33 results about "Substance addiction" patented technology

A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. Medical conditions are treated by administering a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of its exo-R-mecamylamine, said amount being sufficient to ameliorate the medical condition. The medical conditions include but are not limited to substance addiction (involving nicotine, cocaine, alcohol, amphetamine, opiate, other psychostimulant and a combination thereof), aiding smoking cessation, treating weight gain associated with smoking cessation, hypertension, hypertensive crisis, Tourette's Syndrome and other tremors, cancer (such as small cell lung cancer), atherogenic profile, neuropsychiatric disorders (such as bipolar disorder, depression, an anxiety disorder, schizophrenia, a seizure disorder, Parkinson's disease and attention deficit hyperactivity disorder), chronic fatigue syndrome, Crohn's disease, autonomic dysreflexia, and spasmogenic intestinal disorders.

A pharmaceutical composition includes a therapeutically effective amount of exo-R-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-S-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. Medical conditions are treated by administering a therapeutically effective amount of exo-R-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of its exo-S-mecamylamine, said amount being sufficient to ameliorate the medical condition. The medical conditions include but are not limited to substance addiction (involving nicotine, cocaine, alcohol, amphetamine, opiate, other psychostimulant and a combination thereof), aiding smoking cessation, treating weight gain associated with smoking cessation, hypertension, hypertensive crisis, Tourette's Syndrome and other tremors, cancer (such as small cell lung cancer), atherogenic profile, neuropsychiatric disorders (such as bipolar disorder, depression, an anxiety disorder, schizophrenia, a seizure disorder, Parkinson's disease and attention deficit hyperactivity disorder), chronic fatigue syndrome, Crohn's disease, autonomic dysreflexia, and spasmogenic intestinal disorders.

The invention relates to methods of administering pharmaceutical compositions and dosage forms comprising the sertindole derivatives nor-sertindole, 5-oxo-sertindole, dehydro-sertindole, and dehydro-nor-sertindol. The methods of the invention are directed to the treatment and prevention of neuroleptic and related disorders such as, psychotic disorders, depression, anxiety, substance addiction, memory impairment and pain.

This invention relates to compositions containing combinations of a balanced PC composition and one or more cannabinoids, a natural or synthetic derivative thereof, or a salt thereof, and kits containing such combinations and methods of using such combinations to treat subjects suffering from addiction to substances and related diseases or disorders. This invention also relates to the synergistic effect of such combination therapies in humans.

The invention pertains to systems and methods for preventing or reducing the probability of human addiction to various substances and/or treating those currently or previously addicted to substances. The invention includes a sensing mechanism to detect a presence of the addictive substance or a condition resulting from the presence of the addictive substance, a signaling mechanism to generate a signal as a result of the sensing mechanism detecting the presence of the addictive substance or a condition resulting from the presence of the addictive substance, and a receiving mechanism to provide at least one response as a result of receiving as input the signal generated by the signaling mechanism

The invention relates to an application of a lead compound namely L-corydalmine (L-CDL) of isoquinoline compounds on treating diseases related with addiction. The diseases comprise drug addiction (heroin, opium, methyl amphetamine, morphine, marihuana, cocaine, and the like), nicotine addiction, and alcohol addiction, and also comprise novel drug addiction (stimulant type novel drugs) and brain damage caused by novel drugs.

Disclosed herein are compounds of formula (I); as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, and methods of using these compounds for the treatment of substance addiction.

A pharmaceutical composition to be administered to mammals via the mucosal route consisting of a vehicle system comprising mono-/dietherglycerides conjugated with a water soluble polymer groups selected from PEG's containing 2-30 polyoxyethylene units, an antigen and optionally a bacterial toxin for the augmentation of immune responses for vaccination, immunisation, treatment of allergy, treatment of cancer, treatment of infectious disease, treatment of an autoimmune disease, Alzheimer's, substance addiction or the treatment of a disease which is fully or partially controlled by the body immune system.

