16 results about "Placenta extract" patented technology

The invention discloses an active exosome stent coating based on traditional Chinese medicine enhanced secretion promotion and a preparation method and application thereof, and belongs to the technical field of biological medicine and interventional instruments. The stent coating comprises exosomes, wherein the exosomes comprise myocardial cell active exosomes and human mesenchymal stem cell active exosomes which are intensified and secreted by traditional Chinese medicines; wherein the traditional Chinese medicines comprise placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, lycium ruthenicum peptide, cnidium lactone, curculigo orchioides extract and morinda officinalis extract; the intervention concentration of each component added into cells is 2-50 [mu] g / mL; the light-cured gel matrix is prepared from methacrylated gelatin, a photoinitiator and polyether 127; tacrolimus; the final concentration of the exosome is 1 * 10 < 9 >-12 * 10 < 9 > particles / mL, and the final concentration of the tacrolimus is 5-25 mu g / mL. The coating can be coated on the surface of the poly-L-lactic acid degradable stent to prepare the degradable stent, and has obvious vascular repair promoting capability.

The invention relates to the technical field of cosmetics, and discloses an umbilical cord blood moisturizing essence composition, an umbilical cord blood moisturizing essence as well as a preparation method and application of the umbilical cord blood moisturizing essence. The composition contains a hydrolyzed placenta extract, placenta protein, an umbilical cord extract, a guava fruit extract, a radix gentianae extract, decapeptide-4, nonapeptide-1, a lactobacillus fermentation product and a yeast fermentation product filtrate. The umbilical cord blood moisturizing essence prepared from the composition has multiple effects of moisturizing, repairing and resisting aging, and is mild, safe, excellent in stability and high in active ingredient retention rate.

The present invention discloses an active exosome scaffold coating based on traditional Chinese medicine enhanced secretion, its preparation method and application, belonging to the technical field of biomedicine and interventional devices. The scaffold coating of the present invention includes: exosomes, including cardiomyocyte active exosomes and human mesenchymal stem cell active exosomes enhanced by traditional Chinese medicine; wherein, the traditional Chinese medicine includes: placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, black wolfberry peptide, osthole, curculigo rhizome extract, and morinda officinalis extract; the intervention concentration of each component added to the cells is 2-50 μg / mL; a photocurable gel matrix, including methacrylated gelatin, a photoinitiator, and polyether 127; tacrolimus; the final concentration of exosomes is 1×10 9 ~12×10 9 particles / mL, and the final concentration of tacrolimus is 5-25 μg / mL. This coating can be coated on the surface of a poly-L-lactic acid degradable stent to prepare a degradable stent, which has obvious ability to promote blood vessel repair.

To provide a novel method of using a placenta extract, focusing on suppressing the growth of cancer cells.SOLUTION: The use of a placenta extract intends to suppress the growth of cancer cells. The use of a placenta extract also intends to provide the placenta extract as an active ingredient in a pharmaceutical preparation that suppresses the proliferation of cancer cells while allowing normal cells to proliferate.SELECTED DRAWING: Figure 1

This invention provides a method for producing odor-reduced placenta extract that virtually eliminates the characteristic odor contained in raw placenta that has been excreted. [Solution] A method for producing odorless placenta extract comprising an enzymatic decomposition step S02 in which an enzyme is added to the placenta that has been expelled late and enzymatic decomposition is performed, and a lactic acid bacteria decomposition step S03 in which lactobacilli are added to the placenta obtained in the enzymatic decomposition step S02 and lactic acid bacteria decomposition is performed.

The application discloses a biomass quantum dot enabled double-effect grading repair whitening and anti-aging mask formula and a preparation method thereof. The formula comprises a cleaning and anti-irritation mask and a functional mask. The cleaning and anti-irritation mask and the functional mask both comprise the following raw materials: water, glycerol, propylene glycol, butylene glycol, 1,2-hexanediol, 1,2-pentanediol, tripartite grass leaf / root extract, dandelion leaf extract, p-hydroxyacetophenone, radix stephaniae tetrandrae extract, ethylhexylglycerin, polysorbate-80, palmitoyl pentapeptide-4, ethanol, umbilical cord extract, phenoxyethanol, hydrolyzed placenta extract, palmitoyl tripeptide-1, sodium hyaluronate, hydroxyethyl cellulose, disodium hydrogen phosphate, sodium dihydrogen phosphate, polysorbate-60, sodium polyglutamate, tremella fuciformis fruiting body extract and biomass quantum dots. The biomass quantum dots are added in an amount of 0.5-1.2 parts by weight in the cleaning and anti-irritation mask and in an amount of 1.0-1.7 parts by weight in the functional mask.

