86 results about "Dendritic Polymers" patented technology

The invention relates to a CO2 absorbent with high cycle capacity and high cycle stability and application of the CO2 absorbent, and belongs to the technical field of atmospheric CO2 pollution treatment in the environmental protection industry. The CO2 absorbent is a polyamide-amine dendritic polymer (represented by PAMAM-2 (2 + G) NH2, G is the algebra, and 2 (2 + G) is the number of terminal amino groups), wherein primary amino is used as a terminal group, alkylene diamine is used as a core, and the algebra G is 1-5. The polyamidoamine dendritic polymer provided by the invention has the advantages of high-density terminal amino groups, high CO2 absorption capacity, large circulation capacity and high circulation absorption stability.

The invention discloses a liquid cell product, a preparation method thereof and a preserving fluid for preparing the liquid cell product, and belongs to the technical field of immunodetection. The dendritic polymer is creatively added into the preserving fluid for preparing the liquid cell product, the cell morphology in the liquid cell product can be improved, and a thermal acceleration test proves that the preserving fluid can maintain the cell morphology in the liquid cell product for a long time. When the preservation solution is used for preparing the liquid cell quality control product for immunodetection, quality control spots with complete circles can be formed after sample application on slides made of different materials, it can be obviously judged that cells in the liquid cell quality control product are dispersed very uniformly after immunohistochemical staining, and the preservation solution has very high application value.

In certain embodiments, the present invention relates to dendrimer-like hyperbranched macromolecules for use in several uses, such as medical or biopharmaceutical applications, or non-medical or industrial applications, such as antibody purification, cosmetic applications, catalytic applications, applications in electronics, agriculture, food, filtration, and other applications. In an embodiment, the present invention relates to a hyperbranched macromolecule for drug delivery comprising a polyethylene glycol (PEG) unit and at least one active agent conjugated to the hyperbranched macromolecule. In addition, methods for synthesizing, purifying and characterizing such hyperbranched macromolecules and methods of treating medical conditions, such as treating ocular diseases, are provided.

The invention belongs to the technical field of polylactic acid filter materials, and discloses an antibacterial electret polylactic acid composition for melt-blowing, a preparation method of the antibacterial electret polylactic acid composition, polylactic acid granules, application of the polylactic acid granules and polylactic acid melt-blown cloth, the antibacterial electret polylactic acid composition for melt-blowing comprises polylactic acid, a plasticizer, a composite electret and a guanidine salt polymer, optionally a dispersant and optionally an antioxidant; relative to 100 parts by weight of polylactic acid, the content of the plasticizer is 0.5-2 parts by weight, the content of the composite electret is 0.5-3 parts by weight, the content of the guanidine salt polymer is 0.3-3 parts by weight, the content of the dispersing agent is 0-0.3 part by weight, and the content of the antioxidant is 0-0.2 part by weight; the composite electret comprises tourmaline powder, a hindered amine light stabilizer, hydroxy stearate and a dendritic polymer. The composite electret and the guanidine salt polymer are added into the polylactic acid composition, so that the antibacterial polylactic acid melt-blown cloth with excellent antibacterial effect and efficient filtering efficiency is prepared.

The present invention deals with the development of novel nanocomposite paints for biofouling removal coatings, which result from the mixing of two components, where the first component is an epoxy resin (component A) and the second component is a suitably modified polymerization agent (hardener). These hardeners are modified with hydrophobic nanoparticles based on functional dendritic polymers with symmetric or asymmetric architecture or based on functional inorganic nanoparticles (metal or metalloid nanoparticles or a mixture thereof). Both the polymeric nanoparticles and the inorganic nanoparticles were modified with suitable lipophilic groups. These nanocomposite paints addressed by the present invention exhibit organic microfilm control properties and can be effectively applied to objects immersed in seawater as biofouling removal coatings.

