150 results about "Autonomic Drugs" patented technology

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, plant extracts, botanicals, nutraceuticals, cosmeceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis

The composition of Chinese patent medicine for curing cardio-cerebral vascular diseases comprises (wt%) 82-87% of bran and coarse grain, 13-18% of plant medicinal material for curing cerebrovascular disease and microscale of saccharifying enzyme and lactobacillin, which is characterized by that the composition of said plant medicinal material comprises (wt%) 28-37% of main medicinal material, 23-30% of secondary medicinal materials, 27-41% of auxiliary medicinal material and 5-7% of flavouring material, and its preparation method includes the following steps: selecting materials, pulverizing,mixing, steaming, cooling, inoculating, showering, sterilizing, filtering, inspection, packaging and putting in storage.

The invention belongs to the technical field of plant drugs, and particularly relates to a method for extracting danshensu with high-purity from Salvia miltiorrhiza, which comprises the following steps: extracting solution is extracted from the Salvia miltiorrhiza medicine material containing danshensu by using a hot dripping method; the pH value of the extracting solution is adjusted by acid, the impurities are cleared and concentrated in a pressure reducing way; the eluting is carried out by using a macro porous adsorption resin and the danshensu is enriched; then concentration is carried out at low temperature, freezing and drying are carried out into solid; finally, ethanol is used for heating and dissolving, and the filter liquor is concentrated at low temperature after being filtered and precipitated, a crystallization is precipitated and the danshensu is obtained and the purity of the danshensu is more than 90 percent. The method for extracting danshensu with high-purity from Salvia miltiorrhiza has simple technology, high extracting efficiency, little pollution and low production cost, which can be controlled and is suitable for mass production.

The present invention related to safe plant drug for treatment of liver disease, specifically, this invention proves a safe plant drug Schisandrin and its preparation. Schisandrin has the following pharmaceutical functions: increasing tumor suppresson genes express activity, decreasing activity of oncogenes, increasing immune function, increasing liver DNA synthesis, decreasing serum alamine aminotransferase activity, increasing glutathione level, increasing glutathione reductase activity, decreasing lipid peroxidation of liver, increasing hepatic microsomal monooxygenases activity, increasing ATP content in liver, increasing energy metabolism activity, decreasing density lipoprotein oxidation, protecting gastrointestinal function, increasing killer cell activity, increasing complement activity, decreasing induced liver cancer activity and decreasing grown of cancer cells.

The invention discloses a process for preparing hirudin by using blood- suction leeches, as well as its use, the preparing process consists of pulping leeches, formulating suspension and drying. The substance can be prepared into capsules, soft capsules, granules and tablets. The obtained medicament can be used for treating cardiovascular and cerebrovascular diseases including cerebral apoplexy, hypertension, hyperlipemia and coronary disease.

The invention discloses a Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on the metabonomics and a research method, which relates to a research method for a natural plant medicine action mechanism. The invention aims at solving the problems that the existing single pharmacology method cannot systematically and comprehensively evaluate the action mechanism of the natural plant medicine. The method comprises the following steps: (1) detecting and analyzing a urine metabolite of a diabetic rat after being induced by streptozotocin and intervened by rubus suavissimus; (2) selecting nine rubus suavissimus antidiabetic related urine potential markers, and identifying the potential markers; and (3) selecting six metabolic pathways of the rubus suavissimus for resisting the diabetics, and analyzing. By adopting the Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway and the research method, the antidiabetic action mechanism of the rubus suavissimus can be more comprehensively, efficiently, rapidly and integrally evaluated without deviation, and evidence can be provided for the description and further development of the national medicine action mechanism.

The invention provides a rosin type diterpene derivative as well as a preparation method and application thereof. The derivative is a compound with structure shown in a general formula I, II or III which is shown in the description or an addition salt formed by the compound and an acid or an alkali which is acceptable in pharmacy, wherein R1 is hydrogen, hydroxyl or alkoxy or acyloxy of C1-C3; R2 is saturated or unsaturated alkyl of C1-C3, oxygen-containing alkyl of C1-C3 or acid of C1-C3 and ester or salt of the acid; the derivative is prepared in the way that Clerodendrum bungei as a labiatae clerodendrum plant is used as a raw material and subjected to solvent extraction, and column chromatography separation and purification. According to the invention, on the basis that the rosin type diterpene derivative is obtained through separation, the fact that the compound has the function of suppressing the expression of SREBP is confirmed, a lead compound is provided for developing medicines capable of treating dyslipidemia, and important significance on the development of new application of natural products and botanical drugs is achieved.

An antineoplastic 'actinidine' in the form of coated tablet, capsule, mixture, softgel, particle, injection, or liposome is prepared from the root of lianoid pear through decocting, concentrating, filtering, chromatography with macroreticular resin, eluting by organic solvent, chromatography, concentrating, absorbing by polyamide, eluting and concentrating.

