136 results about "Autonomic Drugs" patented technology

The composition of Chinese patent medicine for curing cardio-cerebral vascular diseases comprises (wt%) 82-87% of bran and coarse grain, 13-18% of plant medicinal material for curing cerebrovascular disease and microscale of saccharifying enzyme and lactobacillin, which is characterized by that the composition of said plant medicinal material comprises (wt%) 28-37% of main medicinal material, 23-30% of secondary medicinal materials, 27-41% of auxiliary medicinal material and 5-7% of flavouring material, and its preparation method includes the following steps: selecting materials, pulverizing,mixing, steaming, cooling, inoculating, showering, sterilizing, filtering, inspection, packaging and putting in storage.

The invention belongs to the technical field of plant drugs, and particularly relates to a method for extracting danshensu with high-purity from Salvia miltiorrhiza, which comprises the following steps: extracting solution is extracted from the Salvia miltiorrhiza medicine material containing danshensu by using a hot dripping method; the pH value of the extracting solution is adjusted by acid, the impurities are cleared and concentrated in a pressure reducing way; the eluting is carried out by using a macro porous adsorption resin and the danshensu is enriched; then concentration is carried out at low temperature, freezing and drying are carried out into solid; finally, ethanol is used for heating and dissolving, and the filter liquor is concentrated at low temperature after being filtered and precipitated, a crystallization is precipitated and the danshensu is obtained and the purity of the danshensu is more than 90 percent. The method for extracting danshensu with high-purity from Salvia miltiorrhiza has simple technology, high extracting efficiency, little pollution and low production cost, which can be controlled and is suitable for mass production.

The invention discloses a Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway based on the metabonomics and a research method, which relates to a research method for a natural plant medicine action mechanism. The invention aims at solving the problems that the existing single pharmacology method cannot systematically and comprehensively evaluate the action mechanism of the natural plant medicine. The method comprises the following steps: (1) detecting and analyzing a urine metabolite of a diabetic rat after being induced by streptozotocin and intervened by rubus suavissimus; (2) selecting nine rubus suavissimus antidiabetic related urine potential markers, and identifying the potential markers; and (3) selecting six metabolic pathways of the rubus suavissimus for resisting the diabetics, and analyzing. By adopting the Guangxi rubus suavissimus antidiabetic potential marker metabolic pathway and the research method, the antidiabetic action mechanism of the rubus suavissimus can be more comprehensively, efficiently, rapidly and integrally evaluated without deviation, and evidence can be provided for the description and further development of the national medicine action mechanism.

The invention provides a rosin type diterpene derivative as well as a preparation method and application thereof. The derivative is a compound with structure shown in a general formula I, II or III which is shown in the description or an addition salt formed by the compound and an acid or an alkali which is acceptable in pharmacy, wherein R1 is hydrogen, hydroxyl or alkoxy or acyloxy of C1-C3; R2 is saturated or unsaturated alkyl of C1-C3, oxygen-containing alkyl of C1-C3 or acid of C1-C3 and ester or salt of the acid; the derivative is prepared in the way that Clerodendrum bungei as a labiatae clerodendrum plant is used as a raw material and subjected to solvent extraction, and column chromatography separation and purification. According to the invention, on the basis that the rosin type diterpene derivative is obtained through separation, the fact that the compound has the function of suppressing the expression of SREBP is confirmed, a lead compound is provided for developing medicines capable of treating dyslipidemia, and important significance on the development of new application of natural products and botanical drugs is achieved.

An antineoplastic 'actinidine' in the form of coated tablet, capsule, mixture, softgel, particle, injection, or liposome is prepared from the root of lianoid pear through decocting, concentrating, filtering, chromatography with macroreticular resin, eluting by organic solvent, chromatography, concentrating, absorbing by polyamide, eluting and concentrating.