The application discloses a kind of polypeptide modified long afterglow nano-complex and its preparation method and application, nano-complex, for core-shell structure, core-shell structure is composed of the core body in inside and the shell that surrounds core body, core body is long afterglow nanomaterial, shell is by polypeptide modification and modified molecule modification, and drug loaded dendritic polymer;The nano-complex of the application can realize multiscale imaging to osteoclast, through in vivo afterglow imaging and in vivo two-photon microscopic imaging, the morphology, migration and distribution of osteoclast can be more accurately analyzed, avoid photo toxicity and background interference, improve imaging sensitivity;The nano-complex of the application is loaded with osteoporosis treatment drug alendronate ALN, and treatment drug can be replaced according to actual demand, and treatment scheme is adjusted, so that the drug loading system has universality.

The invention discloses a fire coal dispersing agent and application thereof in preparation of an efficient coal-saving liquid additive, a preparation method of the fire coal dispersing agent comprises the following steps: S1, mixing dipentaerythritol, ethylene oxide, a strong alkali catalyst and a first solvent, and heating for reaction to obtain a dendritic polymer; s2, mixing the dendritic polymer, 1, 2-distearoyl phosphatidyl glycerol (sodium salt), a strong acid catalyst, a polymerization inhibitor and a second solvent, and heating for reaction to obtain a fire coal dispersing agent; the molecular structure of the fire coal dispersant contains anionic groups, the anionic groups and metal cations in a catalyst, a sulfur-fixing agent, a rare earth compound and other substances of the efficient coal-saving liquid additive have electrostatic interaction, and hydrogen-bond interaction exists between the dispersants and between the dispersants and other substances. The dispersing effect of the fire coal dispersing agent is remarkably improved, so that the content of combustible components in the efficient coal-saving liquid additive is remarkably reduced, and the combustion efficiency of coal is improved.

The present invention provides delivery-enhancing polymers capable of being encapsulated in nanoparticles to enhance release of payload from the nanoparticle wherein the delivery-enhancing polymer comprises a polyamine comprising tertiary amine. The delivery-enhancing polymer may comprise methylated polyethylenimine (mPEI), branched PEI (bPEI), PAMAM dendrimer and / or histidine polymer.

The invention belongs to the technical field of polylactic acid filter materials, and discloses a composite electret, a polylactic acid composition, a preparation method of the composite electret, polylactic acid granules, application of the polylactic acid granules and polylactic acid melt-blown cloth, and the composite electret comprises tourmaline powder, a hindered amine light stabilizer, hydroxy stearate and a dendritic polymer. The composite electret provided by the invention is a novel organic-inorganic composite electret, and can solve the problems that the addition amount of common inorganic electrets is large, so that polylactic acid melt-blown fibers are too thick, the yarn breaking rate is high, and the filtering efficiency is low.

The invention discloses a drug delivery system containing loaded adriamycin as well as a preparation method and application of the drug delivery system. The drug delivery system comprises poly (beta-amino ester) coupled with adriamycin, wherein the surface of the poly (beta-amino ester) is coated with dextran sulfate, and the poly (beta-amino ester) takes a fourth-generation lysine dendritic molecule Lys-G4 as a core. The drug delivery system has a pH-dependent drug release characteristic, has remarkable toxicity to C6 and U87MG glioma cells, has the capabilities of inducing apoptosis, inhibiting migration and targeting subcellular localization, and can effectively penetrate through a blood-brain barrier model and 3D tumor spheres. The delivery system is compounded with PLA-PEG-PLA thermosensitive hydrogel, and the thermosensitive hydrogel with a drug storage function is successfully constructed. Good tumor inhibition effect and biocompatibility are shown in nude mouse subcutaneous and in-situ glioma models. The invention not only provides a new strategy for overcoming the blood brain barrier, but also can effectively reduce the systemic toxicity, and opens up a new research thought and method for glioma treatment.

