109 results about "Angina pain" patented technology

A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.

The invention relates to a quality control method of Yixinshu traditional chinese medicine preparation for nourishing qi, restoring pulse, and activating blood circulation to dissipate blood stasis, belonging to medicine domain. The Yixinshu traditional chinese medicine preparation is composed of panax, astragalus root, radix salviae miltiorrhizae, lityturf root, chinese magnoliaving, chuanxiong rhizome and haw, with ability of nourishing qi, restoring pulse, activating blood circulation to dissipate blood stasis, nourishing yin and production of body fluid, applicable for the patients who suffer for deficiency of both vital energu and yin, heart-throb knotted pulse, chest oppression, chest pain, and angina pectoris of coronary heart disease. At present, on clinical usage, it is applied extensively in the treatment of angina pectoris, myocardial ischemia, various type of arrhythmias, atrial premature beat, chest pain, angina pectoris of coronary heart disease and so on. The said quality control method provides the criterion of detection, means of detection, technical method and so on for the associated production and detection mechanism, therefore the quality of Yixinshu traditional chinese medicine preparation can be better controlled to ensure the safety of the said preparation. The quality method can better guide the production to make the production process control more strict and reasonable, therefore the users could have an overall acquaintance with the product quality.

The invention relates to an effective method of extracting puerarin and green food medicines made by it, and the steps include: using alcohol to soak, extracting several times, evaporating the alcohol, converting the extract into water solution, filtering out suspended substances; adopting polymeric absorbent to absorb, concentrating and drying and obtaining Gegen extract, by absorbing and eluting, further making flavone glycoside and terpene inner ester reach the specified indexes. Putting the extracted puerarin in drinks, beers, distilled spirits, teas, milk powders, etc; or adding the puerarin in the tablets, capsules, and electuaries or injectas. The pure plant natural food has proper taste. The Gegen is moderate, peppery and sweet, disperses the internal coldness and relieves the heat of muscle, promotes blood circulation, quenching the thirst and detoxicates alcohol toxicity, etc. and it has good curing effect on high blood pressure, coronary heart disease, heartstroke, dispels the wind, etc.

The invention discloses a medicine combination of adjusting hypertension, hyperlipidemia and angina, consisting of astragalus, panax, salvia, cynostemma, americanwater plantain, ginkgo biloba, panax notoginseng, hawthorn, mythic fungus, schisandra, fragrant solomonseal rhizome and wolfberry fruit. The medicine combination of the invention has the advantages of invigorating qi and replenishing yin, activating blood and stabilizing pain, nourishing heart and calming mind, replenishing qi and nourishing blood, supplementing spleen and invigorating kidney, promoting moisture and urination, clearing heat, detoxifying and cooling blood, reducing tension, clearing liver, reducing lipid, nourishing yin, improving eyesight, reinforcing kidney, reducing sugar, dual directionally regulating and etc. Meanwhile, the medicine has an obvious effect on treating hypertension, hyperlipidemia, angina, and the hypertensions and anginas caused by unknown reasons.

The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

The invention belongs to the medication technical field, which discloses the medicine and the preparation method for treating the coronary heart disease and miocardial infarction. The medicine is mainly prepared from ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali and Chinese angelica, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig and liquorice, or ginseng root, dwarf lilyturf tuber, Chinese magnoliavine fruit, radix astragali, Chinese angelica, cassia twig, liquorice, danshen root, red peony root, radix notoginseng and safflower, according to certain ratios of weights. The invention can be made to any type of medicament that can be accepted by the clinic or pharmacology, which is the good quality oral preparation. The medicine has effects of Qi-replenishing, Yin-nourishing and pulse-invigorating and blood circulation activating to dissipate blood stasis and lipid lowing, which can be used to curing the chest distress, hard breathe, heart-throb, angina and arrhythmia caused by coronary heart disease and miocardial infarction, the recovery period of the cerebral thrombosis and the sequelae of the cerebral thrombosis, the effects are obvious.

Improved, low-cost, scalable process for the preparation of 4-formylbenzofuran starting from 4-methylbenzofuran, wherein the novel 4-dibromobenzofuran is obtained as an intermediate . According to the method of the invention, 4-methylbenzofuran is brominated to obtain novel 4-dibromobenzofuran, which is then hydrolyzed to obtain 4-formylbenzofuran. 4-Formylbenzofura is a key intermediate in the production of isradipine for the treatment of hypertension and angina.

