Silver-ion supramolecular antibacterial hydrogel as well as preparation method and application thereof

Abstract

The invention discloses supramolecular hydrogel and also discloses a preparation method and application of the supramolecular hydrogel. The supramolecular hydrogel disclosed by the invention is prepared from a 2-deoxy-2-fluoro-guanosine analogue and silver ions. The silver-ion supramolecular antibacterial hydrogel provided by the invention has the advantages of simplicity in preparation, low toxicity, good biocompatibility, excellent stable performance and the like; the silver ions can be effectively alleviated and the antibacterial activity is good; especially, the silver-ion supramolecular antibacterial hydrogel has relatively high antibacterial activity on methicillin-resistant staphylococcus aureus ATCC25923 and ATCC33591, and fusobacterium nucleatum; the silver-ion supramolecular antibacterial hydrogel is prepared into an antibacterial material and has a relatively good application prospect.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a silver ion supramolecular antibacterial hydrogel. Background technique [0002] Silver ions have broad-spectrum antibacterial activity, and have antibacterial effects on Gram-negative bacteria, Gram-positive bacteria, fungi and some viruses, so it has a long history as an antibacterial material. Silver ion hydrogel is a new type of gel antibacterial material, because it continuously and effectively releases silver ions, kills bacteria in the wound and surrounding areas, thereby improving the wound healing environment. However, most of the silver ion hydrogels currently on the market are prepared by traditional chemical cross-linking methods, and their poor mechanical properties and instability limit the expansion of their application fields. [0003] In the past few decades, guanine derivatives have received extensive attention in the fields of structural biology, medicinal...

AI Technical Summary

Problems solved by technology

However, the current guanine nucleoside hydrogels prepared by guanine derivatives have poor stability and have the problem of rapid crystallization and disintegration; for example: water prepared by 2-deoxy-2-fluoro-guanosine The gel will disintegrate in 30 minutes at the fastest and 15 hours at the slowest (Hang Zhao, et al, Supramolecular Isoguanosine Assemblies Form Hydrogels with Excellent Long-Term Stability, ChemPlusChem 2017, 82, 826-833.)

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