22 results about "Allium macrostemon" patented technology

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

This invention provides a traditional Chinese medicine compound for treating viral myocarditis, belonging to the field of traditional Chinese medicine pharmaceutical technology. The compound consists of Forsythia suspensa, Fagopyrum dibotrys, Pseudostellaria heterophylla, Rhodiola rosea, Citrus medica, Allium macrostemon, Poria cocos, Gynostemma pentaphyllum, Salvia miltiorrhiza, Dalbergia odorifera, Cynanchum paniculatum, and Valeriana. This traditional Chinese medicine compound exhibits significant protective effects against viral myocarditis, specifically by significantly reducing damage to H9c2 cardiomyocytes caused by CVB3 virus. Its mechanism of action is closely related to downregulating the expression of inflammatory factors TNF-α and IL-6 and inhibiting the inflammatory response. Simultaneously, within the experimental concentration range, the compound shows no toxicity to cardiomyocytes, demonstrating good biocompatibility. Furthermore, this compound can significantly reduce myocardial tissue damage in a viral myocarditis model mouse by inhibiting the in vivo inflammatory response and regulating oxidative stress imbalance, providing a safe and effective new treatment option for the clinical treatment of viral myocarditis.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

This invention discloses a warming and dispersing medicinal and edible composition and its preparation method. This invention relates to the field of traditional Chinese medicine health food technology. The active ingredients of the composition are extracted from the following medicinal and edible materials: 3-10 parts by weight of dried ginger, 2-8 parts by weight of cinnamon, 5-15 parts by weight of Allium macrostemon, and 10-30 parts by weight of Astragalus membranaceus. Small molecule extract particles are prepared through processes such as β-cyclodextrin inclusion and wet granulation, significantly improving the dissolution rate and bioavailability of the active ingredients. The product is also convenient to prepare, easy to carry, and suitable for long-term use. In terms of safety, all raw materials are medicinal and edible substances. Clinical trials have proven that the overall effective rate for symptoms of Yang deficiency such as aversion to cold, cold limbs, lethargy, and loose stools is over 94%, with no obvious toxic side effects. It can be safely used for daily health maintenance and auxiliary conditioning of those with Yang deficiency and cold constitution. Pure coconut powder is used as a flavoring material, resulting in a rich aroma and good taste.

The present application mainly relates to the separation and identification and application of active ingredients in traditional Chinese medicine, and specifically discloses a separation and purification of a steroidal saponin compound in Allii Macrostemonis Bulbus. According to the physical and chemical properties and high-resolution electrospray mass spectrometry (HR-ESI-MS), one-dimensional / two-dimensional nuclear magnetic resonance spectroscopy (1D- / 2D-NMR) and other spectral technologies, the structure of the compound is identified, the structure is analyzed and the molecular formula is determined, and finally named as Allii Macrostemonis Bulbus saponin U. The pharmacological activity of Allii Macrostemonis Bulbus saponin U is studied through in vitro cell experiments, and it is found that Allii Macrostemonis Bulbus saponin U significantly improves the cell viability of mouse hippocampal neurons after glutamate treatment, has good neuroprotective activity, and can be used for the preparation and application of anti-nerve injury drugs.

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine compound and preparation for treating coronary heart disease and a preparation method and application of the traditional Chinese medicine compound and preparation. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10-30 parts of astragalus membranaceus, 5-15 parts of rhodiola rosea, 10-30 parts of salvia miltiorrhiza, 5-15 parts of ligusticum wallichii, 10-30 parts of trichosanthes kirilowii maxim, 5-15 parts of allium macrostemon, 5-15 parts of folium ginkgo, 10-30 parts of radix puerariae, 10-30 parts of radix ophiopogonis, 3-10 parts of schisandra chinensis, 15-30 parts of oyster, 5-15 parts of cassia twig and 3-10 parts of liquorice. Animal experiment results show that the traditional Chinese medicine composition provided by the invention has remarkable and multi-aspect curative effect advantages in the aspect of treating a coronary heart disease rat model. The traditional Chinese medicine composition not only can enhance myocardial contractility and recover heart blood pumping function, but also can inhibit inflammatory response, relieve myocardial damage, effectively relieve myocardial structure damage and protect myocardial tissue integrity. In addition, a proportional experiment result shows that the effect of the composition provided by the invention can be obviously weakened by losing any medicine pair, so that all the medicines in the formula cannot be absent.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