A method of producing a phytomedicinal therapeutic for the prevention and control of a disease selected from the group consisting of obesity, cardiovascular disease, and diabetes, and conditions related thereto is provided which comprises extracting peanut shells with a solvent, removing a substantial portion of the solvent to produce a concentrated extract. Phytomedicinal compositions are provided that comprise an effective amount of at least one coumarin compound or one coumarin derivative derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL). Phytomedicinal compositions are provided that comprise at least an effective amount of coumarin derivatives (6,7-dihydroxycoumarin-esculetin, and esculetin-like compounds). A method for the prevention and / or treatment of treatment of a condition selected from the group consisting of obesity, cardiovascular disease, and diabetes, is provided which comprises administering a composition comprising an effective amount of at least one coumarin derivative, including 6,7-dihydroxycoumarin (esculetin), derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL).

A composite vegetative medicine for decreasing blood sugar and blood fat and treating diabetes is prepared from 3 plants including saccate narra, roughhair fig, etc and Cr, V and Zn. Its preparing process and its quality control method are also disclosed.

This invention relates to the field of drug discovery. Specifically, it describes a method (“Inverted Drug Screening” or “IDS™”) of identifying therapeutics from ethnobotanical (EB) preparations by repeatedly fractionating and testing fractions from EB sources. One aspect of the invention relates to quinic acid derivatives (e.g., derivatives of 3,5-dicaffeoyl quinic acid) for the treatment of respiratory syncytial virus (RSV) infection.

The present invention relates to the use of a therapeutically effective amount of cannabidiolic acid (CBDA) in the treatment of epilepsy. In one embodiment the CBDA is used in the treatment of generalised seizures, preferably tonic-clonic seizures. Preferably the CBDA used is in the form of a botanical drug substance in which the CBDA content is greater than 60%, and most preferably, it is a highly purified extract of cannabis such that the CBDA is present at greater than 95%, through 96% and 97% to most preferably, greater than 98% of the total extract (w / w) and the other components of the extract are characterised. In particular the cannabinoids tetrahydrocannabinol (THC) or tetrahydrocannabinol acid (THCA) have been substantially removed. Alternatively, the CBDA may be synthetically produced.

The invention relates to a botanical drug compound recipe for preventing and treating microwave radiation injury. According to the invention, it is found that botanical drugs mainly consisting of peony root, milkvetch root, duckweed and red sage root can be used for preparing a medicine used for preventing and treating microwave radiation injury. According to results of abundant experiments of detection of learning and memory capacity of rats, hippocampal amino acid neurotransmitters, sperm motility, the rate of teratosperm, myocardial metabolic enzyme (CK-MB, LDH and AST activity) and the content of Ca<2+> in serum of rats, the number of peripheral blood lymphocytes and the like, the medicine provided in the invention has an obvious treatment effect on injury to the brain, reproduction, the heart and immunity of rats caused by microwave radiation, and the effect is superior to that of medicines on the market.

The present invention provides a delivery system for active and functional ingredients. In particular, the delivery systems of the present invention find particular application in the delivery of active and functional ingredients, such as medicaments, pharmaceuticals, nutritional supplements, botanicals, cosmeceuticals etc. Further, the invention relates to a delivery system for oral or topical administration of such active and functional ingredients. The invention is a delivery system based on a particulate gel precursor that acts both as the bodying agent,as well as the dispersing and suspending agent in the formulation. By modifying the level of precursor and process conditions, a broad range of product consistencies can be achieved ranging from thin liquid suspension to firm or semi solid gel. The precursor gel is a particulate linear chain fuctan gel. Inulin is a preferred fructan.

This invention relates to new safe botanical drug, which is used for treatment and prevention of influenza and increasing immune function. Specifically, this invention provides a method for producing pure Banlangensu (PBLG), BLG's Polysaccharide and Isatin B.

A detection method of blood plasma danshensu and salvianolic acid B of dissipating blood stasis botanical is disclosed. The method includes: (1) pretreating mammalian plasma sample: applying the plasma with medicine to small column of Waters Oasis HLB activated by methanol and water; after leaching and eluting, drying and enriching the eluent; after redissolving with mobile phase, measuring by UPLC / MS; (2) UPLC / MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C18, 2.1′100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v / v / v, mobile phase B: acetonitrile-formic acid 100:0.1 v / v; MS condition: electric spraying ion source (ESI), detecting with negative ion mode, scanning at the range of m / z 150-800. The method can be used for pharmacokinetics study of danshensu and salvianolic acid B in dissipating blood stasis botanical.

