Medical hydrogel composition, medical hydrogel as well as preparation method and application of medical hydrogel

A technology of hydrogel and composition, which is applied in the field of medical hydrogel composition, can solve the problems of surrounding cell stimulation and high price, and achieve good antibacterial and biodegradability, low swelling degree and biocompatibility Good results

Active Publication Date: 2016-09-28
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Patent document CN101843925A provides a kind of low swelling hydrogel, the swelling degree of hydrogel is about -50% to about 50%, but the raw material used in this patent is trilysine, the price is expensive, and the prepared low The swelling hydrogel is alkaline, because in the human body, the environment of most tissues is neutral, if the implant is alkaline, it will have a more serious stimulating effect on the surrounding cells

Method used

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  • Medical hydrogel composition, medical hydrogel as well as preparation method and application of medical hydrogel
  • Medical hydrogel composition, medical hydrogel as well as preparation method and application of medical hydrogel
  • Medical hydrogel composition, medical hydrogel as well as preparation method and application of medical hydrogel

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preparation example Construction

[0056] The present invention also provides a preparation method of medical hydrogel,

[0057] dissolving the first component in the first buffer solution to obtain the first mixed solution;

[0058] Dissolving the second component in the second buffer solution to obtain a second mixed solution;

[0059] mixing the first mixed solution with the second mixed solution to obtain a medical hydrogel;

[0060] Wherein, the first component includes polylysine and polyethyleneimine; the second component includes four-arm-polyethylene glycol-succinimide glutarate, four-arm-polyethylene glycol -One or more of succinimide succinate, four-arm-polyethylene glycol-succinimide carbonate.

[0061] After the first mixed solution in the medical hydrogel composition of the present invention is mixed with the second mixed solution, for example, a double mixer can be used to mix, and the nucleophilic reagent (polylysine and polyethylene sulfide) in the first mixed solution Amine) and the electro...

Embodiment 1

[0075] Take 0.5g of 4-arms-PEG-SG (weight average molecular weight 15kDa, the same below) and dissolve it in 5mL of acidic disodium hydrogen phosphate buffer solution with a pH of 5.60 to obtain a solution A with a concentration of 100mg / mL; take 20mg of ε-polylysine (weight-average molecular weight 3500Da, polymerization degree 25-35, the same below) and 80 mg of polyethyleneimine (number-average molecular weight 1800 Da, the same below) were dissolved in 5 mL of alkaline buffer solution with pH 9.90 , to obtain solution B with a concentration of 20mg / mL; spray solution A and solution B through the double mixer in equal doses to form medical hydrogel I.

Embodiment 2

[0077] Take 0.5g of 4-arms-PEG-SG and dissolve it in 5mL of acidic disodium hydrogen phosphate buffer solution with a pH of 5.60 to obtain a solution A with a concentration of 100mg / mL; take 50mg of ε-polylysine and 50mg of Polyethylenimine was dissolved in 5 mL of physiological saline with a pH of 7.4 to obtain a solution B with a concentration of 20 mg / mL; the solution A and solution B were sprayed in equal doses through a double mixer to form a medical hydrogel II.

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Abstract

The invention relates to a medical hydrogel composition, a medical hydrogel as well as a preparation method and an application of the medical hydrogel. The medical hydrogel composition consists of a first component and a second component, wherein the first component includes polylysine and polyethyleneimine; the second component includes one or more of 4arm-polyethylene glycol-succinimidyl glutarate, 4arm-polyethylene glycol-succinimidyl succinate and 4arm-polyethylene glycol-succinimidyl carbonate, wherein the polymerization degree of the polylysine is above 20, preferably 25-35. The medical hydrogel disclosed by the invention is low in swelling degree, which is just 10-50%, and the medical hydrogel is applicable to narrow parts that cranial, spinal and peripheral nerves are densely distributed. In addition, the medical hydrogen disclosed by the invention is good in biocompatibility and is excellent in antibacterial property and biodegradability. Moreover, the medical hydrogel disclosed by the invention is also non-irritant to tissues.

Description

technical field [0001] The invention relates to a medical hydrogel composition, a medical hydrogel and a preparation method and application thereof, belonging to the technical field of biomedicine. Background technique [0002] Clinically, medical hydrogels can be used in wound sealing, anti-adhesion or drug loading in vivo. Hydrogel is a gel with water as the dispersion medium. It has a three-dimensional space network structure. It cannot be dissolved in water, but can swell in water, absorb a large amount of water, and increase the volume of the hydrogel. However, in the narrow areas where the brain, spine and peripheral nerves are densely distributed, the highly swellable hydrogel will cause compression on the peripheral nerves, which may interfere with the normal function of the body, and in severe cases, compressive necrosis may occur in the surrounding tissues. [0003] At present, most of the clinical medical hydrogels have high swelling degree, such as Coseal mixed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/26A61L31/14A61L31/04A61L31/06A61L26/00
CPCA61L26/0052A61L26/008A61L27/26A61L27/52A61L31/041A61L31/145C08L77/04C08L79/02C08L71/02A61L31/06A61L27/18A61L27/58A61L31/148A61L24/0015A61L24/0031A61L24/10A61L26/0028A61L26/0066A61L31/043A61L31/16A61L2300/414A61L15/20A61L26/00A61L31/04A61L31/14C08J3/075C08K5/00A61L24/043
Inventor 林丽敏杨亚亚马骋邓坤学袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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