The present application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine preparation for treating coronary heart disease and a preparation method thereof. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 22-28 parts of Astragalus membranaceus, 20-25 parts of Prenanthes altissima, 13-18 parts of Panax notoginseng, 10-15 parts of small Rhododendron, 8-13 parts of Radix Paeoniae Rubra, 7-12 parts of Allium macrostemon, and 3-8 parts of Glycyrrhiza uralensis. In the traditional Chinese medicine preparation, Astragalus membranaceus and Prenanthes altissima are the monarch drugs for tonifying qi and promoting blood circulation; Panax notoginseng and small Rhododendron are the minister drugs for activating blood and dispelling wind; Radix Paeoniae Rubra and Allium macrostemon are the auxiliary drugs for clearing heat and cooling blood and for dredging yang and resolving stasis; and Glycyrrhiza uralensis is the ministerial drug for regulating all drugs. The traditional Chinese medicine preparation has the functions of tonifying qi, activating blood, dredging collaterals and relieving pain, and has the effects of improving blood circulation, regulating blood fat and preventing blood stasis, thereby providing important guiding significance for the treatment of coronary heart disease and the development of drugs.

The invention relates to application of a qi-regulating and blood-activating preparation in a medicine for preventing or treating altitude stress, and belongs to the technical field of medicine application. The qi-regulating and blood-activating preparation is prepared by extracting and processing fructus cinnamoii, borneol, ligusticum wallichii and allium macrostemon. Experimental research shows that the qi-regulating and blood-activating preparation can effectively improve plateau hypoxia athletic ability and heart functions, can effectively improve plateau hypoxia lung tissue inflammation infiltration, reduces alveolar wall thickness, reduces lung tissue fibrosis, and reduces myocardial cell LDH release, thereby achieving the effect of effectively preventing and treating acute altitude stress.

The invention relates to application of a qi-regulating and blood-activating preparation in preparation of a medicine for preventing or treating heart failure, and belongs to the technical field of medicine application. The qi-regulating and blood-activating preparation is prepared from fructus cinnamoii, blumea balsamifera, ligusticum wallichii and allium macrostemon, and the preparation can be a dripping pill, a capsule, a tablet, a granule or a solution. Experiments show that the qi-regulating and blood-activating preparation can effectively treat heart failure, especially heart failure after myocardial infarction, and can reduce the infarction area of the heart, improve inflammatory lesion of the heart and improve myocardial fibrosis; the proliferation of myocardial cells induced by blood oxygen deprivation can be promoted, and the apoptosis of the myocardial cells can be improved. The use is convenient;

The application provides an in-vitro culture method for cultivating Allium fistulosum unpollinated ovary and application thereof, and belongs to the technical field of plant tissue culture.The method comprises the following steps: taking the intact ovary of Allium fistulosum which is not pollinated as an explant, and performing induction culture, proliferation culture and rooting culture.Through the culture of the intact ovary and the one-step induction differentiation method, the method is simple, the induction rate is high, the operability is strong, a large number of Allium fistulosum unpollinated ovary culture regenerated plants can be obtained, and breeding materials which can be applied to the selection and breeding of different Allium fistulosum types are screened out, compared with the traditional breeding method, the breeding period is greatly shortened.

The invention relates to the technical field of animal breeding, in particular to an under-forest antibiotic-free native chicken breeding method based on precise regulation and control of food and medicine homologous components, which comprises the following steps: selecting a broad-leaf mixed forest with the slope of less than or equal to 15 degrees, the pH value of 6.0-7.5, the organic matter of more than or equal to 1.5% and the annual sunshine of more than or equal to 1200 hours, dividing the broad-leaf mixed forest into three equal-area partitions, arranging a preservative bamboo isolation fence, and sowing allium macrostemon and houttuynia cordata, and performing sunshade net maintenance for 22 + / -3 days until the seedling height reaches the standard, and then performing rotation grazing and stocking. The method comprises the following steps: carrying out plant extract disinfection every day, carrying out padding micro-ecological fermentation treatment and carrying out hermetia illucens resource utilization. And the vegetation regeneration rate in the pasturing period is greater than or equal to 85%. The sick and weak chickens are fed with allium macrostemon-herba houttuyniae juice, the incidence rate of intestinal diseases is remarkably reduced, the technical pain point of traditional under-forest breeding is solved, meanwhile, a raw material replacement scheme, climate adaptation parameters and the variety adaptation range are expanded, and unification of ecological benefits, economic benefits and social benefits is achieved.

