Silver-ion supramolecular antibacterial hydrogel as well as preparation method and application thereof

A supramolecular hydrogel, silver ion technology, applied in the direction of antibacterial drugs, topical antibacterial agents, medical preparations of inactive ingredients, etc., can solve the problems of disintegration and poor stability of hydrogels, and achieve low toxicity, The effect of good stability and good application prospects

Active Publication Date: 2018-09-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current guanine nucleoside hydrogels prepared by guanine derivatives have poor stability and have the problem of rapid crystallization and disintegration; for example: water prepared by 2-deoxy-2-fluoro-guanosine

Method used

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  • Silver-ion supramolecular antibacterial hydrogel as well as preparation method and application thereof
  • Silver-ion supramolecular antibacterial hydrogel as well as preparation method and application thereof
  • Silver-ion supramolecular antibacterial hydrogel as well as preparation method and application thereof

Examples

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Embodiment 1

[0035] The preparation of embodiment 1 antibacterial hydrogel of the present invention

[0036] (1) 2-deoxy-2-fluoro-guanosine analogs were dissolved in 1 mL of water to form a 2-deoxy-2-fluoro-guanosine analog solution with a concentration of 2.85 mg / mL;

[0037] (2) Silver nitrate was added to the 2-deoxy-2-fluoro-guanosine analogue solution so that the silver ion concentration was 0.03mol / mL to obtain 1mL of mother liquor;

[0038] (3) Heating the mother liquor to 90° C. to 100° C., cooling to room temperature to form a gel, and obtaining the silver ion supramolecular antibacterial hydrogel.

[0039] Wherein, the structural formula of the 2-deoxy-2-fluoro-guanosine analog of the present embodiment is:

[0040]

Embodiment 2

[0041] Embodiment 2 The preparation of antibacterial hydrogel of the present invention

[0042] (1) 2-deoxy-2-fluoro-guanosine analogs are dissolved in 1mL of water to form a 2-deoxy-2-fluoro-guanosine analog solution with a concentration of 1.75mg / mL;

[0043] (2) adding silver ions to the 2-deoxy-2-fluoro-guanosine analogue solution so that the silver ion concentration is 0.025mol / mL to obtain 1mL mother liquor;

[0044] (3) Heating the mother liquor to 90° C. to 100° C., cooling to room temperature to form a gel, and obtaining the silver ion supramolecular antibacterial hydrogel.

[0045] Wherein, the structural formula of the 2-deoxy-2-fluoro-guanosine analog of the present embodiment is:

[0046]

Embodiment 3

[0047] Embodiment 3 The preparation of antibacterial hydrogel of the present invention

[0048] (1) 2-deoxy-2-fluoro-guanosine analogs are dissolved in 1mL of water to form a 2-deoxy-2-fluoro-guanosine analog solution with a concentration of 7mg / mL;

[0049](2) adding silver ions to the 2-deoxy-2-fluoro-guanosine analog solution so that the concentration of silver ions is 0.05mol / mL to obtain 1mL mother liquor;

[0050] (3) Heating the mother liquor to 90° C. to 100° C., cooling to room temperature to form a gel, and obtaining the silver ion supramolecular antibacterial hydrogel.

[0051] Wherein, the structural formula of the 2-deoxy-2-fluoro-guanosine analog of the present embodiment is:

[0052]

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Abstract

The invention discloses supramolecular hydrogel and also discloses a preparation method and application of the supramolecular hydrogel. The supramolecular hydrogel disclosed by the invention is prepared from a 2-deoxy-2-fluoro-guanosine analogue and silver ions. The silver-ion supramolecular antibacterial hydrogel provided by the invention has the advantages of simplicity in preparation, low toxicity, good biocompatibility, excellent stable performance and the like; the silver ions can be effectively alleviated and the antibacterial activity is good; especially, the silver-ion supramolecular antibacterial hydrogel has relatively high antibacterial activity on methicillin-resistant staphylococcus aureus ATCC25923 and ATCC33591, and fusobacterium nucleatum; the silver-ion supramolecular antibacterial hydrogel is prepared into an antibacterial material and has a relatively good application prospect.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a silver ion supramolecular antibacterial hydrogel. Background technique [0002] Silver ions have broad-spectrum antibacterial activity, and have antibacterial effects on Gram-negative bacteria, Gram-positive bacteria, fungi and some viruses, so it has a long history as an antibacterial material. Silver ion hydrogel is a new type of gel antibacterial material, because it continuously and effectively releases silver ions, kills bacteria in the wound and surrounding areas, thereby improving the wound healing environment. However, most of the silver ion hydrogels currently on the market are prepared by traditional chemical cross-linking methods, and their poor mechanical properties and instability limit the expansion of their application fields. [0003] In the past few decades, guanine derivatives have received extensive attention in the fields of structural biology, medicinal...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K47/26A61K9/06A61P31/04A61P1/02A61P31/02
CPCA61K9/06A61K33/38A61K47/26A61P1/02A61P31/02A61P31/04
Inventor 赵雪峰赵行韩向龙曾昕白丁陈谦明
Owner SICHUAN UNIV
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