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Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof

A technology for arrhythmia and angina pectoris, applied in the field of traditional Chinese medicine compositions, can solve problems such as large toxic side effects, high treatment costs, and repeated illnesses

Active Publication Date: 2009-01-14
广东宏兴集团股份有限公司宏兴制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many Chinese and Western patent medicines for the treatment of cardiovascular and cerebrovascular diseases in the market, but most of them are not ideal. Although most of them have a certain therapeutic effect, some have relatively large toxic and side effects, and some have high treatment costs.

Method used

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  • Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof
  • Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof
  • Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the preparation of pill

[0059] Take 1500 parts by weight of Panax notoginseng, crush it into coarse powder, reflux extract with 80% ethanol, filter, concentrate the filtrate under reduced pressure until it has no ethanol smell, adjust the pH to 6.0 with 20% hydrochloric acid solution, leave it overnight, filter, and use the filtrate Extract by diethyl ether shaking, discard the diethyl ether, extract with n-butanol saturated with water, combine the n-butanol solution, recover n-butanol under reduced pressure, dry in vacuum at 60°C, and make Panax notoginseng saponins for later use; take buffalo horn thin slices, add 8 times the amount of water, decocted twice, each time for 8 hours, combined the decoction, filtered, the filtrate was concentrated into a thick paste, and dried at 80°C to obtain a buffalo horn dry extract for later use; take 1500 parts by weight of Panax notoginseng and musk 5 Parts by weight, 40 parts by weight of Calculus Calculus, 200 pa...

Embodiment 2

[0060] Embodiment 2: the preparation of capsule

[0061] Take 9000 parts by weight of Panax notoginseng, crush it into coarse powder, reflux extract with 50% ethanol, filter, concentrate the filtrate under reduced pressure until it has no ethanol smell, adjust the pH to 6.0 with 30% hydrochloric acid solution, leave it overnight, filter, and use the filtrate Extract by diethyl ether shaking, discard the diethyl ether, extract with n-butanol saturated with water, combine the n-butanol solution, recover n-butanol under reduced pressure, and dry it in vacuum at 80°C to make Panax notoginseng saponins for later use; take buffalo horn thin slices, add 8 times the amount of water, decocted twice, each time for 10 hours, combined the decoction, filtered, the filtrate was concentrated into a thick paste, and dried at 80°C to obtain a buffalo horn dry extract for later use; take 6000 parts by weight of Panax notoginseng and musk 5 Parts by weight, 40 parts by weight of Calculus Calculu...

Embodiment 3

[0062] Embodiment 3: the preparation of tablet

[0063] Take 6000 parts by weight of Panax notoginseng, crush it into a coarse powder, extract it with 80% ethanol under reflux, filter, concentrate the filtrate under reduced pressure until it has no ethanol smell, adjust the pH to 6.0 with 20% hydrochloric acid solution, leave it overnight, filter, and use the filtrate Extract by diethyl ether shaking, discard the diethyl ether, extract with n-butanol saturated with water, combine the n-butanol solution, recover n-butanol under reduced pressure, dry in vacuum at 60°C, and make Panax notoginseng saponins for later use; take buffalo horn thin slices, add 8 times the amount of water, decocted 3 times, 8 hours each time, combined the decoction, filtered, the filtrate was concentrated into a thick paste, and dried at 80°C to obtain a buffalo horn dry extract for later use; take 9000 parts by weight of Panax notoginseng and musk 20 Parts by weight, 40 parts by weight of Bezoar Bezoar...

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Abstract

The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating coronary heart disease, angina pectoris, arrhythmia and hyperlipidemia and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, arrhythmia, and hyperlipidemia are the number one killers that endanger human health and life worldwide. In my country alone, 3 million people die of cardiovascular and cerebrovascular diseases every year, averaging every 10 seconds One person died, first in line. Cardiovascular and cerebrovascular diseases have the characteristics of high morbidity, high mortality, high disability rate, and high recurrence rate. For patients with cardiovascular and cerebrovascular diseases, they have the characteristics of repeated and continuous medication. There are many Chinese and Western patent medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/16A61K9/20A61K9/48A61P3/06A61P9/06A61P9/10A61K31/045A61K31/575A61K35/32A61K35/413A61K35/55A61K35/56A61K35/618A61K35/65
Inventor 李志勇张惜强赖怀恩苏和明郑少鑫
Owner 广东宏兴集团股份有限公司宏兴制药厂
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