The invention relates to the technical field of silica powder production, and particularly provides a production process of spherical silica powder. The production process comprises the following steps of S1, material selection; S2, crushing; S3, grinding into powder; S4, acid pickling and impurity removal; S5, flotation; S6, dehydrating; S7, drying, specifically, granules prepared in the step S6 are conveyed into a drying cylinder, a smashing device is arranged in the drying cylinder, the granules are scattered into powder raw materials through rotation of a transverse pipe and an air outlet pipe on the smashing device, and an air supply device arranged on the drying cylinder provides hot air for the air outlet pipe; and S8, calcining, specifically, the raw materials are dried through the drying cylinder in the production process of the spherical silica powder, the smashing device and the air supply device are arranged in the drying cylinder, the moist and caked powder raw materials are scattered through the smashing device in the drying process and dried through the air supply device, and airflow blown out by the air supply device flows into the air outlet pipe of the smashing device firstly, and then flows into the drying cylinder from the air outlet pipe to dry the powder raw materials.