Injectable cartilage repair supramolecular hydrogel and preparation method thereof

Abstract

The invention is applicable to the technical field of hydrogel and provides an injectable cartilage repair supramolecular hydrogel and a preparation method thereof. The supramolecular hydrogel comprises acrylated beta-cyclodextrin, gelatin and chondroitin sulfate, wherein the gelatin and the chondroitin sulfate are connected through an amido bond; the acrylated beta-cyclodextrin is combined with a benzene ring in the gelatin through hydrophobic action subject and object; and the acryloyl groups of the acrylated beta-cyclodextrin form double-bond crosslinking.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an injectable supramolecular hydrogel for cartilage repair and a preparation method thereof. Background technique [0002] Cartilage defect is a common clinical orthopedic disease, arthroscopy found that about 60% of the joints have cartilage defects. If not treated in time, 60%-75% of the lesions can progressively develop into osteoarthritis, seriously affecting the patient's motor function, and even ending his career. Since articular cartilage is not vascularly innervated, its regenerative capacity is very limited. Therefore, in the fields of biomaterials and medicine, cartilage defect repair has always been a research hotspot. So far, cartilage defect repair has not been effectively solved. As the gold standard for the treatment of articular cartilage defects, autologous chondrocyte transplantation has been recognized by scholars, but there are problems such a...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an injectable supramolecular hydrogel for cartilage repair, aiming at simultaneously solving the problems of poor self-repair performance of the existing hydrogel, non-injectable, difficult fixation and loss from the defect site

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