160 results about "Polyethylenimine" patented technology

The present invention relates to surface-functionalized extracellular vehicles. Specifically, the present invention relates to exosomes surface-functionalized with lactosylated polyetheneimine (PEI-LA), such surface-functionalized exosomes as drug delivery vehicles, 5 compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to liver.

The application provides a self-driven BCG-nanoparticle complex and a preparation method thereof, and belongs to the fields of biological medicine and nanomaterials. The complex is a composite of BCG and cerium oxide nanoparticles with urease activity, the cerium oxide nanoparticles are coupled to the surface of the BCG in an asymmetric distribution through modified polyethyleneimine, and specifically, the surface of the BCG is connected to several modified polyethyleneimine derivatives through chemical bonds and electrostatic adsorption, and the polyethyleneimine derivatives wrap the cerium oxide nanoparticles through electrostatic adsorption. The complex can be self-driven by using the gas release and ion concentration change caused by the catalytic decomposition of urea in the environment, significantly enhances the adhesion and retention of BCG on the bladder wall, effectively overcomes the defects of low delivery efficiency and insufficient immune activation of traditional BCG therapy, simultaneously improves the tumor immune microenvironment, and can be used for preparing high-efficiency and low-toxicity bladder cancer treatment drugs.

The application discloses a toughened composite polyurethane impact-resistant material based on dynamic covalent bond energy regulation, and belongs to the technical field of polyurethane materials. A double dynamic covalent network containing DA bonds and disulfide bonds is constructed by reacting polyurethane prepolymer, furfurylamine, cystine diethyl ester and bismaleimide, then nano molybdenum disulfide is modified by silane, then a metal-polyphenol / polymer composite interface layer is constructed on the surface of aramid fiber by tannic acid-iron complex and polyethyleneimine, finally, the components are mixed, impregnated and hot-pressed to obtain the composite polyurethane material. The application effectively dissipates impact energy through the reversible rupture and recombination of dynamic covalent bonds, and enhances the interfacial bonding force between components by using multiple interface modification, so that the material has excellent impact resistance, high strength, high ductility and efficient self-repairing function, solves the problems of easy damage of the interface of traditional composite materials, insufficient impact resistance and irreversible damage, and has wide application prospect in the fields of safety protection and buffer components.

The utility model discloses a waterproof and breathable antibacterial fabric for vamp, which comprises a breathable surface layer and a breathable lining cloth. The inside of the breathable surface layer is coated with a liquid rubber coating. The breathable surface layer and the liquid rubber coating are punctured to form densely distributed conical micropores. The cross-sectional area of the micropores gradually decreases from the inside to the outside. The breathable surface layer and the breathable lining cloth are bonded by glue. The breathable lining cloth is coated with a quaternary ammonium polyethylene imine zinc oxide or cuprous oxide particle solution coating. The conical micropores are opened in the liquid rubber coating. When the inside gas expands and generates pressure on the inside opening of the conical micropores, the pressure formed at the opening of the conical micropores is transmitted to the front end to form strong air pressure, and the front end of the conical micropores is opened under pressure. Conversely, liquid cannot enter from the front end of the conical micropores, forming an efficient waterproof and breathable effect. The breathable lining cloth is coated with a quaternary ammonium polyethylene imine zinc oxide or cuprous oxide particle solution coating, which has good antibacterial effect and is beneficial to foot health.

The present invention provides targeting polyplexes comprised of (i) nucleic acids, in particular nucleic acids encoding pharmaceutically active peptides or proteins, and (ii) targeting conjugates comprising LPEI and PEG fragments that are connected by discrete linkages formed through defined, chemoselective reactions. Thus, the LPEI fragment is bonded in a linear end- to-end fashion to a single PEG fragment. The linear conjugates are further conjugated to a targeting fragment to enable selective interaction with a particular cell type. The polyplexes selectively deliver the nucleic acids to the targeted cells resulting in high expression and efficient protein translation as well as secretion of the encoded pharmaceutically active proteins.

