormones such as indoleacetic acid, and then the supramolecular hydrogel is formed through electrostatic interaction between the hectorite and the quaternary ammonium salt modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape provided by the invention has charges and cavities, can include various plant hormones, has the effects of regulating soil salinity and promoting plant growth, and has a synergistic effect with plants in a saline-alkali soil improvement technology to improve the improvement effect. The hydrogel disclosed by the invention is based on multiple non-covalent interaction, has the advantage of controllably releasing plant hormones, and is cooperated with plant remediation to realize sustainable environmental remediation.

Supramolecular hydrogels comprising (i) at least one polymer and (ii) extracellular vesicles; processes for production thereof; and methods of use.

The application provides a nucleoside supramolecular hydrogel and a preparation method and application thereof, and belongs to the field of biological materials. The nucleoside supramolecular hydrogel is prepared from 2,2'-diamino-2'-deoxyadenosine and cyanuric acid as raw materials. The nucleoside supramolecular hydrogel has good stability, can effectively promote alveolar bone defect bone repair and periodontitis bone defect repair, and has a wide application prospect in the preparation of bone defect repair materials.

The embodiment of the invention discloses supramolecular hydrogel, a hydrogel composition as well as a preparation method and application of the supramolecular hydrogel. Wherein the supramolecular hydrogel has the effect of good fluidity. The preparation method of the supramolecular hydrogel comprises the following steps: dissolving cystine in an acid aqueous solution to obtain a first mixture; adding chitosan into the first mixture, mixing, and stirring until the mixture is clarified to obtain a second mixture; carrying out first purification on the second mixture to obtain a first purified substance with the molecular weight greater than or equal to a first preset value, so as to prepare a supramolecular hydrogel precursor; beta-glucan and the supramolecular hydrogel precursor are uniformly mixed, and a third mixture is obtained; carrying out second purification on the third mixture to obtain a second purified substance with the molecular weight greater than or equal to a second preset value, and then freeze-drying the second purified substance into powder to obtain a powder substance; a first solvent is added into the powder for redissolving, and supramolecular hydrogel is prepared; wherein the first solvent is water.

The application belongs to the technical field of three-dimensional culture and delivery of cells, and discloses a gelatin / hyaluronic acid porous hydrogel composed of a biomimetic extracellular matrix for three-dimensional culture and delivery of dendritic cells and a preparation method thereof. The method uses a semi-interpenetrating polymer network composed of methacrylic anhydride modified gelatin (GelMA) and oxidized hyaluronic acid (OHA) as a matrix, introduces temperature-responsive gelatin microspheres and dendritic cells at the same time, and then constructs a three-dimensional supramolecular hydrogel cell in-vitro culture model with decoupled pore size and stiffness after the gelatin microspheres are melted by increasing the temperature. The supramolecular hydrogel has the advantages of convenient use, simple operation, biological safety and the like, and can be used in the fields of three-dimensional culture, delivery and tumor immunotherapy of dendritic cells.

The invention relates to the technical field of self-assembly supramolecules, in particular to supramolecular hydrogel based on double-ended amphiphilic molecules as well as a preparation method and application of the supramolecular hydrogel. The double-end-group amphiphilic molecule provided by the invention has a structural formula as shown in a formula 1, and n is any integer in a range of 8-28. The double-end-group amphiphilic molecule can form supramolecular hydrogel in pure water, the supramolecular hydrogel has a very good selective removal effect on heavy metal ions in water, trace heavy metal ions in water can be selectively removed through a filtering system constructed by utilizing the supramolecular hydrogel, the treated water meets the related requirements of drinking water, and the application prospect is wide. Meanwhile, ions such as sodium, potassium and magnesium essential to the human body cannot be removed, heavy metal ions can be selectively removed through simple filtration, extra wastewater is not generated, and secondary pollution is avoided. The method is simple in process and relatively low in cost, is expected to replace the traditional reverse osmosis membrane technology, and has relatively good economic value.

The application discloses a 3D printing high-strength supramolecular hydrogel and application thereof in bone defect repair. The high-strength supramolecular hydrogel is formed by hydrogen bond, ion interaction and hydrophobic association non-covalent cross-linking of a positively charged high-molecular polymer, a negatively charged functional monomer and a photoinitiator, and has a dynamic network structure. The hydrogel has a structure similar to an extracellular matrix, has self-healing, viscoelasticity and dynamics, and is beneficial to cell adhesion, proliferation, migration and differentiation. The hydrogel has superfast gelation, realizes second-level gelation solidification, and can accurately 3D print a microporous structure due to triple forces of strong hydrogen bond, electrostatic interaction and hydrophobic interaction. The hydrogel has good biodegradability, and the degradation rate can be designed by adjusting ingredients and cross-linking density, so that the degradation rate is matched with the speed of new bone formation, and finally, the scaffold material is completely replaced by new bone tissue.

The invention discloses intelligent response type supramolecular hydrogel as well as a preparation method and application thereof, and the supramolecular hydrogel with pH / ROS / sugar responsiveness is constructed by carrying out supramolecular integration on G-quadruplex supramolecular hydrogel (G4) formed by lipoic acid (LA) and guanosine derivatives. According to the hydrogel, LA deprotonation is triggered through an alkaline environment of G4 to form LA salt, a three-dimensional cross-linked structure is constructed through ion hydrogen bonds and intermolecular hydrogen bonds of carboxyl and a G4 network, no harsh reaction conditions are needed in the preparation process, and the problem of inverse ring-closing depolymerization of an LA-based material is solved. The supramolecular hydrogel has the following advantages: (1) the supramolecular hydrogel has dynamic responsiveness to diabetes wound microenvironment (pH, ROS and sugar), and realizes on-demand drug release; (2) the beverage has the functions of resisting oxidation, resisting bacteria and reducing blood sugar; (3) the mechanical property is adjustable, and injection type or patch type dressings can be prepared; and (4) the wound dressing has high stability, can promote healing of diabetic wounds, has anti-inflammatory and antibacterial effects, and is suitable for development of intelligent wound dressings.