16 results about "Angina pain" patented technology

The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: Pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack, angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis, atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

The present invention relates to an extended release multiparticulate composition comprising a plurality of discrete units, each discrete unit comprising ranolazine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The said multiparticulate composition is sprinkled onto soft foods or liquids for oral administration. Further, the multiparticulate composition is bioequivalent to the marketed extended release tablet. It further relates to a process of preparation of said multiparticulate composition and method of treatment of patients suffering from angina by administering said composition.

The invention relates to a traditional Chinese medicine composition for preventing and treating cardiovascular diseases through thunder-fire moxibustion, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from radix salviae miltiorrhizae, rhizoma chuanxiong, rhizoma galangae, fructus piperis longi and rhizoma corydalis. According to the traditional Chinese medicine composition, the prescription medicine with the effects of being fragrant, pungent and capable of warming meridians and dredging collaterals is applied by selecting acupoints according to an external treatment method of thunder-fire moxibustion, the effects of fragrant warming and dredging, dispersing blood stasis and dredging collaterals can be achieved, a series of symptoms of chest stuffiness and pains caused by internal blockage of cold evil are treated, coronary artery slow blood flow is treated, angina attack is rapidly relieved, and the frequency and degree of angina are relieved; the average volume ratio of C-reactive protein and leukocyte / platelets is reduced, and the life quality of a patient is improved.

The invention relates to granules for promoting blood circulation to remove meridian obstruction and a preparation method thereof. Ginkgo leaves, fried spina date seeds, astragalus membranaceus, radix puerariae, hawthorn, salvia miltiorrhiza, allium macrostemon, rhodiola rosea, fructus lycii, acanthopanax, schisandra chinensis and radix ophiopogonis are selected as raw materials, the raw materials are decocted, filtered, concentrated and granulated, the materials are all selected from natural traditional Chinese medicine components, the effects of promoting blood circulation to remove blood stasis and activating meridians to stop pain are achieved, and the traditional Chinese medicine composition has a remarkable curative effect on chest stuffiness, cardiodynia, dizziness, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals. The traditional Chinese medicine composition has obvious curative effects on symptoms such as hypertension, hyperlipidemia and cerebral arteriosclerosis, has no side effect on the body, is simple in preparation method and low in production cost, and has application and popularization prospects.

The present invention is related to methods of treating cardiac arrhythmia, angina, or a migraine in a patient in need thereof, with a therapeutically effective amount of a compound having a structure according to the formula:the method comprising nasally administering to the patient (i) a first dose, and (ii) a second dose of an aqueous composition comprising a pharmaceutically acceptable acetate or methanesulfonate salt of compound I, or a racemate or enantiomer thereof, wherein the acetate or methanesulfonate salt of compound I, or the racemate or enantiomer thereof, is dissolved in the aqueous composition at a concentration of 350 mg / mL±50 mg / mL, and wherein the second dose of the compound is administered between 5 minutes and 25 minutes after the first dose.

The invention provides a composition, a traditional Chinese medicine composition and application thereof. Specifically, the invention provides a composition which comprises coix seeds, radix aconiti carmichaeli and musk. The composition can prevent and treat coronary heart disease angina pectoris, improve the attack frequency of angina pectoris, relieve the symptoms of chest distress and pain when angina pectoris attacks, and improve the long-term prognosis effect and life quality.

The application discloses a composition of Qixuebengzhi recipe and belongs to the field of traditional Chinese medicines; the composition is mainly prepared from bupleurum, immature fruit of citrus, persicae semen, safflower, chuanxiong and red peony root; the application is based on the concept of treating heart and body simultaneously, and through the ascending and descending of qi and the regulating of liver qi of bupleurum and immature fruit of citrus, the composition can dredge the liver and regulate qi, and through the dispersing of persicae semen and safflower, the composition can dredge the channels and remove stasis, and through the combination of chuanxiong and red peony root, the composition can regulate qi and blood, and the combination of the medicines can directly attack the core pathogenesis of qi stagnation and blood stasis; clinical verification shows that the composition can not only significantly improve the TCM syndromes such as chest pain and chest distress of patients and the frequency of angina pectoris attacks, but also quickly relieve anxiety and depression and improve sleep quality.

