The invention discloses an application of a sheep
placenta extract in preparation of a
medicine for improving polycystic ovarian syndrome, and relates to the technical field of biological
medicine, the
medicine is used for improving endocrine disorder and abnormal
inflammation caused by the polycystic ovarian syndrome, and particularly for reducing the
plasma androgen level and increasing the
plasma estrogen level and the
plasma progestational
hormone level; the level of an inflammatory factor TNF-alpha is reduced, and the level of an inflammatory factor IL-10 is increased. The sheep
placenta extract can improve ovarian polycystic lesions caused by polycystic ovarian syndrome (PCOS) in a targeted manner, and experiments show that after intervention of the sheep
placenta extract, the number of macroscopic cystic follicles in rat
ovary is reduced, the weight of the
ovary with abnormal
weight gain is remarkably reduced, the cystic
follicle ratio in ovarian
histopathology detection is greatly reduced, and the sheep
placenta extract has a good application prospect. The ratio of the number of the
corpus luteum is closer to normal, and the
pathological injury of the polycystic ovarian syndrome is repaired from the organ level.