The invention relates to a demulsification composite preparation for oil-water separation in cooperation with nitrogen injection and a preparation method and application thereof, and belongs to the technical field of nitrogen injection oil extraction. The demulsifying agent provided by the invention is prepared from the following components in parts by weight: 100 to 200 parts of PAMAM (Polyamidoamine) dendritic polymer, 100 to 150 parts of polyoxyethylene polyoxypropylene ether, 90 to 120 parts of maleic anhydride, 50 to 100 parts of biological agent, 50 to 100 parts of low-temperature-resistant demulsifying agent, 40 to 100 parts of oleic acid and 5 to 15 parts of inositol hexaphosphate. The demulsifier provided by the invention can quickly and efficiently realize thorough oil-water separation in a low-temperature environment, and is suitable for an oil displacement production process for oil-water separation in cooperation with nitrogen injection.

The present invention provides polyethylene glycol-modified polylysine, its preparation method, a nanovaccine, and its application. The polyethylene glycol-modified polylysine comprises a dendritic polymer initiator and chiral polylysine linked by amide bonds. By grafting polyethylene glycol onto the side chains of polylysine, the present invention modulates charge density and enhances nanoparticle migration to lymph nodes. Finally, the nanovaccine is prepared by binding to antigens through electrostatic adsorption. Research has shown that the resulting antigen-complexed nanovaccine promotes endocytosis by antigen-presenting cells (APCs) and their migration to lymph nodes, activating immune cells there. It can stimulate dendritic cells (DCs) to mature and release inflammatory cytokines. It also promotes antigen cross-presentation by DCs in vivo, triggering a strong antigen-specific immune response.

The application discloses a coal combustion dispersant and application thereof in preparation of high-efficiency coal-saving liquid additives. The preparation method of the coal combustion dispersant comprises the following steps: S1. mixing dipentaerythritol, ethylene oxide, a strong base catalyst and a first solvent, and performing a warming reaction to obtain a dendritic polymer; and S2. mixing the dendritic polymer, 1,2-distearylphosphatidylglycerol (sodium salt), a strong acid catalyst, a polymerization inhibitor and a second solvent, and performing a warming reaction to obtain the coal combustion dispersant. The coal combustion dispersant contains an anion group in a molecular structure. The anion group has electrostatic action with metal cations in catalysts, sulfur-fixing agents and rare earth compounds of the high-efficiency coal-saving liquid additives. In addition, hydrogen bond action exists between the dispersants and between the dispersants and other substances. Therefore, the dispersion effect of the coal combustion dispersant is remarkably improved, and the content of combustible components of the high-efficiency coal-saving liquid additives is remarkably reduced, and the combustion efficiency of coal is improved.

The invention discloses a polymer nano-enzyme as well as a preparation method and application thereof. The nano-enzyme comprises a nano-enzyme core modified by a surface modifier and a dendritic polymer coupled with the surface modifier. The preparation method of the polymer nano-enzyme comprises the following steps: preparing a nano-enzyme precursor, and then washing the nano-enzyme precursor to obtain a first intermediate; the nano-enzyme precursor is a nano-enzyme core modified by a surface modifier; preparing a first intermediate dispersion liquid, and adding an activator dispersion liquid and a stabilizer dispersion liquid into the first intermediate dispersion liquid to obtain an activation system; the invention also discloses an application of the polymer nano-enzyme. The polymer nano-enzyme provided by the invention can be used as an enzyme label substitute to be widely applied to enzyme-linked immunosorbent assay, immunohistochemistry, immunochromatography, chemiluminescence and other biochemical detection methods, and signal amplification with high sensitivity, wide pH and high temperature tolerance is realized.