The present disclosure relates to compositions and methods, including prodrugs of (S)-3-(3-(((3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H- benzo[d]azepin-2-one that find use in the treatment of diseases and disorders, such as therapies for cardiovascular disease, including cardiac arrhythmias, including, without limitations, sinus tach (e.g. inappropriate sinus tachycardia (IST)), postural orthostatic tachycardia syndrome (POTS), coronavirus (COVID-19) (e.g. long COVID) and COVID-associated cardiovascular abnormalities, supraventricular tachycardia (SVT), tachycardia (e.g. rapid heart rate, atrial tachycardia), heart failure (e.g. congestive heart failure (CHF), systolic heart failure, pediatric heart failure, chronic heart failure), myocardial ischaemia, angina (e.g. angina pectoris), myocardial infarct, rhythm disturbances (e.g. supraventricular rhythm disturbances), chest pain, cardiomyopathy, coronary artery disease, and left ventricular dysfunction (LVD).

The application discloses a medicine for treating angina pectoris and myocardial bridge, and the medicine is prepared from safflower, campion flower, panax notoginseng, kudzu flower, ginseng and rose flower. The medicine has the effects of benefiting qi and activating blood, and is used for treating chest distress and chest pain caused by angina pectoris and myocardial bridge, and is suitable for people with qi deficiency and blood stasis type angina pectoris and myocardial bridge.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating thoracic obstruction and blood stasis type cardiovascular diseases and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from radix salviae miltiorrhizae, radix curcumae, rhizoma corydalis, ligusticum wallichii, pseudo-ginseng, rhizoma pinelliae preparata, fructus trichosanthis, fructus aurantii immaturus, allium macrostemon and cassia twig. The traditional Chinese medicine composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis and relieving pain, is mainly used for treating chest stuffiness and pains and qi stagnation and blood stasis type cardiovascular diseases, and is particularly suitable for patients suffering from coronary heart disease and angina pectoris. Besides, on the basis of a traditional medical formula, a modern preparation process is utilized and deeply optimized, and a dynamic decoction process and a one-step granulation technology are adopted, so that the preparation method has the advantages of simple and convenient preparation process, high efficiency, energy conservation, less damage to effective components and the like.

The present invention is related to methods of treating cardiac arrhythmia, angina, or a migraine in a patient in need thereof, with a therapeutically effective amount of a compound having a structure according to the formula:the method comprising nasally administering to the patient (i) a first dose, and (ii) a second dose of an aqueous composition comprising a pharmaceutically acceptable acetate or methanesulfonate salt of compound I, or a racemate or enantiomer thereof, wherein the acetate or methanesulfonate salt of compound I, or the racemate or enantiomer thereof, is dissolved in the aqueous composition at a concentration of 350 mg / mL±50 mg / mL, and wherein the second dose of the compound is administered between 5 minutes and 25 minutes after the first dose.

The invention provides a composition for treating myocardial cell hypoxia and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of radix rehmanniae, 5 to 15 parts of caulis spatholobi, 5 to 10 parts of radix ophiopogonis, 5 to 7 parts of liquorice root, 3 to 7 parts of radix polygoni multiflori, 2 to 5 parts of colla corii asini, 2 to 5 parts of fructus schisandrae chinensis, 2 to 5 parts of radix codonopsis, 1 to 5 parts of tortoise shell processed with vinegar, 5 to 8 parts of fructus ziziphi jujubae and 3 to 8 parts of ramulus cinnamomi. The preparation method comprises the following steps: adding water into the vinegar-processed tortoise shells, heating and decocting for 2-3 hours, then adding the caulis spatholobi, the codonopsis pilosula and the Chinese dates, decocting for 1-2 hours, filtering, and concentrating filtrate for later use; adding colla corii asini, heating, and uniformly stirring to obtain a mixture; the preparation method comprises the following steps: crushing rehmannia, radix ophiopogonis, liquorice, polygonum multiflorum, schisandra chinensis and cassia twig, soaking in an alcohol aqueous solution, percolating for 20-24 hours, and collecting percolate; and combining the mixture with the percolate, and concentrating under reduced pressure. Through the action mechanism of tonifying qi, nourishing yin, promoting coronary circulation and relieving pain, the treatment effect is jointly achieved. The traditional Chinese medicine composition can be used for treating myocardial cell ischemia caused by coronary heart disease, angina pectoris, arrhythmia and the like.