The invention discloses a medicine for treating tracheitis and bronchitis and a preparation method thereof. The natural botanical drugs chosen by the invention comprise peucedanum root, white mulberry bark, loquat leaf, bitter apricot seed, ephedra, baikal skullcap root, etc. The medicine of the invention has the efficacies of clearing away the lung-heat to purge heat, resolving phlegm to relieve cough, preventing asthma and sending down abnormally ascending. Tests and studies indicate that the medicine of the invention has obvious anti-infectious effects on the infection of mice caused by staphylococcus aureus and has obvious inhibitory action on ear dwelling caused by xylene and on leg dwelling of rats caused by 1% carrageenin, which indicates that the medicine has obvious anti-inflammatory action; in addition, the medicine of the invention has obvious effects on relieving cough, resolving phlegm and relieving asthma, which can be used for treating tracheitis and bronchitis in clinical practice.

The invention belongs to the field of biological engineering, and particularly relates to a method for improving the content of betulin and oleanolic acid in a birch cell by utilizing MeJA (methyl-jasmonate) and SA (salicyl acid), which comprises the following steps of: inoculating a birch tissure culture seedling stem to NT + 0.1 mg / L of 6-BA and 0.01 mg / L of TDZ culture mediums to induce birch callus, and obtaining a birch suspension cell with high content of total triterpenes through multi-time subculture, screening and suspension culture; inoculating the screened cell into the same liquid culture medium, wherein the inoculation amount is 3g / 100ml; adding 100mu Mum / L of MeJA and 50mg / L of SA when the shake culture is performed at the seventh day; after 24-48h, obtaining the product; and detecting the content of total triterpenes, betulin and oleanolic acid in the cell. Through the comparison of the two kinds of processing methods, the content of total triterpenes is improved by 21.6-31.7%, the content of oleanolic acid is improved by 277.4-369.34%, and the content of betulin is improved by 44.42-179.58%. The application of the invention provides a new path for solving the problem of shortage of natural plant drug resources and realizing large-scale industrial production of betulin and oleanolic acid drugs.

The invention relates to a method for simultaneously determining 5 alkaloids in Sini agent vegetable drug plasma, which comprises the following steps: (1) taking medicated plasma of a mammal given Sini agent vegetable drugs, adding bulleyaconitine A (interior label), alkalifying with ammonia water, scrolling, adding ethyl acetate for extraction, scrolling, centrifugating, extracting the subnatant with ethyl acetate twice, merging the ethyl acetate layers, blow-drying with nitrogen, and dissolving the residue with a mobile phase; and (2) HPLC-MS-MS (high performance liquid chromatograph-mass spectrometer-mass spectrometer) determination: the mobile phases comprise a phase A acetonitrile-0.1% glacial acetic acid (1:99, v / v) and a phase B acetonitrile-water (99:1, v / v); the mass spectrometer conditions are as follows: electric spray ion source (ESI) and cation detection mode; and the detection ions are as follows: aconitine m / z 646.3->586.3, mesaconine m / z 632.3->572.3, hypaconitine m / z 616.3->556.3, benzoylmesaconine m / z 590.3->558.3, and benzoylaconine m / z 604.3->554.3. The method is suitable for pharmacokinetic research of aconitine, hypaconitine, mesaconine, benzoylmesaconine and benzoylaconine in Sini agent vegetable drugs in a mammal.

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-90 wt% and medicinal supplementary material the rest. The medicine is prepared into tablet, coated tablet, oral controlled release preparation, capsule, etc. and is used in treating hyperlipemia, atherosclerosis, coronary heart disease and other cardiac and cerebral vascular diseases.

The invention discloses a navel paste for treating mammary gland hyperplasia diseases. The navel paste is prepared by processed polygala root, Chinese angelica, curcuma zedoary, frankincense, rhizoma cyperi, radix angelicae, schizonepeta spike, costus root, mint, jasmine, trichosanthes kirilowii Maxim, Astragalus mongholicus, radix curcumae, peach kernel, root of red-rooted salvia, sangusis draconis, borneol and muskone. The preparation method comprises the following steps of grinding all the medicines, except from the muskone and the borneol, into fine power of 80-150 meshes, adding the ground fine muskone and the borneol after honey preparing, and then evenly mixing in the paste subjected to honey preparing, and preparing the externally applied navel paste with each packet of 5-8g. The navel paste mainly aims at etiology and pathogenesis of the mammary gland hyperplasia diseases; the guiding ideologies of the treatment plan are based on activating blood circulation and removing blood stasis, resolving hard lumps, removing stasis and detumescence, and eliminating stagnation to stop pain. The selected medicines are natural plant medicines, and have the functions of eliminating breast lumps and enhancing the resistance; and the navel paste is exact in curative effect, fast in effect, free of toxic and side effect, high in cure rate through clinical verification, reasonable in used medicines and scientific in compatibility.

