5 results about "Neuronal regeneration" patented technology

In one aspect, the present disclosure provides nano and microstructures of conducting polymers which may be used in the treatment of neuron regeneration. In some embodiments, the microstructures may be a microcup or a nanogroove structure. The present disclosure also provides methods of preparing the conducting polymer coated microstructures and methods of using these compositions or structures.

The present disclosure provides new and innovative compositions of Neuronal regeneration-promoting cells (NRPCs), methods for generating NRPCs, and methods of treating subjects having damaged nerve cells using NRPCs. In an embodiment, the NRPCs are induced from tonsil-derived mesenchymal stem cells and express CD26, CD106, CD112, CD121a, and CD141, wherein CD121a has an expression level of about 30% or higher, the expression level measured immediately after thawing the NRPCs from a frozen state. Furthermore, the NRPCs are configured to promote formation of axons on neuronal cells.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

The invention belongs to the technical field of medicines, and relates to a 2, 4-disubstituted pyridine derivative, in particular to a compound as shown in a formula (II) and structural forms such as nitrogen oxides, isomers, solvates and pharmaceutically acceptable salts of the compound. Furthermore, the invention also discloses a preparation method and pharmaceutical application of the 2, 4-disubstituted pyridine derivative, and the 2, 4-disubstituted pyridine derivative can be used as a PI3Kalpha agonist and is used for preventing or treating PI3Kalpha activation-related body disorder and the like, including but not limited to heart protection of ischemia reperfusion injury, neuron regrowth after nerve injury and the like.

This disclosure provides novel and innovative compositions of neuronal regeneration-promoting cells (NRPCs), methods for generating NRPCs, and methods for treating subjects having damaged nerve cells using NRPCs. In one embodiment, the NRPCs are derived from tonsil-derived mesenchymal stem cells and express CD26, CD106, CD112, CD121a, and CD141, where CD121a has an expression level of approximately 30% or higher, and this expression level is measured immediately after thawing the NRPCs from a thawed state. Furthermore, the NRPCs are configured to promote axon formation on neuronal cells.