104 results about "Dendritic Polymers" patented technology

The invention relates to a CO2 absorbent with high cycle capacity and high cycle stability and application of the CO2 absorbent, and belongs to the technical field of atmospheric CO2 pollution treatment in the environmental protection industry. The CO2 absorbent is a polyamide-amine dendritic polymer (represented by PAMAM-2 (2 + G) NH2, G is the algebra, and 2 (2 + G) is the number of terminal amino groups), wherein primary amino is used as a terminal group, alkylene diamine is used as a core, and the algebra G is 1-5. The polyamidoamine dendritic polymer provided by the invention has the advantages of high-density terminal amino groups, high CO2 absorption capacity, large circulation capacity and high circulation absorption stability.

The invention discloses a TREM-1 inhibitory peptide nano-particle which is prepared by the following steps: by taking a dendritic polymer PAMAM as a carrier, coupling a TREM-1 inhibitory peptide with amino groups on the carrier by utilizing the characteristic of polyamino groups on the surface of the PAMAM, and coupling a brain-targeted peptide with the other part of amino groups on the carrier through MAL-PEG2000-NHS, so as to obtain the TREM-1 inhibitory peptide nano-particle. And modifying the residual amino groups on the carrier with PEG (Polyethylene Glycol) to obtain the nano-particles. The nanoparticles can relieve encephaledema, neuroinflammation injury and blood brain barrier damage caused by traumatic craniocerebral injury, improve cognitive impairment and long-term prognosis after trauma, and have a very high curative effect on clinical treatment of craniocerebral injury.

The present invention provides a heparin affinity chromatography medium and a preparation method thereof. The heparin affinity chromatography medium comprises a porous polymer microsphere matrix modified with a polyamide-amine dendrimer to obtain a modified matrix; heparin is coupled to the modified matrix to obtain the heparin affinity chromatography medium. The heparin affinity chromatography medium of the present invention has a high adsorption capacity for target biomolecules, significantly improving separation efficiency; and also exhibits high mechanical strength.

The invention discloses a liquid cell product, a preparation method thereof and a preserving fluid for preparing the liquid cell product, and belongs to the technical field of immunodetection. The dendritic polymer is creatively added into the preserving fluid for preparing the liquid cell product, the cell morphology in the liquid cell product can be improved, and a thermal acceleration test proves that the preserving fluid can maintain the cell morphology in the liquid cell product for a long time. When the preservation solution is used for preparing the liquid cell quality control product for immunodetection, quality control spots with complete circles can be formed after sample application on slides made of different materials, it can be obviously judged that cells in the liquid cell quality control product are dispersed very uniformly after immunohistochemical staining, and the preservation solution has very high application value.

The invention relates to the technical field of reverse osmosis scale inhibitor preparation, and particularly discloses a concentrated water reverse osmosis scale inhibitor and a preparation method thereof.The scale inhibitor comprises 8-10 parts of pentaerythritol, 10-30 parts of acrylic acid, 10-30 parts of a triallyl borate monomer, 5-10 parts of a zinc acrylate monomer, 3-6 parts of a vinyl sulfonic acid monomer and 10-30 parts of a poly (butylene succinate) prepolymer. According to the reverse osmosis scale inhibitor, pentaerythritol serves as a central core, a good starting site is provided for construction of a dendritic structure, acrylic acid and pentaerythritol are subjected to an esterification reaction, each hydroxyl group reacts with acrylic acid to be connected with an acrylate branched chain, a first-generation dendritic structure is formed, and the first-generation dendritic structure is formed; the preparation method comprises the following steps: firstly preparing a dendritic polymer, then introducing a boron element, a zinc element and a sulfonic acid group through a copolymerization reaction to enhance the scale inhibition effect of the dendritic polymer, and finally performing condensation with a poly (butylene succinate) (PBS) chain segment to improve the biodegradability of the dendritic polymer.

In certain embodiments, the present invention relates to dendrimer-like hyperbranched macromolecules for use in several uses, such as medical or biopharmaceutical applications, or non-medical or industrial applications, such as antibody purification, cosmetic applications, catalytic applications, applications in electronics, agriculture, food, filtration, and other applications. In an embodiment, the present invention relates to a hyperbranched macromolecule for drug delivery comprising a polyethylene glycol (PEG) unit and at least one active agent conjugated to the hyperbranched macromolecule. In addition, methods for synthesizing, purifying and characterizing such hyperbranched macromolecules and methods of treating medical conditions, such as treating ocular diseases, are provided.

