The invention discloses porous
polycaprolactone microspheres for tissue filling and a preparation method of the porous
polycaprolactone microspheres, and relates to the field of biomedical materials. The
microsphere is composed of
polycaprolactone, the
diameter of the
microsphere is 40-70 [mu] m, the
dispersion coefficient of the
microsphere is less than 5%, the
porosity of the microsphere is 55-85%, and the surface of the microsphere is provided with a uniform open pore structure formed by
tridecane. According to the preparation method, a microfluidic technology is adopted, a
tridecane-containing polycaprolactone
dichloromethane solution is taken as a dispersion phase, a
polyvinyl alcohol aqueous solution is taken as a continuous phase, an oil-in-water
emulsion is formed through microchannel shearing, and curing, washing and freeze-
drying are performed to obtain the
tridecane-containing polycaprolactone /
polyvinyl alcohol composite material. The microspheres disclosed by the invention have excellent monodispersity and a porous structure, and can remarkably promote
fibroblast proliferation and
collagen secretion and induce moderate
inflammatory response to activate tissue regeneration. The process is simple and controllable, and the obtained microspheres have injectability and a
tissue repair promoting function and have application prospects in the field of
soft tissue repair.