15 results about "Glutarates" patented technology

The invention discloses a synthesis method of a glutaric acid ester compound, which comprises the following steps: reacting a propionate compound as shown in a formula 1 with a diazo compound as shown in a formula 2 in a solvent in a nitrogen atmosphere in the presence of a reducing agent under the illumination condition of visible light, and after the reaction is completed, separating out the glutaric acid ester compound, thereby obtaining the glutaric acid ester compound. And separating and purifying the reaction mixture to obtain the glutaric acid ester compound as shown in the formula 3. The propionate compound and the diazo compound are used as reaction substrates, the compound can be generated through reaction under mild conditions, the yield of the target product is improved, operation is easy and convenient, the reaction conditions are mild, the price of raw materials and solvents used in the whole process is low, and cost control is facilitated.

The invention discloses a volatile oil supported hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of medicine preparation. The composite material comprises sporopollen microcapsules loaded with volatile oil, and hydrogel formed by crosslinking four-arm polyethylene glycol amine and four-arm polyethylene glycol succinimide glutarate. The preparation method comprises the following steps: degreasing plant pollen, carrying out acid treatment to obtain sporopollen microcapsules, mixing the sporopollen microcapsules with volatile oil, and then blending and cross-linking with a polyethylene glycol derivative solution. The composite material can efficiently load volatile oil, realizes long-acting slow release, has excellent antibacterial performance and an effect of promoting wound healing, and can be used for treating chronic wounds such as diabetic foot ulcer and the like.

The present disclosure relates to a medical tissue adhesive for pancreatic plugging and the preparation method and use thereof. The medical tissue adhesive composition forming the medical tissue adhesive of the present disclosure comprises a medical tissue adhesive component and a chelating agent component; wherein the medical tissue adhesive component comprises a first component and a second component, the first component comprises four-arm polyethylene glycol amine, and the second component comprises four-arm-polyethylene glycol-succinimidyl glutarate; wherein m and n are natural numbers; and the chelating agent component comprises polyphenol. The medical tissue adhesive prepared from the medical tissue adhesive composition of the present disclosure is capable of firmly binding to the surface of the pancreatic tissue, and is capable of withstanding the dynamic pressure as a result of pancreatic juice leakage and the enzymatic degradation activity of pancreatic juice. More importantly, the medical tissue adhesive of the present disclosure has an excellent antibacterial ability and is capable of preventing the infection caused by the long-term accumulation of the leaked pancreatic juice.

The invention relates to the synthesis of the compound of formula (I), which is an intermediate of the gadolinium-based contrast agent (GBCA) gadopiclenol, the latter being marketed as a contrast medium for magnetic resonance imaging (MRI), through the synthesis of di-ethylene triamine tri-alkylated with glutarate esters or glutaric acid.

The invention discloses a preparation method of a glutaric acid derivative, and relates to the technical field of glutaric acid derivative preparation. The preparation method comprises the following steps: in an inert atmosphere, uniformly mixing 2-fluoroacrylate, 2-alkyl acrylate, a cobalt catalyst and a reducing agent in an organic solvent to obtain a mixed system; the mixed system is subjected to an illumination reaction of 365-455 nm, and alkenylated glutarate is prepared; and hydrolyzing the alkenyl glutaric acid ester to obtain the glutaric acid derivative. The glutaric acid derivative prepared by the method is milder in reaction condition, and has step economy and atom economy; and the reaction conditions are mild, the substrate range is wide, the substrate functional group compatibility is good, and the product can be further converted into complex functional molecules. The derivative products provide a new strategy for obtaining novel high polymer material precursors such as polyurethane and polyamide.