A method of producing a phytomedicinal therapeutic for the prevention and control of a disease selected from the group consisting of obesity, cardiovascular disease, and diabetes, and conditions related thereto is provided which comprises extracting peanut shells with a solvent, removing a substantial portion of the solvent to produce a concentrated extract. Phytomedicinal compositions are provided that comprise an effective amount of at least one coumarin compound or one coumarin derivative derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL). Phytomedicinal compositions are provided that comprise at least an effective amount of coumarin derivatives (6,7-dihydroxycoumarin-esculetin, and esculetin-like compounds). A method for the prevention and/or treatment of treatment of a condition selected from the group consisting of obesity, cardiovascular disease, and diabetes, is provided which comprises administering a composition comprising an effective amount of at least one coumarin derivative, including 6,7-dihydroxycoumarin (esculetin), derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL).

A composite vegetative medicine for decreasing blood sugar and blood fat and treating diabetes is prepared from 3 plants including saccate narra, roughhair fig, etc and Cr, V and Zn. Its preparing process and its quality control method are also disclosed.

The invention relates to a botanical drug compound recipe for preventing and treating microwave radiation injury. According to the invention, it is found that botanical drugs mainly consisting of peony root, milkvetch root, duckweed and red sage root can be used for preparing a medicine used for preventing and treating microwave radiation injury. According to results of abundant experiments of detection of learning and memory capacity of rats, hippocampal amino acid neurotransmitters, sperm motility, the rate of teratosperm, myocardial metabolic enzyme (CK-MB, LDH and AST activity) and the content of Ca<2+> in serum of rats, the number of peripheral blood lymphocytes and the like, the medicine provided in the invention has an obvious treatment effect on injury to the brain, reproduction, the heart and immunity of rats caused by microwave radiation, and the effect is superior to that of medicines on the market.

The present invention provides a delivery system for active and functional ingredients. In particular, the delivery systems of the present invention find particular application in the delivery of active and functional ingredients, such as medicaments, pharmaceuticals, nutritional supplements, botanicals, cosmeceuticals etc. Further, the invention relates to a delivery system for oral or topical administration of such active and functional ingredients. The invention is a delivery system based on a particulate gel precursor that acts both as the bodying agent,as well as the dispersing and suspending agent in the formulation. By modifying the level of precursor and process conditions, a broad range of product consistencies can be achieved ranging from thin liquid suspension to firm or semi solid gel. The precursor gel is a particulate linear chain fuctan gel. Inulin is a preferred fructan.

The invention discloses a medicine for treating tracheitis and bronchitis and a preparation method thereof. The natural botanical drugs chosen by the invention comprise peucedanum root, white mulberry bark, loquat leaf, bitter apricot seed, ephedra, baikal skullcap root, etc. The medicine of the invention has the efficacies of clearing away the lung-heat to purge heat, resolving phlegm to relieve cough, preventing asthma and sending down abnormally ascending. Tests and studies indicate that the medicine of the invention has obvious anti-infectious effects on the infection of mice caused by staphylococcus aureus and has obvious inhibitory action on ear dwelling caused by xylene and on leg dwelling of rats caused by 1% carrageenin, which indicates that the medicine has obvious anti-inflammatory action; in addition, the medicine of the invention has obvious effects on relieving cough, resolving phlegm and relieving asthma, which can be used for treating tracheitis and bronchitis in clinical practice.

The invention belongs to the field of biological engineering, and particularly relates to a method for improving the content of betulin and oleanolic acid in a birch cell by utilizing MeJA (methyl-jasmonate) and SA (salicyl acid), which comprises the following steps of: inoculating a birch tissure culture seedling stem to NT + 0.1 mg/L of 6-BA and 0.01 mg/L of TDZ culture mediums to induce birch callus, and obtaining a birch suspension cell with high content of total triterpenes through multi-time subculture, screening and suspension culture; inoculating the screened cell into the same liquid culture medium, wherein the inoculation amount is 3g/100ml; adding 100mu Mum/L of MeJA and 50mg/L of SA when the shake culture is performed at the seventh day; after 24-48h, obtaining the product; and detecting the content of total triterpenes, betulin and oleanolic acid in the cell. Through the comparison of the two kinds of processing methods, the content of total triterpenes is improved by 21.6-31.7%, the content of oleanolic acid is improved by 277.4-369.34%, and the content of betulin is improved by 44.42-179.58%. The application of the invention provides a new path for solving the problem of shortage of natural plant drug resources and realizing large-scale industrial production of betulin and oleanolic acid drugs.

