8 results about "Autotaxin" patented technology

An anhydrous crystalline form of autotaxin (ATX) inhibitor and methods to prepare the same. Pharmaceutical formulations comprising autotaxin (ATX) inhibitor or a pharmaceutically acceptable salt thereof

The present invention relates to a novel benzimidazolone derivative compound as an autotaxin inhibitor.

The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and / or prevention of diseases and disorders mediated by Autotaxin.

Disclosed herein are autotaxin inhibitor compounds, polymorphic forms, pharmaceutical compositions, and the method of use and preparation thereof. Some embodiments relate to crystalline forms of Compound 1 and salts thereof.

The present invention provides novel azabicycle derivative compounds, their hydrates, their solvates, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions for the prevention or treatment of autotaxin-related diseases containing them as active ingredients. The azabicycle derivative compounds according to the present invention exhibit excellent inhibitory activity against autotaxin and can be usefully used for the treatment and prevention of autotaxin inhibition-related diseases, including fibrous diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, metabolic diseases, cancer and cancer metastasis, ocular diseases, cholestatic and other forms of chronic pruritus, and acute or chronic organ transplant rejection.

To provide means for treating inflammatory airway or fibrotic diseases.SOLUTION: The present invention relates to N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IPF) or systemic sclerosis (SSc). The present description discloses exemplary compounds (e.g. pages 57 to 75; examples 1.1 to 5) as well as relevant biological data thereof (e.g. pages 15 to 21, tables 1 to 9). An exemplary compound is e.g. 1-(6-(4-(((6-((6-(trifluoromethyl) pyridin-3-yl)methoxy)pyridazin-3-yl)amino)methyl)phenyl)-2,6- diazaspiro[3.3]heptan-2-yl)ethan-1-one (example 1.1).SELECTED DRAWING: None

This invention relates to a novel benzimidazolon derivative compound as an autotaxin inhibitor.

The present invention provides a new class of aromatic heterocyclic compounds as ATX (Autotaxin) inhibitors, pharmaceutical compositions comprising the compounds, and the use of the compounds and compositions in the treatment of diseases in mammals having a pathological characteristic of increased expression of ATX (Autotaxin), wherein the compounds have the structure of Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitroso, metabolite, prodrug, or mixture thereof; wherein, R 1 , Ar 1 , Ar 2 , Ar 3 , W, Y, Z and Cy have the definitions described in the present invention.