The application discloses a polymer crosslinking system with a siloxane structure for deep profile control. A preparation method of the polymer crosslinking system for deep profile control comprises the following steps: S1, in an inert atmosphere, under the condition that an initiator exists, performing a polymerization reaction on nonionic monomers, anionic monomers and an epoxy monomer in water to obtain an epoxy polymer; S2, in an inert atmosphere, performing a grafting reaction on polyethyleneimine, an epoxy compound-1 and an epoxy compound-2 in an organic solvent to obtain a silicon-containing polymer; and S3, performing a crosslinking reaction on the epoxy polymer and the silicon-containing polymer in water to obtain the polymer crosslinking system. The polymer crosslinking system has certain delayed crosslinking characteristics and excellent temperature resistance and salt resistance.

This invention discloses a cationic lipid molecule based on lipoic acid derivatives for mRNA delivery, its preparation method, and its uses. The cationic lipid molecule is prepared by reacting lipoic acid with a hydrophilic amine, wherein the hydrophilic amine is one of 4A1, 5A1, or 6A2. The cationic lipid molecule synthesized in this invention contains a protonated nitrogen atom that can bind to negatively charged nucleic acids and form highly stable nanoparticles with polyethyleneimine (PEI), thus improving nucleic acid loading and demonstrating its excellent application in mRNA delivery.

This invention relates to the field of functional fiber materials technology, specifically to a meta-aramid cooling fiber and its preparation method. The preparation method involves: dissolving branched polyethyleneimine in an acetate buffer solution, adding a nano-scale cooling material for modification, and then obtaining the modified aminated cooling material through solid-liquid separation; thoroughly homogenizing the modified aminated cooling material in an organic solvent, then adding it to a meta-aramid polymerization solution capped with acyl chloride for reaction to obtain a modified cooling meta-aramid solution; and spinning the modified cooling meta-aramid solution using a dry-jet wet spinning process to obtain the meta-aramid cooling fiber. This invention effectively combines meta-aramid with the modified cooling material in a specific manner, which can effectively increase the cooling factor of the fiber fabric, improve wearing comfort, and maintain the mechanical strength of the fiber.

This invention discloses a method for preparing a covalent organic framework-cellulose composite aerogel and its application, belonging to the field of porous functional materials and solar energy utilization technology. The composite aerogel uses cellulose nanofibers as a framework, constructs a cross-linked network through γ-glycidoxypropyltrimethoxysilane and polyethyleneimine, and introduces a covalent organic framework material as a functional component. Through directional freeze-drying and lyophilization, an aerogel material with a directional continuous pore structure is formed. The covalent organic framework material has tunable molecular structure and optical properties, enabling the composite aerogel to simultaneously possess light absorption, photothermal conversion, and photocatalytic reaction activity. The directional pore structure facilitates rapid water transport and vapor escape, and inhibits salt accumulation, thereby improving the solar interfacial evaporation efficiency. By controlling the structural type and loading content of the covalent organic framework, the synergistic process of photothermal evaporation and photocatalytic hydrogen peroxide production can be achieved, improving the overall solar energy utilization efficiency.

This invention discloses a lightweight sound-absorbing building material, its preparation method, and its application in ceiling components, relating to the field of lightweight building materials technology. The lightweight sound-absorbing building material of this invention consists of a porous plate and a glaze layer on the surface of the porous plate. The glaze layer is formed by spraying glaze onto the surface of the porous plate; the porous plate is formed by sintering a plate-forming composition; the plate-forming composition includes the following raw materials: waste foamed ceramic powder, diatomaceous earth, hollow glass microspheres, cellulose nanocrystals, bilayer fibers, a foaming agent, and an ethanol solution of polyethyleneimine. The core-shell structure bilayer fibers introduced in this invention, with a mesoporous barium titanate-silica composite phase as the core and an MXene-graphene composite phase as the shell, effectively improve the material's sound absorption and noise reduction capabilities; the introduction of hollow glass microspheres and cellulose nanocrystals further enhances the material's lightweight properties, flexural strength, and sound absorption and noise reduction capabilities. Therefore, this invention has broader application prospects.

