169 results about "Glutarates" patented technology

Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is E. coli. The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).

A heavy oil cleaning composition comprising: a) a blend of dibasic esters comprising dialkyl methylglutarate and at least one of a dialkyl adipate or dialkyl ethylsuccinate; b) at least one terpene; and c) at least one surfactant. Also described are methods for delivering a solvent at reduced concentration comprising the steps of: a) obtaining a terpene-based solvent; and b) mixing the terpene-based solvent with a carrier fluid (the carrier fluid comprising a microemulsion of i) a blend of dibasic esters selected from the group consisting of dialkyl methylglutarate, dialkyl adipate, dialkyl ethylsuccinate, dialkyl succinate, dialkyl glutarate and any combination thereof, ii) at least one surfactant selected from the group consisting of a terpene alkoxylate, an alcohol alkoxylate and any combination thereof; and iii) water) in order to obtain a mixture to clean heavy oils.

An environmentally-friendly cleaning composition for oil cleaning comprising (a) a blend of dibasic esters, (b) one or more surfactants (c) and, optionally, (d) water or a solvent. The dibasic esters are be derived from a blend of adipic, glutaric, and succinic diacids, and, in one particular embodiment, the blend comprises dialkyl adipate, dialkyl methylglutarate and dialkyl ethylsuccinate, wherein the alkyl groups individually comprise a C₁-C₁₂ hydrocarbon group. The one or more surfactants are typically chosen from alcohol alkoxylate, an alkyl phenol ethoxylate, a terpene, a terpene alkoxylate or any derivates thereof. Optionally, additional components or additives including delaminates such as pinene and d-limonene, fragrances, whiteners, stabilizers, thickeners and the like can be added to the composition.

An environmentally-friendly cleaning composition for industrial and consumer applications comprising (a) a blend of dibasic esters, (b) one or more surfactants (c) and, optionally, (d) water or a solvent. The dibasic esters are be derived from a blend of adipic, glutaric, and succinic diacids, and, in one particular embodiment, the blend comprises dialkyl adipate, dialkyl methylglutarate and dialkyl ethylsuccinate, wherein the alkyl groups individually comprise a C₁-C₁₂ hydrocarbon group. The one or more surfactants are typically chosen from alcohol alkoxylate, an alkyl phenol ethoxylate, a terpene, a terpene alkoxylate or any derivates thereof. Optionally, additional components or additives including delaminates such as pinene and d-limonene, fragrances, whiteners, stabilizers, thickeners and the like can be added to the composition. The industrial or consumer application selected from the group consisting of a graffiti cleaner, a painted-substrate cleaner, an ink cleaner, a metal substrate cleaner, a plastic substrate cleaner, an environmentally friendly cleaner, a stain-spot cleaner, an industrial hand cleaner, a resin cleaner, a tar resin cleaner, a textile cleaner, a paint stripper and any combination thereof.

The invention is about a method of measuring the content of blood ammonia, and it also concerns the reagent box of blood ammonia diagnosis. This invention belongs to the field of medical testing and measuring technology. The reagent box is consisted of buffer solution, 2ú¡ketoglutarate, reduced coenzyme, adenosine triphosphate, phosphoenolpyruvate, glutamate dehydrogenase, glutamate kinase, pyruvate kinase, lactate dehydrogenase and stabilizer. Firstly, we cause an enzyme-coupled reaction through mixing the sample and the reagent according to a certain proportion of volume; secondly, put the final reactant under the biochemical analyzer and test the absorbance variational situation (speed) of dominant wavelength; then we can get the content of blood ammonia. By using this invention, we can get the necessary measuring result with high sensitiveness and fine precision through biochemical analyzer, and the result would not be contaminated by material of internal and exogenous sources. Thus, this method can be conveniently promoted and applied.

The invention relates to the following general formula compound (I) and use of the general formula compound in preparing anti-inflammatory and anti-endotoxin medicines. In formula I, R is an acid solubilizing side chain of hydroxide radical in an arctigenin molecule, and can be an acid group or side chain imported through alkylation reaction or acylating reaction, such as sulphonic acid ester, sulfuric acid ester, organic phosphate, succinate, propionic ether, butyric ester, semi-succinate, semi-glutaric acid ester, semi-tartrate, semi-phthalic acid ester, m-benzene sulfonic acid ester and so on.