The invention relates to the field of drug preparations, and discloses a preparation method for a metoprolol succinate sustained release preparation, and a preparation method thereof. The method comprises the following steps: firstly, coating solution with well prepared raw materials and auxiliary materials onto blank pellets to form a medicating layer, coating a well prepared swelling layer and a sustained release layer on the medicating layer, and finally filling the coated pellets into hard capsules. The method is simple to operate, short in production period, high in efficiency, low in cost, controllable in process, the pellets are evenly coated, the appearance is round and normal and uniform, the stability is good, and the sustained release preparation is convenient to use and used for fully reducing the drug use frequencies of patients with hypertention and angina.

A process for extracting ginkgo juice features that the seeds and leaves of ginkgo are immersed in alcohol. The extracted ginkg juice can be added to beverage, beer, spirit, food, and medicine for playing its medical roles, such as improving immunity and treating loss of memory, hepertension, coronary heart disease, angina pectoris, hyperlipemia, etc.

The present invention relates to total ovateleaf holly saponin for treating coronary heart disease, angina, apoplexy and other cardiac and cerebral vascular diseases, its medicine composition and extracting process. Ovateleaf holly bark is extracted with alcohol, and the extract is added with water and centrifuged to obtain precipitate and supernatant. The precipitate is alcohol reflux extracted, and the extract is treated through filtering, filtrate concentrating, drying and other steps to obtain the first part of total saponin. The supernatant is treated through concentrating, centrifuging, water washing of the precipitate and drying to obtain the second part of total saponin. These two parts of total saponin are merged to obtain the total ovateleaf holly saponin, which may be added with supplementary material and further treated to obtain various kinds of oral preparations and injection.

The invention provides a Gelan Xinning soft capsule for treating coronary disease and angina and a preparation method of the Gelan Xinning soft capsule. The medicine comprises the following raw materials in parts by weight or is composed of the following raw materials in parts by weight: 4 to 60 parts of radix puerariae general flavones, 1 to 30 parts of fructus crataegi extract, 0.4 to 10 parts of gynostemma pentaphylla general flavones, 5 to 100 parts of soybean oil or salad oil, 0.1 to 3 parts of beewax, 0.4 to 10 parts of hydrogenated palm oil, 0.2 to 5 parts of soyabean lecithin, 0.01 to 0.5 parts of dimeticone, 8 to 150 parts of gelatin, 3 to 80 parts of glycerol, 8 to 150 parts of purified water and 0.01 to 0.8 parts of ethylparaben. The preparation method of the medicine provided by the invention is simple, the processing cost is low, the efficacy is remarkable and the Gelan Xinning soft capsule is free from any toxic and side effects.

The invention relates to a medicament for treating coronary heart disease and angina and a preparation method of granular formulation thereof. The medicament takes traditional Chinese medical scienceprinciple as a basis, adopts a pure traditional Chinese medicine formaula, is reasonably prepared from raw material medicines such as milk veteh, Pueraria lobata, mistletoe, Salvia Miltiorrhiza, hawthorn, rhizoma ligustici wallichii, and the like by weight, and is prepared and processed by extracting effective components combining with modern technology. The invention has the effects of nourishingQi, invigorating the circulation of blood, invigorating pulse and tonifying the kidney. The medicine provided by the invention combines various kinds of medicine for treating patients with the deficiency of vital energy or patients suffered from the deficiency of the kidney with the symptom of chest distress, palpitation, hypodynamia, giddiness, lassitude in loin and legs, and the like caused bycoronary heart disease and angina. The medicament provided by the invention can obviously reduce the whole blood viscosity, plasma viscosity, fibrinogen viscosity and hematokrit of rats with blood stasis by pharmacodynamic experiment, and can obviously accelerate RBC electrophoresis, which indicate that the medicament can obviously recover the stickiness, concentration, coagulation and gathering of blood stasis type and has the function of blood circulation invigoration.

The invention discloses a medicine composition for treating cardio-cerebral-vascular diseases and a preparation method and application thereof, belonging to the field of traditional Chinese medicines. The effective component of the medicine composition comprises total sapogenin and total alkaloid extracted from traditional Chinese herb trichosanthes kirilowii Maxim and allium macrostemon. The medicine composition which can be made into proper preparation forms has good treatment effects on coronary disease, angina, arteriosclerosis, chest pain, hyperlipoidemia and the like. The invention also discloses preparation methods of the total sapogenin and the total alkaloid.

