106results about How to "Fast removal rate" patented technology

The invention discloses an antibody coupling drug targeting on EGFR, a preparation method thereof and uses thereof. The antibody-conjugated drug targeting EGFR is named LR004-VC-MMAE consisting of anantibody, a cytotoxic drug and a linker, wherein the antibody drug conjugate has a structure represented by the formula I, wherein mAb is an LR004 monoclonal antibody, n=2-8. The novel antibody-conjugated drug LR004-VC-MMAE can not only target EGFR antigen, but also has strong cytotoxicity to tumor cells. Compared with LR004 itself, it did not affect the affinity, endocytosis and targeting of theantibody, and better retained its biological function. Compared to LR004, the antitumor effect of LR004-VC-MMAE antibody-conjugated drug is significantly improved, and the tumor disappeared. Comparedto LR004, LR004-VC-MMAE antibody-conjugated total antibody showed longer half-life, slower clearance rate, lower concentration of free MMAE in plasma, shorter half-life and faster clearance rate, which is conducive to reduce toxicity.

The mixed defatting stove includes one stove body with a solvent inlet in the lower part and connected via a pump to a solvent storage device, a solvent outlet, a protecting gas inlet in the lower part, a gas exhaust port in the upper part, a solvent vapor inlet in the upper part and connected to solvent distiller, and has a heater on the side wall of the stove body, a blower on the upper part of the stove body to homogenize gas inside the stove, and an atomizer on the upper part of the stove and connected via a pump to a catalytic defatting acid storing device outside the stove body. The mixed defatting stove may meet the requirement of different defatting processes, including single or simultaneous solvent defatting, vapor defatting, condensed vapor defatting, catalytic defatting and siphonic defatting.

The invention discloses a method for rapidly and stably starting a wastewater nitrite type mixotrophic desulfurization and denitrification system. The method comprises the following steps: controlling ecological factors in stages by virtue of a three-step method, respectively creating an anaerobic environment favorable for improving the activities of sulfur-autotrophic nitrate microbes, mixotrophic nitrate microbes and mixotrophic nitrite microbes, and promoting rapid formation of different functional floras, so that the complexity of the micro flora is reduced. According to the start method disclosed by the invention, stable operation of the desulfurization and denitrification process under high load conditions is promoted, the starting time is reduced, the stability of the system is enhanced, and after the system is started, the removal rate of sulfides and nitrite can rapidly reach 100 percent, the removal rate of the organic matters can be over 90 percent, the yield of elemental sulfur is high and is always over 80 percent, subsequent high-efficiency recovery of the elemental sulfur is promoted, and the wastes are recycled.

The invention discloses a processing method for ultrathin plain glass based on consolidated abrasive, which is characterized by comprising the following steps: firstly, taking ground plain glass of which the thickness is less than or equal to 0.5mm as a raw material; secondly, adopting a polishing pad of diamond consolidated abrasive of which the granularity is less than or equal to 28 micrometers, controlling the polishing temperature to 20-40oC, polishing pressure of 100-1000g/cm<2>, pH value of a polishing solution of 8-11, flow velocity of 100-500ml/min and polishing rotation speed of 10-500r/min to obtain a middle glass product of which the thickness is 0.2-0.3mm; thirdly, polishing the polishing pad of diamond consolidated abrasive of which the granularity is less than or equal to 10 micrometers, controlling the polishing temperature to 20-40oC, polishing pressure of 100-500g/cm<2>, pH value of a polishing solution of 8-11, flow velocity of 100-500ml/min and polishing rotation speed of 10-300r/min; and putting the middle glass product onto a polisher to polish to obtain ultrathin glass of which the thickness is less than or equal to 0.15mm. The processing method has the advantages of simple process, no pollution, high efficiency and low cost, and size material with a larger length or width and thickness ratio can be processed.

The invention discloses a semiconductor chip photo-electro-chemical mechanical polishing machining method and device. A chip is fixedly bonded to a polishing head through electrically-conductive adhesive. The lower portion of the chip is connected with a positive pole of an external power source through wires at an inner ring and an outer ring of an electrically-conductive sliding ring. A polishing pad is bonded to the bottom of a counter electrode disc. The counter electrode disc is fixed to the bottom of a polishing disc, and a through hole is machined in the position, corresponding to the polishing disc, of the counter electrode disc. The counter electrode disc is connected with a negative pole of the external power source through wires at the inner ring and the outer ring of an electrically-conductive sliding ring located above the counter electrode disc. Ultraviolet light transmitted by an ultraviolet light source can be cast to the surface of the chip through the through hole. Apolishing solution can be sprayed into the through hole and enter the contact area of the chip and the polishing pad. By means of the photo-electro-chemical mechanical polishing machining device, themachining method can be well implemented; the machining device has the advantages that the device is easy to operate and implement, and technological parameters can be flexibly adjusted; and the effects that in the practical machining process of the gallium nitride chip, the removal rate is high, and the surface quality achieved after machining is high are achieved.