The invention provides a preparation process and a quality evaluation method of trichosanthes kirilowii maxim, allium macrostemon and pinellia ternate decoction formula granules, and relates to the technical field of medicine preparation and quality detection. The preparation process of the snakegourd fruit, allium macrostemon and pinellia ternate decoction formula granules comprises the following steps: S1, crushing snakegourd fruit, allium macrostemon and pinellia ternate to obtain a mixed medicinal material, soaking the mixed medicinal material in a solvent, decocting, refluxing and concentrating to obtain a fluid extract; s2, mixing and drying the fluid extract and auxiliary materials to obtain extract powder; s3, mixing the extract powder, auxiliary materials and a wetting agent to obtain a soft material, granulating and drying to obtain the snakegourd fruit, allium macrostemon and pinellia ternate decoction formula granules. The quality evaluation method comprises a thin-layer identification method, a fingerprint spectrum method and a content detection method. The invention provides an optimal preparation process of the trichosanthes kirilowii Maxim, allium macrostemon and pinellia ternate decoction formula granules, establishes a quality standard of the trichosanthes kirilowii Maxim, allium macrostemon and pinellia ternate decoction formula granules, and has great significance for large-scale popularization and clinical use specifications of the trichosanthes kirilowii Maxim, allium macrostemon and pinellia ternate decoction formula granules

The invention discloses a traditional Chinese medicine composition for soothing liver, regulating qi, activating yang and removing stasis. The traditional Chinese medicine composition is prepared from, by weight, 15-30 parts of radix bupleuri, 20-40 parts of trichosanthes kirilowii maxim, 15-30 parts of immature bitter orange, 15-25 parts of allium macrostemon and 15-35 parts of ginger. On the basis of deep analysis of complex pathogenesis of liver depression and phlegm stagnation, chest yang deficiency and spleen dysfunction, the invention provides the traditional Chinese medicine composition with the core treatment rule of soothing liver and regulating qi, activating yang and removing stasis and tonifying spleen and reducing phlegm, and the Chinese thorowax root is used as the monarch material to soothe liver and relieve depression and regulate qi activity; trichosanthes kirilowii maxim and immature bitter orange are used as ministerial drugs for relieving chest stuffiness, reducing phlegm, allium macrostemon is used as an assistant to activate yang and remove stasis; the ginger is used as a guide to warm middle and harmonize stomach and harmonize drug properties. The medicines cooperate to form the compatibility characteristics of soothing liver without hurting yin, reducing phlegm without helping cold, activating yang without consuming qi and tonifying spleen without nourishing greasy feeling, and the traditional Chinese medicine composition is especially suitable for complicated syndromes of phlegm, qi and deficiency mingling.

This invention provides a pharmaceutical composition for improving hyperlipidemia, comprising total alkaloids from Trichosanthes kirilowii and total saponins from Allium macrostemon. The present invention applies the combination of total alkaloids from Trichosanthes kirilowii and total saponins from Allium macrostemon to treat hyperlipidemia. In vivo models demonstrate that the total alkaloids from Trichosanthes kirilowii and total saponins from Allium macrostemon of this invention have a synergistic effect in treating hyperlipidemia.

This invention utilizes *Allium macrostemon* to obtain its aqueous extract, petroleum ether extract, dichloromethane extract, ethyl acetate extract, and n-butanol extract. The effects of these aqueous extracts and extracts of different polarities on the learning and memory functions of D-galactose-induced aging model mice were investigated using Y-maze, darkness avoidance, Morris water maze, and laser speckle cerebral blood flow assays. Reactive oxygen species (ROS), SOD, and MDA were also measured. Multiple experiments demonstrated that *Allium macrostemon* can improve memory function in mice. Furthermore, the effects of *Allium macrostemon* extract on arecoline- or oxidative tremor-induced tremor behavior in mice were studied. The results showed that *Allium macrostemon* extract can effectively shorten the duration of tremors, proposing a new application for *Allium macrostemon* extract in the preparation of drugs for the prevention and / or treatment of neurodegenerative diseases, providing broad application prospects for the treatment or adjuvant therapy of neurodegenerative diseases.

The invention relates to a carbon quantum dot prepared by taking a traditional Chinese medicine allium macrostemon as a carbon source and an application of the carbon quantum dot in cisplatin-induced acute kidney injury, and can effectively solve the problems of insufficient pertinence of existing support treatment and limitation of lack of effective long-term intervention means. The obtained CQDs can be used for in-vivo intervention to reduce the levels of renal injury markers and proinflammatory factors in an AKI state and inhibit phosphorylation activation of a JNK and NF-kappa B related pathway, so that cisplatin-induced renal tissue injury is relieved; meanwhile, the mitochondrial damage expression is improved on the ultrastructure level, and a certain protection effect is achieved on related glomerular structures.

