49 results about "Myocardial metabolism" patented technology

The invention relates to a botanical drug compound recipe for preventing and treating microwave radiation injury. According to the invention, it is found that botanical drugs mainly consisting of peony root, milkvetch root, duckweed and red sage root can be used for preparing a medicine used for preventing and treating microwave radiation injury. According to results of abundant experiments of detection of learning and memory capacity of rats, hippocampal amino acid neurotransmitters, sperm motility, the rate of teratosperm, myocardial metabolic enzyme (CK-MB, LDH and AST activity) and the content of Ca<2+> in serum of rats, the number of peripheral blood lymphocytes and the like, the medicine provided in the invention has an obvious treatment effect on injury to the brain, reproduction, the heart and immunity of rats caused by microwave radiation, and the effect is superior to that of medicines on the market.

The invention discloses a natural health-care plant beverage, particularly relates to a compound kudzu vine root beverage having effects of clearing away heat, removing toxicity, dispelling alcohol effect. The ompound kudzu vine root beverage consists of kudzu vine roots 6-15 parts, liquorice 3-9 parts, konjac flour 1-5 parts, gastrodia elata 1-5 parts and honeysuckle 1-5 parts. Total flavones and puerarin in the kudzu vine root have the effects of improving myocardial metabolism, expanding blood vessels, improving microcirculation and regeneration capability of hepatic cells, recovering liver functions, enhancing a detoxifying function of liver and preventing the liver from being damged, and the natural health-care functional beverage is produced by compounding konjac, the gastrodia elata, the honeysuckle and the liquorice which have high nutritional value. The beverage is good in taste and low in production cost. In addition, the beverage has the effects of reducing blood pressure, blood fat and blood sugar, clearing away heat and toxicity, dispelling alcohol effect, restoring consciousness and the like, is mainly used for relieving dizziness, lacking in strength, headache, regurgitation, vomiting and the like caused by drinking, and can accelerate alcohol oxidation, enables the alcohol to be free of toxicity, contract and protect gastric mucosa and slow down alcohol absorption.

The invention provides a preparation method and application of a myocardial metabolism PET imaging agent trans-2-(2-(5-(fluorine [18F]) tridecyl) cyclopropyl) acetic acid (a compound I for short). Comprising the following steps: a nucleophilic substitution reaction: mixing activated < 18 > F ions with a solution containing a compound I tert-butyl ester precursor, and carrying out the nucleophilic substitution reaction to obtain an intermediate product solution containing the compound I tert-butyl ester; and a tert-butyl ester group removal reaction: adding an acidic solvent into the intermediate product solution of the tert-butyl ester of the compound I, and carrying out the tert-butyl ester group removal reaction to obtain a product containing the compound I. The yield and the labeling rate are improved, and the radiochemical purity is high.

The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.

The invention discloses an NLARI heart rate module-based heart and an autonomic nerve function assessment method. Heart rate variation is modeled via a non-linearity autoregression integration model describing a random elastic system; and heart rate feature indexes and assessment reference range can be derived via parameter-quantization of relative functions of the heart and the autonomic nerve via the model. An assessment system formed by the heart rate feature indexes can be derived in internal-external environment of a cardiovascular system; cardiovascular system and autonomic nerve function assessment can be provided including myocardial metabolism and function, autonomic nerve system and humoral balancing adjusting functions, metabolism level and changes; and cardiogenic stroke death risk indexes can be also improved. Approximate algorithm or chip elements for frequency-domain analysis can be unnecessary, so the method is convenient and high-efficient; and the method integrates biological signal analysis technology and communication network technology, so the whole people health industry development can be promoted.

The microdialysis technique and device of the present invention can be used to study metabolic aspects of human and animal organs. When a microdialysis catheter is for example placed into the substance of a beating heart, there is always concern for problems with the catheter position. Further, there is always a risk for damage to heart tissue as well as to the catheter. The present invention is designed to avoid such damages, and a study has confirmed that data obtained from the epicardial probe of the present invention reflects the state of the myocardial metabolism. In anesthetized normoventilated pigs (n=20), a sternotomy was performed and a Gore-tex suture snare was placed around a branch of the left anterior descending (LAD) artery. One microdialysis probe was inserted in the myocardial tissue supplied by the snared LAD branch. Another microdialysis probe was placed on the epicardial surface above the myocardial probe. The protocol included four, ten minute ischemic periods (intervention group) followed by a forty minute ischemic period. The control group was only exposed to a forty minute ischemic period. It was possible to place the microdialysis probes of the present invention on the epicardial surface, and to recover samples reflecting the myocardial metabolic state of the heart. It was also possible to measure rapid changes in concentrations especially for lactate, where ischemia periods as short as ten minutes resulted in detectable increases. A similar pattern was found when analysing glucose and glycerol concentrations in paired samples. Data obtained from the device and method of the present invention, placed on the epicardial surface showed a similar pattern compared to data from a standard probe placed in the myocardium. Thus, the epicedial application of the present invention is useful for perioperative monitoring during cardiac surgery.

The invention discloses an establishing method of a rat atrial fibrillation model for simulating characteristics of human diseases. The establishing method comprises the steps that 1) an experimentalrat is raised to 35-45 weeks; 2) for the experimental rat, overload of the rat heart pressure is induced by cervical transverse aortic constriction, and a TAC model rat is formed; 3) after the transverse aortic constriction is carried out on the TAC model rat for 1-2 weeks, small animal ultrasonic treatment is conducted to detect a two-dimensional ultrasonic image and color Doppler flow image of blood vessels of a constriction part; 4) after the TAC model rat is constructed for 6-9 weeks, the inner diameter of the left atrium is detected through small animal ultrasonic treatment, the myocardial metabolism is detected by adopting PET, and the occurrence of atrial remodeling is verified; 5) after the transverse aortic constriction is carried out on the TAC model rat for 6-9 weeks, atrial fibrillation is induced through esophageal electrostimulation, a bioelectrical signal recorder is used for recording an electrocardiogram of the experimental rat body surface, and the rat atrial fibrillation model is obtained through verification. The constructed rat atrial fibrillation model can reflect the characteristics of the clinical human diseases, and the establishing method is simpler, moreconvenient, more economical and more efficient.

The invention discloses a method convenient for myocardial metabolism development. The method comprises the following steps of S1, determining a research population; S2, regulating blood sugar and performing developing; S3, evaluating image quality; S4, performing visual analysis; S5, performing quantitative analysis; S6, performing quantitative analysis on heart function and myocardial viability;and S7, performing counting. According to the method, trimetazidine can increase the glucose metabolism level of normal or ischemic myocardium of a diabetic patient to different extents, remarkably improve the image quality of 18F-FDG myocardial metabolism imaging (MMI), potentially improve the accuracy of gated PET quantitative parameter measurement, is safe and effective, and is combined with an oral glucose load/intravenous injection insulin method for use. Compared with a normal blood sugar hyperinsulinism holder technology, the method disclosed by the invention is more convenient to operate, and clinical application and popularization are facilitated.

The invention provides a preparation method and application of a liquid composition of a myocardial metabolism PET imaging agent trans-2-(2-(5-fluorine [18F] tridecyl) cyclopropyl) acetic acid (compound I for short), and the preparation method comprises the following steps: purifying a crude product containing the compound I by high performance liquid chromatography; wherein a mobile phase used in the high performance liquid chromatography purification step comprises ethanol and water. According to the present invention, the experiment process scheme is optimized, the use amount of the compound I tert-butyl ester precursor is changed, the reaction time for achieving the same labeling rate is shortened, the radioactivity of the initial 18F ion is improved, the labeling rate is improved, and the yield is improved.

