Nerve conduit and preparation method thereof
A technology of nerve conduit and electrospinning, which is applied in medical science, prosthesis, etc., and can solve problems such as adverse reactions and low cytotoxicity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0104] Example 1
[0105] (1) Choose hydrophilic gelatin and silk fibroin, the mass ratio of the two is 70:30, the solvent is formic acid, and the mass fraction of the spinning solution is 15%. Add the spinning solution to the syringe of the electrostatic spinning device to adjust the trace amount. The speed of the syringe pump is 8 ml / h, the receiving distance is 10 cm, and the voltage is 20 kV. The electrospinning machine is turned on and spinning is performed to prepare the inner layer of the cell scaffold with an average fiber diameter of 800-1000 nm;
[0106] (2) Choose hydrophobic L-polylactic acid and ε-caprolactone copolymerized polymer materials, the mass ratio of the two is 50:50, the number average molecular weight is 310,000, and the mass ratio of gelatin and silk fibroin is 70:30 As the solute, dissolve in hexafluoroisopropanol to obtain a spinning solution with a mass fraction of 12%, based on the mass ratio of (L-polylactic acid and ε-caprolactone: gelatin and silk ...
Example Embodiment
[0109] Example 2
[0110] (1) Choose hydrophilic chondroitin sulfate and hyaluronic acid, the mass ratio of the two is 70:30, formic acid is used as the solvent, the mass fraction of the spinning solution is 12%, and the spinning solution is added to the syringe of the electrostatic spinning device Adjust the speed of the micro-injection pump to 10 ml / h, the receiving distance is 12 cm, the voltage is 20 kV, turn on the electrospinning machine, spin on the cylindrical rotor, and prepare the cell scaffold with an average fiber diameter of 1000~1500nm Floor;
[0111] (2) Choose a mixture of hydrophobic polycaprolactone, chondroitin sulfate and hyaluronic acid with a mass ratio of 70:30 as the solute, and dissolve it in hexafluoroisopropanol to obtain a spinning solution with a mass fraction of 10%. And according to (polycaprolactone: chondroitin sulfate and hyaluronic acid) mass ratio of 25:75, 50:50, 75:25 to prepare three different mixed solutions, adjust the micro-injection pum...
Example Embodiment
[0114] Example 3
[0115] (1) Preparation such as Figure 4 Rotor with groove shown;
[0116] (2) Choose hydrophilic chondroitin sulfate and hyaluronic acid, the mass ratio of the two is 70:30, and the mass fraction of the spinning solution is 12%. Add the spinning solution to the syringe of the electrostatic spinning device and adjust the micro syringe pump The speed is 10 ml / h, the receiving distance is 12 cm, the voltage is 20 kV, and spinning is performed to prepare the inner layer of the cell scaffold with an average fiber diameter of 1000-1500 nm; then the groove is coated with water-soluble gelatin gel;
[0117] (3) Choose hydrophobic L-polylactic acid and ε-caprolactone, the mass ratio of the two is 50:50, which is a copolymer material, the number average molecular weight is 310,000, and the total mass of chondroitin sulfate and hyaluronic acid The mixture with a ratio of 70:30 is used as the solute, which is dissolved in hexafluoroisopropanol to obtain a spinning solution ...
PUM
Property | Measurement | Unit |
---|---|---|
Average pore size | aaaaa | aaaaa |
Average pore size | aaaaa | aaaaa |
Thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap