42 results about "Dendritic Polymers" patented technology

The invention relates to a CO2 absorbent with high cycle capacity and high cycle stability and application of the CO2 absorbent, and belongs to the technical field of atmospheric CO2 pollution treatment in the environmental protection industry. The CO2 absorbent is a polyamide-amine dendritic polymer (represented by PAMAM-2 (2 + G) NH2, G is the algebra, and 2 (2 + G) is the number of terminal amino groups), wherein primary amino is used as a terminal group, alkylene diamine is used as a core, and the algebra G is 1-5. The polyamidoamine dendritic polymer provided by the invention has the advantages of high-density terminal amino groups, high CO2 absorption capacity, large circulation capacity and high circulation absorption stability.

The invention discloses a liquid cell product, a preparation method thereof and a preserving fluid for preparing the liquid cell product, and belongs to the technical field of immunodetection. The dendritic polymer is creatively added into the preserving fluid for preparing the liquid cell product, the cell morphology in the liquid cell product can be improved, and a thermal acceleration test proves that the preserving fluid can maintain the cell morphology in the liquid cell product for a long time. When the preservation solution is used for preparing the liquid cell quality control product for immunodetection, quality control spots with complete circles can be formed after sample application on slides made of different materials, it can be obviously judged that cells in the liquid cell quality control product are dispersed very uniformly after immunohistochemical staining, and the preservation solution has very high application value.

The invention discloses a drug delivery system containing loaded adriamycin as well as a preparation method and application of the drug delivery system. The drug delivery system comprises poly (beta-amino ester) coupled with adriamycin, wherein the surface of the poly (beta-amino ester) is coated with dextran sulfate, and the poly (beta-amino ester) takes a fourth-generation lysine dendritic molecule Lys-G4 as a core. The drug delivery system has a pH-dependent drug release characteristic, has remarkable toxicity to C6 and U87MG glioma cells, has the capabilities of inducing apoptosis, inhibiting migration and targeting subcellular localization, and can effectively penetrate through a blood-brain barrier model and 3D tumor spheres. The delivery system is compounded with PLA-PEG-PLA thermosensitive hydrogel, and the thermosensitive hydrogel with a drug storage function is successfully constructed. Good tumor inhibition effect and biocompatibility are shown in nude mouse subcutaneous and in-situ glioma models. The invention not only provides a new strategy for overcoming the blood brain barrier, but also can effectively reduce the systemic toxicity, and opens up a new research thought and method for glioma treatment.

The invention relates to a demulsification composite preparation for oil-water separation in cooperation with nitrogen injection and a preparation method and application thereof, and belongs to the technical field of nitrogen injection oil extraction. The demulsifying agent provided by the invention is prepared from the following components in parts by weight: 100 to 200 parts of PAMAM (Polyamidoamine) dendritic polymer, 100 to 150 parts of polyoxyethylene polyoxypropylene ether, 90 to 120 parts of maleic anhydride, 50 to 100 parts of biological agent, 50 to 100 parts of low-temperature-resistant demulsifying agent, 40 to 100 parts of oleic acid and 5 to 15 parts of inositol hexaphosphate. The demulsifier provided by the invention can quickly and efficiently realize thorough oil-water separation in a low-temperature environment, and is suitable for an oil displacement production process for oil-water separation in cooperation with nitrogen injection.

This invention discloses a dendritic hybrid branched polymer copper bonding agent and its preparation method, belonging to the field of printed circuit board surface treatment technology. The active ingredient of this bonding agent is a three-dimensional dendritic polymer formed by grafting hybrid branches containing benzimidazole, triazole, and thiol groups onto a branched polyethyleneimine backbone through molecular design. Its aqueous solution contains 0.1%–5.0% of the polymer, 0.5%–10.0% of carboxylic acid, 0.01%–1.0% of surfactant, and the balance water. The preparation method includes polymer synthesis and the preparation of its aqueous solution. The synthesis process involves steps such as amine activation, functional group grafting, and thiol deprotection. This invention achieves ultra-high adhesion between the copper surface and dry film, wet film, or solder resist ink without completely corroding the copper surface, through the synergistic effect of multiple functional groups and the high-density bonding sites of the dendritic structure. Simultaneously, it perfectly maintains the smoothness of the copper surface, significantly reduces high-frequency signal transmission loss, and has the advantages of being environmentally friendly and having good process compatibility, making it particularly suitable for the manufacture of high-frequency, high-speed PCBs.

Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

The invention relates to a polymer composition for electrostatic spinning and a degradable electrostatic spinning microfiber filtering material. The polymer composition comprises a polymer and a plasticizer, the polymer is a degradable high polymer material, and the plasticizer is a dendritic polymer and polyphenolic acid. In the electrostatic spinning process, by adding the plasticizer and controlling the spinning process, the high-efficiency and low-resistance microfiber filtering material which is free of thermal bonding among fibers, has a fluffy three-dimensional network structure and has certain mechanical properties is prepared, the gram weight of microfibers is 0.01-200g / m < 2 >, the filtering efficiency is greater than 99.850%, and the resistance is less than 238Pa. The preparation process is simple, and the filtering material has a wide application prospect in the fields of masks, protective clothing, operating gowns, air purification, especially high-efficiency air filtration under the action of a certain external field force.

Processes for preparing an alkylated phenolic ester and provided and comprise reacting an alkylating agent with a phenolic ester at an elevated temperature in the presence of a polar solvent and at least about 5 equivalents of a base. Compositions comprising the compounds described herein and a ribonucleic acid are also described, as are methods of delivering ribonucleic acids to cells in a patient using the compositions described herein.

A class of drug-loaded macromolecules and their preparation methods are disclosed. Specifically, the macromolecules are dendritic polymers loaded with drugs and pharmacokinetic modifiers, particularly involving the linking of drugs to dendritic polymers via specific linkers. These macromolecules can be used to regulate drug release rates, specifically through the selection of linkers.

The application relates to a method for constructing a quantitative structure-activity relationship of a dendrimer molecular structure and salt tolerance and application. According to the quantitative structure-activity relationship, the salt tolerance of an oil field chemical polymer can be obtained according to the molecular structure of the dendrimer, without needing to pass through traditional experiments or complicated molecular simulation dynamics calculation. Meanwhile, the quantitative structure-activity relationship can be used to quickly screen the dendrimer with good salt tolerance, and has a good reference significance for the rapid design and research and development of the salt-resistant polymer for drilling fluid and even oil field chemicals.

The application discloses a kind of fluorine-free oil-proof agent of dendritic crosslinking structure and preparation method thereof, comprising the following steps: vinyl siloxane monomer, hydrogen-containing siloxane monomer, unsaturated double bond organic monomer copolymerization obtains dendritic structure silicon resin, dendritic structure silicon resin and solvent are mixed to obtain fluorine-free oil-proof agent of dendritic crosslinking structure;The molecular weight of vinyl siloxane monomer is 1000-3000;The molecular weight of hydrogen-containing siloxane monomer is 1000-3000;Unsaturated double bond organic monomer is any one or combination in vinyl aromatic monomer or olefin monomer.The dendritic structure silicon resin of the application has excellent comprehensive performance by unique molecular structure design, combines the advantages of dendritic polymer and silicon resin, has excellent comprehensive performance.High heat resistance enables it to be used stably in high temperature environment.

The present application relates to solid waste treatment technical field, and disclose the application method of early strength solid waste base cementing material suitable for high flow filling in mine filling, raw material composition includes: yellow phosphorus slag, slag, stainless steel slag, fly ash, phosphogypsum, coal gangue, blast furnace water slag, composite early strength activator, polycarboxylate superplasticizer and polyamide-amine dendritic polymer, the present application technical scheme adopts mechanical activation, plasma etching, sodium silicate synergistic excitation composite modification process to treat yellow phosphorus slag, mechanical activation breaks the glass body structure of yellow phosphorus slag through ultrafine grinding, increases specific surface area and active site, plasma etching forms rough etching appearance on the surface of yellow phosphorus slag, further improves surface reactivity, sodium silicate synergistic excitation promotes the generation of hydration product through chemical action, the three together makes the activity of yellow phosphorus slag significantly improve, thereby speeds up the hydration reaction process.

The invention discloses a cotton-polyester blended fabric one-bath dyeing auxiliary agent and a preparation method thereof. The auxiliary agent is prepared by carrying out partial hydrophobization and quaternization on the tail end primary amine group of 2.0-generation polyamide-amine dendrimer and hyperbranched polyethyleneimine with specific molecular weight and branching degree, wherein the molar ratio of the hydrophobization tail end to the quaternary ammonium salt tail end is 1: 9 to 1: 1. The preparation method comprises the following steps: carrying out a controllable amidation reaction under the protection of an inert gas to introduce a C12-C18 alkyl hydrophobic chain, then carrying out a complete quaternization reaction to introduce a trimethyl quaternary ammonium iodate group, and finally carrying out dialysis purification and impurity residue detection to obtain the product. A hydrophobic terminal and a quaternary ammonium salt terminal are simultaneously constructed on a multi-branched polymer skeleton, and the auxiliary agent realizes the synergistic effect of dispersion isolation of a disperse dye and efficient dyeing acceleration and hydrolysis inhibition of a reactive dye, so that the dye uptake and the color fastness are improved in polyester cotton bath dyeing, and the dosage of inorganic salt is reduced.

Compositions are provided that can be used to deliver a tRNA or tRNA derivative to a cell.SOLUTION: The disclosure provides nanoparticle compositions comprising a tRNA and an amino lipid delivery compound. The amino lipid delivery compound can be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid having one or more hydrophobic moieties. In some embodiments, these compositions can be administered to a patient to treat a genetic disease or disorder, such as cystic fibrosis, Duchenne muscular dystrophy, or cancer.SELECTED DRAWING: None

Compositions for delivery of tRNA as nanoparticles and methods of use thereof. The present disclosure relates generally to the fields of genetic diseases and disorders and pharmaceutical formulations. In some aspects, the present disclosure provides nanoparticle compositions comprising a tRNA and an aminolipid delivery compound. The aminolipid delivery compound can be a dendrimer, a dendron or dendritic lipid, a polymer (e.g., a polyamide or polyester), or a lipid having one or more hydrophobic components. In some embodiments, these compositions can be administered to a patient to treat a genetic disease or disorder, such as cystic fibrosis, Duchenne muscular dystrophy, or cancer.

The application relates to the technical field of lithium ion batteries, in particular to a binder for a negative electrode, a preparation method of the binder and a negative electrode sheet, and the preparation method comprises the following steps: using a dendritic polymer polyamide amine, butadiene, styrene and methacrylic acid as raw materials to prepare a seed emulsion; adding grafting monomers to the seed emulsion to carry out emulsion polymerization, obtaining a reaction emulsion; adding alkali liquor to the reaction emulsion to carry out demulsification, obtaining the binder for the negative electrode. The binder with a dendritic three-dimensional structure is prepared by using the dendritic molecule polyamide amine-poly (butadiene-styrene-methacrylic acid) as the seed emulsion, the binder combines the introduced elastic segments and rigid segments, the binder has excellent mechanical properties and flexibility when being used for a silicon-carbon negative electrode material, a larger buffer space is provided in a silicon particle expansion process, stress can be effectively released, molecular chain breakage can be avoided, and silicon particle expansion can be effectively inhibited.

The invention is directed to a crosslinkable flame-retardant coating composition comprising the following components:a) a dendritic polymer having hydroxyl groups, wherein the dendritic polymer has a hydroxyl number in the range of 80 to 800,b) a polyol having at least 3 hydroxyl groups,c) an ammonium polyphosphate compound,d) a base coat polymer selected from a polycarbamate resin or a polymer bearing carboxyl groups, ande) a crosslinker for crosslinking the base coat polymer selected from a compound having two or more aldehyde groups, acetals or hemiacetals of the aldehydes, or a polycarbodiimide.Such a cross-linkable flame-retardant coating composition improves the overall appearance of the cross-linked base coating on a substrate and also imparts improved flame-retardancy.

The invention relates to the technical field of feed additives, and discloses a plant small peptide chelate for an animal feed additive and a preparation method, the chelate is a microcapsule with a multi-layer core-shell structure, the particle size range of the microcapsule is 50-200 [mu] m, and the microcapsule sequentially comprises an active inner core, an active outer core and a plant small peptide chelate from inside to outside, the plant-derived small peptide-microelement chelate composition comprises a plant-derived small peptide-microelement chelate loaded on a dendritic polymer carrier, the intestinal tract positioning release layer wraps the active core and is composed of cross-linked polysaccharide hydrogel, and the cross-linked polysaccharide hydrogel is formed by cross-linking of a cleavable substrate peptide; the anti-oxidation protection layer wraps the intestinal tract positioning release layer; the coat wraps the anti-oxidation protection layer; according to the invention, high temperature and oxidative stress in feed processing and storage are effectively resisted, programmed delivery of stomach protection, precise enzyme trigger release in small intestines and microbe response in large intestines is realized, and the availability of active ingredients is improved.

The disclosure relates to the design and synthesis of selected ligands, dendrimers, polymers and other solid phase substrates for selective chelation of rare earth elements (i.e. lanthanides), and use of those selective ligands for synthesis of resins, polymers and other types of solid supports for separation and recovery of lanthanides from aqueous media. Recovery of critical elements from aqueous media occurs in a simple two-step process: pre-concentration of REE on the adsorbent and recovery by acid elution. The present invention can be used for design of selective ligands immobilized on solid substrates for extraction of various constituents, such as lanthanides, actinides, radionuclides, trace metals, etc., from aqueous media.

The invention discloses a high-strength light glass fiber plate and a preparation method thereof. The glass fiber plate takes glass fiber as a reinforcing body and resin as a matrix, and is characterized in that the surface of the fiber is coated with a composite impregnating compound consisting of a hybrid reinforcing interface agent containing an amino silane coupling agent, a PAMAM-G3 dendritic polymer and nano silicon carbide, a film-forming agent and the like. The preparation method comprises the following steps: preparing a hybrid reinforcing interface agent, preparing a composite impregnating compound, coating in a glass fiber drawing process, drying, laying, carrying out vacuum infiltration on resin, and carrying out segmented curing molding. According to the invention, a high-toughness transition layer is constructed between the fiber and the resin through a synergistic interface enhancement technology, and the interface bonding strength and the stress transfer efficiency are remarkably improved, so that the board is endowed with excellent mechanical properties and thermal aging stability while the density of the board is reduced. The obtained glass fiber plate has high strength, light weight and durability, and is suitable for the fields of light weight structures such as buildings and traffic.

A filler implant includes a support of hybrid heterogeneous hydrogel which is formed by a copolymer including: a dendrimer monomer which is functionalised by an ethylene radical, an acryl amide compound which is selected from an N-substituted methacrylamide and N-substituted acrylamide, a cross-linking agent and a bioactive copolymerisable material. The support is formed by microbeads which have a diameter between 1.5 micrometres and 10 micrometres and it predominantly contains by weight the acrylamide compound. The microbeads are assembled to form aggregates which contain between 5 and 50 microbeads. The aggregates are connected by cross-linking points in order to define a penetrating porous network which defines three-dimensional percolating paths. The penetrating porous network is formed by pores, the majority of the volume of which has a diameter between 10 and 30 micrometres. The support has a viscoelastic nature with a modulus of elasticity between 1 and 200 kPa.

This invention relates to a polymeric probe for assessing sialylation levels in vivo. It uses a dendritic polymer with alkyne-terminated branches as a carrier, and its surface is simultaneously modified with galactose, cyanidin 5 fluorescent dye, and folic acid. The detection protocol involves subcutaneously injecting the prepared polymeric probe into the tumor region of tumor-bearing mice. Folic acid-mediated targeted endocytosis allows the polymeric probe to enter the tumor cells. In vivo sialylates bind sialic acid to the galactose terminal of the polymeric probe. Sodium periodate is used to oxidize the sialic acid terminal in mouse tumor tissue sections to form an aldehyde group, which is then further coupled with an acylhydrazide fluorescein molecule. Fluorescence signals from cyanidin 5 and fluorescein are simultaneously collected using fluorescence microscopy, and the fluorescence intensity of fluorescein in the superimposed region of the two fluorescence signals is obtained using software, which can then be used to assess the sialylation level of the tumor tissue.

The application relates to a bone cement material and a preparation method and application thereof, and belongs to the technical field of bone tumor treatment medical devices. The preparation method comprises the following steps: 1) preparing a hydroxyapatite suspension liquid and mixing with an adriamycin diluent, adding ammonia water to adjust the pH value to be not less than 8.5, stirring uniformly after adding an adhesive to obtain component A; 2) preparing a coupling reaction of 4-bromomethyl phenyl boronic acid and a third-generation polyamidoamine dendritic polymer to obtain G3-PBA, adding quercetin into the G3-PBA solution, and obtaining component B after ultrasonic dissolution; and 3) preparing calcium phosphate powder, mixing with component B, stirring uniformly, and then manually stirring uniformly after adding component A to obtain the bone cement material. The quercetin in the bone cement material can be quickly released, effectively antibacterial, and conducive to early bone healing by regulating immunity, and the adriamycin can be long-acting released and has no long-term residue, so that the bone cement material also has a long-acting bone tumor treatment effect.

The invention provides a high-efficiency scale inhibitor for high-concentration iron-manganese-aluminum scale in the lithium iron phosphate industry. The high-efficiency scale inhibitor is prepared from the following components in percentage by weight: 5-15% of PAPEMP; 5 to 15 parts of a PASP derivative; 5 to 15 parts of PESA; 5-10 parts of a dendritic polymer; 1-5 parts of compound amino acid; and the balance water. Aiming at the characteristic that intermediate cooling water containing iron, manganese and aluminum ions is easy to generate indissolvable compounds, the product has the best chelating performance on the iron, manganese and aluminum ions by utilizing the synergistic interaction effect of the organic polyhydric alcohols and the inorganic ligands; the added dispersing agent can increase the surface tension of the scale inhibition main body and reduce the surface activity, and the solubility of the scale inhibition main body is hardly influenced, so that the capture rate of ions such as iron, manganese and aluminum is improved; the special dendritic polymer has a strong steric hindrance effect, effectively prevents mutual collision and aggregation of scaling particles, can passivate microorganisms in water, and prevents the microorganisms from agglomerating and adhering to the surface of an instrument to form a microbial film.

This invention discloses an Angiopep-2 modified fluorescent polyamide-amine dendritic polymer and its preparation method, as well as a method for preparing nanoparticles based thereon, belonging to the field of nanomaterials technology. The preparation method includes the following steps: mixing the polyamide-amine dendritic polymer with a first phosphate buffer to obtain solution I; mixing maleimide-polyethylene glycol-N-hydroxysuccinimide with the first phosphate buffer to obtain solution II; mixing solution I and solution II and reacting them, followed by ultrafiltration purification to obtain intermediate A; dissolving Angiopep-2 in a second phosphate buffer and reacting it with intermediate A, followed by freeze-drying to obtain intermediate B; dissolving intermediate B in a dimethyl sulfoxide solution to obtain solution III; dissolving fluorescein isothiocyanate in a dimethyl sulfoxide solution to obtain solution IV; mixing solutions III and IV and reacting them under a protective gas atmosphere in the dark; freeze-drying to obtain the Angiopep-2 modified fluorescent polyamide-amine dendritic polymer.

A biobased water repellent auxiliary agent and a method of manufacturing the same are provided. The biobased water repellent auxiliary agent includes a molecular complex composed of a polyurethane (PU) dendrimer and a water-based polyurethane dispersion (PUD). The PU dendrimer is formed by polymerizing a trifunctional-group-containing biobased material and an aliphatic linear isocyanate. The water-based PUD includes a monomer derived from the trifunctional-group-containing biobased material, a monomer derived from a cyclic isocyanate, and a monomer derived from a hydrophilic compound. The molecular complex is formed by copolymerizing the PU dendrimer, the trifunctional-group-containing biobased material, the cyclic isocyanate, and the hydrophilic compound.

The embodiment of the invention provides a composite leather material and a preparation method thereof, the material is composed of an aluminum foil layer, a carbon fiber reinforced PVC layer, and a silicon-dendritic polymer-silver nanoparticle xerogel antibacterial and antiviral coating, and can be coated with a BAC layer. 75HV type PVC is used as a base material of the PVC layer, 4mm and 10phr short carbon fibers are added, the PVC layer is subjected to hot-pressing compounding with aluminum foil after banburying and film casting, the antibacterial coating is prepared from orthosilicic acid and silver nanoparticle / PEI composite solution and is coated twice, and the process and performance rationality are proved by attached drawings. The tensile strength of the material is 48.9 MPa, the tear strength is 14.7 kN / m, the VOC emission is 3.975 mg / m, the antibacterial and antiviral performance is excellent, compared with a common PVC foil, the mechanical and test accuracy and the environmental protection property are remarkably improved, migration test traces are clear, and the material is suitable for color migration test scenes of leather quality detection.

A dendritic polymer comprising: (a) a central core; and (b)(i) at least one 2-deoxyglucose surface branching unit conjugated to the central core; or (b)(ii) at least one trehalose surface branching unit conjugated to the central core; or (b)(iii) at least one 2-deoxyglucose surface branching unit conjugated to the central core and at least one trehalose surface branching unit conjugated to the central core.

The invention discloses a medium-erosion-resistant high-performance polyurethane elastomer composite material and a preparation method thereof, and belongs to the technical field of high polymer materials. The composite material is prepared from composite silicon dioxide A, composite silicon dioxide B, diphenylmethane diisocyanate, polycarbonate diol, polytetrahydrofuran glycol, a polyamide-amine dendritic polymer, 1, 4-butanediol, an organic bismuth catalyst and an auxiliary agent. The composite silicon dioxide A is nano silicon dioxide grafted and modified by PEG2000, and the composite silicon dioxide B is nano silicon dioxide grafted and modified by PCL800-OH. A'hard segment-stable region-soft segment 'three-phase structure is constructed, and a guiding mechanism is formed by utilizing polarity difference of composite silicon dioxide A and B, so that the polyamide-amine dendritic polymer is accurately positioned in an interface region, and the technical problems that the mechanical property of traditional polyurethane is quickly attenuated in a harsh medium environment, auxiliaries are easy to separate out and the like are effectively solved; and synergistic improvement of high strength and high medium resistance is realized.

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.