This invention discloses a dendritic hybrid branched polymer copper bonding agent and its preparation method, belonging to the field of printed circuit board surface treatment technology. The active ingredient of this bonding agent is a three-dimensional dendritic polymer formed by grafting hybrid branches containing benzimidazole, triazole, and thiol groups onto a branched polyethyleneimine backbone through molecular design. Its aqueous solution contains 0.1%–5.0% of the polymer, 0.5%–10.0% of carboxylic acid, 0.01%–1.0% of surfactant, and the balance water. The preparation method includes polymer synthesis and the preparation of its aqueous solution. The synthesis process involves steps such as amine activation, functional group grafting, and thiol deprotection. This invention achieves ultra-high adhesion between the copper surface and dry film, wet film, or solder resist ink without completely corroding the copper surface, through the synergistic effect of multiple functional groups and the high-density bonding sites of the dendritic structure. Simultaneously, it perfectly maintains the smoothness of the copper surface, significantly reduces high-frequency signal transmission loss, and has the advantages of being environmentally friendly and having good process compatibility, making it particularly suitable for the manufacture of high-frequency, high-speed PCBs.

Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

The invention belongs to the technical field of biological medicines, and particularly relates to a tumor microenvironment response type nano-drug based on linear-dendritic polymers. The preparation method comprises the following steps: connecting a dendritic fragment to a polymer skeleton through an enzyme-cleavable peptide chain, and coupling a chemotherapeutic drug to a dendritic periphery through a pH-unstable hydrazone bond to obtain an amphiphilic polymer prodrug; the stable nanoparticles are obtained by screening polymeric monomers, can be efficiently taken by tumor cells, and have advantages in tumor tissue penetration and tumor resistance; the polymer prodrug can also load an adenosine receptor antagonist drug to prepare a nano-drug, and the nano-drug reverses adenosine-mediated immunosuppression to realize a synergistic effect of the adenosine receptor antagonist drug and a chemotherapeutic drug; the nano-drug and the PD-1 antibody cooperate to further improve the immune response in vivo and the anti-TNBC effect. The polymer prodrug and nano-drug synthesized by the invention have good prospects in the aspect of treating TNBC.

The invention relates to a polymer composition for electrostatic spinning and a degradable electrostatic spinning microfiber filtering material. The polymer composition comprises a polymer and a plasticizer, the polymer is a degradable high polymer material, and the plasticizer is a dendritic polymer and polyphenolic acid. In the electrostatic spinning process, by adding the plasticizer and controlling the spinning process, the high-efficiency and low-resistance microfiber filtering material which is free of thermal bonding among fibers, has a fluffy three-dimensional network structure and has certain mechanical properties is prepared, the gram weight of microfibers is 0.01-200g / m < 2 >, the filtering efficiency is greater than 99.850%, and the resistance is less than 238Pa. The preparation process is simple, and the filtering material has a wide application prospect in the fields of masks, protective clothing, operating gowns, air purification, especially high-efficiency air filtration under the action of a certain external field force.

Processes for preparing an alkylated phenolic ester and provided and comprise reacting an alkylating agent with a phenolic ester at an elevated temperature in the presence of a polar solvent and at least about 5 equivalents of a base. Compositions comprising the compounds described herein and a ribonucleic acid are also described, as are methods of delivering ribonucleic acids to cells in a patient using the compositions described herein.

The application provides a preparation method of dopamine (DA) modified polyamide-amine dendrimer, which comprises amino terminal dopamine carboxylation, synthesis of carboxylated dopamine with a protective group, synthesis of carboxylated dopamine with a protective group modified polyamide-amine dendrimer, and synthesis and application of dopamine modified polyamide-amine dendrimer. The application utilizes the firm adhesion performance of DA in a marine humid environment, the antibacterial performance and the osteogenic induction performance of PAMAM-NH2 cationic polymer, introduces DA into the surface of PAMAM-NH2 to synthesize a new high polymer material DA-PAMAM-NH2, detects the long-acting antibacterial and osteogenic induction performance of the system as a bifunctional coating on the surface of an implant, and evaluates the role of the system in improving the clinical durability of the implant.

The application discloses a kind of block copolymer polypeptides, polymer fiber and its preparation method and purposes.The block copolymer polypeptide includes dendritic polymer and polypeptide chain connected with the dendritic polymer, the polypeptide chain is composed of structural unit shown in formula I and structural unit shown in formula II, the dendritic polymer is connected with the structural unit shown in formula I by amide bond, the structural unit shown in formula I is connected with the structural unit shown in formula II by amide bond;And.The block copolymer polypeptide of the application can make the functional unit that should form beta-fold conformation with metastable alpha-helix chain growth, later can be converted into beta-fold again metastable alpha-helix, and good stability;The polymer fiber formed has high mechanical property, can be widely used in high toughness composite, degradable biomedical materials and intelligent drug delivery system and other key fields.