The application discloses a preparation method of an environment-friendly chitosan-based heavy metal adsorption air-precipitated bead, and comprises the following steps: preparing chitosan water-precipitated beads through acid-base neutralization solidification, loading the ammonia metal organic framework UiO-66-NH2 prepared through hydrothermal reaction on the chitosan water-precipitated beads through Schiff base reaction of a crosslinking agent, and then further loading polyethylene imine on the composite water-precipitated beads through the same loading means. The CS-UiO-GA-PEI-GA air-precipitated bead adsorbent is prepared through freeze-drying of the water-precipitated beads by a freeze dryer. The secondary crosslinking method gives the adsorbent certain mechanical strength, and provides a basis for regeneration and circulation of the adsorbent; the nitrogen-rich polyethylene imine and the high-porosity UiO-66-NH2 greatly enrich the active adsorption sites of the adsorbent, and significantly improve the adsorption capacity of the adsorbent for Cr(VI); and the removal rate of the adsorbent for Cr(VI) is up to 100% in the detection limit range of Cr(VI).

This invention provides a mica composite nanofiltration membrane, its preparation method, and its application. The method includes the following steps: mixing a polyethyleneimine solution with a mica nanosheet dispersion to undergo a composite reaction, obtaining a composite nanosheet dispersion; and permeating the composite nanosheet dispersion through a porous substrate membrane under negative pressure, causing the composite nanosheets in the dispersion to deposit on the porous substrate membrane, thus obtaining the mica composite nanofiltration membrane. Through the synergistic effect of each step, the flux and separation efficiency of the mica composite nanofiltration membrane are effectively improved. It maintains long-term operational stability in the nanofiltration of dye aqueous solutions, achieving efficient separation of dyes and salts. Furthermore, the preparation method of this invention is simple, convenient, and low-cost. The resulting mica composite nanofiltration membrane can efficiently achieve nanofiltration separation, meeting the high performance requirements of nanofiltration membranes in various fields. It possesses high economic and practical value.

This invention relates to the field of printing technology, specifically to a pH-responsive cationic white ink, its preparation method, and its application. This invention introduces a pH-responsive cationic polymer as the core stabilizing component. By dynamically controlling the charge state of the polymer, it achieves long-term stable storage of the ink under neutral conditions and enhanced adhesion under acidic conditions, effectively resolving the inherent contradiction between stability and adhesion in DTF white ink. Using a pH-responsive cationic polymer formed from polyethyleneimine and acid as the core stabilizing component effectively solves the contradiction between storage stability and transfer adhesion in existing technologies, achieving a pattern wash resistance of 60-75 times.

The application provides an artificial soil modifier and a preparation method and application thereof, and belongs to the technical field of artificial soil modification. The artificial soil modifier comprises 25-60 parts of acrylic acid, 15-50 parts of acrylamide, 0.05-1.0 parts of a crosslinking agent, 0.1-1.5 parts of an initiator, 3-20 parts of polyethylene imine, 3-20 parts of potassium dihydrogen phosphate, 3-20 parts of ammonium dihydrogen phosphate and 5-40 parts of biochar. The acrylic acid and the acrylamide are copolymerized by free radicals to form a polymer with a three-dimensional network structure, and the polymer loads the biochar and phosphate nutrients. Nutrients such as phosphate ions are diffused and released through the ion concentration difference inside and outside the gel. The polyethylene imine is rich in amino groups and can participate in the formation of the three-dimensional network structure in an ionic crosslinking mode, and the amino groups can also adsorb heavy metals through coordination chelation or electrostatic adsorption, so that the heavy metal passivation function is realized.

This invention provides a deep moderating and displacement system suitable for fractured reservoirs, its preparation method, and its application. The moderating and displacement system comprises the following raw materials in parts by weight: 0.2-1 parts of partially hydrolyzed polyacrylamide (HPAM), 0.1-0.6 parts of polyethyleneimine (PEI), 0.2-0.4 parts of silane-modified micron-sized inorganic fibers, 0.1-0.8 parts of encapsulated citric acid, 0.02-0.2 parts of heat stabilizer, 0.02-0.1 parts of metal ion complexing agent, and 196.9-199.36 parts of water. The moderating and displacement system of this invention has low initial viscosity, small injection pressure gradient, strong shear recovery ability, significant deep plugging effect, and excellent long-term thermal stability. Furthermore, it can be adjusted according to the target reservoir temperature and the dominant fracture aperture, achieving effective adaptation to fractured reservoirs with different apertures.