The invention provides a traditional Chinese medicine composition for preparing a medicine for treating pulmonary fibrosis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for preparing the medicine for treating pulmonary fibrosis is prepared from raw materials through the steps of volatile component extraction, water-soluble component extraction, concentration and preparation, and the raw materials are prepared from, by mass, 20-40 parts of astragalus membranaceus, 20-40 parts of oldenlandia diffusa, 20-40 parts of dandelion, 15-30 parts of trichosanthes kirilowii maxim, 15-30 parts of allium macrostemon, 10-20 parts of polygonum cuspidatum and 15-25 parts of fructus perillae. , 8-16 parts of Ligusticum wallichii, and 4-10 parts of licorice. The composition plays an anti-fibrosis role by regulating immune balance, inhibiting a TGF-beta1 / Smad3 signal channel, improving microcirculation, relieving oxidative stress and the like, achieves a synergistic effect of '1 + 1gt, 2', and has a good clinical application prospect.

This invention discloses a compound traditional Chinese medicine preparation for early intervention in atherosclerotic plaques and its preparation method. The compound traditional Chinese medicine preparation comprises main ingredients and excipients. The main ingredients include a blood-activating and stasis-removing group, a phlegm-resolving and turbidity-reducing group, and a qi-tonifying and spleen-strengthening group. The blood-activating and stasis-removing group comprises the following ingredients in weight percentage: Panax notoginseng 1-3 parts, Salvia miltiorrhiza 12-18 parts, and Gentiana scabra 10-12 parts. The phlegm-resolving and turbidity-reducing group comprises the following ingredients in weight percentage: Trichosanthes kirilowii 40-25 parts, Allium macrostemon 25-15 parts, Ligusticum chuanxiong 6-12 parts, Pinellia ternata 5-8 parts, Citrus reticulata 6-12 parts, and Acorus tatarinowii 6-12 parts. The qi-tonifying and spleen-strengthening group comprises the following ingredients in weight percentage: Poria cocos 12-18 parts, Codonopsis pilosula 12-18 parts, and Glycyrrhiza uralensis 5-8 parts. The weight ratio of the blood-activating and stasis-removing group, the phlegm-resolving and turbidity-reducing group, and the qi-tonifying and spleen-strengthening group is 1-5:1-5:1-5. It has the effect of treating both phlegm and blood stasis, and can significantly stabilize vulnerable atherosclerotic plaques. It can be used to treat atherosclerotic cardiovascular diseases and has the advantages of definite curative effect, no toxic side effects, low cost, and easy promotion and application.

This invention discloses an effective medicinal and edible pill formula for restoring and nourishing the lungs, and its preparation method, belonging to the technical field of medicinal and edible pill formulas. The formula consists of dried tangerine peel, black sesame seeds, platycodon root, mulberry fruit, ginger, peach kernel, apricot kernel, radish seed, lotus leaf, jujube seed, cassia seed, fresh reed rhizome, allium macrostemon, tangerine peel, elsholtzia ciliata, monk fruit, and ginkgo. The formula is based on restoring and nourishing the lungs, starting with regulating qi and focusing on clearing the lungs. By opening the lungs and large intestine, the formula enhances the lung's descending function, dispels pathogens and strengthens the body's resistance, relieves wind and soothes the throat, thereby clearing away pathogenic heat and achieving the purpose of resolving phlegm and nodules. It is beneficial for treating cough, asthma, and repairing lung cells and eliminating nodules after yang deficiency. Furthermore, by enhancing the compatibility of the ascending herbs, a positive cycle is formed on the basis of nourishing the lungs, which in turn nourishes the skin and hair.

This invention discloses a compound traditional Chinese medicine eczema ointment and its preparation method, relating to the field of traditional Chinese medicine technology. The compound traditional Chinese medicine eczema ointment comprises the following components by weight: 5-15 parts of Acorus tatarinowii extract, 5-10 parts of Terminalia chebula extract, 5-10 parts of Gynostemma pentaphyllum extract, 5-15 parts of Paeonia lactiflora extract, 5-15 parts of Salvia miltiorrhiza extract, 1-10 parts of Allium macrostemon extract, 5-15 parts of Dictamnus dasycarpus root bark extract, 5-10 parts of Pueraria lobata extract, 5-10 parts of Astragalus membranaceus extract, 10-20 parts of Hedyotis diffusa extract, 0.1-1 part of borneol, and 300-600 parts of cream base. The compound traditional Chinese medicine eczema ointment prepared by this invention exhibits excellent antibacterial properties and stability.

This application provides a formula for invigorating qi, warming yang, and regulating the heart, and its preparation method. The formula comprises the following components in parts by weight: cinnamon twig 5-10, codonopsis root 6-14, atractylodes rhizome 5-14, salvia root 6-14, poria cocos 5-14, chuanxiong rhizome 6-14, trichosanthes fruit 5-15, allium macrostemon 6-15, and red peony root 5-10. This technical solution improves exercise capacity and cardiac function.