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Nerve conduit and preparation method thereof

A nerve catheter and electrospinning technology, which can be used in catheters, devices for human tubular structures, medical science, etc., can solve problems such as adverse reactions and low cytotoxicity

Active Publication Date: 2012-09-26
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] (3) The materials used must have low cytotoxicity and slight local tissue adverse reactions, etc.;

Method used

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  • Nerve conduit and preparation method thereof
  • Nerve conduit and preparation method thereof
  • Nerve conduit and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0105] (1) Select hydrophilic gelatin and silk fibroin, the mass ratio of the two is 70:30, the solvent is formic acid, the mass fraction of the spinning solution is 15%, and the spinning solution is added to the syringe of the electrospinning device, and the micro amount is adjusted The speed of the syringe pump is 8 ml / hour, the receiving distance is 10 cm, and the voltage is 20 kV. Turn on the electrospinning machine and perform spinning to obtain the inner layer of the cell scaffold with an average fiber diameter of 800-1000 nm;

[0106] (2) Select hydrophobic L-polylactic acid and ε-caprolactone copolymerized polymer materials, the mass ratio of the two is 50:50, the number average molecular weight is 310,000, and the mass ratio of gelatin and silk fibroin is 70:30 As a solute, it is dissolved in hexafluoroisopropanol to obtain a spinning solution with a mass fraction of 12%, and based on the mass ratio of (L-polylactic acid and ε-caprolactone: gelatin and silk fibroin) 25...

Embodiment 2

[0110] (1) Select hydrophilic chondroitin sulfate and hyaluronic acid, the mass ratio of the two is 70:30, use formic acid as the solvent, and the mass fraction of the spinning solution is 12%, and add the spinning solution into the syringe of the electrospinning device , adjust the rate of the micro-injection pump to 10 ml / hour, the receiving distance to 12 cm, and the voltage to 20 kV, turn on the electrospinning machine, and spin in a cylindrical rotor to obtain a cell scaffold with an average fiber diameter of 1000-1500 nm layer;

[0111](2) Select hydrophobic polycaprolactone, a mixture of chondroitin sulfate and hyaluronic acid at a mass ratio of 70:30 as the solute, dissolve it in hexafluoroisopropanol to obtain a spinning solution with a mass fraction of 10%, And prepare three different mixed solutions according to the mass ratio of (polycaprolactone: chondroitin sulfate and hyaluronic acid) 25:75, 50:50, 75:25, adjust the speed of the micro-injection pump to 5 ml / hou...

Embodiment 3

[0115] (1) Prepared as Figure 4 grooved rotor shown;

[0116] (2) Select hydrophilic chondroitin sulfate and hyaluronic acid, the mass ratio of the two is 70:30, the mass fraction of the spinning solution is 12%, add the spinning solution into the syringe of the electrospinning device, and adjust the micro-syringe pump The rate is 10ml / hour, the receiving distance is 12cm, the voltage is 20kV, and spinning is carried out to obtain the inner layer of the cell scaffold with an average fiber diameter of 1000-1500nm; then, water-soluble gelatin gel is coated on the groove;

[0117] (3) Choose hydrophobic L-polylactic acid and ε-caprolactone, the mass ratio of the two is 50:50, it is a copolymerized polymer material, the number average molecular weight is 310000, and the total mass of chondroitin sulfate and hyaluronic acid A mixture with a ratio of 70:30 was used as a solute, dissolved in hexafluoroisopropanol to obtain a spinning solution with a mass fraction of 12%, and accord...

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Abstract

The invention discloses a nerve conduit and a preparation method thereof. The nerve conduit consists of an inner layer, an outer layer and at least one minitype cavity for storing a bioactive factor solution, wherein the inner layer is of a hydrophilic cell scaffold layer, and the outer layer is of a hydrophobic nerve conduit scaffold layer. The nerve conduit can further comprise a transition layer between the inner layer and the outer layer. The preparation method of the nerve conduit comprises the steps of preparing the inner layer by adopting an electrostatic spinning method, then adding the material for preparing the cavity, then preparing the outer layer, and taking out or dissolving the material for preparing the cavity, thus obtaining the nerve conduit. The nerve conduit has the minitype cavity, so that bioactive factors can be loaded by a manner of injection, soaking and the like as required before operation, thus not only leading the production quality to be easily controlled, but also being capable of greatly improving the survival rate of the bioactive factors, more efficiently promoting the regeneration of nerves, and enhancing the restoration effect of nerves.

Description

technical field [0001] The invention belongs to the field of biomedical materials and implantable medical devices, and in particular relates to a nerve guide and a preparation method thereof. Background technique [0002] The nervous system is one of the most important organs in the human body, which controls the sensory and motor functions of the human body. Various traumas such as compression, stretching, tearing, cutting, and other factors such as ischemia, tumors, etc. will cause partial or complete damage to the nervous system, resulting in loss of function and other neurological diseases. The repair and functional reconstruction of defective nerves is one of the difficult problems to be overcome by human beings. [0003] The neuronal axons of peripheral nerves can extend under appropriate conditions and grow longer than the injured area to achieve the purpose of nerve regeneration. With the help of neurosurgery, especially the development of microneurosurgery, the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/11A61F2/04A61L29/16A61L29/14
Inventor 徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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