The application relates to the technical field of solar cells, in particular to a perovskite solar cell, a preparation method thereof and a photovoltaic module. The perovskite solar cell provided by the embodiment of the application comprises a buffer layer, the buffer layer is arranged between an electrode structure and a carrier functional layer, and the buffer layer comprises a polyethylene imine derivative. The long-chain structure of the polyethylene imine derivative can physically block high-energy particles in a sputtering process, significantly reduce the physical damage to an organic charge transport layer and a perovskite active layer of an underlying layer, eliminate the negative influence of transparent electrode preparation, improve the transmission and extraction of electrons in the perovskite solar cell, improve the photoelectric conversion efficiency and stability of the perovskite solar cell, and reduce the photoelectric conversion efficiency decay rate.

This invention relates to a fractured solid-phase alkylation material, its preparation, and its application. Using epoxy-based microspheres as a carrier, polyethyleneimine, an acid-fractureable linker arm, and iodoacetic acid-N-succinamide ester are sequentially modified via covalent bonding to prepare the fractured solid-phase alkylation material. This material selectively reacts with thiol groups on proteins, enabling efficient enrichment and processing of proteins in complex biological samples such as cells, tissues, and body fluids. By cleaving the linker arm under acidic conditions, the protein and peptide fragments can be released without damage, potentially providing important technical support for deep proteomic coverage analysis and protein variant analysis.

This invention belongs to the field of environmental remediation material preparation technology, and provides a porous structure-controlled activated carbon for formaldehyde adsorption and its preparation method. Eutectic microparticles are prepared by co-melting a potassium-containing activator with a nitrogen-containing precursor, which can achieve in-situ low-temperature micropore etching and nitrogen atom doping during heat treatment. Simultaneously, a microgel is prepared by complexing and self-assembling tannic acid and polyethyleneimine and mild cross-linking. This microgel acts as a soft template during the carbonization stage, constructing a continuous mesoporous network and providing abundant surface alkaline sites for the carbon skeleton. Furthermore, an inorganic nano-skeleton reinforcing agent is introduced during the forming stage, and the mechanical strength of the material is improved by microgelation treatment of the particle surface. During heat treatment, a microporous-mesoporous hierarchical pore structure is formed. Through acid washing purification and surface re-alkalization treatment, activated carbon particles with highly efficient formaldehyde capture and strong locking capabilities are obtained, showing broad application prospects in the field of indoor air purification.

The present invention relates to compositions comprising RNA, preferably messenger RNA (mRNA), more preferably self-amplifying RNA (saRNA), and polymers, in particular cationic polymers, such as polyethylenimine (PEI), poly-L-Lysin (PEL), polyvinylamine (PVA) or polyallylamine (PAA), where individual RNA molecules are present in solution. In the formulations, the RNA is preferentially present in the form of monomers, dimers, timers or oligomers, but not as aggregates comprising a large number of RNA molecules per aggregate, in particular large polyplex nanoparticles. The formulations display improved transfection efficacy and they can be used for delivery of RNA to a subject, where they have an improved dose response relationship in comparison to formulations where large aggregates in the form of polyplex nanoparticles are present.

This invention discloses a PVDF-modified ultrafiltration membrane based on a tannic acid crosslinking network, its preparation method, and its applications. The membrane is prepared by a phase inversion membrane fabrication method using polyethyleneimine, tannic acid, polyvinylidene fluoride (PVDF), and N,N-dimethylacetamide (NDM). The pyrogallol structure abundant in the tannic acid molecule can coordinate with metal ions and also form a robust covalent crosslinking network with the amine-rich polyethyleneimine through Michael addition and Schiff base reactions. This network firmly anchors TA to the membrane surface and pores, solving the problem of TA loss in traditional modifications. The introduction of TA imparts lasting hydrophilicity to the membrane, significantly improving pure water flux and separation efficiency. Simultaneously, the hydrophilic and positively charged surface synergistically constructed by TA and PEI effectively inhibits the adsorption and deposition of pollutants, endowing the membrane with excellent antifouling performance and operational stability. This PVDF membrane, prepared through a green and simple co-crosslinking strategy, shows broad application prospects in complex water treatment and bioseparation.