The present invention provides methods for treating a substance addiction- related behavior in a patient with a substance addiction, comprising the step of locally administering a therapeutically effective amount of a botulinum neurotoxin to a location on the patient's body or in the vicinity of the area which comes into contact with a smoking tool or addictive substance, thereby altering, reducing or eliminating sensations associated with behaviors associated with substance addiction. Botulinum neurotoxin may be administered to a dermal, subdermal, mucosal or submucosal location or to a muscle area or in the vicinity of the location to which a smoking tool or addictive substance contacts.

The invention discloses an application of mTOR (mammalian Target of Rapamycin) serving as a target to screening of a medicament for treating nicotine addiction. The mTOR is taken as a target for preparing a medicament for treating nicotine substance addiction. An effective medicament acting target is provided for the treatment of symptoms such as nicotine substance addiction and excitability, and can be used for radically treating nicotine substance addiction.

The invention relates to a drug containing a heterocyclic system of a hexatomic ring with nitrogen as a heteroatom, in particular to an application of hirsutine in preparing a drug for preventing and treating opioid substance addiction or amphetamine substance dependence. The drug is composed of the hirsutine and a pharmaceutically acceptable auxiliary material, wherein, the hirsutine content is 5-85%. The drug is oral preparation such as a tablet or a capsule and the like.

The invention provides methods and compositions for treating opioid addiction by identifying patients at high risk of failing opioid agonist replacement therapy before therapy has begun. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

Disclosed are pharmaceutical compositions comprising a benzodiazepine, an alcohol aversive agent, and an abuse aversive agent, and methods of use in preventing alcohol or cocaine abuse.

The invention relates to a novel application of a high-selectivity 5-hydroxytryptamine 5-HT2C receptor agonist WAY163909. A molecular formula of the high-selectivity 5-hydroxytryptamine 5-HT2C receptor agonist WAY163909 is C14H18N2, the molecular weight is 214.30600, and the high-selectivity 5-hydroxytryptamine 5-HT2C receptor agonist WAY163909 is white powder and has good water solubility. The invention discloses the application of the high-selectivity 5-hydroxytryptamine 5-HT2C receptor agonist WAY163909 in preparation of medicines for inhibiting addiction and withdrawl reactions of opioid substances such as morphine, or the application in preparation of the medicines for inhibiting the addiction and withdrawl reactions of morphine substances. According to the novel application disclosed by the invention, the latest researches show that WAY163909 (0.5-1.0mg/kg) can be used for significantly reducing the horizontal movement distance, horizontal movement speed and the withdrawal reactions of mice after morphine-dependent mice are subjected to naloxone precipitation. The novel application disclosed by the invention discovers that WAY163909 can be used for rescuing and treating the addiction and withdrawl reactions produced by the opioid substances such as morphine in clinical treatment and can be used for treating the possible recurrences for the first time.

The present invention provides for the treatment of disorders related to TLR7/8 overexpression or abherrant activation, wherein the disorder is selected from multiple sclerosis, Alzheimer's Disease, myositis, stroke, ischemia, CNS neuropathies, systemic lupus erythematosus, lupus nephritis, Sjogren's syndrome, Guillain-Barr syndrome, alcoholic hepatitis, non-alcoholic steatohepatitis, congenital heart block, autoimmune hepatitis, autoimmune pancreatitis, adult onset Still's disease, drug-induced neurological disorders, and substance addiction, using a compound of Formula (I).

The invention provides methods for treating impulse control disorders in patients with catechol-o-methyl-transferase inhibitors. The invention also provides methods for treating patients with obsessive compulsive disorders and substance addictions with catechol-o-methyl-transferase inhibitors.

The present invention relates to 3-(1,2,3,6-tetrahydropyridin-2-yl)pyridine glutarate or a pharmaceutically acceptable solvate thereof, to a crystal thereof and to a polymorph of this crystal It further relates to the medicinal use of each of these, in particular in the treatment or prophylaxis of substance addiction or inflammation