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Nano-liposome emulsion and preparation method thereof

A nano-liposome and emulsion technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as reducing the sensitization effect of seaweed extracts, and achieve enhancement and extension of beauty repair, promotion of growth and improvement. Repair and reduce allergic reactions

Inactive Publication Date: 2014-06-25
烟台新时代健康产业日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a nano-liposome emulsion to solve the deficiency in the application of seaweed extract in the preparation of existing cosmetics, and to avoid or reduce the sensitization caused by direct contact between seaweed extract and skin epidermal cells

Method used

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  • Nano-liposome emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Weigh 20.0g of seaweed extract, 10.0g of soybean lecithin, 1.0g of cholesterol and 0.01g of vitamin E for cooling and ultrasonic solubilization, add 10.0g of Tween 80, heat up to 55-60°C, and fully stir until uniform Oil phase, keep warm for 10min.

[0031] 2. Weigh 15.0g of glycerin, add it to 44.0g of pure water, raise the temperature to 55-60°C, stir evenly to form the water phase, and keep it warm for 10min.

[0032] 3. Pump the oil phase material into the water phase for premixing, adjust the rotation speed to 10000r / min for high-speed homogenization for 20 minutes, and keep warm at 55-60°C for 10 minutes to make the primary emulsion.

[0033] 4. Move the primary emulsion to a high-pressure homogenizer, and carry out high-pressure homogenization circulation treatment under a pressure of 80 MPa. Take out the emulsion when it becomes transparent or translucent, and cool it down to room temperature naturally to obtain the skin repair function nano liposome emulsio...

Embodiment 2

[0035] 1. Weigh 10.0g of seaweed extract, 15.0g of soybean lecithin, 2.0g of cholesterol and 0.1g of vitamin E to cool and sonicate, add 10.0g of Tween 80, heat up to 55-60°C, and fully stir until uniform Oil phase, keep warm for 10min.

[0036] 2. Weigh 20.0g of glycerin, add it to 42.9g of pure water, raise the temperature to 55-60°C, stir evenly to form the water phase, and keep it warm for 10min.

[0037] 3. Pump the oil phase material into the water phase for premixing, adjust the rotation speed to 10000r / min for high-speed homogenization for 20 minutes, and keep warm at 55-60°C for 10 minutes to make the primary emulsion.

[0038] 4. Move the primary emulsion to a high-pressure homogenizer, and carry out high-pressure homogenization circulation treatment under a pressure of 100 MPa. Take out the emulsion when it becomes transparent or translucent, and cool it down to room temperature naturally to obtain the skin repair function nano liposome emulsion coated with seaweed...

Embodiment 3

[0040] 1. Weigh 15.0g of seaweed extract, 20.0g of egg yolk lecithin, 3.0g of stigmasterol and 0.05g of vitamin C for cooling and ultrasonic dissolution, add 20.0g of polyethylene glycol 4000, heat up to 55-60°C, and stir thoroughly Until the oil phase is uniform, keep warm for 10 minutes.

[0041] 2. Weigh 10.0g of propylene glycol, add it to 32.0g of pure water, raise the temperature to 55-60°C, stir evenly to form the water phase, and keep it warm for 10min.

[0042] 3. Pump the oil phase material into the water phase for premixing, adjust the rotation speed to 10000r / min for high-speed homogenization for 20 minutes, and keep warm at 55-60°C for 10 minutes to make the primary emulsion.

[0043] 4. Move the primary emulsion to a high-pressure homogenizer, and carry out high-pressure homogenization circulation treatment under a pressure of 120MPa. Take out the emulsion when it becomes transparent or translucent, and cool it down to room temperature naturally to obtain the sk...

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Abstract

The invention relates to nano-liposome emulsion. A seaweed extract is packaged inside a nano-liposome. The nano-liposome emulsion contains 10wt%-20wt% of the seaweed extract, 10wt%-20wt% of lecithin, 1wt%-3wt% of a propping agent, 0.01wt%-0.1wt% of an antioxidant, 10wt%-20wt% of a solubilizer and 10wt%-20wt% of a stabilizing agent. According to the invention, the nano-liposome emulsion inside which the seaweed extract is packaged is prepared at first and has a skin regeneration function, and a product has relatively good water solubility and can be randomly mixed with a skin care preparation, so that a functional cosmetic is relatively convenient and efficient in preparation. A liposome packaging process can be used for improving the stability of the seaweed extract and the compatibility of the seaweed extract in a cosmetic system; the carrying function of the liposome is beneficial for the seaweed extract to go deep into a deep layer of the skin, thus a sensitization response caused by direct contact between the seaweed extract and the epidermic cells of the skin is reduced or avoided, and the seaweed extract is also fully takes the effects.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano liposome emulsion and a preparation method of the emulsion. Background technique [0002] With the decline of the quality of people's surrounding environment, the acceleration of the pace of life and the intensification of work pressure, our outermost protective organ-the skin suffers more and more external damage. The defects or incompleteness of the epidermis, the shedding or deposition of pigments, the hyperplasia and formation of scars, and the defects of the skin nervous system and tiny blood vessels have become increasingly prominent. Faced with this situation, people's requirements for cosmetic functions have gradually shifted from simple covering to cosmetic restoration. [0003] As one of the oldest known plants on the earth, seaweed is a low-level cryptogamous plant that widely grows in the ocean with rich varieties and abundant yield. Biologically active sub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/14A61K8/06A61Q19/00
Inventor 毕利顺邹鹏飞邵茜隋海松赵乐荣潘松浩
Owner 烟台新时代健康产业日化有限公司
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