The invention discloses a medicated food for preventing and treating atherosclerosis. The medicated food is composed of the following raw materials in parts by weight: 500 to 1000 parts of crucian, 15 to 30 parts of red sage root, 5 to 10 parts of radix astragali, 5 to 10 parts of ginger, and 12 to 24 parts of jujube. The invention further discloses a preparation method and applications of the medicated food. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, is accord with the principle on treating atherosclerosis, and is capable of treating atherosclerosis effectively. The medicated food has a good effect during the preclinical phase of atherosclerosis, is capable of well preventing and treating coronary atherosclerotic cardiopathy, carotid atherosclerosis, renal atherosclerosis, and the like, and can be used to assist the therapy. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, has the advantages of fresh and delicious taste, rich nutrients, simple preparation, and low cost, is suitable for large-scale promotion and application, and has a good medical prospect.