Chiral supramolecular nucleoside hydrogel based on boron ester bonds as well as preparation method and application of chiral supramolecular nucleoside hydrogel

Abstract

The invention relates to chiral supramolecular nucleoside hydrogel based on a boron ester bonds as well as a preparation method and application of the chiral supramolecular nucleoside hydrogel, and particularly provides supramolecular hydrogel which is obtained by mixing guanine nucleoside and borate as raw materials in a solvent, wherein the guanine nucleoside is D-guanine nucleoside and/or L-guanine nucleoside. The supramolecular hydrogel has excellent stability, injectability and self-repairability, also has good biocompatibility, does not show obvious acute toxicity in animal bodies, can be degraded in vivo, and can be used as an extracellular matrix for 3D culture of cells. The supramolecular hydrogel provided by the invention has a very good application prospect in the field of tissue engineering as a scaffold material.

Description

technical field [0001] The invention belongs to the field of hydrogels, and in particular relates to a chiral supramolecular nucleoside hydrogel based on boron ester bonds, a preparation method and application thereof. Background technique [0002] Oral mucosal disease refers to the general term for various types and numerous diseases that occur on the oral mucosa and soft tissues. In clinical work, some oral mucosal diseases often manifest as persistent, extensive and severe erosions or ulcers, such as oral lichen planus, severe recurrent aphthous ulcers, etc.; the histopathological manifestations of such diseases are Defects of partial or full-thickness epithelium. Current treatment methods include removal of primary factors, drug therapy, surgery, and laser therapy. However, due to some shortcomings such as unknown or difficult to remove primary factors, poor drug treatment effect or large side effects, traditional treatment methods are difficult to meet clinical needs....

AI Technical Summary

Problems solved by technology

However, the guanosine molecule itself has a tendency to escape from the network structure. As time goes on, more and more molecules escape from the network, gather with each other, and gradually form crystals or precipitates, leading to the collapse of the gel, which seriously affects the life of the gel. and stable

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