The invention discloses a preparation method of medicinal 6-arm-polyethylene glycol-succinimide glutaric acid ester (amido bond), which comprises the following steps: reacting 6-arm-polyethylene glycol-amino with glutaric anhydride to obtain a reaction solution 1; adding an organic solvent B into the reaction liquid 1, stirring, pulping, filtering and drying to obtain 6-arm-polyethylene glycol-glutaric acid (amido bond); mixing 6-arm-polyethylene glycol-glutaric acid (amido bond) with a condensing agent, dropwise adding organic alkali, and reacting to obtain reaction liquid 2; adding N-hydroxysuccinimide, and reacting to obtain a reaction solution 3; concentrating under reduced pressure, dropwise adding n-hexane into the filtrate to separate out solid, stirring and pulping to obtain pulp; and filtering, washing a filter cake with n-hexane, and drying to obtain the medicinal 6-arm-polyethylene glycol-succinimide glutaric acid ester (amido bond). The method has the advantages of mild reaction conditions, high reaction rate, few byproducts and high yield, the content is more than 99.0%, the acid value is less than 0.10, and the quality indexes all meet the standards of pharmaceutical enterprises.

The present application relates to a kind of visible hydrogel, the iodine-containing polyethylene glycol in the first phase solution is 4 arm-polyethylene glycol-2,3,5-triiodo-benzamide-succinimidyl glutarate or 4 arm-polyethylene glycol-2,4,6 triiodo-benzamide-succinimidyl glutarate or 8 arm-polyethylene glycol-2,3,5-triiodo-benzamide-succinimidyl glutarate or 8 arm-polyethylene glycol-2,4,6-triiodo-benzamide-succinimidyl glutarate, the amino compound in the second phase solution is tri-l-lysine, polyethyleneimine, four arm amino polyethylene glycol or eight arm amino polyethylene glycol.The present application also relates to the preparation method of the above-mentioned visible hydrogel.The visible hydrogel according to the present application is two different liquids, i.e.the first phase solution and the second phase solution, before polymerization, after mixing two liquids, polymerization into hydrogel when using, can be closely fitted with tissue and can be developed under X-ray.

The invention relates to medical tissue glue for pancreas plugging as well as a preparation method and application of the medical tissue glue. The medical tissue glue composition for forming the medical tissue glue disclosed by the invention comprises a medical tissue glue component and a chelating agent component, wherein the medical tissue glue component comprises a first component and a second component, and the first component comprises four-arm polyethylene glycol amine; the second component is prepared from four arm-polyethylene glycol-succinimide glutaric acid ester; wherein m and n are natural numbers; the chelating agent component comprises polyphenol. The medical tissue glue prepared from the medical tissue glue composition disclosed by the invention can be firmly adhered to the surface of pancreatic tissue and can bear dynamic pressure of pancreatic juice leakage and enzymatic degradation activity of pancreatic juice, and more importantly, the medical tissue glue disclosed by the invention has excellent antibacterial ability and can prevent infection caused by long-term accumulation of pancreatic juice leakage.

This invention provides a self-adhesive biological patch, its preparation method, and its uses. The self-adhesive biological patch of this invention comprises: a substrate having a fibrous structure; and an adhesive coating present on at least one surface of the substrate, the adhesive coating comprising a first layer and a second layer, wherein the first layer is made from polyethylene glycol succinimide glutarate and natural plant extracts, and the second layer is made from polyethylene glycol amine; furthermore, the first and second layers are cross-linked under wetting conditions to form a cross-linked network structure, thereby loading at least a portion of the natural plant extracts within the cross-linked network structure. The self-adhesive biological patch of this invention can firmly adhere to tissue surfaces and can be applied directly without additional preparation, avoiding damage to surrounding normal tissue caused by additional sutures or staples.

The invention discloses self-repairing hydrogel based on non-dynamic covalent bonds and application, and belongs to the technical field of biological materials. According to the hydrogel, an amido bond is introduced, the efficient and complete self-repairing capacity is achieved, unreacted N-hydroxysuccinimide glutarate (NHS-ester) on a fracture interface is introduced into the hydrogel, the NHS-ester and amino (-NH2) can rapidly form a covalent bond, and initial state repairing can be achieved within a short time without external stimulation. The self-repairing behavior originates from NH2 / NH3 + balance, the NH2 / NH3 + balance maintains the consumption of amino groups in the reaction, and the balance is used as a storage for gradual release of free amino groups, so that covalent bonds are rebuilt for a long time, and the hydrogel has long-term repairing and repeated self-repairing capabilities.