The invention relates to a traditional Chinese medicine agent for treating the coronary heart disease and relates to the technical field of traditional Chinese medicines. The agent comprises components as follows: flos inulae, dwarf lilyturf tuber, Chinese magnoliavine fruit, ginseng, Chinese arborvitae kernel, safflower, cistanche, poria cocos, milkvetch root, common curculigo rhizome, eucommia bark, snakegourd fruit, human placenta, Chinese yam, danshen root, red date, Chinese angelica, liquorice root, epimedium herb, Chinese wolfberry, argy wormwood, albiziae cortex, amur cork-tree, red peony root and caterpillar fungus. The agent has effects of tonifying qi, nourishing yin, strengthening hearts and blood vessels, calming nerves, improving myocardial metabolism, enhancing cardiac functions, promoting blood circulation and adjusting blood pressure; meanwhile, the agent has functions of warming yang, alleviating water retention, activating blood, removing blood stasis, strengthening the hearts, promoting blood circulation, promoting diuresis and diminishing swelling; besides, the agent can increase the coronary blood flow and improve myocardial ischemia and anoxia so as to relieve stenocardia.

The invention discloses a preparation method of a traditional Chinese medicine with the effect of health care, which comprises the following steps: 1) cleaning and drying the Chinese medicinal materials; 2) mixing a part of the medicinal materials and putting them into a crusher for crushing; 3) putting the remaining medicinal materials into a In a frying pan, add an appropriate amount of water for decocting; 4) Divide the fine particles obtained by crushing in step 2) into equal parts, and then put them into step 3) and stir thoroughly; 5) Concentrate to 1/3 of the original volume. The antihypertensive health-care traditional Chinese medicine of the present invention, through the rational proportioning of each traditional Chinese medicine raw material, and utilizes the synergistic effect between each component, it has good curative effect to hypertensive patient, high safety and little side effect to human body, is beneficial to reduce myocardial Oxygen consumption, improve myocardial metabolism, enhance myocardial contractility, reduce blood viscosity, improve microcirculation disorders, and also prevent and treat stroke; among them, astragalus can strengthen the heart and diuresis, lower blood pressure and reduce urine protein, and improve kidney function.

The invention provides a method for establishing an acute plateau hypobaric and hypoxic myocardial injury animal model. The method comprises the following steps: firstly, setting three stages of altitude increasing, high altitude maintaining and altitude decreasing, simulating the altitude of 8500 meters, continuously operating for 216 hours, limiting the change rate of the simulated altitude to be 0.45 +/-0.04 m/s, enabling the air flow in a cabin to be stable, the air to be homogeneous and the oxygen content to be constant, and finally, obtaining the acute HAMI animal model. In addition, model-related characteristic change verification is carried out through 18F-FDG PET/CT myocardial metabolism imaging and small animal cardiac ultrasound in combination with FITC-BSA vascular leakage experiments, special staining of myocardial pathology and other means. According to the method for establishing the acute plateau hypobaric and hypoxic myocardial injury animal model, an optimization device and related specific parameter conditions required by modeling are defined, characteristic description is carried out on the model through a multi-mode combined verification means, and the animal model which is stable, reliable and capable of being continuously observed is provided for related research in the field.

The invention discloses a hypoglycemic traditional Chinese medicine with a health-care function. The hypoglycemic traditional Chinese medicine comprises the following raw materials in parts by weight:parasitic loranthus, cyclocarya paliurus, momordica grosvenori, stevia rebaudiana, mulberry, ligusticum wallichii, achyranthes bidentata, prunella vulgaris, dogbane leaves, Bidens pilosa L., nacre mother-of-pearl, gastrodia elata, radix puerariae, radix scrophulariae, rhizoma alismatis, spina date seeds, oriental wormwood, concha haliotidis, herba siegesbeckiae, radix paeoniae rubra, cortex moutan, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma atractylodis macrocephalae, radix astragali, lumbricus, radix gentianae, radix rehmanniae, dried radix rehmanniae, rhizoma anemarrhenae, cortex phellodendri, radix polygoni multiflori, rhizoma curcumae and flos sophorae. According to the invention, through reasonable matching of the traditional Chinese medicine raw materials and the synergistic effect of all the components, the hypoglycemic traditional Chinese medicine is good in curative effect on hypertension patients, high in safety, small in side effect on human bodies and beneficial to reduction of myocardial oxygen consumption, improvement of myocardial metabolism, enhancement of myocardial contractility, reduction of blood viscosity, and improvement of microcirculation disturbance and prevention and treatment of apoplexy. The radix astragali can strengthen heart, promote diuresis, reduce blood pressure, reduce urine protein and improve kidney functions.