The invention belongs to the technical field of polylactic acid filter materials, and discloses an antibacterial electret polylactic acid composition for melt-blowing, a preparation method of the antibacterial electret polylactic acid composition, polylactic acid granules, application of the polylactic acid granules and polylactic acid melt-blown cloth, the antibacterial electret polylactic acid composition for melt-blowing comprises polylactic acid, a plasticizer, a composite electret and a guanidine salt polymer, optionally a dispersant and optionally an antioxidant; relative to 100 parts by weight of polylactic acid, the content of the plasticizer is 0.5-2 parts by weight, the content of the composite electret is 0.5-3 parts by weight, the content of the guanidine salt polymer is 0.3-3 parts by weight, the content of the dispersing agent is 0-0.3 part by weight, and the content of the antioxidant is 0-0.2 part by weight; the composite electret comprises tourmaline powder, a hindered amine light stabilizer, hydroxy stearate and a dendritic polymer. The composite electret and the guanidine salt polymer are added into the polylactic acid composition, so that the antibacterial polylactic acid melt-blown cloth with excellent antibacterial effect and efficient filtering efficiency is prepared.

The present invention deals with the development of novel nanocomposite paints for biofouling removal coatings, which result from the mixing of two components, where the first component is an epoxy resin (component A) and the second component is a suitably modified polymerization agent (hardener). These hardeners are modified with hydrophobic nanoparticles based on functional dendritic polymers with symmetric or asymmetric architecture or based on functional inorganic nanoparticles (metal or metalloid nanoparticles or a mixture thereof). Both the polymeric nanoparticles and the inorganic nanoparticles were modified with suitable lipophilic groups. These nanocomposite paints addressed by the present invention exhibit organic microfilm control properties and can be effectively applied to objects immersed in seawater as biofouling removal coatings.

The application discloses a kind of polypeptide modified long afterglow nano-complex and its preparation method and application, nano-complex, for core-shell structure, core-shell structure is composed of the core body in inside and the shell that surrounds core body, core body is long afterglow nanomaterial, shell is by polypeptide modification and modified molecule modification, and drug loaded dendritic polymer;The nano-complex of the application can realize multiscale imaging to osteoclast, through in vivo afterglow imaging and in vivo two-photon microscopic imaging, the morphology, migration and distribution of osteoclast can be more accurately analyzed, avoid photo toxicity and background interference, improve imaging sensitivity;The nano-complex of the application is loaded with osteoporosis treatment drug alendronate ALN, and treatment drug can be replaced according to actual demand, and treatment scheme is adjusted, so that the drug loading system has universality.

The invention relates to the technical field of biochemistry, and provides a pesticide nano-composite and a preparation method and application thereof, the pesticide nano-composite comprises a dendritic polymer (SSP) and a drug molecule connected with the dendritic polymer through a hydrogen bond and / or Van der Waals force; the drug molecules are selected from at least one of benomyl, carbendazim and thiophanate-methyl; according to the drug compound, aggregation of drug molecules can be avoided, the drug effect of the drug molecules can be improved, the lasting period of the drug molecules can be prolonged, and the usage amount of the drug molecules is reduced; a solution containing the medicine compound is sprayed in the plant growth process and used for inhibiting growth of the aureocystis aureocystis and / or verticillium dahliae; the method is simple and convenient in process and wide in applicability.

The invention discloses a fire coal dispersing agent and application thereof in preparation of an efficient coal-saving liquid additive, a preparation method of the fire coal dispersing agent comprises the following steps: S1, mixing dipentaerythritol, ethylene oxide, a strong alkali catalyst and a first solvent, and heating for reaction to obtain a dendritic polymer; s2, mixing the dendritic polymer, 1, 2-distearoyl phosphatidyl glycerol (sodium salt), a strong acid catalyst, a polymerization inhibitor and a second solvent, and heating for reaction to obtain a fire coal dispersing agent; the molecular structure of the fire coal dispersant contains anionic groups, the anionic groups and metal cations in a catalyst, a sulfur-fixing agent, a rare earth compound and other substances of the efficient coal-saving liquid additive have electrostatic interaction, and hydrogen-bond interaction exists between the dispersants and between the dispersants and other substances. The dispersing effect of the fire coal dispersing agent is remarkably improved, so that the content of combustible components in the efficient coal-saving liquid additive is remarkably reduced, and the combustion efficiency of coal is improved.

