[<18>F] AlF marked positron emission tomography (PET) polypeptide probe and preparation method thereof

A labeling and probe technology, applied in the field of radiolabeled compounds, can solve the problems of unsatisfactory pharmacokinetic properties, large changes in polypeptide activity, and poor in vivo stability, and achieve excellent pharmacokinetic properties, high tumor site uptake, and clearance rate. quick effect
CN104725473AInactive Publication Date: 2015-06-24THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIV
Publication Date
2015-06-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a [<18>F] AlF marked positron emission tomography (PET) polypeptide probe and a preparation method thereof. The probe comprises TMTP1 polypeptide and NOTA, which are connected together, and the structural formulae of the TMTP1 polypeptide and the NOTA are shown in the description. According to the [<18>F] AlF marked positron emission tomography (PET) polypeptide probe and the preparation method thereof, a glycine is added to the TMTP1, and a G-TMTP1 polypeptide is designed, so that the polypeptide does not influence the biological activity after being radioactively marked; furthermore, 18F is taken as a radionuclide, and the G-TMTP1 polypeptide is marked by utilizing a [<18>F] AlF-NOTA method, so that the obtained [<18>F] AlF-marked PET polypeptide probe has excellent pharmacokinetics properties, the background cleaning rate is high, the liver uptake rate is low, in-vivo stability is good, the uptake rate of tumor site is high, highly metastatic tumor can be diagnosed specifically, and the polypeptide probe can be applied to diagnosis or therapeutic evaluation of highly metastatic malignant tumor.
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Description

technical field

[0001] The invention belongs to the field of radiolabeled compounds, in particular to a [ 18 F] AlF labeled PET polypeptide probe and its preparation method. Background technique

[0002] According to the current development trend of cancer, the incidence of cancer worldwide will increase by 50% in 2020, and the number of new cancer patients in the world will reach 15 million each year (the World Health Organization recently published "World Cancer Report"). Early detection and early treatment of tumors is the most effective way to reduce the mortality of cancer patients. At present, in developing countries, 80% of cancer patients are only discovered in the late stages of cancer. Tumor metastasis is an important biological characteristic of malignant tumors. It is the main reason for the failure of tumor treatment and the main cause of death of tumor patients. About 70% of the newly diagnosed cancer patients can control their disease through surgery, adjuva...

Claims

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