The invention provides a binuclear platinum (II)-diphosphonic acid coordination compound, a preparation method and an application thereof, and belongs to the field of anti-cancer drugs. The binuclear platinum (II)-diphosphonic acid coordination compound has the structural formula shown in the description, wherein n is 2, 3, 4 or 5. The preparation method of the binuclear platinum (II)-diphosphonic acid coordination compound comprises the following steps: diphosphonic acid derivative and Pt(en)(OSO3)(H2O) are reacted under the function of Ba(OH)2 to obtain the binuclear platinum (II)-diphosphonic acid coordination compound. According to the compound, a link arm of C between diphosphonates is expanded; quinary aromatic amine (namely imidazole) is introduced in, so that at the initial usage stage of the coordination compound, the coordination compound has high intake in tumour cells and long residence time; and the aggregation concentration of the coordination compound in other non-targeted tissues is greatly reduced.

The invention discloses a device and method for removing ammonia nitrogen, nitrite nitrogen and COD in marine culture wastewater. A water inlet is formed in the top end of an impounding reservoir of the device and communicated with a water outlet in the upper end of an electrochemical reactor, and a water outlet is formed in the lower end of the impounding reservoir and connected with a water inlet in the lower end of the electrochemical reactor. An anode, a bipolar electrode and a cathode are sequentially arranged in the electrochemical reactor through a peristaltic pump, the anode is connected with a positive electrode of a direct-current stabilized power supply, and the cathode is connected with a negative electrode of the direct-current stabilized power supply. A chemical agent does not need to be added, and thus treatment cost can be greatly reduced; free chlorine is constantly generated in situ at the anode, and thus safety performance is improved; the treatment process is clean and quick, and sludge and secondary pollution are avoided; the ammonia nitrogen, nitrite nitrogen and COD removing speed is high, and efficiency is high; only the current size needs to be controlled, and thus control is easy; the device is simple and convenient to operate and maintain.

The invention discloses a sewage treatment system which comprises a grating, a grit tank, a preaeration tank, an anaerobic tank, an anoxia tank, an aerobic tank and a secondary sedimentation tank. Sewage enters the grit tank after being treated by the grating, water discharged from the grit tank sequentially enters a biological treatment unit composed of the anaerobic tank, the anoxia tank and the aerobic tank to be treated, obtained mixed liquid enters the secondary sedimentation tank, two outlets are arranged on the secondary sedimentation tank, one outlet is a discharging port of treated sewage, and the other outlet is a discharging port of surplus sludge. A bypass is arranged on the discharging port of the surplus sludge, and one part of the surplus sludge discharged from the secondary sedimentation tank flows back to the preaeration tank through a sewage backflow pump. Simultaneously, one part of the mixed liquid from the aerobic tank flows back to the anoxia tank through a mixed liquid backflow pump on the bypass. The sewage treatment system has the advantages of being high in nitrobacterium activity, high in nitrification rate, high in ammonia nitrogen removing rate and the like.

The invention discloses a [<18>F] AlF marked positron emission tomography (PET) polypeptide probe and a preparation method thereof. The probe comprises TMTP1 polypeptide and NOTA, which are connected together, and the structural formulae of the TMTP1 polypeptide and the NOTA are shown in the description. According to the [<18>F] AlF marked positron emission tomography (PET) polypeptide probe and the preparation method thereof, a glycine is added to the TMTP1, and a G-TMTP1 polypeptide is designed, so that the polypeptide does not influence the biological activity after being radioactively marked; furthermore, 18F is taken as a radionuclide, and the G-TMTP1 polypeptide is marked by utilizing a [<18>F] AlF-NOTA method, so that the obtained [<18>F] AlF-marked PET polypeptide probe has excellent pharmacokinetics properties, the background cleaning rate is high, the liver uptake rate is low, in-vivo stability is good, the uptake rate of tumor site is high, highly metastatic tumor can be diagnosed specifically, and the polypeptide probe can be applied to diagnosis or therapeutic evaluation of highly metastatic malignant tumor.

