8 results about "Gelatin gel" patented technology

The invention discloses a preparation method of polyphenol-polysaccharide synergistically-improved thermally-stable fish gelatin gel and 3D printing application of the polyphenol-polysaccharide synergistically-improved thermally-stable fish gelatin gel. According to the method, tannic acid and sodium carboxymethyl cellulose are introduced into a fish gelatin system and are fully stirred and mixed, and tannic acid as a cross-linking agent interacts with sodium carboxymethyl cellulose and fish gelatin to construct a more compact three-dimensional gel network, so that the preparation of the polyphenol and polysaccharide synergistically enhanced fish gelatin-based gel is realized. The gel shows excellent printing adaptability and structural stability in 3D printing application, geometric shapes can be accurately formed, the gel has wide application prospects in the fields of personalized food design, biological material manufacturing and the like, and a new technical path is provided for high-value development of fish gelatin.

The invention relates to the technical field of medicines, in particular to sound-induced piezoelectric hydrogel as well as a preparation method and application thereof. The method comprises the following steps: 1) synthesizing a nano-plate by adopting a hydrothermal method; or in the process of synthesizing the nano-plate by the hydrothermal method, adding an iron source into the reaction liquid, and carrying out hydrothermal reaction to obtain the iron-doped nano-plate, (2) carrying out lamellar stripping on the nano-plate to obtain a nano-sheet; and 3) preparing gelatin gel, and then mixing the gelatin gel with the nanosheets obtained in the step 2) to obtain the sound-induced piezoelectric hydrogel. The piezoelectric-like material is innovatively applied to treatment of infected wounds, the piezoelectric-like material serves as a novel piezoelectric material, the acoustic heating effect can be rapidly generated under low-power ultrasonic induction so as to treat the biological membrane infected wounds, and in addition, the temperature rise can promote wound healing by increasing the blood flow volume, promoting cell migration and the like.

The present application provides a gelatin particle and a preparation method thereof, and a hemostatic fluid gelatin composition. The gelatin particle is a cross-linked gelatin particle, and the preparation raw material of the gelatin particle comprises gelatin and a high molecular material containing amino and / or carboxyl; the preparation process of the gelatin particle comprises the steps of forming a gelatin gel from the gelatin and crushing the gelatin gel, wherein the high molecular material is added to mix with the solution of the gelatin or the gelatin gel before or after the formation of the gelatin gel. The gelatin particle and the hemostatic fluid gelatin of the present application can quickly absorb the moisture in the blood after being applied to a bleeding wound, thereby increasing the concentration of red blood cells, blood coagulation factors and the like in the blood, accelerating the endogenous blood coagulation mechanism, and having a good hemostatic effect.

The invention relates to the field of medical application of biological hydrogel, in particular to dexamethasone loaded hydrogel delivered across tympanic membranes and a preparation method of the dexamethasone loaded hydrogel, the hydrogel takes gelatin Gel and dopamine modified hyaluronic acid HADA as base materials, a three-dimensional network structure is formed through enzymatic crosslinking of transglutaminase mTGase, dexamethasone sodium phosphate Dex is loaded, and the hydrogel can be used for preparing the dexamethasone loaded hydrogel. Furthermore, local trans-tympanic membrane middle ear drug delivery and release are realized; specifically, a solution A composed of Gel, HADA and Dex and a solution B composed of mTGase are evenly mixed according to the volume ratio of 4: 1 and dropwise added to the surface of the tympanic membrane through an external auditory canal, and finally Gel-HADA-Dex hydrogel is formed on the surface of the tympanic membrane. Local precise high-concentration drug delivery can be achieved, systemic drug toxicity is avoided, materials are safe, ear toxicity is avoided, meanwhile, adhesion performance is high, drug release is continuous, gradual self-degradation is achieved, manual taking out is not needed, and use convenience is remarkably improved.

The present disclosure provides a preparation method of a reverse osmosis composite membrane, including the following steps: coating a gelatin solution on a non-woven fabric layer and cooling to form a gelatin gel layer; coating a salt solution on a surface of the gelatin gel layer to obtain a gel / non-woven fabric composite membrane; placing the gel / non-woven fabric composite membrane in an aqueous phase solution, transferring into an oil phase solution, and conducting interfacial polymerization to obtain a non-woven fabric / gel / polyamide composite membrane; placing the non-woven fabric / gel / polyamide composite membrane in water, and heating to remove the gelatin gel layer to obtain a non-woven fabric / polyamide composite membrane; and introducing a trimesoyl chloride (TMC) gas from a side where the non-woven fabric layer is away from a polyamide layer in the non-woven fabric / polyamide composite membrane, conducting gas-liquid interfacial polymerization by chemical vapor deposition (CVD), and drying to obtain the reverse osmosis composite membrane.

This invention relates to a myocardial repair patch based on multi-material printing, its preparation, and its application, belonging to the field of bio-3D printing and regenerative medicine technology. The invention uses PLCL and GelMA hydrogel loaded with active cardiomyocytes as bio-inks, and introduces gelatin gel as a heat buffer material. An orthogonal network structure is constructed using multi-material bio-3D printing technology to prepare a myocardial repair patch with excellent dynamic adaptability to the myocardial interface and good biocompatibility. The myocardial injury repair patch prepared by this invention achieves a structure-function integrated design through the synergistic effect of the three materials, significantly overcoming the limitations of single materials in terms of mechanical properties, biological function, or thermal compatibility. The mechanical properties of the myocardial injury repair patch prepared by this invention can precisely match those of natural myocardium, while possessing high cell activity, effectively inhibiting fibrosis, improving myocardial function, and achieving true active repair. Furthermore, the process conditions are controllable, demonstrating good translational potential.

This invention belongs to the field of hydrogel material preparation technology, specifically relating to the preparation and application of an easily dispersible water-retaining agent. The water-retaining agent can be prepared through a simple operation. It is composed of gelatin and vanillin. Due to the grafting effect of vanillin and gelatin, this invention significantly prolongs the solidification time of the gelatin solution, giving the water-retaining agent good fluidity for a longer period, allowing it to be mixed into the application system via injection. Furthermore, through the cross-linking action of transglutaminase, it catalyzes the covalent cross-linking of gelatin chains, making it different from other gelatin gels; it does not melt upon heating after cooling and solidification, exhibiting thermal stability. This water-retaining agent, with its easily dispersible and thermally irreversible properties, has advantages in the mechanical mixing of application systems, which is beneficial for improving the structure of applied products and is expected to be widely used in food pre-processing, biomedical materials, and other fields.

The application provides a hemostatic material and a preparation method thereof. The preparation raw material of the hemostatic material comprises gelatin and a natural polymer material, and the preparation process of the hemostatic material comprises the step of crushing gelatin gel in the presence of the natural polymer material; wherein the gelatin gel is obtained by gelation after cross-linking of the gelatin. The hemostatic material of the application comprises gelatin and a natural polymer material, and the gelatin gel is crushed in the presence of the natural polymer material, so that the particle size of the gel can be reduced, and finally the hemostatic material with good hemostatic effect is obtained.