The application discloses a traditional Chinese medicine composition, preparation and application for treating coronary heart disease angina pectoris or post-PCI angina pectoris of the type of qi deficiency and blood stasis. The traditional Chinese medicine composition is composed of the following raw medicinal materials in weight: 30-40g of Astragalus membranaceus, 20-30g of Pueraria lobata, 10-15g of Rhodiola, 10-15g of Curcuma zedoary, 10-15g of Acorus gramineus Soland and 10-15g of Notopterygium. The application of the traditional Chinese medicine composition is used in the preparation of a medicine for treating coronary heart disease angina pectoris or post-PCI angina pectoris of the type of qi deficiency and blood stasis. The traditional Chinese medicine composition has the effects of treating both the root cause and symptoms and strengthening the body resistance and eliminating pathogenic factors on the coronary heart disease angina pectoris or post-PCI angina pectoris caused by qi deficiency and blood stasis, and can simultaneously supplement qi and raise yang, activate blood and remove stasis, and not forget to strengthen analgesia and warm and resolve cold phlegm, and give consideration to both the main and the secondary. The traditional Chinese medicine composition is well matched, can significantly improve the chest distress and chest pain symptoms of patients, and the total effective rate of the TCM syndrome curative effect reaches 90%.

The invention provides a traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease angina pectoris. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 210 to 290 parts of radix salviae miltiorrhizae, 310 to 390 parts of flos chrysanthemi indici, 210 to 290 parts of radix codonopsis, 210 to 290 parts of fructus trichosanthis, 30 to 70 parts of flos caryophylli, 80 to 120 parts of vinegar-processed rhizoma corydalis, 210 to 290 parts of radix astragali seu hedysari, 210 to 290 parts of rhizoma chuanxiong and 30 to 70 parts of radix notoginseng. The invention further provides application of the traditional Chinese medicine composition. The traditional Chinese medicine decoction has the advantages that clinical and animal experiments prove that the traditional Chinese medicine decoction has a better effect on treating qi deficiency and blood stagnation type coronary heart disease angina pectoris, has the effects of tonifying qi and activating blood, regulating qi and relieving pain, and warming yang and reducing phlegm, and is worthy of popularization.

The present invention discloses a Chinese medicine composition for preventing and treating coronary heart disease and angina pectoris and a preparation method thereof, belonging to the field of Chinese medicine preparations. The Chinese medicine composition is prepared from 17 Chinese medicinal herbs: astragalus, codonopsis, rhodiola, poria, ophiopogon, schisandra, rehmannia root, polygonatum, epimedium, kudzu root, angelica, salvia miltiorrhiza, honeysuckle, kelp, kelp, oyster, and immature bitter orange. The composition of the present invention is well-matched and synergistic, and has the effects of invigorating qi and activating blood circulation, resolving phlegm and unblocking meridians. It is suitable for treating chest pain caused by qi and yin deficiency, phlegm and blood stasis, coronary heart disease, and angina pectoris, as well as pharmacodynamic tests. Pharmacodynamic tests show that the Chinese medicine composition of the present invention can significantly prolong the hypoxia tolerance time of mice, has a certain antagonistic effect on acute myocardial ischemia caused by vasopressin in rats, has a significant reducing effect on ST segment elevation caused by coronary artery ligation in rats, can significantly reduce the range of myocardial infarction caused by coronary artery ligation, and has a reducing effect on hyperlipidemia in rats fed a high-fat diet.

The present invention belongs to a Chinese medicine composition for clinical auxiliary treatment of phlegm and blood stasis syndrome of coronary artery insufficiency and its preparation and specific usage. The technical scheme of the present invention is: 30 parts of Trichosanthes peel, 30 parts of Asarum, 10 parts of Cinnamon bark, 10 parts of Santalum album, 10 parts of Olibanum, and 3 parts of Borneol are ground into fine powder, and vinegar is added to blend into a paste, which is a Chinese medicine patch for treating ischemic angina pectoris. The present invention uses the Chinese medicine composition to apply Xinshu acupoint and Shenmen acupoint in a specific time period to warm and transform phlegm and fluid, promote blood circulation and dredge collaterals, and achieve the purpose of relieving chest pain. The Chinese medicine prepared by the prescription has small toxic and side effects, and is more effective when used in conjunction with the classic acupoint matching method of traditional Chinese medicine, Nazhi method.