The invention relates to a micromolecular sheep placenta extract, a preparation method thereof, a health food and a skin care product. The method comprises the following steps: acquiring a large number of synchronous pregnant goats by utilizing a synchronous estrus technology, taking out fetal goats through an operation when the goats are pregnant for 85-100 days, and taking body homogenate; and repeatedly freezing and thawing to crack the cells, and then carrying out high-temperature denaturation, disinfection and impurity protein precipitation. The method comprises the following steps: performing primary separation by utilizing high-speed centrifugation, then removing harmful substances and impurities such as macromolecular impure proteins, bacteria and endogenous viruses by adopting a 30KD ultrafiltration technology to obtain a pure micromolecular sheep placenta extract product, and further concentrating by using a 1KD ultrafiltration assembly. The micromolecular sheep placenta extract is mixed with other functional components such as sodium hyaluronate and collagen to prepare a product with the effects of maintaining beauty, keeping young, resisting fatigue and enhancing immunity, and the product can be used in the fields of health food, skin care products, wound healing products, scientific research and the like. No organic reagent is involved in the whole preparation process, active substances are reserved through low-temperature operation, and the preparation process is safe, environmentally friendly, low in energy consumption and easy for standardized and large-scale production.

The invention provides a soothing composition and application thereof. The soothing composition comprises a helichrysum italicum extract, rye plant placenta, a glycyrrhiza glabra root extract and a citrus peel extract. The helichrysum italicum extract, the rye plant placenta extract, the glycyrrhiza glabra root extract and the citrus peel extract are matched for use and have a synergistic effect, so that the expression of hyaluronidase and tyrosinase can be better inhibited, the generation of inflammatory factors can be inhibited, the generation of collagen can be promoted, the epidermis cohesion can be enhanced, and the optimal moisturizing state of skin can be maintained; the effect of strengthening the skin barrier for a long time is achieved.

The utility model relates to the technical field of placenta extract purification, and discloses a human placenta extract purifying and filtering device which comprises a bottom cabinet, a material box, a limiting elastic assembly and a carrying disc seat, the material box is fixedly installed on the bottom cabinet through a support, a box cover is fixedly installed at the top of the material box, a top frame is fixedly installed at the upper end of the box cover, and a limiting elastic assembly is fixedly installed at the lower end of the top frame. The limiting elastic assembly is arranged between the top frame and the tray carrying seat, a miniature vibration motor is fixedly installed at the upper end of the tray carrying seat, a rotating motor is fixedly installed at the bottom end of the tray carrying seat, a vertical shaft is fixedly connected to the driving end of the rotating motor, and the vertical shaft penetrates through the box cover and extends into the material box. According to the utility model, the extract can be subjected to double-layer centrifugal filtration treatment, so that the extract can be quickly and thoroughly filtered, and the purification efficiency and effect of the extract can be ensured.

The invention discloses an application of a sheep placenta extract in preparation of a medicine for improving polycystic ovarian syndrome, and relates to the technical field of biological medicine, the medicine is used for improving endocrine disorder and abnormal inflammation caused by the polycystic ovarian syndrome, and particularly for reducing the plasma androgen level and increasing the plasma estrogen level and the plasma progestational hormone level; the level of an inflammatory factor TNF-alpha is reduced, and the level of an inflammatory factor IL-10 is increased. The sheep placenta extract can improve ovarian polycystic lesions caused by polycystic ovarian syndrome (PCOS) in a targeted manner, and experiments show that after intervention of the sheep placenta extract, the number of macroscopic cystic follicles in rat ovary is reduced, the weight of the ovary with abnormal weight gain is remarkably reduced, the cystic follicle ratio in ovarian histopathology detection is greatly reduced, and the sheep placenta extract has a good application prospect. The ratio of the number of the corpus luteum is closer to normal, and the pathological injury of the polycystic ovarian syndrome is repaired from the organ level.

The present invention relates to a composition comprising a placenta extract for preventing or treating liver diseases and improving liver function. More specifically, by comprising a placenta extract, the present invention can reduce fat accumulation associated with fatty liver and reduce serum AST activity and ALT activity, and thus can exhibit a prophylactic or therapeutic effect on fatty liver diseases such as non-alcoholic fatty liver or alcoholic fatty liver, and can exhibit an effect of improving liver health.

