1results about How to "Avoid Oxidative Damage" patented technology

This invention provides a method for decolorizing a steroid intermediate dihydroxy compound, relating to the field of pharmaceutical and chemical technology. The method includes: dissolving the crude dihydroxy compound in a halogenated hydrocarbon solvent; adjusting the pH of the system to 8.0-9.5 with an inorganic base; adding an aqueous sodium hypochlorite solution for chemical oxidation decolorization while maintaining this pH value; determining the reaction endpoint by monitoring color change or redox potential; adjusting the pH after the reaction with a weak acid, followed by separation, concentration, and crystallization to obtain the final product. This invention utilizes the selective oxidation effect of sodium hypochlorite in a specific pH buffer system, replacing the traditional physical adsorption decolorization with activated carbon. While effectively removing fermentation pigments, it avoids the oxidative damage of the 11-hydroxyl group in the steroid skeleton. The product has high purity, produces no waste activated carbon solid waste, is simple to operate, and is easily scaled up industrially.