A class of drug-loaded macromolecules and their preparation methods are disclosed. Specifically, the macromolecules are dendritic polymers loaded with drugs and pharmacokinetic modifiers, particularly involving the linking of drugs to dendritic polymers via specific linkers. These macromolecules can be used to regulate drug release rates, specifically through the selection of linkers.

The application relates to a method for constructing a quantitative structure-activity relationship of a dendrimer molecular structure and salt tolerance and application. According to the quantitative structure-activity relationship, the salt tolerance of an oil field chemical polymer can be obtained according to the molecular structure of the dendrimer, without needing to pass through traditional experiments or complicated molecular simulation dynamics calculation. Meanwhile, the quantitative structure-activity relationship can be used to quickly screen the dendrimer with good salt tolerance, and has a good reference significance for the rapid design and research and development of the salt-resistant polymer for drilling fluid and even oil field chemicals.

The application discloses a kind of fluorine-free oil-proof agent of dendritic crosslinking structure and preparation method thereof, comprising the following steps: vinyl siloxane monomer, hydrogen-containing siloxane monomer, unsaturated double bond organic monomer copolymerization obtains dendritic structure silicon resin, dendritic structure silicon resin and solvent are mixed to obtain fluorine-free oil-proof agent of dendritic crosslinking structure;The molecular weight of vinyl siloxane monomer is 1000-3000;The molecular weight of hydrogen-containing siloxane monomer is 1000-3000;Unsaturated double bond organic monomer is any one or combination in vinyl aromatic monomer or olefin monomer.The dendritic structure silicon resin of the application has excellent comprehensive performance by unique molecular structure design, combines the advantages of dendritic polymer and silicon resin, has excellent comprehensive performance.High heat resistance enables it to be used stably in high temperature environment.

The invention relates to a conductive hydrogel patch and a preparation method and application thereof, the conductive hydrogel patch comprises an inner layer and an outer layer, the outer layer comprises modified gellan gum, and the inner layer comprises a cross-linked network, nanoparticles and a polymer; the cross-linked network is mainly composed of acrylic acid, methacrylic acid N-succinimide ester, alpha-ketoglutaric acid and chitosan, the nanoparticles comprise polypyrrole nanoparticles coated with dopamine, and the polymer comprises a dendritic polymer which is loaded with a fat-soluble drug and is modified by lauryl sodium sulfate. The preparation method comprises the following steps: preparing modified gellan gum; preparing a dendritic polymer loaded with a fat-soluble drug and modified by lauryl sodium sulfate; preparing the polypyrrole nano particles coated with the dopamine; preparing a cross-linked network; and preparing the conductive hydrogel patch. The conductive hydrogel patch is clear in structural layering, synergistic and efficient in function and capable of achieving multi-dimensional accurate intervention and functional repair of a focus area after myocardial infarction.

The present invention relates to the technical field of sludge treatment, and discloses a sewage treatment method based on micro-flocculation filtration, comprising the following steps: (1) adding a polyamide-amine carboxyl-linked third-generation dendritic polymer to an aqueous solution containing polyacrylamide to obtain a mixed solution I; (2) adding a polyamide-amine fifth-generation dendritic polymer to water, and then adding a zeolite modified with an auxiliary agent for ultrasonic dispersion to obtain a mixed solution II; (3) adding the mixed solution I and concentrated sulfuric acid to the mixed solution II, heating the mixture for reaction, and then performing reduced pressure distillation and drying to obtain a flocculant; (4) adding the flocculant to the sewage to be treated, adjusting the pH value of the solution to 6.5-7.5, stirring, letting it stand, and then filtering. The present invention combines an organic flocculant with an inorganic flocculant to obtain a flocculant, and uses the flocculant for sewage treatment, thereby ensuring that the flocculant can quickly form stable flocs in complex water quality, accelerating the formation and sedimentation of the flocs, and improving the removal effect of pollutants.

