Myocardial repair patch based on multi-material printing and preparation and application thereof

By combining multi-material bio-3D printing technology with PLCL, GelMA hydrogel and gelatin hydrogel, a biomimetic anisotropic microstructure myocardial repair patch was constructed, which solved the problems of lack of active myocardial cells and thermal damage in existing patches. It achieved high cell activity, mechanical matching and dynamic interface adaptability, and is suitable for the repair of myocardial infarction and cardiac trauma.

CN122075797APending Publication Date: 2026-05-26SHENYANG INST OF AUTOMATION - CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202610488551.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-14
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing cardiac repair patches lack active cardiomyocytes, cannot directly participate in the reconstruction of myocardial contractile function, and are prone to cell thermal damage during the printing process. They are difficult to simulate the mechanical and topological properties of myocardial tissue, and lack dynamic interface adaptability and the ability to inhibit fibrosis.

Method used

Using multi-material bio-3D printing technology, a composite cardiac repair patch with biomimetic anisotropic microstructures was constructed by combining PLCL with GelMA hydrogel loaded with active cardiomyocytes and reducing the printing interface temperature through local cooling technology. PLCL provides structural support, GelMA hydrogel maintains cell activity, and gelatin hydrogel acts as a heat buffer layer to absorb heat.

Benefits of technology

It achieves high cell activity and mechanical properties matching natural myocardium, possesses dynamic interface adaptability and the ability to inhibit fibrosis, significantly improving myocardial repair effects, and is suitable for minimally invasive or open-chest surgery for myocardial infarction and cardiac trauma.

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Abstract

The invention discloses a myocardial repair patch based on multi-material printing and preparation and application thereof, and belongs to the technical field of biological 3D printing and regenerative medicine. According to the invention, PLCL and GelMA hydrogel loaded with active myocardial cells are used as bio-ink, gelatin gel is introduced as a thermal buffer material, an orthogonal network structure is constructed by adopting a multi-material biological 3D printing technology, and the myocardial repair patch with excellent myocardial interface dynamic adaptability and good biocompatibility is prepared. According to the prepared myocardial injury repair patch, the structure-function integrated design is achieved through cooperation of the three materials, and the limitation of a single material in the aspects of mechanical properties, biological functions or thermal compatibility and the like is remarkably broken through. The mechanical property of the prepared myocardial injury repair patch can be accurately matched with that of natural myocardium, meanwhile, the myocardial injury repair patch has high cell activity, fibrosis can be effectively inhibited, the myocardial function can be improved, real activity repair can be achieved, the process condition is controllable, and the good transformation prospect is achieved.
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