98 results about "Molecular aggregation" patented technology

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD/AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD/AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light/temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.

The present invention provides a silicon compound represented by Formula (1) and a polymer obtained by using the same, and this makes it possible not only to obtain an organic-inorganic composite material having a distinct structure but also to control the structure of the above polymer as a molecular aggregate.

wherein R¹ is a group independently selected from hydrogen, alkyl having a carbon atom number of 1 to 40, substituted or non-substituted aryl and substituted or non-substituted arylalkyl; in this alkyl having a carbon atom number of 1 to 40, optional hydrogens may be substituted with fluorine, and optional —CH₂— may be substituted with —O—, —CH═CH—, cycloalkylene or cycloalkenylene; in alkylene in this arylalkyl, optional hydrogens may be substituted with fluorine, and optional —CH₂— may be substituted with —O— or —CH═CH—; and A¹ is a group having an α-haloester bond.

The invention provides a phenanthro-carbazole donor-acceptor organic dye and application thereof in a dye-sensitized solar cell, and belongs to the field of organic dyes. The organic dye utilizes the characteristics of phenanthro-carbazole structural units such as a large plane conjugated system and higher fluorescence quantum yield to be connected with the structural units with different electronic withdrawing abilities so as to realize step-by-step regulation and control to the dye molecular energy level; meanwhile, a molecular non-conjugated skeleton is connected with a long alkyl chain, so that the solubility of phenanthro-carbazole units is improved, the difficulty in molecular synthesis and device processing is reduced, and charge transfer among molecules caused by molecular aggregation is reduced; meanwhile, raw materials of phenanthro-carbazole compounds are abundant in source, low in price and easy to cut structurally.

The invention relates to a blue-fluorescence material and an application thereof. The blue-fluorescence material and the application thereof start from the perspective of molecular design, tetraphenyl ethylene is taken as the core, and an electron-donating structure and an electron-withdrawing structure which are provided with anthryl groups are introduced to the two sides of a molecule. The tetraphenyl ethylene has the property of aggregation-induced emission, and the fluorescence quenching phenomenon produced by molecular aggregation can be effectively avoided; anthracene is a stable and efficient blue-fluorescence group, and the two anthracene structures are introduced, so that the number of chromophoric groups is increased, the relative molecular mass of the molecule is increased, the glass-transition temperature of the molecular is increased, and the heat stability of the molecule is enhanced. The D (electron-donating) group and the A (electron-withdrawing) group are introduced, transfer of electric charges inside the molecule can be effectively facilitated, and the luminescence property of the molecule is improved. Experiment results show that the blue-fluorescence material has good heat stability and electroluminescene properties, and when the blue-fluorescence material is used as luminescent layers of blue organic electroluminescence devices, blue-light with better color purity and emitting efficiency can be obtained.

The invention pertains to the technical field of organic and organometalic electro-active material, which more particularly relates to a hyperbranched polyfluorenes material comprising steric blockade and a preparation method thereof. The material introduces high blockade on the basis of hyperbranched polyfluorenes structure to distort considerately the synthesis molecular chain, thus efficiently inhibiting molecular aggregation, avoiding formation of excimer and fluorescence quenching, improving the material with luminous efficiency. As organic electro-active material with high inoxidability, thermal shock resistance and photostability, the material can be widely used in organic electronics industry such as organic/synthesis electroluminescent, photovoltaic cell, organic field-effect transistor and laser etc.

The invention relates to a water-soluble cationic biphenyl aromatic hydrocarbon as well as an inclusion compound and a preparation method thereof. The compound has a structural formula as shown in thedescription, wherein n is equal to 4-7. The inclusion compound is molecular aggregate formed by the steps: taking water-soluble cationic biphenyl [4] aromatic hydrocarbon as a macrocyclic host compound, taking an ATP molecule (Adenosine Triphosphate) as an individual guest molecule, enabling the ATP molecule to enter a cavity of the water-soluble cationic biphenyl [4] aromatic hydrocarbon, and forming the aggregate by virtue of electrostatic interaction and pi-pi interaction. A molar ratio of the water-soluble cationic biphenyl [4] aromatic hydrocarbon to the ATP molecule is 1 to 1. A bindingconstant measured by a thermostatic calorimetric titration experiment (ITC) experiment is (1.05+/-0.07)*10<4>M<-1>. The method has the advantages of being simple in operation and mild in reaction conditions, improves the biological stability of the ATP, and provides a new thought for reducing multidrug resistance (MDR) produced by tumor cells to anticancer drugs.