Described herein is an etching solution suitable for both tungsten-containing metals and TiN-containing materials, which comprises: water; and one or more than one oxidizers; and one or more than one of the components selected from the group consisting of: one or more fluorine-containing-etching compounds, one or more organic solvents, one or more chelating agents, one or more corrosion inhibitors and one or more surfactants.

The invention relates to a technology for purifying and treating ammonia-nitrogen wastewater by using an adsorption method and particularly relates to an adsorbent, a preparation process thereof and an application of the adsorbent to the purification of ammonia-nitrogen wastewater with medium-low concentration. An iron-plated woodchip adsorbent provided by the invention is composed of woodchips and Fe(OH)3. The preparation process comprises the following steps of: washing woodchips by using water for 1-3 times to remove impurities, drying, crushing and screening to ensure that the mass percentage of the woodchips with the particle sizes of 198-350mum is larger than or equal to 80%; subjecting a FeCl3 solution with the concentration of 0.15-0.25mol/L and a NaOH solution to reaction to generate a Fe(OH)3 suspension liquid; and then, sufficiently mixing the screened woodchips and the Fe(OH)3 suspension liquid according to the solid-to-liquid ratio of 0.6-1.0g/10mL, carrying out hydrothermal treatment at the temperature of 30-50 DEG C for 1.5-3h, washing a product by using water until the product is neutral, carrying out suction filtration, and drying the product. When the adsorbent is used for purifying the ammonia-nitrogen wastewater with medium-low concentration, the removal rate of NH4<+>-N is larger than or equal to 90%, and the removal rate of COD (Dissolved Organic Carbon) is larger than or equal to 75%.

A cleaning method for MOCVD (Metal Organic Chemical Vapor Deposition) equipment comprises the following steps: feeding cleaning gas to a reaction chamber of the MOCVD equipment; processing the cleaning gas into plasma through a plasma processing device; increasing the temperature of the inner wall of the reaction chamber to 50 to 250 DEG C; and utilizing the plasma of the cleaning gas to clean the inner wall of the reaction chamber at the temperature of 50 to 250 DEG C. When the cleaning method is adopted, residual sediment on the inner wall of the MOCVD reaction chamber can be removed automatically, the plasma of the cleaning gas causes no damage to the inner wall of the MOCVD reaction chamber, and less time is spent in cleaning.

The invention designs novel 18F labeled p-nitro benzoyl amino acid derivatives. The derivatives are characterized in that one end of the derivatives is provided with 2-fluorine 18-4-nitro benzoyl structure, and the other end of the derivatives is provided with alpha-amino acid derivative structure (derived group R2 is methoxyl group, methylamino group and N,N-dimethylamino group respectively); and substituent R1 is positioned on an alpha site of carbonyl group and is hydrogen, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, benzyl group, 2-methylthio-ethyl group, carboxyethyl group, carboxypropyl group, phenyl or imidazole methyl group. The structures at two ends are directly connected through amido bond. The structure of the derivatives is shown in a formula A. The compounds are simple to synthesize, fast to label, large in the amount of initial absorption and slow to clear in tumor tissue, low in uptake or fast to clear in other normal tissue and blood and high in degree of distinguishing tumor from background. The invention also relates to the application of the compounds serving as a PET brain tumor imaging agent. R2=OMe, HNCH3.

The invention relates to a bone-seeking 99mTc-IPrDP coordination compound, belonging to the fields of radiopharmaceuticals and nuclear medicine. The structural formula of the bone-seeking 99mTc-IPrDP coordination compound is shown in the specification. The preparation method of the coordination compound is as follows: mixing ligand IPrDP, reducing agent, pH buffer solution and pertechnetic acid (99mTcO<4->) solution to react to obtain an IPrDP coordination compound labeled by technetium-99m. The 99mTc-IPrDP coordination compound is used for nuclear medical diagnostic imaging. Through comparison, the product provided by the invention has the advantages of good product specificity, high bone/tissue intake (Am, bone) (% ID/g) and (Am, bone/Am, blood) and good tissue clearance rate, thus being expected to become novel bone imaging agent.

The invention belongs to the technical field of environmental functional nano materials, and discloses a magnetic mesoporous polydopamine composite material with a core-shell structure as well as a preparation method and application of the magnetic mesoporous polydopamine composite material. The preparation method comprises the steps of by taking magnetic nanoparticles as an inner core, a triblockpolymer as a template agent and an organic pore-enlarging agent as an auxiliary template agent, carrying out in-situ oxidative polymerization on dopamine monomers on the surfaces of the magnetic nanoparticles under a weakly alkaline condition to form the magnetic mesoporous polydopamine composite material with the core-shell structure. The preparation method is simple in process, the obtained nano composite material has high specific surface area and pore volume, a large-size mesoporous structure, biocompatibility and strong magnetism, the adsorption capacity of the nano composite material toheavy metal chromium can reach 522.74 mg/g when the nano composite material is used as an adsorption material, and the nano composite material has the characteristics of high adsorption rate, high removal rate and the like, can be recycled, and can be widely applied to the field of environmental governance.