The invention discloses application of hydrogen-enriched myocardium protecting liquid to preparation of medicines for treating myocardial damage. According to the application of the hydrogen-enrichedmyocardium protecting liquid to the preparation of medicinefor treating the myocardial damage, disclosed by the invention, an animal experiment proves that the hydrogen-enriched myocardium protectingliquid has good relieve functions on myocardial contraction dysfunction caused by the myocardial damage and oxygen radical variation caused by the myocardial damage when being used for treating an experimental dog, and the experimental dog treated by the hydrogen-enriched myocardium protecting liquid is capable of effectively reducing generation of myocardium metabolite caused by the myocardial damage, so that the hydrogen-enriched myocardium protecting liquid can be used as the medicine for treating the myocardial damage.

The invention relates to a medicine for treating myocarditis. The medicine is prepared from a traditional Chinese medicine part and a western medicine part; the traditional Chinese medicine part comprises 20g of poria cocos, 15g of cassia twig, 15-20g of astragalus membranaceus, 10-15g of codonopsis pilosula, 10-15 g of caulis spatholobi, 9-12 g of loranthus parasiticus, 6-9 g of peach kernel, 6-9g of safflower, 10-15 g of angelica sinensis, 10-15 g of atractylodes macrocephala, 15-20 g of rhizoma alismatis, 10-15 g of fingered citron, 10-15 g of allium macrostemon, 10-12 g of trichosanthes kirilowii, 8-12g of fried jujube kernel, 10-12g of semen boitae, 6-9g of radix sophorae flavescentis, 9-12g of poria with hostwood and 9g of liquorice root; the western medicine part comprises vitaminB12, coenzyme A, inosine and cytochrome C. when the medicine is used for a patient with myocarditis caused by viral infection, antibiotics and vitamin C should be added. The above six western medicines have the effects of improving myocardial metabolism, sterilizing and inhibiting bacteria. The traditional Chinese and western medicine method is adopted for treating myocarditis, the treatment effect directly reaches the focus, and the recurrence rate is low.

The invention relates to the field of traditional Chinese medicine compositions, and concretely relates to a sustained-release pellet preparation for treating chronic congestive heart failure, and a preparation method thereof. The sustained-release pellet preparation comprises American ginseng, astragalus membranaceus, radix paeoniae rubra, rehmannia, radix ophiopogonis, schisandra chinensis and cassia twig. Based on traditional Chinese medicine theories and a prescription provided by experiences, in combination with achievements of traditional Chinese medicine research in modern medicine, essence of famous ancient prescriptions such as middle-Jiao and Qi tonifying decoction, honey-fried licorice root decoction and pulse-activating powder and research achievements of novel anti-myocardial-injury medicine Xinrong are absorbed, and the sustained-release pellet preparation which takes improvement of myocardial cells and whole body metabolism by a heart strengthening method as a treatment rule and has remarkable effects in the aspects of treating chronic heart failure, resisting myocardial injury, improving myocardial metabolism, improving cardiac pump functions and the like is formed.

The invention provides traditional Chinese medicine capsules for treating a coronary heart disease and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicinecapsules are prepared from the following components: radix rehmanniae praeparata, fructus corni, herba cistanches, processed radix aconiti carmichaeli, radix ginseng, radix ophiopogonis, fructus schisandrae chinensis, cassia twig, liquorice root, radix angelicae sinensis, radix astragali seu hedysari, radix et rhizoma salviae miltiorrhizae, sandalwood, fructus amomi, rhizoma chuanxiong, fructus crataegi, honeysuckle flower, radix scrophulariae, radix rehmanniae, rhizoma seu radix notopterygii and velvet antler. The traditional Chinese medicine capsules can be used for tonifying qi and nourishing yin, strengthening heart and activating pulse and calming the heart and tranquilizing the mind, can be used for improving the myocardial metabolism and enhancing the heart function and have the effect of promoting blood circulation and regulating blood pressure. Meanwhile, the traditional Chinese medicine capsules have the effects of warming yang to promote diuresis and promoting blood circulation and removing blood stasis, and have the effects of strengthening the heart, promoting the blood circulation, promoting diuresis and eliminating swelling. Furthermore, a coronary blood flow can beincreased and myocardial ischemia and anoxia are improved to alleviate angina pectoris.