A method for producing a confection such as chewing gum, as well as the confection so produced, incorporates a blend of physiological cooling agents, including menthyl glutarate and one or more of L-isopulegol and p-menthane-3,8-diol. In another embodiment the blend of physiological cooling agents is made in a modified release structure. The modified release/cooling agents combination is preferably obtained by physically modifying the properties of the combination of cooling agents by coating and drying. When incorporated into gum, these particles are adapted to enhance the shelf stability of the flavor and/or produce a modified release when the gum is chewed. In another embodiment, the blend of physiological cooling agent is included in a confection coating.

The invention belongs to the field of plant protection, and relates to a kasugamycin-containing sterilization composition and an application thereof. The kasugamycin-containing sterilization composition contains effective amounts of A and B, wherein A is kasugamycin, B is one of oxine-copper, copper(succinate+glutarate+adipate), thiediazole copper, humic acid copper, nitroacid copper, copper naphthenate, amino acid copper, copper acetate and sulfamic acid copper, and the mass fraction ratio of A to B is (10:1)-(1:100). The composition can be processed into wettable powder, water dispersible granules, an aqueous emulsion, a microemulsion and a suspending agent, and the mass sum of A and B accounts for 1-80% of the total mass of the preparation. The composition can be used for preventing and treating fungi and bacterial diseases of multiple plants such as rice, wheat, vegetables and fruit trees and has an excellent effect on late blight and gray mold of tomatoes, rice stripe diseases and rice blast, angular leaf spot of watermelons and citrus bacterial canker diseases.

The invention provides a preparation method for a physiological cooling agent--menthyl glutarate. The menthyl glutarate is prepared by reacting menthol with glutaric anhydride in the presence of an acidic catalyst, and a reaction equation is described in the specification, wherein a weight ratio of the acidic catalyst to the menthol is in a range of 0.01 to 0.1, a weight ratio of the glutaric anhydride to the acidic catalyst is 0.6667: 1 to 1: 1, the content of monomenthyl glutarate in an obtained menthyl glutarate mixture is 55 to 75%, the content of dimenthyl glutarate in the obtained menthyl glutarate mixture is 25 to 45%, the acidic catalyst is one or a mixture of two selected from the group consisting of sulfuric acid, phosphoric acid, p-toluenesulfonic acid, oxalic acid, methanesulfonic acid and an acidic resin, a non-polar solvent like hexane, heptane, cyclohexane, toluene and benzene is used in the reaction, reaction temperature is 50 to 110 DEG C, and reaction time is 1 to 15 h. The preparation method provided by the invention needs short reaction time and can prepare a menthyl glutarate product with good fragrance and taste.

The invention relates to a method for preparing a rosuvastatin intermediate which is (R)-3-hydroxy-monomethyl glutarate and hydroxyl-protected (R)-3-hydroxy- monomethyl glutarate. According to the method, (R)-4-cyano-3-hydroxy-methyl butyrate which servers as a substrate is subjected to reaction under the action of an enzyme to generate the (R)-3-hydroxy- monomethyl glutarate, and particularly the enzyme is the recombinant nitrilase, and the reaction is carried out in a aqueous-phase buffering solution with the pH value of 7.0-9.0 at the temperature of 25-35 DEG C. Because the specific recombinant nitrilase is adopted by the method, the problems of ultralow concentration of the substrate and low conversion rate in the existing method for preparing the rosuvastatin intermediate through biological catalysis are solved. The method has the characteristics of mild reaction conditions and high reaction efficiency, is easy and convenient to operate and has important industrial application value.