A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, whirling 3-5 mins, centrifugating at 9600 rpm for 10 mins, drying and enriching the upper layer at 25-30° C., and redissolving with mobile phase; (2) UPLC / MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C18, 2.1′100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v / v / v, mobile phase B: acetonitrile-formic acid 100:0.1 v / v; MS condition: electric spraying ion source(ESI), detecting with positive ion mode, scanning at the range of m / z 150-1200. The method can be used for pharmacokinetics study of schizadrin B in dissipating blood stasis botanical.

The invention provides a method for detecting contents of 14 non-volatile components in a dragon tiger Rendan mini-pill vegetable drug by liquid chromatography-LCQ ion trap mass spectrometry. The method comprises the following steps: firstly preparing a test solution and a control solution, and respectively detecting according to the following method: introducing a sample to a Thermo BDS Hypersil C18 chromatographic column according to the sample size of 1-20 microliters, controlling column temperature to 20-40 DEG C, carrying out gradient elution with a mobile phase composed of a phase A and a phase B at the speed of 0.2-1.5 mL / min according to an established procedure, simultaneously detecting an eluant by the liquid chromatography-LCQ ion trap mass spectrometry to obtain ion chromatograms of a test sample medicine and a control medicine, and detecting each component and its content through comparison of the chromatograms. The phase A of the mobile phase is pure water containing 0.005-0.015% of formic acid (containing 0.2mM of ammonium formate), and the phase B is acetonitrile.

The present invention relates to compositions comprising the botanicals from the Family Ranunculaceae, Subclass: Dicotyledonae; Crassinucelli, Superorder: Ranunculales. Examples of these botanicals include but are not limited to; Actaea, Anemone, Ranunculus, and Nigella, or extracts thereof, which are useful in treating liver diseases, particularly those with viral etiology. More specifically, the compositions of the present invention are derived from various botanicals or medicinal plants. The compositions of the invention have demonstrated outstanding efficacy for treatment of patients with hepatic disorders. Compositions of the present invention have also exhibited immunomodulatory activities. The preferred compositions contain the botanical ingredients in concentrations of not less than 20% w / v. The treatment can be therapeutic or prophylactic and may be administered orally, parenterally, as suppository or via nasal mucosa. The treatment may be delivered in a single dose, multi-doses or via a slow release mechanism.

An antineoplastic Chinese medicine especially for treating cancers is prepared from 5 Chinese-medicinal materials including asafetide, aspongopus, Chinese caterpillar fungus, turmeric, etc. Its preparing process is also disclosed.

The invention provides a method for determining the contents of six volatile components in vegetable drugs of Longhurendan by using a gas chromatography-triple quadrupole mass spectrometry technology. The method comprises the following steps: firstly, preparing a test sample solution and a comparison product solution; detecting according to the following method respectively: feeding a sample into a VF-WAXms capillary tube chromatographic column according to the sample feeding amount of 1-10 microliters, wherein carrier gas is helium gas; adopting a program temperature rising method: maintaining an initial temperature of 60-90 DEG C for 1-2 minutes; raising the temprature to 240-260 DEG C by the temperature rising speed of 25-50 DEG C of each minute and maintaining for 1 minute, wherein the temperature of a sample feeding hole is 240-260 DEG C, the flow is not split, the flow speed is 2.5mL / min, the solvent delaying is 4 minutes and 2 microliters of the samples are fed, thereby obtaining ion chromatograms of test sample drugs and comparison product drugs; and determining all components and contents of all the components through spectrum contrast.

The invention provides a medicament for treating idiopathic edema and a preparation method thereof. The medicine contains pure natural plant drugs of angelica, radix bupleuri, atractylis ovata, Alisma orientale, radix paeoniae alba, tuckahoe, grifola, rhizoma cyperi, motherwort, trumpetweed, cassia twig, and the like. In the medicament, the angelica breaks extravesated blood, nourishes new blood and relaxes vain to eliminate dampness; radix bupleuri, tuckahoe and Alisma orientale soothes liver and strengthens spleen for inducing diuresis to alleviate edema; the atractylis ovata, grifola, and the like, invigorates qi and strengthens the spleen, clears damp and promotes diuresis and blood circulation, and recuperates the body function; the plant drugs are combined to free liver qi and strengthen the spleen, smooth collaterals, avoid moisten, and eliminate edema, so as to ensure the effect of sooth liver and strengthen spleen, smooth collaterals and induce diuresis. Research shows that the medicament has the pharmacological actions of inducing diuresis, reducing capillary permeability, improving microcirculatory disturbance and increasing immunologic function, and the like, treats idiopathic edema etiologically and semeiologically, and has the advantages and characteristics of multiple levels and treatment on principal and subordinate of traditional Chinese medicine.