The present invention provides delivery-enhancing polymers capable of being encapsulated in nanoparticles to enhance release of payload from the nanoparticle wherein the delivery-enhancing polymer comprises a polyamine comprising tertiary amine. The delivery-enhancing polymer may comprise methylated polyethylenimine (mPEI), branched PEI (bPEI), PAMAM dendrimer and / or histidine polymer.

The invention belongs to the technical field of polylactic acid filter materials, and discloses a composite electret, a polylactic acid composition, a preparation method of the composite electret, polylactic acid granules, application of the polylactic acid granules and polylactic acid melt-blown cloth, and the composite electret comprises tourmaline powder, a hindered amine light stabilizer, hydroxy stearate and a dendritic polymer. The composite electret provided by the invention is a novel organic-inorganic composite electret, and can solve the problems that the addition amount of common inorganic electrets is large, so that polylactic acid melt-blown fibers are too thick, the yarn breaking rate is high, and the filtering efficiency is low.

The invention discloses a drug delivery system containing loaded adriamycin as well as a preparation method and application of the drug delivery system. The drug delivery system comprises poly (beta-amino ester) coupled with adriamycin, wherein the surface of the poly (beta-amino ester) is coated with dextran sulfate, and the poly (beta-amino ester) takes a fourth-generation lysine dendritic molecule Lys-G4 as a core. The drug delivery system has a pH-dependent drug release characteristic, has remarkable toxicity to C6 and U87MG glioma cells, has the capabilities of inducing apoptosis, inhibiting migration and targeting subcellular localization, and can effectively penetrate through a blood-brain barrier model and 3D tumor spheres. The delivery system is compounded with PLA-PEG-PLA thermosensitive hydrogel, and the thermosensitive hydrogel with a drug storage function is successfully constructed. Good tumor inhibition effect and biocompatibility are shown in nude mouse subcutaneous and in-situ glioma models. The invention not only provides a new strategy for overcoming the blood brain barrier, but also can effectively reduce the systemic toxicity, and opens up a new research thought and method for glioma treatment.

The invention belongs to the technical field of anti-tumor materials, and discloses a modified dendritic PAMAM polymer hydrogel as well as a preparation method and application thereof. The method comprises the following steps: reacting a modified dendritic PAMAM polymer with oxidized dextran in a water-containing system to obtain the modified dendritic PAMAM polymer hydrogel, the structural formula of the modified dendritic PAMAM polymer is as shown in formula I; the dendritic PAMAM is a fifth-generation polymer, and n is an integer from 1 to 128. The modified dendritic PAMAM polymer hydrogel provided by the invention is used for preparing antitumor drugs. The hydrogel disclosed by the invention has a relatively strong anti-tumor effect; small molecule drugs or antibody drugs are entrapped, so that the tumor immune microenvironment can be jointly regulated and controlled, and the anti-tumor effect is further enhanced. # imgabs0 #

The invention relates to a demulsification composite preparation for oil-water separation in cooperation with nitrogen injection and a preparation method and application thereof, and belongs to the technical field of nitrogen injection oil extraction. The demulsifying agent provided by the invention is prepared from the following components in parts by weight: 100 to 200 parts of PAMAM (Polyamidoamine) dendritic polymer, 100 to 150 parts of polyoxyethylene polyoxypropylene ether, 90 to 120 parts of maleic anhydride, 50 to 100 parts of biological agent, 50 to 100 parts of low-temperature-resistant demulsifying agent, 40 to 100 parts of oleic acid and 5 to 15 parts of inositol hexaphosphate. The demulsifier provided by the invention can quickly and efficiently realize thorough oil-water separation in a low-temperature environment, and is suitable for an oil displacement production process for oil-water separation in cooperation with nitrogen injection.

The present invention provides polyethylene glycol-modified polylysine, its preparation method, a nanovaccine, and its application. The polyethylene glycol-modified polylysine comprises a dendritic polymer initiator and chiral polylysine linked by amide bonds. By grafting polyethylene glycol onto the side chains of polylysine, the present invention modulates charge density and enhances nanoparticle migration to lymph nodes. Finally, the nanovaccine is prepared by binding to antigens through electrostatic adsorption. Research has shown that the resulting antigen-complexed nanovaccine promotes endocytosis by antigen-presenting cells (APCs) and their migration to lymph nodes, activating immune cells there. It can stimulate dendritic cells (DCs) to mature and release inflammatory cytokines. It also promotes antigen cross-presentation by DCs in vivo, triggering a strong antigen-specific immune response.

