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Host-guest supramolecular hydrogel, and preparation method and application thereof

A supramolecular hydrogel, host-guest technology, applied in prosthetics, medical science, bandages, etc., can solve problems such as poor mechanical strength, achieve the effect of increasing Young's modulus, improving coupling efficiency, and improving mechanical properties

Active Publication Date: 2018-02-02
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art, and provide a host-guest supramolecular hydrogel and its preparation method and application, which can well improve the poor mechanical strength of existing natural polymer hydrogel materials. disadvantages while maintaining its good biocompatibility characteristics

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  • Host-guest supramolecular hydrogel, and preparation method and application thereof
  • Host-guest supramolecular hydrogel, and preparation method and application thereof
  • Host-guest supramolecular hydrogel, and preparation method and application thereof

Examples

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Embodiment 1

[0030] The host-guest supramolecular hydrogel provided in this example is composed of host-guest supramolecules and methacrylic anhydride gelatin (GelMA) through ultraviolet (UV) induced free radical copolymerization, and has good mechanical strength and biocompatibility. Wherein, the host-guest supramolecular hydrogel adopts 2-hydroxyl-4-(2-hydroxyethoxy)-2-methylpropiophenone (I2959) as a photoinitiator, and the hydrogel mass fraction is GelMA accounting for 10 % to 15%, host and guest supramolecules account for 2% to 15%, initiators account for 0.1% to 0.5%, and the rest is deionized water ≥ 70%. β-cyclodextrin (β-CD-AOI) modified by isocyanoethyl acrylate as host-guest supramolecule 2 ) and propylated 1-bromoadamantane (A-TEG-Ad) in water as a solvent by host-guest coupling, chemically modified β-cyclodextrin grafted with isocyanoethyl acrylate The ratio is 1.5 to 2.5 (that is, 1.5 to 2.5 hydroxyl groups on a β-cyclodextrin react with isocyanoethyl acrylate), and the mol...

Embodiment 2

[0040] The preparation method of the host-guest supramolecular hydrogel provided in this embodiment comprises the following steps:

[0041] 1) In a nitrogen atmosphere, 5 g of β-cyclodextrin recrystallized twice was dissolved in 25 mL of anhydrous DMF, 1.07 g of isocyanoethyl acrylate was added dropwise to the reaction system, and 25 μL of stannous octoate was added as a catalyst. Fully stir the reaction at room temperature for 4 hours, then use 400mL of cold acetone to precipitate the product, redissolve the resulting precipitate in 10mL of water, and then use acetone to precipitate, repeat twice, and vacuum dry to obtain β-CD-AOI 2 , the yield was 85%.

[0042] 2) Dissolve 10g of 1-bromoadamantane and 1mL of triethylamine in 200mL of tetraethylene glycol solution, reflux at 110°C for 1 day, wash with dilute hydrochloric acid solution and deionized water, and extract with dichloromethane. The organic phase was collected, dried and rotary evaporated. The obtained product was...

Embodiment 3

[0048] The preparation method of the host-guest supramolecular hydrogel provided in this embodiment comprises the following steps:

[0049] 1) In a nitrogen atmosphere, 5 g of β-cyclodextrin recrystallized twice was dissolved in 25 mL of anhydrous DMF, 1.07 g of isocyanoethyl acrylate was added dropwise to the reaction system, and 25 μL of stannous octoate was added as a catalyst. Fully stir the reaction at room temperature for 4 hours, then use 400mL of cold acetone to precipitate the product, redissolve the resulting precipitate in 10mL of water, and then use acetone to precipitate, repeat twice, and vacuum dry to obtain β-CD-AOI 2 , the yield was 85%.

[0050] 2) Dissolve 10g of 1-bromoadamantane and 1mL of triethylamine in 200mL of tetraethylene glycol solution, reflux at 110°C for 1 day, wash with dilute hydrochloric acid solution and deionized water, and extract with dichloromethane. The organic phase was collected, dried and rotary evaporated. The obtained product was...

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Abstract

The invention discloses a host-guest supramolecular hydrogel, and a preparation method and an application thereof. The host-guest supramolecular hydrogel is prepared through initiating the copolymerization of free radicals by host-guest supramolecule and methacrylic anhydride gelatin (GelMA) under an ultraviolet light (UV ) condition, and has good mechanical strength and biocompatibility. The host-guest supramolecule is prepared through the host-guest coupling of acryloyloxyethyl isocyanate-modified beta-cyclodextrin (beta-CD) and allyl 1-bromoadamantane. Compared with pure GelMA hydrogel, thehost-guest supramolecular hydrogel has the advantages of good mechanical properties, control of the mechanical strength of the hydrogel by adjusting the concentration of the host-guest supramolecule,and good biocompatibility. The host-guest supramolecular hydrogel also has the advantages of simple preparation process, mild conditions, effective improvement of the mechanical strength, and good application prospect in the field of tissue repair engineering.

Description

technical field [0001] The invention relates to the technical field of biomaterial production, in particular to a host-guest supramolecular hydrogel and its preparation method and application. Background technique [0002] In tissue repair engineering, biohydrogel is a material that is most similar to human soft tissue in terms of water content, biological structure and physical properties, and has become one of the hotspots in the field of biomaterials in recent years. Among them, natural polymer materials, such as collagen, gelatin, hyaluronic acid, and chitosan, have better biocompatibility than synthetic polymer materials, and are biopolymer materials with great potential. [0003] However, the disadvantage is that hydrogels prepared purely from natural polymers usually have poor mechanical strength, degrade too quickly, and are inconvenient to take in clinical applications. This brings great challenges to the practical application of natural polymer hydrogels in the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F291/12C08F2/48C08F214/16C08B37/16A61L26/00A61L27/52A61L27/50A61L27/22A61L27/20C08L51/00
CPCA61L26/0023A61L26/0038A61L26/0061A61L26/008A61L27/20A61L27/222A61L27/50A61L27/52C08B37/0012C08F2/48C08F290/00C08J3/075C08J2351/00C08F214/16C08L5/16
Inventor 施雪涛王志芳
Owner SOUTH CHINA UNIV OF TECH
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