The invention discloses a low-temperature-resistant PVC cable material formula. The low-temperature-resistant PVC cable material is composed of following raw materials including, by weight, 30-40 parts of PVC resin, 10-15 parts of ultralow density polyethylene, 3-8 parts of beta-nucleating agents, 3-6 parts of polyolefin thermoplastic elastomers, 3-6 parts of octene-ethylene copolymer, 5-8 parts of poly(propylene glutarate), 3-7 parts of POE elastomer flexibilizers, 1-3 parts of antioxidants, 2-5 parts of silicon carbide fibers, 1-3 parts of nano-barium sulfate, 2-4 parts of silver loaded zeolite, 2-5 parts of glass fibers, 4-10 parts of nanometer titania, 5-10 parts of magnesium hydroxide, 1-3 parts of flexibilizers, 3-6 parts of paraffin, 3-5 parts of silane coupling agents and 1-4 parts of plasticisers. The PVC resin is used as the main component, and the ultralow density polyethylene, the beta-nucleating agents, the poly(propylene glutarate) and the POE elastomer flexibilizers are added for composite treatment, so that the low temperature resistance of PVC cables is improved, and the PVC cables are good in gloss.

Provided is a refreshing composition to be used in foods, drinks, compositions for oral cavity and perfume compositions having a pleasant, refreshing feeling of menthol imparted thereto, said refreshing composition being capable of enhancing the refreshing feeling without increasing the content of menthol, improving the long-lasting properties of the refreshing feeling and having good handling properties when added to products such as chewing gums. A powdery refreshing composition that is prepared by contacting a mixture in an atomized state with a cold gas stream and thus powdering the mixture, said mixture containing a refreshing substance comprising menthol and menthol analogue(s), preferably menthol and one or more kinds of menthol analogues selected from the group consisting of menthyl 3-hydroxybutyrate, menthyl lactate, menthyl glutarate, 3-L-menthoxypropane-1,2-diol, menthyl acetate, isopulegol, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide and menthone 1,2-glyceryl acetal, together with a stabilizer.

A hydrogel composition for application to vascular puncture site of an animal to arrest bleeding and promote hemostasis mixes a biocompatible, synthetic, electrophilic polymer component comprising a poly(ethylene glycol) (PEG) Succinimidyl Glutarate having a functionality of four and a molecular weight of about 10,000 g/mole, with a biocompatible, synthetic, nucleophilic polymer component comprising a blend of a poly(ethylene glycol) (PEG) Amine having a functionality of four and a molecular weight of about 10,000 g/mole, and a Poly-L-Lysine hydrobromide having a molecular weight of greater than about 8000 g/mole.

The invention discloses a bronopol-containing bactericidal composition. The bactericidal composition contains an active ingredient A and an active ingredient B, the active ingredient A is selected from bronopol, the active ingredient B is any one compound selected from the following compounds: copper oxychloride, cuppric nonyl phenolsulfonate, oxine-copper, kasugamycin, validamycin, moroxydine hydrochloride, polyoxin, copper(succinate+glutarate+adipate), zhongshengmycin, xinjunan acetate, and zinc thiazole, and the weight ratio of the active ingredient A to the active ingredient B is 1:70 to 70:1. The composition provided by the invention has higher activity on various diseases of a plurality of crops, and an obvious synergistic effect, enlarges the bactericidal spectrum, and has the characteristics of a small medicine using amount, resistance to rain erosion, and an obvious synergistic effect.

The invention discloses a preparation method for 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one. The method comprises the following steps: (1) mixing and reacting glutaric anhydride and methanol to obtain mixture 1 which contains monomethyl glutarate and glutaric acid; (2) mixing the mixture 1 with dichloromethane and rinsing an obtained mixture with an saturated sodium chloride solution to obtain monomethyl glutarate; (3) mixing and reacting monomethyl glutarate with thionyl chloride to obtain methyl 4-(chlorofomyl)butyrate; and (4) mixing methyl 4-(chlorofomyl)butyrate with (S)-4-phenyloxazolidinone at a temperature of 0 to 5 DEG C within 3 to 3.5 h and carrying out condensation to obtain 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one.

