Compound polypeptide nanometer vesicles with skin repair function and preparing method and application thereof

A technology for skin repair and nanovesicles, which is applied in the field of composite polypeptide nanovesicles and its preparation, can solve the problems of inability to achieve full-effect repair, poor product stability, and single repair mechanism, so as to promote microcirculation, high-efficiency self-deformation, The effect of reducing drug toxicity

Inactive Publication Date: 2019-06-14
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many products aimed at repairing the skin barrier, but the following problems generally exist: 1) The repair mechanism is single and the efficiency is low: the product only targets the repair of the stratum corneum, and cannot achieve full repair; 2) The stability of the product is poor: some products with strong repair Components are insoluble and easy to separate out, such as ceramide, cholesterol, etc.; 3) Low absorption rate: physiologically active protein components, such as fibronectin, EGF, and active polypeptides, have high molecular weight, short half-life, and unstable structure. The biggest problem in delivery is that these protein components have low skin penetration

Method used

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  • Compound polypeptide nanometer vesicles with skin repair function and preparing method and application thereof
  • Compound polypeptide nanometer vesicles with skin repair function and preparing method and application thereof
  • Compound polypeptide nanometer vesicles with skin repair function and preparing method and application thereof

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preparation example Construction

[0039] The present invention also provides a method for preparing the composite polypeptide nanovesicles with skin repairing function according to the above technical solution, comprising the following steps:

[0040] (1) mixing the hydrophilic active components in the regeneration and repairing active polypeptides, antioxidant active polypeptides, natural moisturizing active factors, and microcirculation-promoting active components with water, and dissolving in a water bath at 40-75° C. to obtain a water phase;

[0041] (2) Mix the regeneration and repair active polypeptide, antioxidant active polypeptide, natural moisturizing active factor, lipophilic active ingredient in microcirculation-promoting active ingredient, lipid wall material, cholesterol and polyol, and water bath at 45-70° C. melted to obtain an oil phase;

[0042] (3) mixing the water phase obtained in the step (1) with the oil phase obtained in the step (2), and after the micronization treatment, a micron-scal...

Embodiment 1

[0056] Mix 0.01% fibronectin, 0.05% oligopeptide-1, 0.5% carnosine, 0.1% hyaluronic acid, 0.2% sodium polyglutamate, 0.1% nicotinamide, 0.01% EGF with the balance of water at 55°C Stir and dissolve to a transparent solution under water bath conditions to obtain an aqueous phase, which is for subsequent use;

[0057] 0.01% Acetyl Tetrapeptide-15, 1% Squalane, 2% Soy Lecithin, 10% Propylene Glycol, 10% Glycerol, 2% 1,2-Hexanediol, 5% Ceramide, 0.1% Cholesterol in Stir and melt under the condition of 55 ℃ water bath to obtain an oil phase, which is for later use;

[0058] The water phase is added to the oil phase, and after the mixing is completed, high-speed shearing and emulsification are performed for 5 minutes under the condition of a rotating speed of 5500 rpm to obtain a micron-scale dispersion;

[0059] The micron-sized dispersion was emulsified by high-speed shearing for 1 min under the condition of rotating speed of 12000 rpm to obtain composite polypeptide nanovesicles...

Embodiment 2

[0062] Mix 1% fibronectin, 0.01% oligopeptide-1, 0.5% sodium polyglutamate with the remaining amount of water, stir and dissolve in a water bath at 45°C to a transparent solution to obtain an aqueous phase, which is for later use;

[0063] 3% soybean lecithin, 2% egg yolk lecithin, 0.2% adenosine, 0.1% palmitoyl tripeptide-8, 0.02% hexapeptide-9, 0.05% dipeptide-4, 8% propylene glycol, 15% glycerol, 5 % 1,2-pentanediol and 0.2% cholesterol were stirred and melted in a water bath at 45°C to obtain an oil phase, which was used for later use;

[0064] The water phase is added to the oil phase, and after the mixing is completed, high-speed shear emulsification is performed for 3 minutes under the condition of a rotating speed of 6500 rpm to obtain a micron-scale dispersion;

[0065] The micron-sized dispersion was homogenized twice at a temperature of 35° C. and a homogenization pressure of 500 bar to obtain composite polypeptide nanovesicles with skin repairing function.

[0066...

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Abstract

The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a composite polypeptide nanovesicle with skin repairing function and a preparation method and application thereof. Background technique [0002] The skin barrier is an important protective structure of human skin. The skin barrier broadly includes physical barrier, pigment barrier, nerve barrier, and immune barrier. The narrow sense of the skin barrier mainly refers to the physical barrier, which is mainly composed of sebum film, keratin, lipid, brick wall structure, dermal mucopolysaccharides, mucopolysaccharides, etc., which can resist external harmful substances, irritants, sunlight entering , while moisturizing and regulating anti-inflammatory effect. [0003] In recent years, sensitive skin, poor skin tolerance, and post-operative repair of medical aesthetic lasers are all caused by weak or damaged skin barrier. At present, there are many products aimed at re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/14A61Q19/00
Inventor 刘卫洪延涵罗丹吴雨桐闻庆韩非
Owner WUHAN BEST CARRIER NANO TECH
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