The invention discloses a traditional Chinese medicine health-care component capable of enhancing immunity. The traditional Chinese medicine health-care component comprises the following raw materialsin parts by weight: parasitic loranthus, anoectochilus roxburghii, dried ginger, liquorice, mulberry, ligusticum wallichii, achyranthes bidentata, prunella vulgaris, dogbane leaf, sticktight, nacre mother of pearl, gastrodia elata, kudzuvine root, radix scrophulariae, rhizoma alismatis, spina date seed, oriental wormwood, concha haliotidis, herba siegesbeckiae, radix paeoniae rubra, cortex moutan, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma atractylodis macrocephalae, radix astragali, lumbricus, radix gentianae, radix rehmanniae, dried rehmannia root, rhizoma anemarrhenae, cortex phellodendri, radix polygoni multiflori, rhizoma curcumae, flos sophorae, flos chrysanthemi, lily and rhizoma arisaematis. According to the invention, through reasonable matching of the traditionalChinese medicine raw materials and the synergistic effect of all the components, the traditional Chinese medicine health-care component is good in curative effect on hypertension patients, high in safety, small in side effect on human bodies and beneficial to reduction of myocardial oxygen consumption, improvement of myocardial metabolism, enhancement of myocardial contractility, reduction of blood viscosity, improvement of microcirculation disturbance and prevention and treatment of apoplexy. The radix astragali can strengthen heart, promote diuresis, reduce blood pressure, reduce urine protein and improve kidney functions.

The invention discloses a nutrition powder capable of improving anorexia. The nutrition powder comprises dextrose, chicken's gizzard-membrane powder, poria cocos powder, reed rhizome powder, Chinese yam powder, hawthorn fruit powder, snow pear powder and dietary fibers. The nutrition powder contains rich protein, fat, carbohydrate, vitamins, minerals and dietary fibers, is good in color, aroma, taste and mouth feel, is beneficial for human body to absorb, can stimulate sense organs of consumers, promote appetite and improve anorexia, and can improve the oxygen metabolism of myocardium and generate beneficial effects on myocardial metabolism under the combined action of a plurality of the contained vitamins. Meanwhile, the nutrition powder can dilate blood vessel, improve microcirculation,reduce blood vessel resistance and increase blood flow, can not only resist eye aging and stimulate brains cells, but also significantly resist dysmnesia caused by scopolamine, is beneficial to enhancing brains and the memory of the human body, can well improve dysgnosia, poor memory and senile dementia, is comprehensive in nutrients, green, safe, and convenient to eat, and can be widely applied to food production and processing industry.

The invention discloses a health-care traditional Chinese medicine capable of decreasing internal heat and relaxing bowels. The health-care traditional Chinese medicine comprises the following raw materials in parts by weight: parasitic loranthus, cyclocarya paliurus, momordica grosvenori, stevia rebaudiana, prunella vulgaris, dogbane leaves, sticktight, nacre mother-of-pearl, gastrodia elata, radix puerariae, radix scrophulariae, rhizoma alismatis, spina date seeds, oriental wormwood, concha haliotidis, herba siegesbeckiae, radix paeoniae rubra, cortex moutan, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma atractylodis macrocephalae, radix astragali, lumbricus, radix gentianae, radix rehmanniae, dried rehmannia root, rhizoma anemarrhenae, cortex phellodendri, radix polygoni multiflori, rhizoma curcumae, flos sophorae, flos chrysanthemi, bulbus lilii and rhizoma arisaematis. According to the invention, through reasonable matching of the traditional Chinese medicine raw materials and the synergistic effect of all the components, the health-care traditional Chinese medicine is good in curative effect on hypertension patients, high in safety, small in side effect on human bodies and beneficial to reduction of myocardial oxygen consumption, improvement of myocardial metabolism, enhancement of myocardial contractility, reduction of blood viscosity, improvement of microcirculation disturbance and prevention and treatment of apoplexy. The radix astragali can strengthen heart, promote diuresis, reduce blood pressure, reduce urine protein and improve kidney functions.