The invention provides a self-adhesive biological patch as well as a preparation method and application thereof. The self-adhesive biological patch comprises a base body, wherein the base body is of a cellosilk structure; the adhesive coating exists on at least one surface of the base body, the adhesive coating comprises a first layer and a second layer, raw materials of the first layer comprise polyethylene glycol succinimide glutarate and natural plant extraction active matter, and raw materials of the second layer comprise polyethylene glycol amine; moreover, the first layer and the second layer can be cross-linked under a wetting condition to form a cross-linked network structure, so that at least part of the natural plant extraction active matter is loaded inside the cross-linked network structure. The self-adhesive biological patch disclosed by the invention can be firmly adhered to the surface of tissue, can be directly applied without additional preparatory work, and avoids damage to surrounding normal tissue caused by additional suturing or nailing.

The invention discloses a synthesis method of a uniform sialylated AFP-L3 antigen, serum polyclonal antibody preparation and application thereof, and belongs to the field of immunology, the uniform sialylated AFP-L3 antigen comprises a sialylated AFP-L3 glycopeptide antigen or a sialylated AFP-L3 glycoprotein antigen, and the synthesis method comprises the following steps: transferring a carbohydrate chain to a starting substrate by using Endo-M N175Q transglycosylation reaction to obtain an intermediate I; wherein the starting substrate comprises a glycopeptide Fmoc-ATKVN (GlcNAc) FTEAQKAALDV-NH2 or an AFP (Alpha Fetal Protein) protein which is expressed in HEK293T and is subjected to hydrolysis treatment; modifying the intermediate I through fucose transferase FuT8 to obtain an intermediate II; the intermediate II is modified and extended through galactose transferase GalT and sialyltransferase SiaT, and an intermediate III or a sialylated AFP-L3 glycoprotein antigen is obtained; the sialylated AFP-L3 glycopeptide antigen is obtained through the steps that the sialylated AFP-L3 glycopeptide antigen is obtained, the intermediate III is subjected to Fmoc removal treatment and then conjugated with bis-succinimide glutaric acid ester and hemocyanin, and the serum polyclonal antibody generated based on the antigen has high titer and specificity.

Patent specification 10 2024 003 476.5, dated October 23, 2024, describes phthalates, maleates, succinates, glutarates, adipates, citrates, and terephthalates, as well as cyclohexanedicarboxylic acid diisononyl esters (DINCH), diethylene glycol dibezoate, and tri-(2-ethylhexyl)trimellilate (TEHTM) as cleaners for removing dirt deposits from headlights. A combination of these cleaners with siloxanes creates a product that completely removes the dirt deposits and seals the open micro-craters on the headlight coating. It is expected that treating a headlight with this method will not violate the German Road Traffic Regulations (StVZO) because the same product used during manufacturing is applied to the headlight surface.

Disclosed herein are salts and solid forms of 4-hydroxy-N,N-diisopropyltryptamine hemi-glutarate (4-OH-DIPT), e.g., 4-OH-DIPT hemi-glutarate, 4-OH-DIPT hemi-succinate, 4-OH-DIPT hemi-succinate hydrochloride, and 4-OH-DIPT hemi-glutarate hydrochloride. The solid form may be a salt and / or a crystalline form of the 4-OH-DIPT, such as a polymorph of 4-OH-DIPT or a salt thereof. Also disclosed are methods for making the solid forms and methods for administering the solid forms. The disclosed solid forms of 4-OH-DIPT are useful for treating neurological disease and / or a psychiatric disorder in a subject.