The invention relates to a method for simultaneously determining 5 alkaloids in Sini agent vegetable drug plasma, which comprises the following steps: (1) taking medicated plasma of a mammal given Sini agent vegetable drugs, adding bulleyaconitine A (interior label), alkalifying with ammonia water, scrolling, adding ethyl acetate for extraction, scrolling, centrifugating, extracting the subnatant with ethyl acetate twice, merging the ethyl acetate layers, blow-drying with nitrogen, and dissolving the residue with a mobile phase; and (2) HPLC-MS-MS (high performance liquid chromatograph-mass spectrometer-mass spectrometer) determination: the mobile phases comprise a phase A acetonitrile-0.1% glacial acetic acid (1:99, v/v) and a phase B acetonitrile-water (99:1, v/v); the mass spectrometer conditions are as follows: electric spray ion source (ESI) and cation detection mode; and the detection ions are as follows: aconitine m/z 646.3->586.3, mesaconine m/z 632.3->572.3, hypaconitine m/z 616.3->556.3, benzoylmesaconine m/z 590.3->558.3, and benzoylaconine m/z 604.3->554.3. The method is suitable for pharmacokinetic research of aconitine, hypaconitine, mesaconine, benzoylmesaconine and benzoylaconine in Sini agent vegetable drugs in a mammal.

The invention discloses a navel paste for treating mammary gland hyperplasia diseases. The navel paste is prepared by processed polygala root, Chinese angelica, curcuma zedoary, frankincense, rhizoma cyperi, radix angelicae, schizonepeta spike, costus root, mint, jasmine, trichosanthes kirilowii Maxim, Astragalus mongholicus, radix curcumae, peach kernel, root of red-rooted salvia, sangusis draconis, borneol and muskone. The preparation method comprises the following steps of grinding all the medicines, except from the muskone and the borneol, into fine power of 80-150 meshes, adding the ground fine muskone and the borneol after honey preparing, and then evenly mixing in the paste subjected to honey preparing, and preparing the externally applied navel paste with each packet of 5-8g. The navel paste mainly aims at etiology and pathogenesis of the mammary gland hyperplasia diseases; the guiding ideologies of the treatment plan are based on activating blood circulation and removing blood stasis, resolving hard lumps, removing stasis and detumescence, and eliminating stagnation to stop pain. The selected medicines are natural plant medicines, and have the functions of eliminating breast lumps and enhancing the resistance; and the navel paste is exact in curative effect, fast in effect, free of toxic and side effect, high in cure rate through clinical verification, reasonable in used medicines and scientific in compatibility.

A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, whirling 3-5 mins, centrifugating at 9600 rpm for 10 mins, drying and enriching the upper layer at 25-30° C., and redissolving with mobile phase; (2) UPLC/MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C₁₈, 2.1′100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v/v/v, mobile phase B: acetonitrile-formic acid 100:0.1 v/v; MS condition: electric spraying ion source(ESI), detecting with positive ion mode, scanning at the range of m/z 150-1200. The method can be used for pharmacokinetics study of schizadrin B in dissipating blood stasis botanical.

The invention provides a method for detecting contents of 14 non-volatile components in a dragon tiger Rendan mini-pill vegetable drug by liquid chromatography-LCQ ion trap mass spectrometry. The method comprises the following steps: firstly preparing a test solution and a control solution, and respectively detecting according to the following method: introducing a sample to a Thermo BDS Hypersil C18 chromatographic column according to the sample size of 1-20 microliters, controlling column temperature to 20-40 DEG C, carrying out gradient elution with a mobile phase composed of a phase A and a phase B at the speed of 0.2-1.5 mL/min according to an established procedure, simultaneously detecting an eluant by the liquid chromatography-LCQ ion trap mass spectrometry to obtain ion chromatograms of a test sample medicine and a control medicine, and detecting each component and its content through comparison of the chromatograms. The phase A of the mobile phase is pure water containing 0.005-0.015% of formic acid (containing 0.2mM of ammonium formate), and the phase B is acetonitrile.