A compound of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, Wherein Q, R², Ar, A and R¹ are as defined in claim 1. The claimed compounds are gap junction blockers useful for the treatment or prevention of a range of conditions including migraine, epilepsy, non-epileptic seizures, brain injury (including stroke, intracranial haemorrhage and trauma induced), pain, neurodegenerative disease or cardiovascular disease including myocardial infarction, coronary revascularization or angina.

The invention is directed to the use of at least one CBx modulator wherein the CBx modulator is selected from the group consisting of CB1 agonists; CB2 agonists; CB2 partial agonists; CB2 antagonists; CB2 inverse agonists; and dually acting compounds which are both a CB1 agonist and a CB2 agonist; and mixtures thereof, as KATP channel modulator for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans. The invention further relates to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans comprising administering to a subject in need thereof an effective amount of at least one CBx modulator having KATP channel modulating properties.

The invention discloses Yuge powder with functions of weight loss and beauty. The Yuge powder is prepared from the following raw materials in part by weight: 10 to 89 parts of Amorphophalms konjac, 10 to 89 parts of the root of kudzu vine and 1 to 20 parts of mulberry leaf. The invention also discloses a preparation method for the Yuge powder. The preparation method comprises the steps of preparation of Pueraria flavone, preparation of Amorphophalms konjac fine powder, preparation of mulberry leaf powder and preparation of the Yuge powder. The formula of the Yuge powder is unique, and the rawmaterials are cheap and convenient to obtain; the preparation method is simple; and the prepared Yuge powder can be used for weight loss, also has a beauty function, and has certain effects of treating patients suffering from hypertension, angina, diabetes, hyperlipidemia and the like.

The invention discloses a medicine composition for treating hypertension, heart disease and angina pectoris, which compris blood scorpion, pangolin, leech, storax and borneol. The medicine composition for treating hypertension, heart disease and angina pectoris has therapy effects of waking up a patient from unconsciousness, inducing resuscitation, relieving blood status for stagnation, activating blood to promote menstruation, keeping calm and relieving pain, removing pathogenic heat from blood, reducing blood pressure and spasmolysis, and has significant effect in treating various hypertensions, heart diseases and angina pectoris.

The invention belongs to the medical technical field and discloses a drug combination for the cardiovascular disease and the preparation method of the drug combination. The drug combination contains the pharmacodynamic components of the raw materials of drugs of danshen root, Szechwan lovage rhizome, panax notoginseng, milkvetch root and storax. In order to achieve a better curative effect, a leech, tonka beans and peach nuts can also be added into the drug combination; in order to further improve the curative effect, rosewood, axillary choerospondias fruit and earthworms can be added into the drug combination. The drug combination of the invention has the efficacies of promoting the circulation of qi to induce resuscitation, activating blood circulation for removing blood stasis, dredging channels for alleviating pain etc. and is used for preparing the drugs for remedying the cerebral infarction convalescence of the coronary heart disease, the angina pectoris or the arteriosclerosis, the syndrome of which belong to the qi stagnation and blood stasis with the symptoms of chest pain, oppression in the chest, shortness of breath, heart throb, inefficaciousness of limbs, inarticulacy etc. The drug combination of the invention can be made into any preparation type, which is acceptable in the clinic and the pharmacy, and the oral preparation is preferential.

The invention relates to a cotinus coggygria scop compound preparation, which is prepared from cotinus coggygria scop, rhizoma corydalis and hawkthorn in proportion, wherein the dosage of the cotinus coggygria scop is equal to that of the hawkthorn, and the dosage of the rhizoma corydalis is not more than 2/3 of that of the cotinus coggygria scop or the hawkthorn. The cotinus coggygria scop compound preparation can be used as an anticoagulant and antithrombotic drug, an abirritation drug, a drug for activating blood circulation to dissipate blood stasis and reducing the whole blood viscosity, a drug for improving the organism anti-hypoxia effect, and a drug for treating coronary heart disease or coronarism or miocardial infarction. The cotinus coggygria scop compound preparation not only improves the curative effect of the cotinus coggygria scop, but also reduces the dosage, and is used for easing pain and treating cardiovascular and cerebrovascular disease. Comparative experiments prove that the compound preparation has equivalent anticoagulant activity and abirritation as aspirin, and has the function of organism hypoxia resistance.