Zwitterionic dendrimers and zwitterionic polymers and methods of making the zwitterionic dendrimers / polymers are provided herein. Also provided are amphiphilic dendrimers and amphiphilic telodendrimers with one or more zwitterionic dendron / polymer / linear group(s) / moiety(s) covalently bonded thereto. The amphiphilic dendrimers and amphiphilic telodendrimers are useful in protein binding and drug delivery. The amphiphilic dendrimers and amphiphilic telodendrimers are used in methods of treatment and / or imaging.

The invention discloses a construction method of a sequencing library for detecting high-resolution chromatin interaction of plants. The method comprises the following steps: mixing a purified to-be-detected plant cell nucleus with a dendritic high-molecular compound, irradiating for 30 minutes under ultraviolet light, crosslinking to obtain a crosslinked compound, digesting the crosslinked compound by using protease K, digesting for 30-45 minutes by using DNaseI, and connecting an enzyme-digested product by using a bridge linker to obtain a connecting product containing a target DNA fragment, and finally, enriching and purifying the connected product to obtain the interacting chromatin DNA captured by the dendritic high-molecular compound. By using the method disclosed by the invention, experimental data of high-resolution chromatin interaction in the plant can be captured, and the method can be used for identifying the interaction between gene promoter regions in a whole genome range of the plant.

The application discloses a coal combustion dispersant and application thereof in preparation of high-efficiency coal-saving liquid additives. The preparation method of the coal combustion dispersant comprises the following steps: S1. mixing dipentaerythritol, ethylene oxide, a strong base catalyst and a first solvent, and performing a warming reaction to obtain a dendritic polymer; and S2. mixing the dendritic polymer, 1,2-distearylphosphatidylglycerol (sodium salt), a strong acid catalyst, a polymerization inhibitor and a second solvent, and performing a warming reaction to obtain the coal combustion dispersant. The coal combustion dispersant contains an anion group in a molecular structure. The anion group has electrostatic action with metal cations in catalysts, sulfur-fixing agents and rare earth compounds of the high-efficiency coal-saving liquid additives. In addition, hydrogen bond action exists between the dispersants and between the dispersants and other substances. Therefore, the dispersion effect of the coal combustion dispersant is remarkably improved, and the content of combustible components of the high-efficiency coal-saving liquid additives is remarkably reduced, and the combustion efficiency of coal is improved.

The invention discloses a polymer nano-enzyme as well as a preparation method and application thereof. The nano-enzyme comprises a nano-enzyme core modified by a surface modifier and a dendritic polymer coupled with the surface modifier. The preparation method of the polymer nano-enzyme comprises the following steps: preparing a nano-enzyme precursor, and then washing the nano-enzyme precursor to obtain a first intermediate; the nano-enzyme precursor is a nano-enzyme core modified by a surface modifier; preparing a first intermediate dispersion liquid, and adding an activator dispersion liquid and a stabilizer dispersion liquid into the first intermediate dispersion liquid to obtain an activation system; the invention also discloses an application of the polymer nano-enzyme. The polymer nano-enzyme provided by the invention can be used as an enzyme label substitute to be widely applied to enzyme-linked immunosorbent assay, immunohistochemistry, immunochromatography, chemiluminescence and other biochemical detection methods, and signal amplification with high sensitivity, wide pH and high temperature tolerance is realized.

This invention discloses a dendritic hybrid branched polymer copper bonding agent and its preparation method, belonging to the field of printed circuit board surface treatment technology. The active ingredient of this bonding agent is a three-dimensional dendritic polymer formed by grafting hybrid branches containing benzimidazole, triazole, and thiol groups onto a branched polyethyleneimine backbone through molecular design. Its aqueous solution contains 0.1%–5.0% of the polymer, 0.5%–10.0% of carboxylic acid, 0.01%–1.0% of surfactant, and the balance water. The preparation method includes polymer synthesis and the preparation of its aqueous solution. The synthesis process involves steps such as amine activation, functional group grafting, and thiol deprotection. This invention achieves ultra-high adhesion between the copper surface and dry film, wet film, or solder resist ink without completely corroding the copper surface, through the synergistic effect of multiple functional groups and the high-density bonding sites of the dendritic structure. Simultaneously, it perfectly maintains the smoothness of the copper surface, significantly reduces high-frequency signal transmission loss, and has the advantages of being environmentally friendly and having good process compatibility, making it particularly suitable for the manufacture of high-frequency, high-speed PCBs.

Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

The invention belongs to the technical field of biological medicines, and particularly relates to a tumor microenvironment response type nano-drug based on linear-dendritic polymers. The preparation method comprises the following steps: connecting a dendritic fragment to a polymer skeleton through an enzyme-cleavable peptide chain, and coupling a chemotherapeutic drug to a dendritic periphery through a pH-unstable hydrazone bond to obtain an amphiphilic polymer prodrug; the stable nanoparticles are obtained by screening polymeric monomers, can be efficiently taken by tumor cells, and have advantages in tumor tissue penetration and tumor resistance; the polymer prodrug can also load an adenosine receptor antagonist drug to prepare a nano-drug, and the nano-drug reverses adenosine-mediated immunosuppression to realize a synergistic effect of the adenosine receptor antagonist drug and a chemotherapeutic drug; the nano-drug and the PD-1 antibody cooperate to further improve the immune response in vivo and the anti-TNBC effect. The polymer prodrug and nano-drug synthesized by the invention have good prospects in the aspect of treating TNBC.

The invention relates to a polymer composition for electrostatic spinning and a degradable electrostatic spinning microfiber filtering material. The polymer composition comprises a polymer and a plasticizer, the polymer is a degradable high polymer material, and the plasticizer is a dendritic polymer and polyphenolic acid. In the electrostatic spinning process, by adding the plasticizer and controlling the spinning process, the high-efficiency and low-resistance microfiber filtering material which is free of thermal bonding among fibers, has a fluffy three-dimensional network structure and has certain mechanical properties is prepared, the gram weight of microfibers is 0.01-200g / m < 2 >, the filtering efficiency is greater than 99.850%, and the resistance is less than 238Pa. The preparation process is simple, and the filtering material has a wide application prospect in the fields of masks, protective clothing, operating gowns, air purification, especially high-efficiency air filtration under the action of a certain external field force.

Processes for preparing an alkylated phenolic ester and provided and comprise reacting an alkylating agent with a phenolic ester at an elevated temperature in the presence of a polar solvent and at least about 5 equivalents of a base. Compositions comprising the compounds described herein and a ribonucleic acid are also described, as are methods of delivering ribonucleic acids to cells in a patient using the compositions described herein.

The application provides a preparation method of dopamine (DA) modified polyamide-amine dendrimer, which comprises amino terminal dopamine carboxylation, synthesis of carboxylated dopamine with a protective group, synthesis of carboxylated dopamine with a protective group modified polyamide-amine dendrimer, and synthesis and application of dopamine modified polyamide-amine dendrimer. The application utilizes the firm adhesion performance of DA in a marine humid environment, the antibacterial performance and the osteogenic induction performance of PAMAM-NH2 cationic polymer, introduces DA into the surface of PAMAM-NH2 to synthesize a new high polymer material DA-PAMAM-NH2, detects the long-acting antibacterial and osteogenic induction performance of the system as a bifunctional coating on the surface of an implant, and evaluates the role of the system in improving the clinical durability of the implant.

The application discloses a kind of block copolymer polypeptides, polymer fiber and its preparation method and purposes.The block copolymer polypeptide includes dendritic polymer and polypeptide chain connected with the dendritic polymer, the polypeptide chain is composed of structural unit shown in formula I and structural unit shown in formula II, the dendritic polymer is connected with the structural unit shown in formula I by amide bond, the structural unit shown in formula I is connected with the structural unit shown in formula II by amide bond;And.The block copolymer polypeptide of the application can make the functional unit that should form beta-fold conformation with metastable alpha-helix chain growth, later can be converted into beta-fold again metastable alpha-helix, and good stability;The polymer fiber formed has high mechanical property, can be widely used in high toughness composite, degradable biomedical materials and intelligent drug delivery system and other key fields.

A class of drug-loaded macromolecules and their preparation methods are disclosed. Specifically, the macromolecules are dendritic polymers loaded with drugs and pharmacokinetic modifiers, particularly involving the linking of drugs to dendritic polymers via specific linkers. These macromolecules can be used to regulate drug release rates, specifically through the selection of linkers.

The application relates to a method for constructing a quantitative structure-activity relationship of a dendrimer molecular structure and salt tolerance and application. According to the quantitative structure-activity relationship, the salt tolerance of an oil field chemical polymer can be obtained according to the molecular structure of the dendrimer, without needing to pass through traditional experiments or complicated molecular simulation dynamics calculation. Meanwhile, the quantitative structure-activity relationship can be used to quickly screen the dendrimer with good salt tolerance, and has a good reference significance for the rapid design and research and development of the salt-resistant polymer for drilling fluid and even oil field chemicals.