The invention discloses an open-pore structure biomedical zinc material with aperture gradient distribution and a preparation method thereof. The material is pure zinc or zinc alloy, wherein open pores which are mutually communicated in the surface and the inner part of the material, and the inner diameters of the open pores are in gradient distribution along an axial direction or a radial direction; the preparation method comprises the following steps: (1) preparing a pore-forming particulate matter, and dividing into macropore, mesopore and micropore particles according to particle size; (2)filling a graphite crucible with the particles, and arranging according to a needed shape and open-pore distribution manner; (3) putting a weight on the particles, and sintering to obtain a preform;(4) putting pure zinc or zinc alloy to replace the weight, vacuum melting, and enabling melt to flow into a gap; (5) introducing argon, and performing pressurized percolation; (6) removing the preformcomponent in a complex. According to the zinc material, the open pores thereof are of a mutually communicated structure, the porosity, aperture, open-pore shape and product corrosion rate are controllable, and the zinc material with layered gradient distribution and radial gradient distribution of aperture is hardly free of pore obturation and pore forming agent residual phenomena.