Preparation method of high-strength ion-responsive lubricating hydrogel

A high-strength, lubricating water technology, applied in the field of ion response, can solve the problems of cartilage tissue physical and chemical properties, wear resistance, damage, etc.

Inactive Publication Date: 2018-07-31
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the increase of age or the occurrence of lesions, the fluid environment in the joint will change accordingly, especially the ionic strength or pH of

Method used

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  • Preparation method of high-strength ion-responsive lubricating hydrogel
  • Preparation method of high-strength ion-responsive lubricating hydrogel
  • Preparation method of high-strength ion-responsive lubricating hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 10.0g of polyvinyl alcohol (molecular weight: 130,000) into a 250mL round bottom flask, add 100.0mL of distilled water, reflux and condense at 90°C for 6 hours under magnetic stirring (1000r / min) to dissolve. Add 0.186 g of glutaraldehyde aqueous solution with a mass fraction of 50%, and adjust the solution to pH=2 with 1 mol / L hydrochloric acid. Transfer the solution into a 50mL centrifuge tube, put it in a water bath at 60°C for 8 hours, wash the prepared polyvinyl alcohol hydrogel in distilled water 6 times, each time for one hour, and wash away the residual glutaraldehyde to obtain polyvinyl alcohol hydrogel .

[0021] Weigh 0.02g chitosan and dissolve in 20.0mL, 1mol / L glacial acetic acid aqueous solution to prepare 0.001g / mL chitosan solution; then add 17.0g acrylamide, 0.04g cross-linking agent N,N- Methylbisacrylamide, 0.2g zinc chloride, stirred and dissolved at room temperature to obtain chitosan-acrylamide-zinc chloride solution;

[0022] Place the pr...

Embodiment 2

[0024] Take 20.0g of 2-acrylamido-2-methylpropanesulfonic acid in a 250mL round bottom flask, add 100.0mL of distilled water, and reflux and condense for 1 hour at 25°C under magnetic stirring (1000r / min) to dissolve the solid. Add 0.6 g of N,N-methylenebisacrylamide as a cross-linking agent, and adjust the solution to pH=2 with 1 mol / L hydrochloric acid. The solution was transferred into a 50mL centrifuge tube and placed in a water bath at 60°C for 3 hours to obtain a 2-acrylamido-2-methylpropanesulfonic acid hydrogel. The prepared 2-acrylamido-2-methylpropanesulfonic acid hydrogel was washed 6 times in distilled water, one hour each time, to wash away the residual cross-linking agent.

[0025] Weigh 0.02g chitosan and dissolve in 20.0mL, 1mol / L glacial acetic acid aqueous solution to prepare 0.001g / mL chitosan solution; then add 17.0g acrylamide, 0.04g cross-linking agent N,N- Methylbisacrylamide, 0.2g zinc chloride, stirred and dissolved at room temperature to obtain chito...

Embodiment 3

[0028] Weigh 10.0g of sodium hyaluronate into a 250mL round bottom flask, add 100.0mL of distilled water, reflux and condense at 90°C for 6 hours under magnetic stirring (1000r / min) to dissolve the solid. Add 0.06 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as a cross-linking agent, and adjust the solution to pH=2 with 1 mol / L hydrochloric acid. The solution was transferred into a 50mL centrifuge tube and placed in a water bath at 60°C for 6 hours to obtain a sodium hyaluronate hydrogel. The prepared sodium hyaluronate hydrogel was washed 6 times in distilled water, each time for one hour, to wash away the residual cross-linking agent.

[0029] Weigh 0.02g chitosan and dissolve in 20.0mL, 1mol / L glacial acetic acid aqueous solution to prepare 0.001g / mL chitosan solution; then add 17.0g acrylamide, 0.04g cross-linking agent N,N- Methylbisacrylamide, 0.2g zinc chloride, stirred and dissolved at room temperature to obtain chitosan-acrylamide-zinc chloride so...

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Abstract

The invention relates to a preparation method of high-strength ion-responsive lubricating hydrogel, belonging to the technical field of ion response. The preparation method combines a high-strength hydrogel material with a synergistic design system of ion-responsive supramolecular hydrogel, and realizes the regulation and control of the surface lubrication of the hydrogel material by regulating the bulk phase of the hydrogel material as well as surface ion species and charged state. On the one hand, the high-strength hydrogel can give good mechanical support to cartilage; on the other hand, the ion-responsive supramolecular hydrogel can undergo gel-sol conversion under the action of external ions, and the factors such as ion species and concentration of the environment in which the hydrogel is located can be further controlled according to complexion situations of different ions by an ion-responsive polymer, so that the purpose of reversible regulation of hydrogel surface lubrication is achieved, and the hydrogel is enabled to automatically adjust the strength and the surface lubrication performance. The high-strength ion-responsive lubricating hydrogel greatly enhances the stability and environmental adaptability of bionic cartilage, thus having a very good medical prospect.

Description

technical field [0001] The invention belongs to the technical field of ion response, and specifically relates to a method for preparing a high-strength ion-responsive lubricating hydrogel capable of reversibly regulating the surface lubrication of the hydrogel by regulating the bulk phase, surface ion species and charged state of the hydrogel material. Background technique [0002] Healthy cartilaginous joints are capable of ultra-low surface friction properties under conditions of high contact pressure. However, with the increase of age or the occurrence of lesions, the fluid environment in the joint will change accordingly, especially the ionic strength or pH of the synovial fluid will change, so that the physicochemical properties of cartilage tissue (such as lubricating ability and wear resistance) may suffer more damage. Therefore, how to design and realize the material to maintain the lubricating properties under the condition of changing ionic strength or species is ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L51/02C08L33/24C08L5/08C08L5/04C08L33/26C08K5/07C08K3/16C08K3/04C08F251/00C08F220/56C08F220/58C08F222/38
CPCC08F220/56C08F220/58C08F220/585C08F251/00C08J3/075C08J2305/04C08J2305/08C08J2329/04C08J2333/24C08J2351/02C08J2433/26C08J2451/02C08K3/042C08K5/07C08K2003/168C08F222/385
Inventor 宋文龙姜钧天
Owner JILIN UNIV
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