Injectable cartilage repair supramolecular hydrogel and preparation method thereof

A technology of supramolecular hydrogel and sulfuric acid cartilage, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of poor self-repair performance of hydrogel, loss of defect parts, and difficult fixation, etc. Injection performance, enhancement effect, super tissue adhesive effect

Inactive Publication Date: 2016-05-18
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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Problems solved by technology

[0005] The purpose of the present invention is to provide an injectable supramolecular hydrogel for cartilage repair, aiming at simultaneously

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  • Injectable cartilage repair supramolecular hydrogel and preparation method thereof
  • Injectable cartilage repair supramolecular hydrogel and preparation method thereof

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[0024] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0025] combine figure 1 , the embodiment of the present invention provides a supramolecular hydrogel, including acryloyl β-cyclodextrin, gelatin and chondroitin sulfate, wherein, the gelatin and the chondroitin sulfate are linked by amide bonds; the acrylic The acylated β-cyclodextrin is combined with the benzene ring in the gelatin through the host-guest interaction through hydrophobic interaction, and the acryloyl group of the acrylylated β-cyclodextrin forms a double bond crosslink.

[0026] In the supramolecular hydrogel provided by the embodiments of the present invention, various sub...

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Abstract

The invention is applicable to the technical field of hydrogel and provides an injectable cartilage repair supramolecular hydrogel and a preparation method thereof. The supramolecular hydrogel comprises acrylated beta-cyclodextrin, gelatin and chondroitin sulfate, wherein the gelatin and the chondroitin sulfate are connected through an amido bond; the acrylated beta-cyclodextrin is combined with a benzene ring in the gelatin through hydrophobic action subject and object; and the acryloyl groups of the acrylated beta-cyclodextrin form double-bond crosslinking.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an injectable supramolecular hydrogel for cartilage repair and a preparation method thereof. Background technique [0002] Cartilage defect is a common clinical orthopedic disease, arthroscopy found that about 60% of the joints have cartilage defects. If not treated in time, 60%-75% of the lesions can progressively develop into osteoarthritis, seriously affecting the patient's motor function, and even ending his career. Since articular cartilage is not vascularly innervated, its regenerative capacity is very limited. Therefore, in the fields of biomaterials and medicine, cartilage defect repair has always been a research hotspot. So far, cartilage defect repair has not been effectively solved. As the gold standard for the treatment of articular cartilage defects, autologous chondrocyte transplantation has been recognized by scholars, but there are problems such a...

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Application Information

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IPC IPC(8): A61L27/20A61L27/22A61L27/26A61L27/52
CPCA61L27/20A61L27/22A61L27/52A61L2430/02C08L5/16C08L5/08C08L89/00
Inventor 王大明王大平冯茜刘威朱伟民段莉边黎明黄江鸿梁宇杰刘启颂熊建义
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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