This invention relates to the field of textile technology and discloses a method for preparing a nano-silver antibacterial and deodorizing ultra-soft sofa fabric. The fabric includes a fiber substrate and a three-dimensional polymer coating in situ cross-linked on its surface. The finishing working solution uses water as a solvent and contains branched polyethyleneimine, nano-silver dispersion, terminal epoxy-modified polydimethylsiloxane, and glacial acetic acid. During solution preparation, glacial acetic acid is used to adjust the pH to 4.5–5.0, causing the polyamine groups to protonate and form a kinetic dormancy state, ensuring stability at room temperature. After padding, a three-stage gradient baking process is performed, where the bound acetic acid is desorbed and vaporized upon heating, restoring the active amine groups to undergo in-situ ring-opening addition cross-linking with the terminal epoxy groups. Polyethyleneimine anchors the nano-silver through multi-toothed chelation, and epitaxial siloxane segments form a comb-like hydrophobic isolation layer. This invention inhibits metal-catalyzed yellowing of the fabric, significantly improves the wash fastness of the antibacterial components, and imparts an excellent soft touch to the fabric through molecular-level lubrication.

This invention provides a high-wear-resistant polyamide composite material and its preparation method. The modified carbon nanotubes of this invention, due to their nanoscale structural characteristics, can effectively exert a nano-reinforcing effect, improving the mechanical strength and anti-slip and wear-resistant properties of the polyamide composite material. On one hand, the fluoroalkyl chains grafted onto their surface improve compatibility with polytetrafluoroethylene (PTFE), while the amide groups from N,N'-methylenebisacrylamide enhance the interfacial bonding between the carbon nanotubes and the nylon matrix, effectively preventing filler agglomeration and precipitation. On the other hand, the hydroxyl groups can interact with the carboxyl groups of the nylon matrix, enhancing the material's mechanical properties and anti-slip and wear-resistant properties. Furthermore, the good interfacial compatibility of the modified carbon nanotubes improves the bonding state between PTFE and the nylon matrix, enhancing material performance. Additionally, this invention modifies glass fibers with polyethyleneimine, which facilitates their interaction with other components, further improving material performance.

This invention relates to the field of wastewater treatment technology, specifically disclosing a coagulant for treating low-temperature, low-turbidity water and its preparation method. The coagulant provided by this invention utilizes composite modified polyferric chloride to provide efficient charge neutralization and colloidal destabilization capabilities at low temperatures, polyethyleneimine to enhance the rapid destabilization of colloidal particles with its high cation density, and modified carboxymethyl inulin to exert long-chain adsorption bridging and net-catching sweeping effects. The three work synergistically to achieve rapid destabilization, aggregation, and sedimentation of colloidal particles in low-temperature, low-turbidity water, effectively solving the problems of poor low-temperature activity and low turbidity removal rate of conventional coagulants.

The present invention relates to the technical field of prevention and control of aquatic animal diseases, and specifically relates to a nanocomposite for a nervous necrosis virus, a preparation method therefor, and the use thereof. Provided in the present invention is a nanocomposite consisting of poly(lactic-co-glycolic acid), polyethyleneimine and a siRNA. Also provided in the present invention are a preparation method for the nanocomposite and the use thereof in the preparation of a drug for improving the survival rate of fish eggs infected with a nervous necrosis virus. The present invention constructs a vector for a capsid protein of the nervous necrosis virus by means of simulating the nervous necrosis virus and expresses same in cells, and screens out a siRNA that can effectively inhibit the expression of the viral capsid protein, thus constructing the nanocomposite for the nervous necrosis virus. The nanocomposite can block NNVs at the embryonic phase (fertilized eggs), thereby improving the survival rate of fish fry, and further opening up new possibilities for the treatment of early stage diseases in fish fry. The method is innovative in the field of artificial breeding of aquatic animals and provides new ideas for virus prevention and control in the field of aquaculture.

The present invention provides an anchor coating agent capable of forming an anchor coating layer with high adhesion and high water-resistant friction properties, and a laminate comprising the anchor coating layer. [Solution] An anchor coating agent is provided, comprising a polyethyleneimine resin, resin (A), and a solvent, wherein resin (A) includes at least one selected from the group consisting of urethane resins, ester resins, epoxy resins, vinyl resins, acrylic resins, and olefin resins.