The invention discloses a cetirizine hydrochloride oral solution, which comprises cetirizine hydrochloride, mannitol, hydroxy propyl cellulose and water. The oral solution provided by the invention effectively covers up the strong titter taste of the active component cetirizine, obviously improves the stability of the oral solution, effectively reduces the chemical degradation and the toxic or side effects of the cetirizine, reduces the molecular aggregation phenomenon of the active component, reduces the using risk and improves the medicine safety.

The invention relates to the technical field of silane coupling agents, in particular to a fluorine-containing silane coupling agent and a preparation method thereof. A formula of the fluorine-containing silane coupling agent comprises the following components in percentage by weight: 98-99 percent of silane coupling agent, 0.001-0.09 percent of fluorine surfactant and 0.01-1.91 percent of catalyst. A liquid prescription of the fluorine-containing silane coupling agent comprises the following components in percentage by weight: 0.5 percent of silane coupling agent, 0.01 percent of fluorine surfactant and 99.49 percent of water. Compared with the prior art, as the adopted fluorine surfactant is resistant to acid, base and high temperature, and the surface tension of a water solution of the fluorine-containing silane coupling agent is generally lower than 20mN/m, the invention can avoid molecular aggregation in a hydrating solution of the silane coupling agent, increase the stability and the permeability of inorganic materials, promote the homogeneity of the silane coupling agent due to low surface tension and further reduce the using amount.

The present invention relates to stable liquid pharmaceutical compositions of curcumin or its pharmaceutically acceptable salts or its derivatives with higher curcumin concentration and improved bioavailability without the use of buffer and/or molecular aggregation inhibitor(s). In accordance with present invention the curcumin is in the solubilized form to make a stable liquid pharmaceutical composition.

The invention relates to a pyrene D-pi-A type asymmetric disc dye compound, and a preparation method of a pyrene derivative material. A length-controllable flexible chain of the asymmetric pyrene derivative material serves as a donator (alkyl or alkoxy phenylacetylene and bis-alkylaniline), and a carboxy side chain serves as a receptor (benzoic acid or iso-cyanoacrylate). The prominent advantages of the pyrene disc compound applied to a dye-sensitized solar cell are simple synthesis and separation, low cost, better photoelectric conversion efficiency, and the like. In addition, electron-withdrawing and electron-donating groups are added through a coupled reaction to form the asymmetric D-pi-A type disc dye compound, and the problem of efficiency reduction caused by dye molecular aggregation is solved by controlling positions of the electron-withdrawing and electron-donating groups. The compound has very high ultraviolet absorption and photoelectric conversion efficiency, and has a wide application prospect in organic-dye-sensitized solar cells.

The invention discloses an organic nanomaterial based on spirofluorene-xanthrene mono-substituted carbazole, a preparation method and application thereof. The organic nanomaterial is prepared by adding a surfactant to the compound SFX-2-Cz, SFX-3'-Cz, or SFX-2'-Cz. The structural formulas of the compounds SFX-2-Cz, SFX-3'-Cz and SFX-2'-Cz are shown as the specification. The nano-structure preparedaccording to the invention has the advantages of regular structural morphology and uniform size, realizes controllable preparation of one-dimensional to two-dimensional organic nanostructures. Corresponding photoluminescence characterization means proves that the optical properties of the organic nanomaterial are strongly dependent on the molecular structure and molecular aggregation mode. The invention shows the application potential of the organic semiconductor materials in future optoelectronic devices.

Disclosed is a macromolecule-crystal forming apparatus and method capable of obtaining a macromolecule crystal in a simplified and efficient manner. The device comprises a first container containing a sample of macromolecule, a second container containing a gel acting as a buffer material during the crystallization of the macromolecule, and a third container containing a precipitant solution having a function of facilitating the aggregation of molecules during the crystallization of the macromolecule. These containers are connected together in a given manner so as to allow the macromolecule sample and the precipitant to be brought into contact with one another through the gel to induce the crystallization of the macromolecule.

A cleanliness monitor for monitoring a cleanliness of a vacuum chamber. The cleanliness monitor may include a mass spectrometer, a molecule aggregation and release unit and an analyzer. The molecule aggregation and release unit is configured to (a) aggregate, during an aggregation period, organic molecules that are present in the vacuum chamber and (b) induce, during a release period, a release of a subset of the organic molecules towards the mass spectrometer. The mass spectrometer is configured to monitor an environment within the vacuum chamber and to generate detection signals indicative of a content of the environment; wherein a first subset of the detection signals is indicative of a presence of the subset of the organic molecules. The analyzer is configured to determine the cleanliness of the vacuum chamber based on the detection signals.