The invention belongs to the field of electric power materials and discloses a preparation method of a polyolefin thermoplastic elastomer flame-retardant cable sheath material. The preparation method utilizes 1-2 parts of magnesium hydroxide, 1-2 parts of alumina, 1-2 parts of lithium-based bentonite, 1-2 parts of aluminum nitride, 2-3 parts of molybdenum disulfide, 2-3 parts of attapulgite, 2-3 parts of forsterite, 3-4 parts of ethyl glutarate, 4-6 parts of silicon nitride, 5-7 parts of triphenyl phosphate, 5-7 parts of silicon carbide, 7-10 parts of egg shells, 7-10 parts of polycarbonate, 8-12 parts of quartz sand, 8-12 parts of polyethylene wax, 8-12 parts of brominated polystyrene, 20-30 parts of chlorinated butyl rubber, 20-40 parts of an ethylene-propylene-diene monomer and 30-40 parts of a polyolefin elastomer. The preparation method has simple and easy processes and improves fire resistance and mechanical properties of the traditional rubber material.

The invention relates to a method for preparing high-molecular weight aliphatic polycarbonate. The method is characterized in that diphenyl carbonate and aliphatic diol are taken as raw materials, and then subjected to two-step reaction of melting ester exchange and polycondensation in a zinc-based catalysis system to obtain the high-molecular weight aliphatic polycarbonate. The zinc-based catalyst takes zinc halide, zinc glutarate and zinc acetate as active components, the active components are loaded on the surface of an inorganic mesoporous material and an organic polymer material to obtain the catalyst, and the carrier mass accounts for 0-95 wt% of that of the catalyst mass. The method has the characteristics of fast reaction rate and high yield, in the invention, diphenyl carbonate and aliphatic diol are rapidly subjected to ester exchange and polycondensation to obtain the high-molecular weight aliphatic polycarbonate. A synthesis polymer is a white solid, the color is good, the number-average molecular weight is more than 100000, the polymer can be used as plastic, and the polymer yield can reach as high as 95%. The method has the advantages of simple process, large synthesis polymer molecular weight, and high yield, and has good industrial application prospect.

The invention discloses a CALB mutant used for preparing a (R)-3-substituted monoalkyl glutarate compound through non-aqueous catalysis, and relates to the technical field of biological engineering. According to the invention, a mutant enzyme is adopted as a catalyst, a 3-substituted glutaric acid compound and an organic alcohol are adopted as raw materials. Under the effect of the biological enzyme, a reaction is carried out in an organic solvent under a temperature of 4-50 DEG C, such that the (R)-3-substituted monoalkyl glutarate compound is prepared. The preparation method provided by the invention has mild reaction conditions. The output of the (R)-3-substituted monoalkyl glutarate compound can be higher than 32.8g/L, the yield can be higher than 82.0%, and the eeR value can be higher than 99%. Post-treatment is simple, atom utilization degree is high, and the requirements of green chemistry is met. With the method, cost can be greatly reduced, and the social demand of the (R)-3-substituted monoalkyl glutarate compound can be satisfied.

This invention relates to a method for synthesizing Mg (OH) 2 flame retardant, more specifically, a precipitation method for synthesizing ultrafine Mg (OH) 2 flame retardant. The method comprises: preparing a mixed aqueous solution of MgSO4 (4-18 g/L), NaOH (5-20 g/L) and sulfonated glutarate modifier (0.01-0.03 g/L), and precipitating under microwave to obtain Mg (OH) 2. The particle sizes of Mg (OH) 2 can be decreased by microwave. Different particle sizes (0.1-3 mu.m) of Mg (OH) 2 can be obtained by adjusting the microwave power and time. At the same time, the addition of sulfonated glutarate anionic surfactant can improve the flame retardancy of Mg (OH) 2 flame retardant.

The invention discloses a compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and Copper(succinate+glutarate+adipate) and a preparation. The compound composition is composed of 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and Copper(succinate+glutarate+adipate), wherein the weight ratio of 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole to Copper(succinate+glutarate+adipate) is (20-1):(1-40). The compound composition disclosed by the invention accounts for 0.1-90% of the weight percentage of a bactericide and can be used for effectively preventing and controlling various bacterial diseases such as citrus canker and cucumber bacterial angular leaf spot disease and fungous diseases such as plasmopara viticola. The compound composition has a remarkable synergistic effect and is high in preventing effect and capable of reducing the dosage of a pesticide as well as preventing and treating costs and also delaying the pesticide resistance.