The present application relates to solid waste treatment technical field, and disclose the application method of early strength solid waste base cementing material suitable for high flow filling in mine filling, raw material composition includes: yellow phosphorus slag, slag, stainless steel slag, fly ash, phosphogypsum, coal gangue, blast furnace water slag, composite early strength activator, polycarboxylate superplasticizer and polyamide-amine dendritic polymer, the present application technical scheme adopts mechanical activation, plasma etching, sodium silicate synergistic excitation composite modification process to treat yellow phosphorus slag, mechanical activation breaks the glass body structure of yellow phosphorus slag through ultrafine grinding, increases specific surface area and active site, plasma etching forms rough etching appearance on the surface of yellow phosphorus slag, further improves surface reactivity, sodium silicate synergistic excitation promotes the generation of hydration product through chemical action, the three together makes the activity of yellow phosphorus slag significantly improve, thereby speeds up the hydration reaction process.

The application provides a nano-polymerase-labeled antibody, a preparation method and application thereof, and relates to the technical field of antibodies.The nano-polymerase-labeled antibody comprises a dendritic polymer, an enzyme, a chain macromolecular polysaccharide and an antibody, the dendritic polymer carries multiple enzymes to form a grape cluster type nano-polymerase; the nano-polymerase is connected with the antibody through the chain macromolecular polysaccharide to form the nano-polymerase-labeled antibody, the enzyme content is increased, the grape cluster type nano-polymerase is formed, the nano-polymerase and the antibody are coupled with the chain macromolecular polysaccharide, the problem of a large steric hindrance caused by direct combination on the antibody is solved, meanwhile, the enzyme content is increased, the penetration capacity of the nano-polymerase-labeled antibody is improved, and the detection sensitivity is increased.The dendritic polymer and the chain macromolecular polysaccharide are activated by using reagents EDC / NHS and sodium periodate, the toxicity of the reagents is reduced, the pollution to the environment is reduced, self-crosslinking is avoided, the yield is increased, and the staining effect of the nano-polymerase-labeled antibody is extremely good.

The invention discloses a cotton-polyester blended fabric one-bath dyeing auxiliary agent and a preparation method thereof. The auxiliary agent is prepared by carrying out partial hydrophobization and quaternization on the tail end primary amine group of 2.0-generation polyamide-amine dendrimer and hyperbranched polyethyleneimine with specific molecular weight and branching degree, wherein the molar ratio of the hydrophobization tail end to the quaternary ammonium salt tail end is 1: 9 to 1: 1. The preparation method comprises the following steps: carrying out a controllable amidation reaction under the protection of an inert gas to introduce a C12-C18 alkyl hydrophobic chain, then carrying out a complete quaternization reaction to introduce a trimethyl quaternary ammonium iodate group, and finally carrying out dialysis purification and impurity residue detection to obtain the product. A hydrophobic terminal and a quaternary ammonium salt terminal are simultaneously constructed on a multi-branched polymer skeleton, and the auxiliary agent realizes the synergistic effect of dispersion isolation of a disperse dye and efficient dyeing acceleration and hydrolysis inhibition of a reactive dye, so that the dye uptake and the color fastness are improved in polyester cotton bath dyeing, and the dosage of inorganic salt is reduced.

Compositions are provided that can be used to deliver a tRNA or tRNA derivative to a cell.SOLUTION: The disclosure provides nanoparticle compositions comprising a tRNA and an amino lipid delivery compound. The amino lipid delivery compound can be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid having one or more hydrophobic moieties. In some embodiments, these compositions can be administered to a patient to treat a genetic disease or disorder, such as cystic fibrosis, Duchenne muscular dystrophy, or cancer.SELECTED DRAWING: None