The invention discloses a synthesis of anionic rare earth complex [RE(III) (DBM) 3bath] (wherein, RE is Eu, Tb, Dy and other rare earth ions; DBM (dibenzoylmethane) is a first ligand; bath (bathophenanthrolinedisulfonic acid disodium salt trihydrate) is a second ligand) which belongs to the field of luminescent material and hydrotalcite composite luminescent ultra slim membrane and preparation method thereof. The concrete steps are as follows: preparing an anionic rare earth organic complex; preparing a hydrotalcite colloidal solution; preparing a rare earth organic complex aqueous solution; assembling substrates after hydrophilic treatment in two solutions alternatively. The invention employs rigid structure of the hydrotalcite layer plate and confinement effect of two dimension space, thereby realizing immobilization of rare earth complex and ordered arrangement on molecule scale, improving homogeneity and continuity of rare earth complex membrane, and reducing fluorescence quenching generated by molecular aggregation between complexes; the membrane preparation process is easy to operate, and accurate controls of luminous intensity of the rare earth complex in the membrane and the membrane thickness can be realized by changing assembling frequencies.

The invention discloses a bridged-ring dithiophene-phenothiazine dye and application thereof in a dye-sensitized solar cell. The bridged-ring dithiophene-phenothiazine dye is a pure organic dye by taking phenothiazine as an electron donor, wherein the phenothiazine electron donor is introduced into bridged-ring dithiophene as an extra electron donor, and the bridged-ring dithiophene is 2,2'-bithiophene wrapped with a cyclic alkyl chain, has relatively high steric hindrance, is beneficial to improving of the optical and electrical properties of the dye and has the effects of inhibiting dye molecular aggregation and electron recombination; and meanwhile, cyanoacetic acid groups are introduced as an electron acceptor and anchored groups. The dye is applied to a working electrode of the dye-sensitized solar cell as a sensitizer, constructs a dense layer on the surface of nanometer titanium dioxide of the working electrode, covers the surface of titanium dioxide, can effectively inhibit electron recombination, increases an open circuit voltage and thus effectively improving the optical and electrical properties of the dye-sensitized solar cell.

The invention relates to a hydrophobic associated polymer intrinsic viscosity determining method. The hydrophobic associated polymer intrinsic viscosity determining method includes the following steps that step S10, a hydrophobic associated polymer solution is prepared, cyclodextrin and a sodium chloride solution are added to the hydrophobic associated polymer solution to prepare a to-be-tested sample solution; step S20, a sodium chloride solution is added to the to-be-tested sample solution, and the mass concentrations C, specific viscosities eta sp and reduced viscosities eta sp/C of the to-be-tested sample solution and the mixed solution are respectively measured; step S30, a excel graphical method is used for determining the intrinsic viscosity [eta]; step S40, the intrinsic viscosity [eta] is inspected. The hydrophobic associated polymer intrinsic viscosity determining method has the advantages that the characteristics of having hydrophobic cavities of the cyclodextrin are utilized to include hydrophobic groups and shield a hydrophobic associating effect, and the influence on intrinsic viscosity determination of the hydrophobic associated polymer of super-molecular aggregation formed by the associating effect is avoided; the measuring accuracy is high, the cyclodextrin has no surface activity, the measuring accuracy is not affected even if the quantity is excessive.

The invention discloses a preparation method of a two-dimensional anion exchange polymer and a membrane thereof, and relates to the technical field of polymer chemistry and fuel cell anion exchange membranes. The preparation method comprises the following steps: (1) designing and synthesizing a quaternary ammonium monomer suitable for two-dimensional self-assembly polymerization; (2) carrying out self-assembly on a quaternary ammonium salt monomer in an aqueous solution of a polar solvent to obtain a two-dimensional supramolecular aggregate solution; (3) adding a free radical initiator into the two-dimensional supramolecular aggregate solution, filling nitrogen to remove oxygen, and performing free radical polymerization reaction to obtain a two-dimensional polymer; and (4) carrying out solution casting on the two-dimensional polymer to obtain the two-dimensional anion exchange polymer membrane. The invention also provides the anion exchange polymer membrane prepared by the method. The preparation method has the beneficial effects that the surface of the formed two-dimensional polymer sheet layer contains a large number of quaternary ammonium hydrophilic groups, so that an ion channel is easy to form, and efficient conduction of anions in the membrane is facilitated.

The invention discloses a fluorescent probe and new application of the fluorescent probe in detection of autolysosome of living cells. The fluorescent probe contains a compound having a structure represented by the following formula or a stereoisomer thereof and countra-ions. The fluorescent probe can form a supramolecular aggregate form through self-assembly in a solution system containing metalsalt ions or an intracellular physiological environment; the fluorescent probe has two excitation wavelengths of 530-570nm and 600-650nm, can realize real-time observation of the autophagy process ofa living cell sample, has the advantages of simple dyeing, low cytotoxicity and small damage to a biological sample, and is not influenced by the pH value in cells.