The invention belongs to the field of electric power materials, and concretely discloses a high-strength high-toughness cable sheath material. The high-strength high-toughness cable sheath material is prepared from the following raw materials in parts by weight: 1-2 parts of quartz sand, 1-2 parts of lithium bentonite, 1-2 parts of attapulgite, 1-2 parts of molybdenum disulfide, 2-3 parts of ethyl glutarate, 3-4 parts of graphite, 3-4 parts of silicon nitride, 5-7 parts of triphenyl phosphate, 6-8 parts of silicon carbide, 7-10 parts of egg shell, 7-10 parts of borax, 8-12 parts of polycarbonate, 8-12 parts of polyethylene wax, 8-12 parts of brominated polystyrene, 30-50 parts of chlorinated butyl rubber, and 30-50 parts of ethylene-propylene-diene rubber. According to the technical scheme, a rubber material is modified, the raw material compatibility is reasonable, and the strength and the toughness of the rubber are greatly improved.

The invention discloses a preparation method of nylon 65 salt. Glutarate is dissolved in a solvent, the mixture is heated to 30-50 DEG C, and a glutarate solution is prepared; hexamethylendiamine is dissolved in a solvent, the mixture is heated to 30-50 DEG C, and a hexamethylendiamine solution is prepared; the hexamethylendiamine solution is dropwise added into the glutarate solution under constant rate stirring at the temperature of 30-50 DEG C, inert gas is introduced for protection, the pH value is monitored by a pH meter in real time, the pH value is controlled to range from 7.20 to 7.90,and the reaction is carried out for 1.5 h to 5.0 h; after the material completely reacts, reduced pressure distillation or direct suction filtration is carried out, and then nylon 65 salt is dried ina vacuum drying box for 24 h at the temperature of 60 DEG C; the dried nylon 65 salt is purified through a purification solvent, the nylon 65 salt is dried, and the pure nylon 65 salt sample is obtained. The prepared nylon 65 salt is high in yield, the pH value is monitored by the pH meter in real time in the reaction process, reaction monitoring is convenient, the reaction conditions are moderate, and operation is easy.

The present invention discloses a preparation method of an efficient catalyst for catalyzing CO2 and epoxy alkane to synthesize a biodegradable material. The preparation method is characterized in that a dipping method and an in situ activation method are adopted to load zinc glutarate on the surface of a silanization modified molecular sieve in a nano-size manner to obtain the highly dispersed inhomogeneous catalyst, wherein the catalyst can be uniformly dispersed in an organic solvent system so as to reduce agglomeration between active centers, and has high catalysis activity. According to the present invention, with application of the catalyst to catalyze copolymerization of CO2 and propylene oxide, the maximum catalysis efficiency achieves 81.5 g of polymer/g of zinc glutarate, the obtained polymerization product Mn is 65800, the polycarbonate segment is 98.4%, and the polymerization product can be completely degraded into CO2 and H2O in the natural environment; and the catalyst has characteristics of simple preparation process and high catalysis efficiency, and the reliable new technology is provided for degradable material synthesis through industrial utilization of CO2 and epoxy alkane.

The invention discloses a pesticide compound, mainly comprising component A and component B, wherein, the component A is bismerthiazol, the component B is kasugamycin compounded with zhongshengmycin or copper (succinate + glutarate + adipate); the component A and the component B are mixed to form compound according to mass ratio of 1 to 50:50 to 1. The application of the pesticide compound is as follow: the compound is put in a mixer in proportion with wetting agent, dispersing agent, binder, disintegrant and packing; then the mixture is mixed uniformly, and then is crushed, dried and sieved, and compounded again; and finally water dispersible granule and wettable powder is produced. The invention has the advantages of the obvious synergized effect, high control efficiency, 92% field control efficiency for angular leaf spot of cucumber, broad control spectrum, reduced consumption cost, low pollution, convenient use, multipurpose ability, labor saving, low material cost, and simple technology.