The invention relates to the technical field of freeze-drying type anti-aging cosmetics, and discloses a composition for a double-dosage form freeze-drying essence, the double-dosage form freeze-drying essence and a preparation method and application of the double-dosage form freeze-drying essence. The composition contains a freeze-drying preparation mixture and an activation solvent mixture in a mass ratio of 1: (2-3), the freeze-drying preparation mixture contains a first main agent and a first auxiliary agent, and the first main agent contains 3-o-ethyl ascorbic acid, an animal umbilical cord extract, sodium hyaluronate, oligopeptide-1 and a hydrolyzed sheep placenta extract; the activating solvent mixture contains a second main agent and a second auxiliary agent, and the second main agent contains schizophyllacin and decapeptide-4. Through double-dosage-form isolation protection, a stepped freeze-drying process and facial three-dimensional network construction, the double-dosage-form freeze-drying essence provided by the invention has higher active component content, more stable performance and longer facial retention time.

The invention discloses a placenta injection ovary local puncture preparation under B ultrasound guidance and a preparation method of the placenta injection ovary local puncture preparation, and relates to the technical field of gynecological interventional diagnosis and treatment, and the placenta injection ovary local puncture preparation comprises the following components by weight: 30-80 parts of placenta extract; 5-20 parts of a stabilizer; 20-50 parts of an osmotic pressure regulator; 1-5 parts of a pH regulator; 0.5 to 2 parts of an antioxidant; and the balance of water for injection. The placenta extract is a mixed active component which is obtained after healthy human placenta is subjected to low-temperature enzymolysis and centrifugal purification and contains polypeptide, growth factors and nucleic acid, the content of the polypeptide is not lower than 1.2 mg / mL, and the content of epidermal growth factors is not lower than 50 pg / mL. The problems of unstable activity and poor local compatibility of a traditional preparation are solved, stimulation is reduced, and the storage period is prolonged; all links are optimized through a whole-process innovative preparation process, active ingredients are reserved to the maximum extent, pollution risks are reduced, batch-to-batch differences are reduced, and the preparation quality is guaranteed.

The application discloses a kind of ovine placenta essence medicinal liquor and preparation method thereof.The application includes the following steps: washing fresh ovine placenta, removing impurity hormone, removing volatile impurities, emulsifying peculiar smell protein, fibrosis peculiar smell protein, ovine placenta essence-yellow rice wine mixture stock solution, ovine placenta essence-yellow rice wine mixture stock solution flocculation impurity removal, mixed honey blending, and completing packaging.The raw materials used for preparing the ovine placenta essence-yellow rice wine mixture include 5 parts of fibrosed ovine placenta, 1-2 parts of Chinese wolfberry, 2-3 parts of red dates, 1-2 parts of fried licorice, 0.5-1 part of dried tangerine or orange peel, and 25-40 parts of yellow rice wine.The application uses ovine placenta as the main drug, extracts yellow rice wine, and combines other Chinese medicinal materials to assist in removing impurities and extracting ingredients, thereby preparing ovine placenta essence medicinal liquor, further enhancing the efficacy of ovine placenta, improving human immunity to prevent diseases, and assisting in the treatment of diseases.

The application belongs to the technical field of bioactive extract preparation, and discloses a preparation method of high-purity animal placenta extract with controlled enzymolysis and molecular weight, which comprises sequentially connected raw material low-temperature homogenization treatment, gradient temperature-controlled enzymolysis, transient mild enzyme inactivation, double-mode membrane fractionation for molecular weight control, low-temperature concentration, activity locking and sterile filtration. The application adopts a complex protease system matched with a segmented gradient temperature-controlled enzymolysis process, and combines a neutral mild pH environment of 6.3-7.8 to accurately control the enzymolysis site and degradation degree, completely solve the technical problems of uncontrollable enzymolysis, excessive degradation or insufficient degradation and excessive large molecule residue caused by single enzymolysis and extensive enzymolysis in the traditional process, and greatly improve the uniformity of the enzymolysis process, thereby guaranteeing the stable quality of the extract from the source and being beneficial to actual application and operation.

The invention relates to the technical field of exosome preservation, in particular to a method for improving exosome stability, which comprises the following preparation steps: a first preservation solution: adding 15% of ultrafiltration purified human plasma extract, 2% of novel saccharide derivative, 0.8% of functional amino acid combination and 0.05% of specific exosome active substance protective agent into a basic buffer solution; the second preservation solution is prepared by taking a special cell culture medium as a solvent and adding 25% of sheep serum, 4% of polysaccharide substances, 1.5% of trace element mixed solution and 0.1% of antioxidant polypeptide; the third preservation solution is prepared by utilizing a buffer system with specific osmotic pressure and pH value, and adding 30% of pig placenta extract, 6% of cyclodextrin derivative, 2% of protein stabilizer and 0.2% of enzyme activity protective agent aiming at enzymes possibly existing in the exosome; the stability of the exosome under different preservation conditions is effectively improved, and the requirements of the exosome in the fields of biomedical research, clinical diagnosis and treatment and the like are better met.