The invention belongs to the technical field of inorganic nanofiber materials, discloses a flexible aluminum-magnesium composite oxide nanofiber membrane, a preparation method thereof and an application thereof in the field of environmental treatment and repair, and particularly suitable for the field of heavy metal adsorption. According to the flexible aluminum-magnesium composite oxide nanofibermembrane, an aluminum source and a magnesium source are used as raw materials, yttrium salt is used as a doping agent, acid is used as a hydrolysis catalyst, at least one of polyvinylpyrrolidone andpolyoxyethylene is used as a spinning assistant, and xerogel fibers are obtained in a solvent system by combining a sol-gel method with an electrostatic spinning technology and then subjected to segmental calcination to obtain the membrane. The flexible aluminum-magnesium composite oxide nanofiber membrane prepared by combining the sol-gel method with the electrostatic spinning technology has theadvantages of large specific surface area, high porosity, excellent mechanical property and good flexibility, has the characteristics of high adsorption rate, high removal rate and the like as an adsorption material, avoids the defects of easy agglomeration, difficult recovery and the like of a powder adsorbent, and can be applied to the field of environmental treatment and repair.

The invention relates to a method for removing VOCs (Volatile Organic Chemicals) through a microwave radiation synergistic double-liquid phase biological filtering tower. According to the method, a microsyringe and an electromagnetic air compressor are respectively connected with a microwave radiation device inlet through pipelines; a thermocouple is accessed to an Fe3O4 wave absorption material of a microwave radiation device; a biological tower bottom gas inlet is connected with a microwave radiation device outlet; one end of a double-liquid phase spraying system is connected with a sprayingliquid inlet at the top of a biological filtering tower; nutrient substances are provided to microorganisms in the biological filtering tower from a double-liquid phase spraying liquid flowing in; acontainer in which the double-liquid phase spraying liquid is stored and a metering pump for providing power to a double-liquid phase spraying pipeline are arranged at the other end of the double-liquid phase spraying system; the microsyringe and the air compressor are powered on, then VOCs are mixed with the air, and at the same time a vacuum air sucking pump is powered on. By adopting the method, the biological filtering removal capacity is increased, and waste gases with relatively large VOC concentrations can be relatively rapidly removed.

The invention constructs recombinant plasmid vector containing tumstatin T7 peptide and gene sequence of derivative T7-NGR thereof and obtains recombinant T7 peptide and T7-NGR fusion protein. The amino acid sequence of the derivative T7-NGR is TMPFLFCNVNDVCNFASRNDYSYWLGSCNGRCVSGCAGRC. The invention combines the generation activity of tumstatin T7 peptide for restricting the tumor neovascularization effectively and high specificity of NGR guide peptide, so as to lead the generation activity of T7 peptide for restricting the tumor neovascularization to be greatly strengthened. The recombinant cloned vectors are respectively identified by sequencing: the direction, position and sequence of integration are correct. The expression vector is transformed into competent E.coli BL21 (DE3) and then is expressed by the induction of IPTG; electrophoresis is carried out on the thalli after cracking; and by Western-Blot identification, the expression product is in accordance with the expected. The pET7N expression vector fusion protein T7-NGR has potential application prospect in the diagnosis and treatment of tumor.

The invention relates to the technical field of single crystal material polishing, and discloses a single crystal material polishing device and polishing method based on inductively coupled plasma. The single crystal material polishing device based on inductively coupled plasma comprises: a rectangular tube, wherein the rectangular tube comprises a first generating tube, a second generating tube arranged outside the first generating tube and a third generating tube arranged outside the second generating tube; an inert gas supply device in communication with the second generation pipe and the third generation pipe; an etching gas supplying device in communication with the first gas generating tube; a spark generator in communication with the torque tube; an inductor coil, wherein an outletof a torque tube is arranged in the inductor coil and is connected with a radio frequency power supply. The single crystal material polishing method based on inductively coupled plasma of the presentinvention is based on the polishing device. The single crystal material polishing device and polishing method based on the inductively coupled plasma body of the invention have the advantages of fastremoval rate, no introduction of sub-surface damage, no need for grinding slurry and no need for post-cleaning.