The present invention relates to compositions comprising the botanicals from the Family Ranunculaceae, Subclass: Dicotyledonae; Crassinucelli, Superorder: Ranunculales. Examples of these botanicals include but are not limited to; Actaea, Anemone, Ranunculus, and Nigella, or extracts thereof, which are useful in treating liver diseases, particularly those with viral etiology. More specifically, the compositions of the present invention are derived from various botanicals or medicinal plants. The compositions of the invention have demonstrated outstanding efficacy for treatment of patients with hepatic disorders. Compositions of the present invention have also exhibited immunomodulatory activities. The preferred compositions contain the botanical ingredients in concentrations of not less than 20% w/v. The treatment can be therapeutic or prophylactic and may be administered orally, parenterally, as suppository or via nasal mucosa. The treatment may be delivered in a single dose, multi-doses or via a slow release mechanism.

An antineoplastic Chinese medicine especially for treating cancers is prepared from 5 Chinese-medicinal materials including asafetide, aspongopus, Chinese caterpillar fungus, turmeric, etc. Its preparing process is also disclosed.

A composition for administration to a subject with dry eye or a dry eye-associated ocular condition is disclosed. The composition includes a botanical active agent in an amount effective for treating, preventing, and/or ameliorating dry eye or a dry eye-associated ocular condition in a subject upon administration of the composition thereto. The botanical active agent comprises a Zingiber officinale extract, an Eriobotrya japonica extract, or combinations thereof. The composition may be adapted for oral administration to the subject, and formulated as a nutraceutical, pharmaceutical, or supplement, e.g. in a single dosage form of a capsule or softgel. A method of treating, preventing, and/or ameliorating dry eye or a dry eye-associated ocular condition in a subject is also disclosed. The method comprises administering an effective amount of the composition to a subject.

The present invention provides a new method for extracting Homoharringtonine (HHT) by culture cells or culture plant tissues. Also, disclosed are methods of obtaining HHT from semi-synthesis and biosynthesis. The present invention disclosed that HHT combined with some botanical drugs could induce cancer cells to resemble normal cells. To add some botanical drugs combined with HHT can significantly increase anticancer effects of HHT. These drugs include Matrine (MAT), Guanzhongsu (GU), Maidongsu (MU), and Indirubin (IND). The experimental data showed that above drugs have strong synergisms effects for treating leukemia and other cancer cells and more safe.

The invention relates to a preparation used for improving the sexual function of a male and resisting fatigue and a preparation method thereof. The preparation is prepared from black bean, semen allii tuberosi, yam, tuckahoe, Chinese wolfberry, Chinese dodder, arginine and zinc gluconate according to the weight ratio of 140-210:120-180:115-175:35-55:30-60:25-40:20-35:0.5-1.5. The preparation used for improving the sexual function of the male and resisting the fatigue and the preparation method thereof, which are provided by the invention, adopt a water cooking extraction method to extract effective components in plant medicines, keep the activity of the effective components and then add the arginine and the zinc gluconate as basic raw materials for replenishing essence and producing sperm, so that the dissolving-out degree of the effective components in the medicines can be greatly enhanced, and the basic raw materials are beneficial to the absorption of the medicines, thereby the bioavailability of the medicines can be enhanced and the curative effect is good. In addition, an experiment proves that the preparation of the invention is innoxious, so that the preparation can not generate toxic or side effect after being taken by a patient for a long time and the safety is good.

The invention relates to a garlic ajoene for curing the cardio-cerebral vascular disease and the cancer, and the preparation method thereof, and belongs to the technical field of the extraction of the herbal medicine. The ajoene of the invention for curing the cardio-cerebral vascular disease is extracted from fresh garlic, and obtained by the chromatography. The ajoene can prevent the thrombus from forming, distend the coronary artery, enhance the immune function, and inhibit the growth of cancer cells. The ajoene can be made into an oral preparation or injection preparation, which is used to treat the cardio-cerebral vascular diseases of arteriosclerosis and cardiac infarction, etc., prevent and cure the cancer and the tumour.