The application discloses a kind of methods for constructing electrochemical immunosensor for detecting apolipoprotein A4, comprising: (1) nitrogen-doped graphene and polyethyleneimine are fully stirred in solvent Composite, then add bipyridine functionalized covalent organic framework material and fully stir Composite, obtain NG-PEI-COF composite material;With bipyridine functionalized covalent organic framework material as carrier, gold nanoparticles, apolipoprotein A4 antibody and toluidine blue are loaded in sequence, to obtain tracer probe;(2) on electrode NG-PEI-COF composite material, gold nanoparticles, apolipoprotein A4 and tracer probe are modified in sequence, to obtain the electrochemical immunosensor of the application.The electrochemical immunosensor constructed by the method shows excellent detection performance for apolipoprotein A4, the marker of depression, good reproducibility and stability, and shows good anti-interference performance for a variety of other markers of depression, can be accurately determined in 0.01~300 ng / mL linear range, detection limit is as low as 2.16 pg / mL, and can be applied to serum sample.

The present disclosure relates generally to modified styrene-maleic anhydride copolymers and lubricants containing them. In various embodiments the disclosure provides a polymer composition that is a reaction product of components comprising: 35-60 parts by weight of a styrene / maleic anhydride copolymer, wherein the styrene / maleic anhydride copolymer comprises: 40-80 wt% styrene residues, and 20-60 wt% maleic anhydride residues, each based on a total weight of the styrene / maleic anhydride copolymer, at least 80 wt% of the styrene / maleic anhydride copolymer being formed of residues of styrene and maleic anhydride; 30-60 parts by weight of a C8-C24 hydrocarbyl primary amine component; and 0.5-5 parts by weight of a polyethyleneimine oligomer component, wherein a total amount of styrene residues, maleic anhydride residues, C8-C24 hydrocarbyl primary amine residues and polyethyleneimine oligomer residues is at least 80 wt% of the polymer composition.

This invention belongs to the field of functional fiber materials technology, specifically relating to a hyperbranched polyethyleneimine-functionalized antifouling polyacrylonitrile fiber, its preparation method, and its applications. The preparation method includes grafting hyperbranched polyethyleneimine and guanidinoacetic acid onto polyacrylonitrile fiber as the main body, forming a three-dimensional network structure on the fiber surface. This material is easy to mass-produce and exhibits excellent mechanical strength. The surface-grafted hyperbranched polyethyleneimine contains a large number of amino groups, which not only improves the material's uranium extraction capability but also has a unique coordination effect on uranium. Simultaneously, the guanidino groups improve the material's antibacterial properties, cutting off microbial adhesion at the source.

The application discloses a kind of network interpenetrating modification based on biological base film coated controlled-release fertilizer and preparation method thereof, belong to controlled-release fertilizer production technical field.The network interpenetrating modification based on biological base film material of the application is prepared by substrate A, substrate B and nutrient release adjusting material according to mass ratio (4-30) :(4-30) :(1-3);The substrate A is biological base epoxy resin;The substrate B is polyethylene imine;The nutrient release adjusting material is at least two kinds of mixture consisting of epoxidized lignin, modified aminocellulose and modified starch.The application improves the controlled-release performance of biological base film material by network interpenetrating modification treatment, and coating reaction can be carried out at normal temperature, which greatly reduces energy consumption and cost.

The application discloses a sewage treatment filtering membrane and a preparation method thereof, and relates to the technical field of membrane materials. In the preparation of the sewage treatment filtering membrane, an amphoteric ion intermediate is reacted with 1,3-propane sulfone lactone to obtain an amphoteric ion monomer; the amphoteric ion monomer and N,N-methylene bisacrylamide are in-situ cross-linked and polymerized in a polyvinylidene fluoride solution to obtain a casting solution; the casting solution is used to prepare a functionalized polyvinylidene fluoride membrane through a non-solvent induced phase separation technology; hydrochloric acid dopamine and polyethylene imine are co-deposited on the surface of the functionalized polyvinylidene fluoride membrane to obtain a porous polyvinylidene fluoride membrane; and copper sulfate pentahydrate is used to catalyze modified indole derivatives to be grafted on the surface of the porous polyvinylidene fluoride membrane, so as to obtain the sewage treatment filtering membrane. The sewage treatment filtering membrane prepared by the application has excellent hydrophilic, anti-pollution and antibacterial properties.