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Application of hydrogen-enriched myocardium protecting liquid to preparation of medicine for treating myocardial damage

A technique for myocardial protection and myocardial injury, applied in the field of medicine, can solve the problems such as the application of hydrogen that has not yet been reported, and achieve the effects of good changes in oxygen free radicals, reduction of the production of myocardial metabolites, and alleviation of changes in oxygen free radicals.

Inactive Publication Date: 2018-05-11
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of hydrogen in the preparation of drugs for the treatment of myocardial injury has not been reported

Method used

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  • Application of hydrogen-enriched myocardium protecting liquid to preparation of medicine for treating myocardial damage
  • Application of hydrogen-enriched myocardium protecting liquid to preparation of medicine for treating myocardial damage
  • Application of hydrogen-enriched myocardium protecting liquid to preparation of medicine for treating myocardial damage

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Experimental program
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Effect test

Embodiment 1

[0031] 1. Animal experiments

[0032] Experimental animals: Experimental dogs (female, 8-12 weeks), purchased from Nanjing Institute of Biomedicine and Shanghai Slack Experimental Animal Co., Ltd. All animal experiments were approved by the Animal Ethics Committee of the Second Military Medical University.

[0033] Take 30 experimental dogs, female, and randomly divide them into 5 groups:

[0034] Sham operation group: the experimental dogs only underwent thoracotomy without transfer to cardiopulmonary bypass, and left ventricular anterior wall myocardial tissue and serum were collected after 6 hours;

[0035] IR group: mainly for conventional cardiopulmonary bypass heart surgery, the bypass time is more than 6 hours, and the myocardial protection solution is used in the past;

[0036] Hydrogen-rich myocardial protection solution 5mL / kg treatment group: add sterile hydrogen-saturated normal saline at a concentration of 5mL / kg to the extracorporeal circulation myocardial prote...

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PUM

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Abstract

The invention discloses application of hydrogen-enriched myocardium protecting liquid to preparation of medicines for treating myocardial damage. According to the application of the hydrogen-enrichedmyocardium protecting liquid to the preparation of medicinefor treating the myocardial damage, disclosed by the invention, an animal experiment proves that the hydrogen-enriched myocardium protectingliquid has good relieve functions on myocardial contraction dysfunction caused by the myocardial damage and oxygen radical variation caused by the myocardial damage when being used for treating an experimental dog, and the experimental dog treated by the hydrogen-enriched myocardium protecting liquid is capable of effectively reducing generation of myocardium metabolite caused by the myocardial damage, so that the hydrogen-enriched myocardium protecting liquid can be used as the medicine for treating the myocardial damage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a hydrogen-rich myocardial protection solution in the preparation of medicine for treating myocardial injury. Background technique [0002] Hydrogen (H 2 ) is an anti-oxidant gas present in the human body, non-toxic and cheap, and it is easy to operate by drinking hydrogen-rich water. In recent years, it has been reported that hydrogen has great potential in the prevention and treatment of diseases. Numerous experiments have been carried out to confirm the properties of hydrogen, showing antioxidant, anti-apoptotic, anti-inflammatory and anti-allergic effects among other properties of the gas. According to reports, after adding hydrogen-rich water to the brain slices of mice for observation for 33 days, it was found that compared with the control, the formation of superoxide could be significantly reduced. In a rat periodontitis model study, it was found th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61P9/00A23L33/10
CPCA23V2002/00A61K33/00A23L33/10A23V2200/326A23V2250/12
Inventor 张宇峰陆雯静李伟王志农奚望殷亮王擎
Owner SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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